Haley Newman, MD¹, Shawn Lee, MD², Petri Pölönen, PhD^3*, Rawan Shraim, MSc^4*, Yimei Li, PhD^5,6,7*, Hongyan Liu, PhD^8*, Tiffaney L. Vincent^1*, Richard Aplenc, MD, PhD^9,10,11, Changya Chen, PhD^12*, Zhiguo Chen, MS^13*, Caroline Diorio, MD^1,14, Kimberly P. Dunsmore, MD^15*, Sumit Gupta, MD, PhD¹⁶, Gang Wu, PhD^17*, Kai Tan, PhD^12,18*, Meenakshi Devidas, PhD, MBA¹⁹, Stuart S. Winter, MD²⁰, Brent L. Wood, MD PhD²¹, Lena E. Winestone, MD²², Jason Xu, PhD²³, Elizabeth A. Raetz, MD²⁴, Mignon L. Loh, MD²⁵, Stephen P. Hunger, MD^1,26, Stanley B. Pounds, PhD^27*, Kira O Bona, MD, MPH²⁸, Charles G. Mullighan, MBBS, MD³, Jun J. Yang, PhD²⁹ and David T. Teachey, MD^1,23,30

¹Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
²Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN
³Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
⁴Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
⁵Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
⁶Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia, PA
⁷Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Phiadelphia, PA
⁸Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA
⁹Division of Oncology and Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA
¹⁰Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA
¹¹Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
¹²Department of Biomedical and Health Informatics, University of Pennsylvania, Philadelphia, PA
¹³Biostatistics, Children's Oncology Group Data Center, Gainesville, FL
¹⁴Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
¹⁵Division of Oncology, University of Virginia Children’s Hospital, Charlottesville, VA
¹⁶Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada
¹⁷Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN
¹⁸Perelman School of Medicine, University of Pennsylvania, Philadephia, PA
¹⁹Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN
²⁰Research Institute and Cancer and Blood Disorders Program, Children's Minnesota, Eagan, MN
²¹Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA
²²Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, Benioff Children's Hospital, San Francisco, CA
²³Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
²⁴Division of Pediatric Hematology and Oncology, Stephen D. Hassenfeld Children's Center for Cancer and Blood Disorders, NYU Langone Health, New York, NY
²⁵Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute and Department of Pediatrics, Seattle Children’s Hospital, University of Washington, Seattle, WA
²⁶Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
²⁷Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
²⁸Department of Pediatric Oncology, Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA
²⁹Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, TN
³⁰Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Rutledge, PA

Valeriya Dimitrova^1,2,3, Noori Sotudeh, PhD^1,2,4*, Birgit Knoechel, MD, PhD^1,2,3,5, Jens G. Lohr, MD, PhD^3,6, Anna Montanaro^1,7*, Sayalee V. Potdar^8*, Julia Frede, PhD, MPhil^2,3,6, Alexandria Van Scoyk^9*, Shruti Bhatt, PhD¹⁰, Praveen Anand, PhD^6*, Jon C. Aster, MD, PhD^2,11, David M Weinstock^12,13 and Anthony G. Letai, MD, PhD^2,10

¹Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
²Harvard Medical School, Boston, MA
³Broad Institute of MIT and Harvard, Cambridge, MA
⁴Broad Institute of MIT and Harvard, Boston, MA
⁵Department of Hematology/Oncology, Boston Children's Hospital, Boston, MA
⁶Department of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Boston, MA
⁷Department of Medicine and Surgery, University of Parma, Parma, Italy
⁸Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA
⁹Dana Farber Cancer Institute, Boston, MA
¹⁰Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
¹¹Brigham and Women's Hospital, Boston, MA
¹²Dana-Farber Cancer Institute, Jamaica Plain, MA
¹³Broad Institute of Harvard and MIT, Boston, MA

Cédric G van der Ham, MSc^1*, Stefan H Lelieveld, PhD^1*, Željko Antic^1,2*, Marley Yeong, MSc^1*, Lianne C Suurenbroek, MSc^1*, Dorette S van Ingen Schenau^1*, Lennart A. Kester, PhD^1,3*, Liset Westera, PhD^1,3*, Edwin Sonneveld, PhD^1,3*, Peter M. Hoogerbrugge, MD, PhD^1,3, Vincent H.J. van der Velden, PhD^4*, Frank N van Leeuwen, PhD¹ and Roland P. Kuiper, PhD^1,5

¹Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
²Institute of Human Genetics, Medical School Hannover, Hannover, Germany
³Dutch Childhood Oncology Group, Utrecht, Netherlands
⁴Department of Immunology, Laboratory Medical Immunology, Erasmus University Medical Center, Rotterdam, Netherlands
⁵Department of Genetics, University Medical Center Utrecht, Utrecht, Netherlands

Britt M T Vervoort^1*, Miriam Butler, PhD^1*, Dorette van Ingen Schenau^1*, Vincent H.J. van der Velden, PhD^2*, Beat Bornhauser, PhD^3*, Jean-Pierre Bourquin, MD, PhD³, Laurens T van der Meer, PhD¹ and Frank N van Leeuwen, PhD¹

¹Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
²Erasmus Medical Center, Rotterdam, Netherlands
³University Children's Hospital Zurich, Zurich, Switzerland

Hanna Thorsson, PhD^1*, Rasmus Henningsson, PhD^2*, Noelia Puente-Moncada, PhD^2*, Carl Sandén, PhD^2*, Signe Modvig, MD, PhD³, Marianne Rissler, MSc^2*, Kajsa Paulsson, PhD², Anders Castor, MD, PhD^4*, Cornelis Jan Pronk, MD, PhD^4*, Hanne Vibeke Marquart, MD, PhD^3*, Kjeld Schmiegelow, MD, DMSc⁵, Christina Orsmark-Pietras, PhD^2*, Henrik Lilljebjörn, PhD^2* and Thoas Fioretos, MD, PhD²

¹Department of Laboratory Medicine, Division of Clinical Genetics, Lund University, Lund, Sweden
²Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden
³Department of Clinical Immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
⁴Childhood Cancer Center, Skane University Hospital, Lund, Sweden
⁵Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

Vera H Jepsen, MSc^1*, Daniel Hein, PhD^1*, Daniel Picard, MSc^1,2,3*, Tobias Lautwein, PhD^4*, Rabea Wagener, PhD^1*, Nan Qin, PhD^1,2,3,5*, Annika Filip, BSc^1*, Merja Heinäniemi, PhD^6*, Arndt Borkhardt, MD^1,3 and Ute Fischer, PhD^1,3*

¹Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University, Medical Faculty, Duesseldorf, Germany
²Institute of Neuropathology, Heinrich Heine University, Medical Faculty, Duesseldorf, Germany
³German cancer consortium (DKTK), partner site Essen/Duesseldorf, Duesseldorf, Germany
⁴Genomics Transcriptomics Laboratory, Biomedical Research Center, Heinrich Heine University, Duesseldorf, Germany
⁵German Cancer Research Center (DKFZ), Heidelberg, Germany
⁶Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland

Rabab Allawati, MPhil^1,2*, Dino Mašić, PhD^1*, Sarah Lawon^1*, Ajay Vora, MD³ and Julie Irving, PhD⁴

¹Birmingham Children’s Hospital, Birmingham, United Kingdom
²Wolfson Childhood Cancer Research Centre, Newcastle University, Newcastle, ENG, United Kingdom
³Department of Haematology, Great Ormond Street Hospital for Children, London, United Kingdom
⁴Wolfson Childhood Cancer Research Centre, Newcastle University, Newcastle upon Tyne, ENG, United Kingdom

Ole Østergaard, Msc, PhD^1*, Hanne Vibeke Marquart, MD, PhD^2*, Maria Thastrup, PhD³, Christian Mirian, MD^4*, Bodil Als-Nielsen, MD, PhD^5*, Kjeld Schmiegelow, Professor M.D. DMSc.^6,7*, Jesper V Olsen, Professor^1* and Signe Modvig, MD, PhD^2,8

¹Novo Nordisk Foundation Center for Protein Research, Proteomics Program, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
²Department of Clinical Immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
³Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark
⁴Dept of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
⁵Dept of Pediatrics and Adolescent Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, DNK
⁶University of Copenhagen, The Institute of Clinical Medicine, Copenhagen, Denmark
⁷Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
⁸Faculty of Medicine, Institute of Clinical Medicine, University of Copenhagen, Denmark., Copenhagen, Denmark

Jiawang Ou^*, Xiuli Xu^*, Zicong Huang^*, Shiyu Deng^*, Cai Zihong^*, Bingqing Tang^*, Xiaojie Liang^*, Zhengwei Wu^*, Yiqian Liu^*, Lingling Zhou^*, Qifa Liu, MD and Hongsheng Zhou^*

Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China

Teena Bhatla, MD¹, Laura Hogan, MD², Xinxin Xu^3*, Lingyun Ji^4*, Andrew J. Carroll, PhD⁵, Nyla A. Heerema, PhD⁶, Mary Shago, PhD^7*, Lia Gore⁸, James A. Whitlock, MD⁹, Stephen P. Hunger, MD¹⁰, Mignon L. Loh, MD¹¹ and Patrick A. Brown, MD¹²

¹Children's Hospital of New Jersey at Beth Israel Medical Center, Newark, NJ
²Stony Brook Children's, Stony Brook, NY
³Children's Oncology Group, Monrovia, CA
⁴University of Southern California, Keck School of Medicine, Los Angeles, CA
⁵Department of Genetics, University of Alabama at Birmingham, Birmingham, AL
⁶Department of Pathology, The Ohio State University, Columbus, OH
⁷Cytogenetics Laboratory, The Hospital for Sick Children, Toronto, ON, Canada
⁸Children's Hospital Colorado, University of Colorado, Aurora, CO
⁹Division of Haematology/Oncology, The Hospital For Sick Children, Toronto, ON, Canada
¹⁰Children's Hospital of Philadelphia, Philadelphia, PA
¹¹Division of Hematology, Oncology, BMT, and Cellular Therapies, Seattle Children's Hospital, Seattle, WA
¹²Bristol Myers Squibb, Princeton, NJ

Jung-Hyun Kim, PhD¹, Liping Li, MD, PhD^1*, Zixin Zhang^2*, Katharina Hayer^3*, Li Luo, PhD^1*, Leslie Cope, PhD^4*, Lingling Xian, MD, PhD^1*, Andrei Thomas-Tikhonenko, PhD⁵ and Linda Resar, MD^1,4,6,7

¹Department of Medicine, Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD
²Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public health, Baltimore, MD
³Children's Hospital of Philadelphia, Philadelphia, PA
⁴Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD
⁵Division of Experimental Pathology, Cancer Pathobiology, Children's Hospital of Philadelphia & University of Pennsylvania, Philadelphia, PA
⁶Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD
⁷Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD

Sarah Aminov, MSc^1*, Orsi Giricz, PhD^2*, R. Alejandro Sica, MD³, Veronika Polishchuk, MD^4*, Bonnie Yates, NP^5*, Hao-Wei Wang, MD, PhD⁶, Yanhua Wang, MD, PhD^7*, Srabani Sahu, MSc^1*, Shanisha Gordon, MSc^1*, Carolina Schinke⁸, Kith Pradhan, PhD^9*, Srinivas Aluri, PhD^1*, Murali Janakiram, MD, MS¹⁰, Stefan K. Barta, MD¹¹, Beamon Agarwal, MD, PhD^12*, Mendel Goldfinger, MD¹³, Aditi Shastri, MD¹⁴, William Matsui, MD¹⁵, Ulrich Steidl, MD, PhD^9*, Joshua Brody, MD¹⁶, Nirali N. Shah, MD¹⁷, Samir Parekh, MD¹⁸ and Amit Verma, MD, MBBS^19*

¹Blood Cancer Institute, Albert Einstein College of Medicine, Bronx, NY
²Leukemia and Lymphoma Society, Rye Brook, NY
³Montefiore Medical Center, New York City, NY
⁴Division of Hematology/Oncology/BMT, Nationwide Children's Hospital, Columbus, OH
⁵Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD
⁶Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD
⁷Department of Pathology, Albert Einstein College of Medicine, Bronx, NY
⁸Myeloma Center, Winthrop P. Rockefeller Institute, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR
⁹Albert Einstein College of Medicine, Bronx, NY
¹⁰Division of Myeloma, Department of Hematology, City of Hope National Medical Center, Duarte, CA
¹¹Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA
¹²Department of Hematopathology, Montefiore Medical Center, New York, NY
¹³Oncology, Montefiore Medical Center/ Albert Einstein College of Medicine, Bronx, NY
¹⁴Oncology, Hematology/Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY
¹⁵MD Health Discovery, University of Texas, Austin, TX
¹⁶Hematology and Medical Oncology, Mount Sinai School of Medicine, New York, NY
¹⁷Pediatric Oncology Branch, National Institutes of Health, Bethesda, MD
¹⁸Department of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY
¹⁹Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY

Anna Østergaard^1,2*, Amir Enshaei, PhD^3*, Rob Pieters, Prof. MD. PhD⁴, Ajay Vora, MD⁵, Martin A. Horstmann, MD⁶, Gabriele Escherich, MD^7*, Bertil Johansson^8,9, Mats Heyman¹⁰, Kjeld Schmiegelow, MD, DMSc¹¹, Peter M. Hoogerbrugge, MD, PhD⁴, Monique L. den Boer, PhD^4,12, Roland P. Kuiper, PhD^4,13, Anthony V. Moorman¹⁴, Judith M. Boer, PhD^4,12 and Frank N van Leeuwen, PhD⁴

¹Oncode institute, Utrecht, Netherlands
²Princess Máxima Centre for Pediatric Oncology, Utrecht, Netherlands
³Translational and Clinical Research Institute, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⁴Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
⁵Department of Haematology, The Children's Hospital, London, United Kingdom
⁶University Medical Center Hamburg-Eppendorf, Hamburg, Germany
⁷Clinic of Pediatric Hematology and Oncology, University Medical Center Eppendorf, Eppendorf, Germany
⁸Lund University Hospital, Lund, Sweden
⁹Department of Clinical Genetics, Pathology, and Molecular Diagnostics, Office for Medical Services, Region Skåne, Lund, Sweden
¹⁰Karolinska University Hospital, Stockholm, Sweden
¹¹Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
¹²Oncode Institute, Utrecht, Netherlands
¹³Department of Genetics, University Medical Center Utrecht, Utrecht, Netherlands
¹⁴Wolfson Childhood Cancer Research Centre, Newcastle University, Newcastle, United Kingdom

V. S. S. Abhinav Ayyadevara, PhD, MS^1*, Gerald Wertheim, MD, PhD^2,3, John Chukinas, BA^4*, Joseph Patrick Loftus, BS^5*, Sung June Lee, BA^6*, Anil Kumar, PhD^7*, Rahul S. Bhansali, MD⁸, Srividya Swaminathan, PhD⁷, Thierry Besson, PhD^9*, Junwei Shi, PhD^10*, John D. Crispino, PhD¹¹, Sarah K Tasian, MD¹², Martin P. Carroll, MD¹³ and Christian Hurtz, PhD¹⁴

¹Fels Cancer Institute for Personalized Medicine, Temple University, Philadelphia, PA
²Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA
³Division of Hematology/Oncology, Department of Medicine, The Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA
⁴Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA
⁵Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA
⁶Systems Biology, City of Hope, Monrovia, CA
⁷Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA
⁸Department of Medicine, Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA
⁹Normandie University, UNIROUEN, INSA Rouen, CNRS, COBRA UMR 6014, 76000, Rouen, France
¹⁰Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
¹¹Experimental Hematology, St. Jude Children's Research Hospital, Memphis
¹²Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
¹³Medicine, University of Pennsylvania, Philadelphia, PA
¹⁴Lewis Katz School of Medicine, Temple University, Philadelphia, PA

Laura Rachele Bettini, MD^1*, Grazia Fazio, PhD^2*, Claudia Saitta, PhD^3*, Sonia Palamini, Graduated student^3*, Chiara Buracchi, PhD, MSc^4*, Stefano Rebellato, Graduated student^3*, Nicola Santoro, MD^5*, Cristiano Simone, MD^6,7*, Andrea Biondi, MD³ and Giovanni Cazzaniga, PhD^8,9*

¹Tettamanti Research Center, Dept. Pediatrics, University of Milano-Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza, AL, Italy
²Tettamanti Research Center, Dept. Pediatrics, Clinica Pediatrica Univ. Milano Bicocca Ospedale San Gerardo, Monza, MB, Italy
³Tettamanti Research Center, Dept. Pediatrics, University of Milano-Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza, Italy
⁴Tettamanti Research Center, Department of Pediatrics, University of Milano - Bicocca/Fondazione MBBM, Monza, Italy
⁵Department of Pediatrics, Policlinico di Bari, Bari, Italy
⁶Medical Genetics, National Institute for Gastroenterology, IRCCS ‘S. de Bellis’ Research Hospital, Castellana Grotte, Italy
⁷Medical Genetics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari Aldo Moro, Bari, Italy
⁸Tettamanti Research Center, Pediatrics, University of Milan Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza, MZ, Italy
⁹Medical Genetics, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy

Catherine D Falkenstein, BS^1*, Lisa M Niswander, MD, PhD², Linda Kessler, BA^3*, Blake Tomkinson, PhD MBA^3*, Francis Burrows, PhD^3* and Sarah K Tasian, MD^2,4

¹Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA
²Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
³Kura Oncology, San Diego, CA
⁴Department of Pediatrics and Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA