Alena Sophie Ehrmann, MSc^1,2*, Miguel Quijada Álamo, PhD^3*, Viola Close, PhD^1*, Min Guo^4*, Claudia Pérez Carretero, MSc, BSc^3*, Luis A Corchete, PhD^3*, Eugen Tausch, MD^1*, Christof Schneider, MD^1*, Hartmut Döhner, MD¹, Stephan Stilgenbauer, MD¹, Franz Oswald, PhD^4*, Jesús María Hernández-Rivas, MD, PhD³ and Daniel Mertens, PhD^1,2*

¹Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany
²"Mechanisms of Leukemogenesis", German Cancer Research Center (DKFZ), Heidelberg, Germany
³Department of Medicine, University Hospital of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center, University of Salamanca, Salamanca, Spain
⁴Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany

Federico Pozzo, PhD^1*, Gabriela Forestieri^2*, Giulia Ianna^1*, Filippo Vit, PhD^1*, Erika Tissino, PhD^1*, Tamara Bittolo, PhD^1*, Lodovico Terzi Di Bergamo^2*, Roberta Laureana, MD^3*, Agostino Tafuri⁴, Annalisa Chiarenza^5*, Francesco Di Raimondo, MD⁵, Jacopo Olivieri, MD^6*, Francesco Zaja, MD^7*, Luca Laurenti, MD^8*, Maria Ilaria Del Principe, MD^3*, Riccardo Bomben, PhD^1*, Antonella Zucchetto, PhD^1*, Davide Rossi, MD, PhD² and Valter Gattei, MD¹

¹Clinical and Experimental Onco-Hematology Unit, Centro Di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
²Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
³Ematologia, Dipartimento di Biomedicina e Prevenzione, Università degli studi di Roma Tor Vergata, Roma, Italy
⁴University Hospital Sant'Andrea-Sapienza, Rome, Italy
⁵Divisione di Ematologia, Ospedale Ferrarotto, A.O.U. Policlinico-OVE, Università di Catania, Catania, Italy
⁶SOC Clinica Ematologica, Azienda Sanitaria Universitaria Friuli Centrale (ASU FC), Udine, Italy
⁷Institute of Hematology, University and Hospital of Trieste, Trieste, Italy
⁸Istituto di Ematologia, Fondazione Policlinico Universitario A. Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy

Claudia Pérez Carretero, MSc, BSc^1*, Miguel Quijada Álamo, PhD^2,3*, Mariana Tannoury^4*, Léa Dehgane^4*, David J. Sanz^5*, Teresa González, PhD^6*, Rocio Benito, PhD^5*, Elise Chapiro, MD, PhD^7*, Maria Hernandez-Sanchez, PhD^5,8*, Ana E. Rodriguez, PhD^5*, Florence Nguyen Khac^9*, Santos A. Susin^4* and Jesús María Hernández-Rivas, MD, PhD^10,11,12

¹Department of Medicine, University Hospital of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center, University of Salamanca, Salamanca, Spain
²Department of Hematology, University Hospital of Salamanca, Salamanca, Spain
³Universidad de Salamanca, IBSAL, Centro de Investigación del Cáncer, IBMCC-CSIC, Salamanca, Spain
⁴Drug Resistance in Hematological Malignancies, Centre de Recherche des Cordeliers, UMRS 1138, INSERM, Sorbonne Université, Université Paris Cité, Paris, France
⁵University of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center, Salamanca, Spain
⁶Unidad de Diagnóstico Molecular y Celular del Cáncer, Centro de Investigación del Cáncer-Universidad de Salamanca (IBMCC, USAL-CSIC); Genética Molecular en Oncohematología, Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain
⁷Laboratory of Hematology, Hopital Pitie-Salpetriere, UPMC Paris 6, INSERMU1138, Paris, France
⁸Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain
⁹Cell Death and Drug Resistance in Hematological Malignancies, Centre de Recherche des Cordeliers, UMRS 1138, INSERM, Sorbonne Université, Université Paris Cité; Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France
¹⁰Hematology Department, University Hospital of Salamanca, Salamanca, Spain
¹¹Cancer Research Center (IBMCC) CSIC, University of Salamanca, Salamanca, Spain
¹²Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain

Lavinia Arseni, PhD^1*, Gianluca Sigismondo, PhD^2*, Johanne U Hermansen^3,4*, Sigrid S Skånland, PhD^3,4*, Eugen Tausch, MD⁵, Stephan Stilgenbauer, MD⁵, Jeroen Krijgsveld, PhD^2*, Peter Lichter, PhD^1*, Marc Zapatka, PhD^1* and Martina Seiffert, PhD^1*

¹Molecular Genetics, German Cancer Research Center, Heidelberg, Germany
²Proteomics of Stem Cells and Cancer, German Cancer Research Center, Heidelberg, Germany
³Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway
⁴K. G. Jebsen Centre for B Cell Malignancies, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
⁵Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany

Laura Polcik^1,2*, Svenja Dannewitz Prosseda, PhD^1*, Chingiz Underbayev, MD, PhD³, Geoffroy Andrieux, PhD^4,5*, Lixia Li, PhD^1*, Danielle-Justine Danner^1*, Driti Ashok^1,2*, Sandra Kissel, MTA^1*, Sara Parsa, PhD^6*, Natalie Koehler, PhD^1,7*, Melanie Börries, PhD^4,5*, Justus Duyster^1*, Elena Bibikova, PhD^6*, Adrian Wiestner, MD^8,9 and Tanja Nicole Hartmann, PhD¹

¹Department of Internal Medicine I, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany
²Faculty of Biology, University of Freiburg, Freiburg, Germany
³Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
⁴Institute of Medical Bioinformatics and Systems Medicine, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany
⁵German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany
⁶AstraZeneca, South San Francisco, CA
⁷CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany
⁸Hematology Branch, National Heart, Lung, and Blood Institute, NIH, NHLBI, Bethesda, MD
⁹Laboratory of Lymphoid Malignancies, Hematology Branch, NHLBI, NIH, Bethesda, MD

Francesca Cuturello, PhD^1*, Federico Pozzo, PhD^2*, Edith Natalia Villegas Garcia, MSc^1*, Francesca Maria Rossi, PhD^2*, Massimo Degan, MD^2*, Paola Nanni, MSc^2*, Ilaria Cattarossi, MSc^2*, Eva Zaina, BSc^2*, Paola Varaschin, BSc^2*, Alessandra Braida, MSc^2*, Michele Berton, MSc^2*, Laura Zannier, BSc^2*, Filippo Vit, PhD^2*, Erika Tissino, PhD^2*, Tamara Bittolo, PhD^2*, Roberta Laureana, MD^3*, Giovanni D'Arena, MD⁴, Luca Laurenti, MD^5*, Agostino Tafuri⁶, Jacopo Olivieri, MD^7*, Francesco Zaja, MD^8*, Annalisa Chiarenza^9*, Maria Ilaria Del Principe, MD^3*, Riccardo Bomben, PhD^2*, Antonella Zucchetto, PhD^2*, Stefano Cozzini^1*, Alessio Ansuini, PhD^1*, Alberto Cazzaniga, PhD^1* and Valter Gattei, MD²

¹Area Science Park, Trieste, Italy
²Clinical and Experimental Onco-Hematology Unit, Centro Di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
³Ematologia, Dipartimento di Biomedicina e Prevenzione, Università degli studi di Roma Tor Vergata, Roma, Italy
⁴Hematology Service, San Luca Hospital, Vallo Della Lucania, Italy
⁵Istituto di Ematologia, Fondazione Policlinico Universitario A. Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy
⁶University Hospital Sant'Andrea-Sapienza, Rome, Italy
⁷SOC Clinica Ematologica, Azienda Sanitaria Universitaria Friuli Centrale (ASU FC), Udine, Italy
⁸Institute of Hematology, University and Hospital of Trieste, Trieste, Italy
⁹Divisione di Ematologia, Ospedale Ferrarotto, A.O.U. Policlinico-OVE, Università di Catania, Catania, Italy

Miguel Quijada Álamo, PhD^1*, Laura Z. Rassenti, PhD², Emanuela M. Ghia, PhD³, Tuan Tran^3*, Monica Spydell^3*, Elsa Molina, PhD^4*, Claudia Pérez Carretero, MSc, BSc^1*, Luis A. Corchete, PhD^1*, Teresa González, PhD^1*, Jesús María Hernández-Rivas, MD, PhD¹ and Thomas J. Kipps, MD, PhD³

¹Department of Medicine, University Hospital of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center, University of Salamanca, Salamanca, Spain
²Moores Cancer Center, University of California, San Diego, La Jolla, CA
³Center for Novel Therapeutics, Moores Cancer Center, University of California, San Diego, La Jolla, CA
⁴Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA

Maria-Veronica Teleanu, MD^1*, Karlheinz Holzmann, Dr.^2* and Jennifer Edelmann^3,4,5*

¹Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT), Heidelberg, Germany
²Genomics Core Facility, Ulm University, Ulm, Germany
³Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
⁴Alb Fils Hospital, Göppingen, Germany
⁵Ulm University Hospital, Ulm, Germany

Huayuan Zhu^1,2,3*, Yeqin Sha^1,2,3*, Yi Miao^1,2,3*, Shuchao Qin^1,2,3, Wei Wu^1,2,3*, Yi Xia^1,2,3*, Tonglu Qiu^1,2,3*, Li Wang^1,2,3*, Lei Fan^1,2,3*, Wei Xu^1,2,3 and Jianyong Li, MD^1,2,3

¹Pukou CLL Center, Pukou division of Jiangsu Province Hospital, Nanjing, China
²Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China
³Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing, China

Stephen Jun Fei Chong, PhD¹, Junyan Lu, PhD^2*, Rebecca Valentin, MD¹, Timothy Z. Lehmberg, BA^1*, Mary C Collins, BS^1*, Charles Herbaux¹, Carsten Utoft Niemann, MD, PhD³, Wolfgang Huber^4*, Thorsten Zenz⁵ and Matthew S. Davids, MD¹

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
²Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, Germany
³Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
⁴EMBL, Heidelberg, DEU
⁵Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, BW, Switzerland

Jennifer E. Bruno, BS^1*, Christine A. Herne, PhD^2*, Andrea M Baran, MS^3*, Karl R. VanDerMeid, BS^2*, Paul M. Barr, MD², Alyssa R. Williams, BS^2*, Sally A. Quataert, PhD^1*, Clive S. Zent, MD² and Charles C. Chu, PhD²

¹Department of Microbiology and Immunology, Center for Vaccine Biology & Immunology, and Human Immunology Center, University of Rochester Medical Center, Rochester, NY
²Wilmot Cancer Institute, Department of Medicine, University of Rochester Medical Center, Rochester, NY
³Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY

Vicente Chapaprieta^1*, Alba Maiques-Diaz^2*, Guillem Clot, PhD^2,3*, Ferran Nadeu, PhD^2,3*, Judith Mateos-Jaimez^2*, Anna Vidal, PhD^2*, Stella Charalampopoulou^2*, Martí Duran-Ferrer^2,3*, Romina Royo^4*, Junyan Lu^5,6*, Thorsten Zenz^7,8, Julio Delgado, MD^3,9,10, Armando Lopez-Guillermo, MD^2,3,11, Elías Campo, PhD MD^3,12,13,14 and José I. Martín-Subero, PhD^2,3,15,16*

¹Oncology and haematology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, AL, Spain
²Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
³Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain
⁴Barcelona Supercomputing Center (BSC), Barcelona, Spain
⁵Molecular Medicine Partnership Unit (MMPU), Heidelberg, Germany
⁶European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
⁷Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, BW, Switzerland
⁸Department of Medical Oncology and Hematology, University Hospital and University of Zürich, Zürich, Switzerland
⁹Hospital Clinic, Barcelona, Spain
¹⁰Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
¹¹Hospital Clínic of Barcelona, Barcelona, Spain
¹²Hospital Clínic de Barcelona, Barcelona, Spain
¹³IDIBAPS, Barcelona, Spain
¹⁴Institut d'Investigacions Biomèdiques August Pi i Sunyer, Departamento De Fundamentos Clínicos, Universitat De Barcelona, Barcelona, Spain
¹⁵Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
¹⁶Departament de Fonaments Clínics, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain

Xiao J. Yan, MD, PhD¹, Florencia Palacios, PhD^1*, Shih-Shih Chen, PhD¹, Wentian Li, PhD^2*, Joanna M. Rhodes, MD, MSCE¹, Jacqueline C. Barrientos, MD, MS¹, Steven L Allen, MD¹, Jonathan E. Kolitz, MD¹, Kanti R Rai, MD¹ and Nicholas Chiorazzi, MD¹

¹Karches Center for Oncology Research, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY
²The Robert S. Boas Center for Genomics & Human Genetics, The Feinstein Institute for Medical Research, Manhasset