Mark Bishton, PhD, MBChB¹, Corinna Woestmann^2*, Franck Morschhauser, MD, PhD^3*, Toby A. Eyre, MBChB, DipMedEd, MRCP, FRCPath, MD^4*, Maria Shin^5*, Aaron Schroeder^6*, Anton Belousov^7*, Haocheng Li^8*, Andrea Knapp^7*, Michael C. Wei⁶, Enkhtsetseg Purev^6* and Alessia Bottos^7*

¹Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom
²Roche Sequencing Solutions, Inc., Potsdam, Germany
³University of Lille, CHU Lille, Lille, France
⁴Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
⁵Roche Molecular Systems, Inc., Pleasanton, CA
⁶Genentech, Inc., South San Francisco, CA
⁷F. Hoffmann-La Roche, Ltd., Basel, Switzerland
⁸Hoffmann-La Roche Ltd, Mississauga, ON, Canada

Ellie Ivanova, PhD^1*, Cosmin A Tegla, MD², Ekaterina Novikova^1*, Alberto M Herrera, MS^3*, Briana Mullins, MS^1*, Jo-Ann Latkowski^4*, Kenneth B. Hymes, MD², Joyoti Dey, Ph.D.^5*, Bin Yang, Ph.D.^5*, Ashwin Gollerkeri, MD^6*, Jared Gollob, PhD, MD^7* and Sergei B. Koralov, PhD^3*

¹NYU School of Medicine, New York
²Perlmutter Cancer Center at NYU Langone Health, New York University School of Medicine, New York, NY
³Department of Pathology, New York University School of Medicine, New York, NY
⁴New York University School of Medicine, New York, NY
⁵Kymera Therapeutics, Watertown, MA
⁶Kymera Therapeutics, Lexington, MA
⁷Kymera Therapeutics, Cambridge, MA

Ilja Kalashnikov, MD^1*, Marja-Liisa Karjalainen-Lindsberg, MD, PhD^2*, Panu Kovanen, MD, PhD^2*, Johannes Dunkel^2*, Annika Pasanen, MD, PhD^1*, Rachel Kositsky, BS^3*, Sarah L. Ondrejka, DO^4*, Eric D. Hsi, MD^4,5, Andrew G Evans, MD, PhD⁶, Mette Ø Pedersen, MD PhD^7*, Peter H. Norgaard, MD, PhD⁷, Anne Ortved Gang, MD PhD^7*, Magdalena Czader, MD, PhD⁸, Jiehao Zhou, MD^8*, Mina L Xu, MD^9*, Nathan Paulson^10*, Ridas Juskevicius, MD^11*, Yasodha Natkunam, MD, PhD^12,13, Abner Louissaint Jr., MD, PhD¹⁴, Haley Martin^14*, Elizabeth Thacker^15*, Cassandra Love³, Shari Tian^3*, Choon Kiat Ong, PhD¹⁶, Chee Leong Cheng, FRCPA, FRCPath, MBBS^16*, Chad M. McCall, MD, PhD^3*, Jean L. Koff, MD, MSc¹⁷, Sheren F. Younes, MD, PhD^13*, Mary Ann Arildsen, MD, PHD^11*, Jennifer R Chapman-Fredricks, MD^18*, Catalina Amador, MD^18*, Yuri Fedoriw, MD^19*, Carla Casulo, MD⁶, Amy Chadburn, MD²⁰, Payal Sojitra, MD^21*, Amir Behdad, MD^22*, Eric Tse, MBBS, PhD, FRCP, FRCPath²³, Kikkeri N Naresh, MD, MBBS²⁴, C. Cameron Yin, MD, PhD²⁵, Rashmi S. Goswami, MD, PhD^26*, Sandeep Dave^3* and Sirpa Leppa, MD, PhD¹

¹University of Helsinki and Helsinki University Hospital, Helsinki, Finland
²Helsinki University Hospital, Helsinki, Finland
³Duke University Medical Center, Durham, NC
⁴Cleveland Clinic, Cleveland, OH
⁵Wake Forest Baptist Medical Center, Winston Salem, NC
⁶University of Rochester Medical Center, Rochester, NY
⁷Copenhagen University Hospital, Herlev, Denmark
⁸Indiana University, Indianapolis, IN
⁹Yale University School of Medicine and Yale Cancer Center, New Haven, CT
¹⁰Yale University School of Medicine, New Haven, CT
¹¹Vanderbilt University Medical Center, Nashville, TN
¹²Stanford University Medical Center, Stanford, CA
¹³Stanford University School of Medicine, Stanford, CA
¹⁴Massachusetts General Hospital, Boston, MA
¹⁵Data Drive Biosciences, Durham, NC
¹⁶National Cancer Centre Singapore, Singapore, Singapore
¹⁷Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA
¹⁸University of Miami Miller School of Medicine, Miami, FL
¹⁹Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
²⁰Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY
²¹Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ
²²Northwestern University Feinberg School of Medicine, Chicago, IL
²³Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong
²⁴Fred Hutchinson Cancer Center, Seattle, WA
²⁵The University of Texas MD Anderson Cancer Center, Houston, TX
²⁶Sunnybrook Health Sciences Centre, Toronto, ON, Canada

Joshua D Brandstadter, MD, PhD, MSc¹, Angelina De Martin^2*, Mechthild Lϋetge^2*, Antonio Ferreira, PhD^3*, Brian T. Gaudette, PhD^4*, Michael Gonzalez, PhD^5*, Yves Stanossek, MD^2*, Edward Camiolo^6*, Gerald Wertheim, MD, PhD⁷, David Allman, PhD^4*, David C Fajgenbaum, MD, MBA, MSc⁵, Jon C. Aster, MD, PhD³, Burkhard Ludewig, PhD^2* and Ivan Maillard, MD, PhD⁸

¹Division of Hematology and Oncology, Abramson Cancer Center University of Pennsylvania, SWARTHMORE, PA
²Institute of Immunobiology, Kantonsspital St. Gallen, St Gallen, Switzerland
³Brigham and Women's Hospital, Boston, MA
⁴Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA
⁵Center for Cytokine Storm Treatment & Laboratory, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
⁶Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA
⁷Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA
⁸Division of Hematology and Oncology, Abramson Cancer Center University of Pennsylvania, Philadelphia, PA

Alexander Xu, PhD¹, Tomohiro Aoki, MD, PhD^2,3, Aixiang Jiang, MSc^2,3*, Alicia Gamboa^1*, Anthony R. Colombo, MS^1,4*, Christian Steidl, MD^2,3 and Akil Merchant, MD¹

¹Cedars-Sinai Medical Center, Los Angeles, CA
²Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada
³Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
⁴Keck School of Medicine of University of Southern California, Los Angeles, CA

Giovanni Manfredi Assanto^1*, Alice Di Rocco, MD^2*, Francesco Malfona, MD^3*, Marcello Capriata, MD^4*, Ilaria Del Giudice, MD, PhD^5*, Luigi Petrucci, MD^6*, Paola Girardi^7*, Gianna Maria D'elia, MD^1*, Maurizio Martelli, MD^8*, Giuseppe Gentile, MD^4*, Alessandra Micozzi, MD^9* and Alessandro Pulsoni^10*

¹Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
²Unit of Hematology, Azienda Ospedaliero-Universitaria Policlinico Umberto I, Roma, Italy
³Hematology, Department of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, AL, Italy
⁴Hematology department of translational and precision medicine, Sapienza University of Rome, Rome, Italy
⁵'Sapienza' University, Hematology, Department of Translational and Precision Medicine, Rome, Italy
⁶Hematology, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy
⁷Sapienza University of Rome, Hematology, department of translational and precision medicine, Rome, ITA
⁸Hematology, Department of Translational and Precision Medicine, Azienda Ospedaliera Policlinico Umberto I, Sapienza University of Rome, Rome, Italy
⁹Hematology, department of Translational and Precision Medicine, Sapienza University of Rome, Rome, ITA
¹⁰Sapienza University of Rome, Rome, Italy

Matias Autio^1,2*, Suvi-Katri Leivonen, PhD^1,2, Oscar Brück, MD, PhD^3,4*, Marja-Liisa Karjalainen-Lindsberg, MD, PhD^5*, Teijo Pellinen, PhD^6* and Sirpa Leppa, MD, PhD^1,2

¹Department of Oncology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
²Research Programs Unit, Applied Tumor Genomics, Faculty of Medicine, University of Helsinki, Helsinki, Finland
³Hematoscope Lab, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
⁴Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
⁵Helsinki University Hospital, Helsinki, Finland
⁶Institute for Molecular Medicine Finland, Helsinki, Finland

Sary El Daker, PhD^1*, Jeeyeon Baik^2*, Ahmet Dogan, MD, PhD², Menglei Zhu, MD, PhD^2*, Mikhail Roshal, MD² and Pallavi K Galera, MBBS²

¹Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
²Department of Pathology and Laboratory Medicine, Hematopathology Service, Memorial Sloan Kettering Cancer Center, New York, NY

Marjukka Pollari, MD, PhD^1,2*, Matias Autio^1,3*, Oscar Brück, MD, PhD^4*, Teijo Pellinen, PhD^5*, Suvi-Katri Leivonen, PhD^1,3 and Sirpa Leppa, MD, PhD^3,6

¹Research Program Unit, Applied Tumor Genomics Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland
²Department of Oncology, Tampere University Hospital, Tampere, Finland
³Department of Oncology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
⁴Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
⁵Institute for Molecular Medicine Finland, Helsinki, Finland
⁶Research Programs Unit, Applied Tumor Genomics, Faculty of Medicine, University of Helsinki, Helsinki, Finland

Binu Kandathilparambil Sasi, PhD¹, Stephen P. Martindale^2*, Samantha J. Shupe, BS^2*, Stacey M. Fernandes, BS^2*, Saurabh Yadav, PhD^1*, John-Hanson Machado^1*, Tycel Phillips, MD^3*, Andrew D. Zelenetz, MD, PhD^4,5 and Jennifer R. Brown, MD, PhD⁶

¹Department of Medical Oncology, Dana-Farber Cancer Institute/Harvard Medical School, Boston, MA
²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
³Department of Medicine, University of Michigan, Ann Arbor, MI
⁴Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York
⁵Weill Cornell Medicine, New York, NY
⁶Chronic Lymphocytic Leukemia Center, Department of Medical Oncology, Dana-Farber Cancer Institute/Harvard Medical School, Boston, MA

Gregoire Martin De Fremont^1*, Anthony Vanjak^2*, Zineb Sbihi^3*, Silene Knapp^2*, Margaux Garzaro^2*, Marwa Chbihi^2*, Benjamin Fournier^4*, Justine Poirot^5*, Antoine Dossier, M.D^3*, Juliette Villemonteix^2*, Veronique Meignin^6*, Lionel Galicier, MD^7*, Rémi Bertinchamp^8*, Jérôme Le Goff, PharmD, PhD^9*, Maud Salmona^10*, Edouard Flamarion^11*, Charles Cassius^12*, Céleste Lebbé^13*, Anne Marie Ronchetti^14*, Sylvain Latour^15*, Guislaine Carcelain, MD, PhD^3*, Eric Oksenhendler^8,16* and David Boutboul, MD, PhD^17,18*

¹INSERM U976 HIPI, équipe INSIGHT, Institut de Recherche Saint Louis, Université de Paris Cité, Paris, France, Hopital Saint-Louis, Paris, FRA
²INSERM U976 HIPI, équipe INSIGHT, Institut de Recherche Saint Louis, Université de Paris Cité, Paris, France, Hopital Saint Louis, Paris, FRA
³INSERM U976 HIPI, équipe INSIGHT, Institut de Recherche Saint Louis, Université de Paris Cité, Paris, France, Hopital Saint Louis, Paris, France
⁴Laboratory of Lymphocyte Activation and Susceptibility to EBV Infection, Institut National de la Santé et de la Recherche Médicale UMR 1163, Imagine Institute ; Université de Paris Cité Paris, France, Institut Imagine, Paris, FRA
⁵INSERM U976 HIPI, Institut de Recherche Saint Louis, Université de Paris Cité, Paris, France, Hopital Saint-Louis, Paris, FRA
⁶APHP, Hopital Saint-Louis, Anatomo-pathologie, PARIS, France
⁷Department of Clinical Immunology, Saint-Louis University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France
⁸Clinical Immunology Department, Hopital Saint Louis, Paris, France
⁹Microbiology, Saint Louis Hospital, APHP Nord Université de Paris, Paris, France
¹⁰Virology Department, Hopital Saint Louis, Paris, France
¹¹Internal Medicine Department, Hopital Européen Georges Pompidou, Paris, France
¹²Dermatology Department, Saint-Louis Hospital, Paris, FRA
¹³Dermatology Department, Hopital Saint Louis, Paris, France
¹⁴Hematology Department, Centre Hospitalier Sud Francilien, Corbeil Essonne, FRA
¹⁵Instutut IMAGINE, Hôpital Necker, Paris, France
¹⁶National Reference Center for Castleman Disease, APHP - Hôpital St Louis, Paris, France
¹⁷National Reference Center for Castleman Disease, Hôpital Saint-Louis, Paris, FRA
¹⁸INSERM U976 HIPI, équipe INSIGHT, Institut de Recherche Saint Louis, Université de Paris Cité, Paris, France, Hôpital Saint-Louis, Paris, Paris, France

Ioanna Xagoraris, MD¹, Konstantina Stathopoulou, MSc^1*, Persa Xyderou, Student^2*, Marzia Palma, MD, PhD^1*, Elias Drakos, MD, PhD^3*, Theodoros P. Vassilakopoulos, MD^4* and George Z. Rassidakis, MD, PhD^1*

¹Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden
²Department of Pathology-Oncology, Karolinska Institute, Stockholm, Sweden
³Department of Pathology, University of Crete Medical School, Heraklion Crete, Greece
⁴Department of Hematology and Bone Marrow Transplantation, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece

Lydie Debaize, PhD¹, Ye Zhang, PhD^2,3*, Adam Langenbucher^2,3*, Huiyun Liu^1*, Michelle Ramseier^4,5,6,7*, Nolawit Mulugeta^2,3*, Nezha Senhaji, PhD^1*, Robert A. Redd, MS^8*, Martin J. Aryee, PhD^6,8,9*, Alex K. Shalek, PhD^4,5,6,7*, David M. Weinstock, MD^1,6, Scott R. Manalis, PhD^2,3* and Mark A. Murakami, MD, MA, MMSc^1,10

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
²Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA
³Departments of Biological Engineering and Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA
⁴Ragon Institute of Massachusetts General Hospital (MGH), MIT and Harvard, Cambridge, MA
⁵Department of Chemistry, Institute for Medical Engineering and Science (IMES), and Koch Institute for Integrative Cancer Research, Cambridge, MA
⁶Broad Institute of MIT and Harvard, Cambridge, MA
⁷Massachusetts Institute of Technology, Cambridge, MA
⁸Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
⁹Department of Biostatistics, Harvard TH Chan School of Public Health, Boston, MA
¹⁰Department of Medicine, Harvard Medical School, Boston, MA

Côme Bommier, MD, MSc^1,2,3, Annarita Conconi, MD^4*, Emanuele Zucca, MD^5,6, Grzegorz S. Nowakowski, MD⁷, James R. Cerhan, MD, PhD^8,9, Catherine Thieblemont, MD, PhD¹⁰ and Jérôme Lambert, MD, PhD^11,12*

¹Hemato-Oncology, Assistance Publique Hôpitaux De Paris, Saint Louis Hospital, Division of, Paris, FRA
²Inserm U1153, Biostatistics department, Saint Louis Hospital, Paris, France
³Université Paris Cité, Paris, France
⁴Division of Hematology, Ospedale degli Infermi, Biella, Italy
⁵IOSI-Oncology Inst. of Southern Switzerland, Bellinzona, Switzerland
⁶Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland
⁷Division of Hematology, Mayo Clinic, Rochester, MN
⁸Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN
⁹Department of Quantitative Health Sciences Research, Mayo Clinic, Rochester, MN
¹⁰Université Paris Cité, Assistance Publique – Hôpitaux de Paris, Saint-Louis Hospital, Hemato-oncology department, Paris, France
¹¹Biostatistical Department, Hôpital Saint Louis, Paris, France
¹²INSERM U1153, Paris, FRA

Christine A. Herne, PhD^1*, Jennifer E. Bruno, BS^2*, Andrea M Baran, MS^3*, Derick R. Peterson, PhD^4*, Tim R. Mosmann, PhD^2*, Sally A. Quataert, PhD^2*, Andrew G Evans, MD, PhD⁵, Charles C. Chu, PhD⁶ and Clive S. Zent, MD¹

¹Wilmot Cancer Institute, Division of Hematology/Oncology, University of Rochester Medical Center, Rochester, NY
²Department of Microbiology and Immunology, Center for Vaccine Biology & Immunology, and Human Immunology Center, University of Rochester Medical Center, Rochester, NY
³Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY
⁴Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY
⁵Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY
⁶Wilmot Cancer Institute, Division of Hematology/Oncology, The Feinstein Institute for Medical Research, Rochester, NY

Ying Yu^1*, ShuHua Yi^2*, Xiong Wenjie^2*, Tingyu Wang^2*, Yuting Yan^2*, Wei Liu^2*, Weiwei Sui^3*, Gang An, MD^4*, Yan Xu^2*, Huimin Liu^3*, Wenyang Huang, MD^3*, Dehui Zou^2* and Lugui Qiu⁴

¹State Key Laboratory of Experimental Hematology, National Clinical Research Cent, Tianjin, China
²State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical Colleg, Tianjin, China
³State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China
⁴State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

Liemei Lv^1*, Yu Zhang^2*, Yiqing Cai^1*, Zhuoya Yu^1*, Xueling Ge, MD^2*, Xiaosheng Fang, MD, PhD^2*, Cong Wang^2*, Ran Kong^1*, Xin Wang^1,2 and Xiangxiang Zhou, PhD^1,2*

¹Department of Hematology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
²Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China

Fan Zhang, M.D.^1*, Xiuhua Su, M.D., Ph.D.^2*, Fei Lu, M.D., Ph.D.^2*, Jingjing Ye, M.D., Ph.D.^2* and Chunyan Ji, md, phd^2*

¹Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, China
²Department of Hematology, Qilu Hospital of Shandong University, Jinan, China

Mario L. Marques-Piubelli, MD^1*, Daniela Dueñas, MD^1*, Lianqun Qiu, MD, PhD^2*, Karen Nahmod, MD, PhD^2*, Jeong Hee Cho, MD, PhD^2*, Mei Jiang^1*, Salome McAllen^1*, Luisa M Solis Soto, MD^1*, Raphael Steiner, MD^3*, Chelsea C. Pinnix, MD, PhD⁴, Ignacio I. Wistuba, MD^1*, Edwin R. Parra, MD, PhD^1* and Francisco Vega, MD, PhD²

¹Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX