Haojie Dong, PhD^1*, Xin He, MD^2*, Lei Zhang, MD¹, Wei Chen, PhD^3*, Yichun Lin, MS^4*, Songbai Liu, PhD^5*, Huafeng Wang, M.D.^6*, Wenfeng Huang, MS^1*, Sierra Min Li, PhD^7*, Yinghui Zhu, PhD^8*, Dandan Zhao, MD^1*, Lucy Ghoda, PhD^9*, Rui Su, PhD¹⁰, Jianjun Chen, PhD¹⁰, Ritin Sharma^11,12*, Patrick Pirrotte, PhD^11,12*, Xiwei Wu, PhD^3*, Weidong Hu, PhD^13*, Weidong Han^14*, Binghui Shen, PhD^15*, Ya-Huei Kuo, PhD¹, Jie Jin, M.D., Ph.D.⁶, Amandeep Salhotra, MD¹⁶, Jeffrey Wang, PhD^4*, Guido Marcucci, MD^16,17, Yun Luo, PhD^4* and Ling Li, PhD¹⁸

¹Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
²Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope National Medical Center, Monrovia, CA
³Integrative Genomics Core, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
⁴Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA
⁵Suzhou Key Laboratory of Medical Biotechnology, Suzhou Vocational Health College, Suzhou, China
⁶Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China, Hangzhou, China
⁷Department of Information Sciences, City of Hope Medical Center, Duarte
⁸Department of Hematologic Malignancies Translational Science, Beckman Research Institute, City of Hope, Duarte, CA
⁹Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematology Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope, Duarte, CA
¹⁰Department of Systems Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
¹¹AIntegrated Mass Spectrometry Shared Resource, City of Hope Comprehensive Cancer Center, Duarte, CA
¹²Cancer & Cell Biology Division, The Translational Genomics Research Institute, Phoenix, AZ
¹³Department of Immunology & Theranostics, City of Hope National Medical Center, DUARTE, CA
¹⁴Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
¹⁵Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope, Duarte, CA
¹⁶Department of Hematology and HCT, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
¹⁷Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA
¹⁸Department of Hematology/HCT, City of Hope National Medical Center, Duarte, CA

Jonathan Scott Rink, PhD^1,2*, Stephen E Henrich, PhD^1*, Alexandra Moxley^3*, Xu Hannah Zhang, PhD⁴, Xiwei Wu, PhD^5*, SonBinh Nguyen, Ph.D.^6*, Christiane Querfeld, MD, PhD⁷, David A Horne, PhD^8*, Steve T Rosen, MD⁹, Leo I. Gordon, MD², Colby Shad Thaxton, MD, PhD^10* and Adam Yuh Lin, MD, PhD²

¹Simpson Querrey Institute for Bionanotechnology, Northwestern University, Chicago, IL
²Department of Medicine, Division of Hematology/Oncology and the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Northwestern University Feinberg School of Medicine, Chicago, IL
³Northwestern University, Feinberg School of Medicine, Chicago, IL
⁴Department of Hematology & Hematopoietic Cell Transplantation, City of Hope, Duarte, CA
⁵Department of Molecular and Cellular Biology, City of Hope, Duarte, CA
⁶Northwestern University, Evanston, IL
⁷Division of Dermatology, City of Hope, Duarte, CA
⁸Department of Molecular Medicine, Beckman Research Institute, City of Hope, Duarte, CA
⁹City of Hope Medical Center, Duarte, CA
¹⁰International Institute for Nanotechnology, Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL

Constanze Schneider, PhD^1,2*, Hermes Spaink^1,2*, Gabriela Alexe, PhD^1,2*, Neekesh V Dharia, MD, PhD^1,2*, Ashleigh Meyer^1*, Delan Khalid^1*, Sebastian Scheich, MD^3,4*, Björn Häupl, PhD^5,6*, Louis M. Staudt, MD, PhD⁴, Thomas Oellerich, MD^3,5* and Kimberly Stegmaier, MD^1,2

¹Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA
²Broad Institute of MIT and Harvard, Cambridge, MA
³Department of Medicine II, Department for Hematology/Oncology, Goethe University Frankfurt, Frankfurt am Main, Germany
⁴Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD
⁵German Cancer Research Center and German Cancer Consortium, Heidelberg, Germany
⁶Department of Medicine II, Hematology and Oncology, University Hospital Frankfurt, Goethe-University, Frankfurt, Germany

Fiorella Charles Cano^1*, Arnold Kloos, PhD^1*, Rucha Yeshwanta Hebalkar, M.Sc.^2*, Razif Gabdoulline, PhD^3*, Thomas Fangmann^1*, Yosef Landesman, PhD^4*, Konstanze Döhner, MD⁵, Halyna R Shcherbata, PhD^2*, Arnold Ganser, MD^3* and Michael Heuser, MD¹

¹Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
²Institute of Cell Biochemistry, Hannover Medical School, Hanover, Germany
³Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hanover, Germany
⁴Karyopharm Therapeutics Inc., Newton, MA
⁵Division of Hematology and Oncology, University Hospital Ulm, Ulm, Germany

Jianli Zhou^1*, Aditya Kulkarni, Ph.D.^1*, Cassandra Love², Lanie Happ^3*, Drew Sturtevant, Ph.D.^1*, Neha Biyani, Ph.D.^1*, Raniero L. Peru y Colón De Portugal, Ph.D.^1*, Kishor Bhatia, Ph.D.^1* and Sandeep S. Dave, MD, MS⁴

¹Lantern Pharma Inc., Dallas, TX
²Duke University Medical Center, Durham, NC
³Data Drive Biosciences, Durham, NC
⁴Duke Cancer Institute, Duke University, Durham, NC

Xinguo Liu, PhD^1*, Yubo Zhou^2*, Yizhe Wu^1*, Xiaomin Luo^2*, Jiangfeng Xie^1*, Xinxin Jin^1*, Haiyan Yang, PhD³, Li Jia^2* and Xinglu Zhou^1*

¹Hangzhou HealZen Therapeutics Co., Ltd., Hangzhou, China
²Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
³Department of Lymphoma, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, China

Maura Lima Pereira Bueno, undergraduate^1*, Leonardo Artico^2*, Adriana Silva Santos Duarte, Ph.D.^1*, Audrey Basso, M.Sc.^3*, Jose Andres Yunes, Ph.D.^2*, Sara T Olalla Saad, MD, Ph.D.⁴ and Fernanda Marconi Roversi, PhD^1*

¹Hematology and Transfusion Medicine Center- University of Campinas/Hemocentro-UNICAMP, Campinas, São Paulo, Brazil
²Boldrini Children’s Center, Campinas, SP, Brasil, Campinas, Brazil
³Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil
⁴Hematology and Transfusion Medicine Center-University of Campinas/Hemocentro-UNICAMP,, UNICAMP, Campinas, Brazil

Marta M. Szmyra^1*, Sandra Haingartner^1*, Sonja Jantscher^1*, Katrin Pansy^1*, Barbara Uhl^1*, Hildegard T. Greinix, MD¹, Peter Neumeister, MD^1*, Eva Bernhart^2*, Christine Beham-Schmid^3*, Michael A. Dengler^4*, Burkhard Klösch^5* and Alexander J.A. Deutsch^1*

¹Division of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
²Division of Molecular Biology and Biochemistry, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria
³Institute of Pathology, Medical University of Graz, Graz, Austria
⁴Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
⁵Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Graz, Austria

Chi-Yang Tseng¹, Yu-Hsuan Fu, M.S.^1,2*, Ang-Chu Huang, M.S.^1*, Da-Liang Ou, PhD^3*, Ching-Ying Kuo, Ph.D.^1* and Liang-In Lin, PhD¹

¹Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan
²Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
³Department of Oncology, National Taiwan University, Taipei, Taiwan

John Dalloul^1,2*, Minyoung Youn, Ph.D.^3*, Kailen Mark^3*, Alexander Powers^1,4*, Ron Dror, Ph.D.^1*, Soichi Wakatsuki, Ph.D.^5,6* and Kathleen M. Sakamoto, MD, PhD³

¹Department of Computer Science, Stanford University, Stanford
²Department of Bioengineering, Stanford University, Stanford, CA
³Department of Pediatrics, Stanford University School of Medicine, Stanford, CA
⁴Department of Chemistry, Stanford University, Stanford
⁵BioSciences Division, SLAC National Accelerator Laboratory, Menlo Park
⁶Department of Structural Biology, Stanford University School of Medicine, Stanford

Sean M Post, PhD¹, Lauren E Chan^2*, Xiaorui Zhang, MS^2*, Oscar Benitez^2*, Kerstin Rahn^3*, Todd Link, PhD^4*, Clifford Stephan^5*, Eun Cho, PhD^6*, Kevin Dalby^6* and Prerna Malaney, BPharm, MS, PhD^7*

¹Department of Leukemia, MD Anderson, Houston, TX
²MD Anderson, Houston
³Department of Intensive Care Medicine, University Hospital RWTH Aachen University, Aachen, Germany
⁴Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX
⁶UT Austin, Austin
⁷Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

Haixiang Yu, PhD¹, Juliana Layzer, MS^1*, Sriram Krishnaswamy, PhD² and Bruce A. Sullenger, PhD^1*

¹Department of Surgery, Duke University Medical Center, Durham, NC
²Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA

Jian-Ming LI, PhD^1,2*, Tenzin Passang^3*, Pankoj Kumar Das^3*, Shuhua Wang, MD^4*, Anish Sen-Majumdar, Ph.D.^5*, Nikolaos Papadantoonakis, MD^6*, Cynthia R. Giver, PhD⁷ and Edmund K. Waller, MD, PhD^2,8

¹Winship Cancer Inst. Emory University, Atlanta, GA
²Winship Cancer Institute, Emory University, Atlanta, GA
³Winship Cancer Institute Department of Hematology and Medical Oncology, Emory University, Atlanta, GA
⁴Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Decatur, GA
⁵Cambium Oncology, Atlanta, GA
⁶Winship Cancer Institute, Hematology/Medical Oncology, Emory University, Atlanta, GA
⁷Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA
⁸Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA

Manickam Alagar, Ph.D^1*, Biaoru Li, MD, PhD¹, Santhosh Vadivelu^2*, Robert Schaub^3*, Chithra D Palani, PhD¹ and Betty S. Pace, MD^4,5

¹Department of Pediatrics, Augusta University, Augusta, GA
²AkiraBio Inc.,, Wellesley, MA
³AkiraBio Inc.,, Wellesley,, MA
⁴Department of Pediatrics, Division of Hematology/Oncology, Augusta University, Augusta, GA
⁵Georgia Cancer Center, Augusta University, Augusta, GA