Hematology Disease Topics & Pathways:
Research, Fundamental Science, MPN, Translational Research, CHIP, genomics, CML, hematopoiesis, Chronic Myeloid Malignancies, Diseases, Biological Processes, Myeloid Malignancies, pathogenesis, Maternal Health
Dr. Anindita Roy will speak about how childhood leukemias, especially those in infants, originate before birth. In this talk she will highlight the importance of fetal specific progenitors and their molecular programs in human hematopoiesis, and how they determine the biology of MLL-AF4+ infant acute lymphoblastic leukemia. She will also explore whether it is possible to use this information to understand the origins and refractory nature of infant leukemia, with the aim of developing better therapeutic strategies.
Dr. Jyoti Nangalia will discuss how adult blood cancers and clonal expansions can also originate in childhood, including before birth. She will highlight what factors might determine their long clonal trajectories such that disease occurs many decades later. She will explore what is known about clonal trajectories across blood cancers and potential opportunities for earlier detection and interventional strategies.