Huihui Fu^*, Xiaomei Zhang^*, Sanxiu He^*, Jun Li^* and Yao Liu, phd, md^*

Department of Hematology-Oncology, Chongqing University Cancer Hospital, Chongqing, China

Daria Gaut, MD¹, Caspian Oliai, MD, MS¹, Jonathan Boiarsky, MD^2*, Shiliang Zhang, MD^2*, Tali Azenkot, MD^3*, Vanessa E. Kennedy, MD⁴, Vishesh Khanna, MD⁵, Karla Olmedo Gutierrez, MD^6*, Navika D. Shukla, MD^7*, Benjamin Moskoff, PharmD^8*, Anand Ashwin Patel, MD⁹, Deepa Jeyakumar, MD⁶, Gabriel N. Mannis, MD¹⁰, Aaron C. Logan, MD, PhD¹¹, Brian A. Jonas, MD, PhD¹² and Gary J. Schiller, MD¹

¹UCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA
²Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA
³Department of Internal Medicine, University of California Davis School of Medicine, Sacramento
⁴University of California San Francisco, San Francisco, CA
⁵Division of Hematology and Blood and Marrow Transplantation, Stanford University Hospital, Menlo Park, CA
⁶Division of Hematology/Oncology, UC Irvine Medical Center, Orange, CA
⁷Department of Medicine, University of Chicago, Chicago, IL
⁸Pharmacy Department, University of California Davis School of Medicine, Sacramento, CA
⁹Department of Medicine, Section of Hematology/Oncology, University of Chicago Medical Center, Chicago, IL
¹⁰Division of Hematology, Department of Medicine, Stanford University Medical Center, Menlo Park, CA
¹¹Division of Hematology and Blood and Marrow Transplantation, University of California, San Francisco, San Francisco, CA
¹²Department of Internal Medicine, Division of Malignant Hematology, Transplantation and Cellular Therapy, University of California Davis School of Medicine, Sacramento, CA

Luis A. Carvajal, PhD^1*, Tressa Hood, MS^1*, Yana Bevan^2*, Richard Dillon, MA PhD MRCP FRCPath³, Nicola Potter, PhD^4*, Ian Thomas^5*, Sean Johnson^5*, Jad Othman, MBBS⁴, Amanda Gilkes^6*, Nigel H. Russell, MD⁷, Adam Sikorski^8*, Pete Ellis^8*, Giovanni Marsico^8*, Greg Jones^8*, Crystal MacKenzie^1*, Zung To^1*, Jorge DiMartino, MD¹ and Pavan Kumar, PhD^1*

¹Kronos Bio, Inc., San Mateo, CA
²King’s College London, London, United Kingdom
³Department of Medical and Molecular Genetics, King's College London, London, ENG, United Kingdom
⁴Department of Medical and Molecular Genetics, King's College London, London, United Kingdom
⁵Centre for Trials Research, Cardiff University, Cardiff, United Kingdom
⁶Division of Cancer and Genetics, Cardiff University, Cardiff, United Kingdom
⁷Guy's Hospital, London, United Kingdom
⁸Inivata Ltd., Babraham Research Park, Cambridge, United Kingdom

Alexander Fischer, MSc, BSc^1*, Roger Mulet-Lazaro, MSc^2*, Margit Nützel^1*, Stanley van Herk, BSc^2*, Hanna Stanewsky^1*, Ute Ackermann^1*, Edith Reuschel, MD^3*, Nicholas Strieder, PhD^4*, Inmaculada Hernandez-Lopez, PhD^4*, Wolfgang Herr, MD⁵, Peter J.M. Valk, PhD², Michael Rehli, PhD^4,5*, Ruud Delwel, MD² and Claudia Gebhard, PhD^1,4*

¹Internal Medicine III, University Hospital Regensburg, Regensburg, Germany
²Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands
³Clinic St. Hedwig Regensburg, Regensburg, Germany
⁴Leibniz Institute for Immunotherapy, Regensburg, Germany
⁵Department of Internal Medicine III, Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany

Joshua J. Lara, BS¹, Alfonso E. Bencomo², Mayra A. Gonzalez^3*, Idaly M. Olivas, MS^2*, Jose L. Lopez^1*, James E. Young, MS^4*, Vanessa V. Velazquez^1*, Steven Glovier, MS^4*, Andres J. Rubio^1*, Sara K. Dang, MS^1*, Jonathan Solecki, BS^4*, Jesse Allen, BS^1*, Desiree N. Tapia, BS^1*, Boranai Tychhon, BS^1*, Gonzalo E. Astudillo, BS^1*, Darshan S. Chandrashekar, PhD^5* and Anna M. Eiring²

¹Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center at El Paso, El Paso, TX
²Department of Molecular and Translational Medicine, Texas Tech University Health Sciences Center at El Paso, El Paso, TX
³Department of Molecular and Translational Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX
⁴Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center at El Paso, El Paso, TX
⁵Department of Pathology-Molecular & Cellular, University of Alabama at Birmingham, Birmingham, AL

Inga Hund, M.Sc.^1*, Maria Hess, M.Sc.^2,3*, Julia Stomper, MD^1*, Gabriele Greve, PhD^1*, Jan Mitschke, PhD^1*, Christoph Niemöller^1*, Tobias Ma^1*, David Uhl, MD^1*, Felicitas R. Thol, MD⁴, Michael Heuser, MD⁴, Gesine Bug, MD^5*, Martina Crysandt, MD^6*, Lutz Peter Mueller, MD^7*, Andreas Neubauer, MD⁸, Justus Duyster^1,9*, Hartmut Dohner, MD¹⁰, Melanie Boerries, MD PhD^2,3,9*, Heiko Becker, MD^1,9* and Michael Luebbert, MD^1,9

¹Department of Hematology, Oncology and Stem Cell Transplantation, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
²Institute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
³Faculty of Biology, University of Freiburg, Freiburg, Germany
⁴Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
⁵Goethe University Frankfurt, University Hospital, Dept. of Medicine, Hematology and Oncology, Frankfurt, Germany
⁶Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany
⁷Department of Internal Medicine IV - Hematology and Oncology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
⁸Hematology, Oncology, Immunology, Philipps University, Marburg, Germany
⁹German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Partner Site Freiburg, Freiburg, Germany
¹⁰Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

Alyssa Obermayer^1*, Sijie Yao, PhD^1*, Jenny L. Smith, MSc, MEd^2*, Rhonda E. Ries, MA^3*, Yi-Cheng Wang, MS^4*, Jason E Farrar, MD⁵, Scott N Furlan, MD^6*, Tim Triche^7*, Xiaotu Ma, PhD^8*, Benjamin J. Huang, MD^9*, Xuefeng Wang, PhD^10*, Soheil Meshinchi, M.D., Ph.D.^3,4,11,12 and Timothy I. Shaw, PhD^13*

¹Moffitt Cancer Center, Tampa, FL
²Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
³Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA
⁴Children's Oncology Group, Monrovia, CA
⁵University of Arkansas For Medical Sciences, Little Rock, AR
⁶Fred Hutchinson Cancer Center, Seattle, WA
⁷Van Andel Institute, Grand Rapids, MI
⁸St. Jude Children's Research Hospital, Memphis, TN
⁹Dept. of Pediatrics, Division of Hematology/Oncology, University of California San Francisco, San Francisco, CA
¹⁰Biostatistics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
¹¹Fred Hutchinson Cancer Research Center, Seattle, WA
¹²Department of Pediatrics, University of Washington, Seattle, WA
¹³Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL

Michael J. Hochman, MD¹, Alexander J. Ambinder, MD, MPH¹, Lukasz P. Gondek, MD, PhD² and Amy E. DeZern, MD¹

¹Division of Hematologic Malignancies, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
²Division of Hematologic Malignancies, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins, Baltimore, MD

Dorian Forte^1*, Rafael J. Argüello, PhD^2*, Roberto Maria Pellegrino^3*, Husam B.R. Alabed^3*, Martina Barone, PhD^1*, Samantha Bruno, PhD^1*, Francesco Fabbri, PhD^4*, Ivan Vannini, PhD^4*, Gianluca Cristiano, MD^1*, Sandra Buratta, PhD^3*, Lorena Urbanelli, PhD^3*, Carla Emiliani, PhD^3,5*, Michele Cavo, MD^1,6* and Antonio Curti, MD, PhD⁷

¹Department of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology "Seràgnoli", University of Bologna, Bologna, Italy
²Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France
³Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy
⁴Biosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy
⁵Centro di Eccellenza sui Materiali Innovativi Nanostrutturati (CEMIN), University of Perugia, Perugia, Italy
⁶IRCCS Azienda Ospedaliero-Universitaria di Bologna, Seràgnoli Institute of Hematology, Bologna, Italy
⁷IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy

Niveditha Ravindra, MD^1*, Laura W. Dillon, PhD^1*, Gege Gui^1*, Christopher S. Hourigan, MD PhD¹ and Alexander J. Ambinder, MD, MPH²

¹Laboratory of Myeloid Malignancies, Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD
²Division of Hematologic Malignancies, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD

Adam J. Lamble, MD¹, Rhonda E. Ries, MA^2*, Todd A. Alonzo, PhD^3,4*, Yi-Cheng Wang, MS^3*, Jason E Farrar, MD⁵, Benjamin J. Huang, MD^6*, Matthew A. Kutny, MD⁷, Jessica A. Pollard, MD⁸, Richard Aplenc, MD, PhD⁹, Alan S. Gamis, MD, MPH¹⁰, Edward A. Kolb, MD¹¹, Todd M. Cooper, DO¹ and Soheil Meshinchi, M.D., Ph.D.¹²

¹Seattle Children's Hospital, Seattle, WA
²Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA
³Children's Oncology Group, Monrovia, CA
⁴Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA
⁵University of Arkansas For Medical Sciences, Little Rock, AR
⁶Dept. of Pediatrics, Division of Hematology/Oncology, University of California San Francisco, San Francisco, CA
⁷Department of Pediatrics, Division of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL
⁸Dana Building 3136, Dana-Farber Cancer Institute, Boston, MA
⁹Children's Hospital of Philadelphia, Philadelphia, PA
¹⁰Children's Mercy Kansas City, Kansas City, MO
¹¹Division of Oncology, Nemours Alfed I. duPont Hospital For Children, Wilmington, DE
¹²Fred Hutchinson Cancer Center, Seattle, WA

Danielle C. Kirkey, MD^1,2,3, Xiaoying Wu, PhD^4*, Rhonda E. Ries, MA^1*, Tiffany A. Hylkema, BS^1*, Yanling Liu, PhD^5*, Pandurang Kolekar, Ph.D^5*, Quang Tran, PhD⁵, Alan S. Gamis, MD, MPH⁶, Richard Aplenc, MD, PhD⁷, Anders E. Kolb, MD⁸, Todd A. Alonzo, PhD^9,10*, Katherine Tarlock, MD^1,2,3, Robert Eisenman, PhD^4* and Soheil Meshinchi, M.D., Ph.D.^1,2,3

¹Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA
²Department of Pediatrics, University of Washington, Seattle, WA
³Division of Hematology and Oncology, Seattle Children's Hospital, Seattle, WA
⁴Basic Science Division, Fred Hutchinson Cancer Center, Seattle, WA
⁵Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN
⁶Hematology/Oncology, Children's Mercy Hospitals and Clinics, Kansas City, MO
⁷Division of Oncology and Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA
⁸Division of Oncology, Nemours/Alfred I. duPont Hospital For Children, Wilmington, DE
⁹Children's Oncology Group, Monrovia, CA
¹⁰Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA

Kinjal Bhadresha, PhD^1*, Sanam Rezaei Benam, MSc^1*, Alexander R. Maldeney, BSc^1*, H. Scott Boswell, MD^1,2, Reuben Kapur, PhD^2,3 and Reza Shahbazi, PhD^1,2,4

¹Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN
²Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN
³Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN
⁴Brown Center for Immunotherapy, Indiana University School of Medicine, Indianapolis, IN

Marie Lue Antony, PhD^1,2*, Klara E Noble-Orcutt, BS, MS^1,2*, Jeffrey Lee Jensen, MD, PhD^3*, Fiona He, MD^1,2 and Zohar Sachs, MD, PhD^1,2

¹Division of Hematology Oncology and Transplantation, Department of Medicine, University of Minnesota, MINNEAPOLIS, MN
²Masonic Cancer Center, University of Minnesota, Minneapolis, MN
³Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC

Upaasana Krishnan^1*, Beena E Thomas, Ph.D^2*, Swati S Bhasin, PhD^2,3, Hope L Mumme, BSc^2,4* and Manoj Bhasin, PhD³

¹Georgia Institute of Technology, School of Biological Sciences, Atlanta, GA
²Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Atlanta, GA
³Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
⁴Department of Biomedical Informatics, Emory University, Atlanta, GA

Catherine Mark, MD^1*, Edward A. Kolb, MD², Bianca F. Goemans, MD, PhD³, Soheil Meshinchi, M.D., Ph.D.⁴, Brenda Gibson^5*, Anke K. Bergmann, MD^6*, Christine J. Harrison, PhD, FRCPath⁷, Cornelis Jan Pronk, MD, PhD^8,9*, Hélène Lapillonne, MD, PhD^10*, Guy Leverger^11*, Evangelia Antoniou, MD¹², Andishe Attarbaschi^13*, Michael Dworzak, MD, PhD^14*, Jan Stary, MD^15*, Daisuke Tomizawa, MD, PhD¹⁶, Monika Lejman^17*, Kjeld Schmiegelow, MD, DMSc¹⁸, Henrik Hasle, MD, PhD¹⁹, Brooklyn Joyce^20*, Markus Schneider, PhD^21* and Oussama Abla, MD²²

¹Toronto Hospital for Sick Children, Toronto, ON, Canada
²Division of Oncology, Nemours Alfed I. duPont Hospital For Children, Wilmington, DE
³Prinses Maxima Centrum, Utrecht, Netherlands
⁴Fred Hutchinson Cancer Center, Seattle, WA
⁵The Royal Hospital for Children, Glasgow, United Kingdom
⁶Department of Human Genetics, Hannover Medical School (MHH), Hannover, Germany
⁷Leukaemia Research Cytogenetics Group, Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, ENG, United Kingdom
⁸Lund University, Lund, SWE
⁹Childhood Cancer Center, Skane University Hospital, Lund, Sweden
¹⁰Pediatric Hematology and Oncology Department, Hôpital Armand Trousseau, Paris, France
¹¹APHP, Paris, France
¹²Department of Pediatrics III, University Hospital Essen, Essen, Germany
¹³Department of Pediatric Hematology and Oncology, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria
¹⁴Department of Pediatrics, St. Anna Children's Hospital and Cancer Research Institute, Medical University of Vienna, Vienna, Austria
¹⁵Dept. of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
¹⁶Division of Leukemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan
¹⁷Children's University Hospital, Lublin, Poland
¹⁸The Institute of Clinical medicine, The Faculty of Medicine, University of Copenhagen, Hellerup, Denmark
¹⁹Department of Pediatrics, Aarhus University Hospital Skejby, Aarhus, Denmark
²⁰Toronto Hospital for Sick Children, Toronto, Canada
²¹Department of Pediatrics III, University Children’s Hospital Essen, University Duisburg-Essen, Essen, Germany
²²Hospital for Sick Children Division of Hematology, Toronto, ON, Canada

Anna Stengel, PhD, Manja Meggendorfer, PhD, Wencke Walter, PhD^*, Constance Baer, PhD, Niroshan Nadarajah^*, Stephan Hutter, PhD^*, Wolfgang Kern, MD, Torsten Haferlach, MD and Claudia Haferlach, MD

MLL Munich Leukemia Laboratory, Munich, Germany

Ka-Won Kang, MD, PhD^1*, Jeong-An Gim^1*, Kunye Kwak^1*, Sunghoi Hong, PhD^2*, Hyun Koo Kim, MD, PhD^1*, Yeonho Choi, PhD^2*, Ji-ho Park, PhD^3* and Yong Park, MD, PhD¹

¹Korea University College of Medicine, Seoul, Korea, Republic of (South)
²Korea University, Seoul, Korea, Republic of (South)
³Department of Bio and Brain Bioengineering, Korea Advanced Institute of Science and Technology (KAIST), Seoul, Korea, Republic of (South)

Christian Rausch^1*, Maja Rothenberg-Thurley, PhD^1*, Annika Maria Dufour, PhD^1*, Stephanie Schneider, PhD^1,2*, Hanna Gittinger, MD^1*, Maria Cristina Sauerland, MSc^3*, Dennis Görlich, PhD^4*, Utz Krug, MD⁵, Wolfgang E. Berdel, MD⁶, Bernhard Josef Woermann⁷, Wolfgang Hiddemann, MD, PhD^1,8,9, Jan Braess, MD^10*, Karsten Spiekermann^8,9,11, Tobias Herold, MD^1,8,9 and Klaus H Metzeler, MD¹²

¹Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Munich, Germany
²University Hospital, LMU Munich, Institute of Human Genetics, Munich, Germany
³Institute of Biostatistics and Clinical Research, University of Muenster, Muenster, Germany
⁴Institute of Biostatistics and Clinical Research, University of Muenster, Münster, Germany
⁵Department of Medicine III, Hospital Leverkusen, Leverkusen, Germany
⁶Department of Medicine A, Hematology and Oncology, University Hospital Muenster, Muenster, Germany
⁷German Society of Hematology and Oncology, Berlin, Germany
⁸German Consortium for Translational Cancer Research (DKTK), Partner Site Munich, Munich, Germany
⁹German Cancer Research Center (DKFZ), Heidelberg, Germany
¹⁰Department of Oncology and Hematology, Hospital Barmherzige Brüder, Regensburg, Germany
¹¹Department of Medicine III, Laboratory for Leukemia Diagnostics (LfL), University Hospital, LMU Munich, Munich, Germany
¹²Department of Hematology, Cell Therapy and Hemostaseology, University Hospital Leipzig, Leipzig, Germany

Arjan A. Van de Loosdrecht, MD, PhD¹, Jacqueline Cloos, Prof^1*, Eva-Maria Wagner-Drouet, MD^2*, Uwe Platzbecker, MD³, Tobias A. W. Holderried, MD^4*, Catharina van Elssen, MD, PhD^5*, Aristoteles Giagounidis, MD⁶, Marij J.P. Welters, PhD^7*, Sjoerd H. van der Burg^7*, Hester J.T. van Zeeburg, PhD^8*, Jeroen Rovers, MD, PhD^8* and Bjorn T. Gjertsen, MD, PhD^9,10

¹Department of Hematology, Amsterdam UMC, location VUmc, Cancer Center Amsterdam, Amsterdam, Netherlands
²Universitätsmedizin der Johannes Gutenberg-Universität, Mainz, Germany
³Universitätsklinikum Leipzig, Leipzig, Germany
⁴Department of Oncology, Hematology, Immuno-Oncology and Rheumatology, University Hospital Bonn, Bonn, Germany
⁵Maastricht University Medical Centre, Maastricht, NLD
⁶Marien Hospital, Düsseldorf, Germany
⁷Department of Medical Oncology, Leiden University Medical Center, Leiden, Netherlands
⁸Mendus AB, Stockholm, Sweden
⁹Haukeland Universitetssykehus, Bergen, Norway
¹⁰Haukeland University Hospital, Bergen, Norway

Sebastian Schwind, MD^1*, Lara Bischof^2*, Marius Bill, MD, PhD^2*, Juliane Grimm, MD^2*, Jule Ussmann, MD^2*, Elizabeth Gaston, MD^2*, Donata Backhaus, MD^2*, Dominic Brauer, MD^2*, Marco Herling, MD^2*, Maximilian Merz, MD², Klaus H. Metzeler, MD², Georg-Nikolaus Franke, MD^2*, Vladan Vucinic, MD^2*, Uwe Platzbecker, MD^2* and Madlen Jentzsch, MD^3*

¹Department for Hematology, Cell Therapy and Hemostaseology, University of Leipzig Medical Center, Leipzig, Saxonia, Germany
²Department for Hematology, Cell Therapy and Hemostaseology, University of Leipzig Medical Center, Leipzig, Germany
³Department for Hematology, Cell Therapy and Hemostaseology, University of Leipzig Medical Center, Leipzig, Sachsen, Germany

Prodromos Chatzikyriakou, PhD^1*, Douglas RA Silveira, MD^1*, Maria del Pilar Casares Aláez^1*, Batchimeg Usukhbayar, PhD^2*, Marlen Metzner, MSc^3*, Paresh Vyas, DPhil, FRCP, FRCPath, MRCP, MRCPath⁴, Anita K. Gandhi, PhD⁵, Alberto Risueño, PhD^6*, Maroof Hasan, MD^5* and Lynn Quek, MBBCh, DPhil, MRCP (UK), FRCPath^1*

¹School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
²University of Oxford, Oxford, GBR
³MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
⁴MRC Molecular Haematology Unit and Oxford Biomedical Research Centre, University of Oxford and Oxford University Hospitals, Oxford, United Kingdom
⁵Translational Medicine Hematology, Bristol Myers Squibb, Summit, NJ
⁶Centre for Innovation and Translational Research Europe, A Bristol Myers Squibb Company, Seville, Spain

Soichiro Nakako, MD^1*, Hiroshi Okamura, MD, PhD^1*, Isao Yokota, PhD, MPH^2*, Yukari Umemoto^1*, Yosuke Makuuchi, MD, PhD^1*, Masatomo Kuno, MD, PhD^1*, Teruhito Takakuwa, MD, PhD^1*, Mitsutaka Nishimoto, MD, PhD^1*, Asao Hirose, MD, PhD^1*, Mika Nakamae, MD, PhD^1*, Yasuhiro Nakashima, PhD, MD^1*, Hideo Koh, MD, PhD^1*, Masayuki Hino, MD, PhD¹ and Hirohisa Nakamae, MD, PhD^1*

¹Hematology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan
²Biostatistics, Graduate School of Medicine, Hokkaido University, Hokkaido, Japan

Onyee Chan, MD¹, Najla Al Ali, MD^1*, Hammad Tashkandi, MBBS², Austin Ellis, MD^3*, Somedeb Ball, MD¹, Justin Grenet, MD⁴, Caroline Hana, MBBCh⁵, Yehuda E. Deutsch, MD⁶, Ling Zhang, MD^7*, Mohammad O Hussaini, MD^8*, Jinming Song, MD, PhD^9*, Seongseok Yun, MD, PhD¹, Chetasi Talati, MD^1*, Andrew Kuykendall, MD¹⁰, Eric Padron, MD¹¹, Alison R. Walker, MD¹, Gail J. Roboz, MD¹², Pinkal Desai, MD, MPH¹², David A. Sallman, MD¹¹, Kendra Sweet, MD¹¹, Rami S. Komrokji¹ and Jeffrey E. Lancet, MD¹

¹Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
²Moffitt Cancer Center, Tampa, FL
³Department of Pathology, Moffitt Cancer Center, Tampa, FL
⁴New York Presbyterian/Weill-Cornell Medical Center, New York, NY
⁵University of Miami/JFK Palm Beach Regional Campus, Boynton Beach, FL
⁶Department of Malignant Hematology and Cellular Therapy at Memorial Health System, Moffitt Cancer Center, Pembroke Pines, FL
⁷Department of Hematopathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁸Department of Hematopathology and Lab Medicine, Moffitt Cancer Center, Tampa, FL
⁹Department of Hematopathology, Moffitt Cancer Center, Tampa, FL
¹⁰Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
¹¹Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL
¹²Division of Hematology and Oncology, Weill Cornell Medicine and The New York-Presbyterian Hospital, New York, NY

Claudia Sargas^1*, Rosa Ayala^2*, Maria Jose Larrayoz^3*, Carmen Chillon, PhD^4*, Estrella Carrillo^5*, Cristina Bilbao, PhD^6*, Esther Prados de La Torre^7*, David Martinez-Cuadron^8,9*, Rebeca Rodríguez-Veiga^10*, Cristina Gil^11*, Teresa Bernal, MD, PhD^12*, Juan Miguel Bergua Burgués^13*, Lorenzo Algarra^14*, Mar Tormo¹⁵, Pilar Martínez Sánchez, M.D.^16*, Elena Soria^17*, Josefina Serrano^18*, Juan Manuel Alonso Dominguez, MD, PhD^19*, Raimundo García-Boyero^20*, Maria Luz Amigo, MD^21*, Pilar Herrera^22*, María J. Sayas^23*, Esperanza Lavilla^24*, Joaquín Martínez-López, MD, PhD^16*, María José Calasanz, PhD^25*, Ramon Garcia-Sanz²⁶, Jose A. Perez-Simon, MD, PhD¹⁷, María Teresa Gómez-Casares, MD, PhD^27*, Joaquín Sánchez-Garcia, MD²⁸, Eva Barragán^9,29* and Pau Montesinos, PhD, MD^30*

¹Molecular Biology Unit, Hospital Universitari i Politécnic-IIS La Fe, Valencia, Spain
²Hematology and Hemotherapy Department, Hospital Universitario 12 de Octubre, CNIO, Complutense University, CIBERONC, Madrid, Spain
³CIMA LAB Diagnostics-Universidad de Navarra, Pamplona, Spain, Pamplona, Spain
⁴Hospital Universitario de Salamanca (HUS/IBSAL), CIBERONC and Center for Cancer Research-IBMCC (USAL-CSIC), Salamanca, Spain, Salamanca, Spain
⁵Instituto de Biomedicina (IBIS / CSIC), Universidad de Sevilla, Hospital Universitario Virgen del Rocio, Sevilla, Spain
⁶Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain
⁷IMIBIC, Hematology, Hospital Universitario Reina Sofía, UCO, Cordoba, Spain
⁸Hematology Department, Hospital Universitari i Politécnic-IIS La Fe, Valencia, Spain
⁹CIBERONC Instituto de Salud Carlos III, Madrid, Spain
¹⁰Hospital Universitari i Politècnic La Fe, Instituto de Investigación Sanitaria La Fe (IISLAFE), Valencia, Spain
¹¹Hospital General Universitario de Alicante, Alicante, Spain
¹²Hospital Universitario Central de Asturias, Instituto Universitario (IUOPA), Instituto de investigación del Principado de Asturias (ISPA), Oviedo, Spain
¹³Hospital San Pedro de Alcántara, Cáceres, Spain
¹⁴Hospital Universitario General de Albacete, Albacete, Spain
¹⁵Hematology Department, Hospital Clínico Universitario-INCLIVA, Valencia, Spain
¹⁶Hematology Department, Hospital Universitario 12 de Octubre, CNIO, Complutense University, Madrid, Spain
¹⁷Hospital Universitario Virgen del Rocío, Instituto de Biomedicina (IBIS / CSIC), Universidad de Sevilla, Sevilla, Spain
¹⁸Hospital Universitario Reina Sofía, Córdoba, Spain
¹⁹Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain
²⁰Hospital General Universitario de Castellón, Castellón de la Plana, Spain
²¹Hospital Universitario Morales Messeguer, Murcia, Spain
²²Hospital Universitario Ramón y Cajal, Madrid, Spain
²³Hospital Universitari Dr. Peset, Valencia, Spain
²⁴Hospital Universitario Lucus Augusti, Lugo, Spain
²⁵Centro de Investigación Médica Aplicada, University of Navarra, Pamplona, Spain
²⁶Hospital Universitario de Salamanca (HUS/IBSAL), CIBERONC and Center for Cancer Research-IBMCC (USAL-CSIC), Salamanca, Spain
²⁷Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain
²⁸IMIBIC, Hematology, Hospital Universitario Reina Sofía, UCO, Córdoba, Spain
²⁹Hospital Universitari i Politécnic-IIS La Fe, Valencia, Spain
³⁰Hematology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain

Lusha Cao, PhD, MS^1*, Yang Xu, BS^2,3*, Tina Glisovic-Aplenc, PhD⁴, Kevin Nestler, BS^4*, Saar Gill, MD, PhD⁵, Kathrin M. Bernt, MD^4,6, Benjamin A Garcia, PhD^7*, Hossein Fazelinia, PhD^1,8*, Lingyu Guan, PhD^2,9*, Yi Xing, PhD^1,2,9* and Richard Aplenc, MD, PhD^4,6

¹Department of Biomedical and Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, PA
²Center for Computational and Genomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA
³Graduate Group in Genomics and Computational Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
⁴Division of Oncology and Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA
⁵Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
⁶Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
⁷Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis
⁸Proteomics Core Facility, The Children's Hospital of Philadelphia, Philadelphia, PA
⁹Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA

Gege Gui^1*, Abigail Wong-Rolle^2*, Laura W. Dillon, PhD^1*, Meghali Goswami, PhD¹, Eddie Martin^3*, Prajan Divakar^4*, Jason Reeves, PhD^4*, Katherine R. Calvo, MD, PhD⁵, Kasper D. Hansen, PhD^6*, Christopher S. Hourigan, MD PhD¹ and Chen Zhao, MD^2*

¹Laboratory of Myeloid Malignancies, Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD
²Thoracic and GI Malignancies Branch, NCI, Bethesda, MD
³Department of Laboratory Medicine, NIH Clinical Center, Bethesda, MD
⁴Nanostring Technologies, Inc., Seattle, WA
⁵Hematology Section, Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD
⁶Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD

Sergiu Pasca^1*, Matthew Guo, BA², Shiyu Wang^3*, Kristin Stokvis, CNP^4*, Audra Shedeck, CRNP^5*, Aparna Pallavajjala^6*, Lisa Haley, MS^7*, Cynthia Shams^2*, Roshni Pallavajjala^2*, Christopher D. Gocke, MD^8*, Amy E. DeZern, MD⁹, Ravi Varadhan, PhD^10*, Richard J. Jones, MD⁵ and Lukasz P. Gondek, MD, PhD¹¹

¹Johns Hopkins University, BALTIMORE, MD
²Johns Hopkins, Baltimore
³Johns Hopkins, Baltimore, MD
⁴Johns Hopkins Hospital, Baltimore
⁵Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
⁶Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD
⁷Johns Hopkins University School of Medicine, Baltimore, MD
⁸Division of Molecular Pathology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD
⁹Division of Hematologic Malignancies, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
¹⁰Oncology Biostatistics and Bioinformatics, Johns Hopkins University, Baltimore, MD
¹¹Division of Hematologic Malignancies, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins, Baltimore, MD

Mark Wunderlich, MS^1*, Jason Clark, MS^2*, Jing Chen, PhD^3* and Lynn Lee, MD²

¹Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
³Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Marcus Matthias Schittenhelm, PD MD^1*, Mihada Bajrami Saipi, MD^2*, Gunnar Blumenstock^3*, Peter JM Valk, PhD⁴, Balazs Györffy^5* and Kerstin Maria Kampa-Schittenhelm, PD MD^1,2

¹Medical Oncology and Hematology, Kantonsspital St. Gallen, St. Gallen, Switzerland
²Department of Hematology, Oncology, Rheumatology and clinical Immunology, University Hospital Tübingen, Tübingen, Germany
³Institute of Clinical Epidemiology and Applied Biometry, Eberhard Karls University Tübingen, Germany, University of Tuebingen, Tuebingen, Germany
⁴Department of Hematology, Erasmus University Medical Center Cancer Institute, Rotterdam, Netherlands
⁵Dept. of Bioinformatics, TTK Momentum Cancer Biomarker Research Group, Budapest, Semmelweis University, Budapest, Hungary

Onyee Chan, MD¹, Najla Al Ali, MS¹, Somedeb Ball, MD¹, Justin Grenet, MD², Caroline Hana, MBBCh³, Yehuda E. Deutsch, MD⁴, Hammad Tashkandi, MBBS⁵, Ling Zhang, MD^6*, Mohammad O Hussaini, MD^7*, Seongseok Yun, MD, PhD¹, Andrew Kuykendall, MD⁸, Eric Padron, MD¹, Gail J. Roboz, MD⁹, Pinkal Desai, MD, MPH⁹, Rami S. Komrokji, MD⁵, Kendra Sweet, MD¹, Jeffrey E. Lancet, MD¹ and David A. Sallman, MD¹

¹Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
²New York Presbyterian/Weill-Cornell Medical Center, New York, NY
³University of Miami/JFK Palm Beach Regional Campus, Boynton Beach, FL
⁴Department of Malignant Hematology and Cellular Therapy at Memorial Health System, Moffitt Cancer Center, Pembroke Pines, FL
⁵Moffitt Cancer Center, Tampa, FL
⁶Department of Hematopathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁷Department of Hematopathology and Lab Medicine, Moffitt Cancer Center, Tampa, FL
⁸Department of Malignant Hematology, H. Lee Mofitt Cancer Center, Tampa, FL
⁹Division of Hematology and Oncology, Weill Cornell Medicine and The New York-Presbyterian Hospital, New York, NY

Blanca Boluda^1*, Claudia Sargas^2*, Rosa Ayala^3*, Maria Jose Larrayoz^4*, María Carmen Chillón Santos, PhD^5*, Estrella Carrillo-Cruz, MD^6*, Cristina Bilbao, PhD^7*, Esther Prados de La Torre^8*, Irene Navarro-Vicente^9*, David Martinez-Cuadron^1,10*, Rebeca Rodríguez-Veiga^11*, Cristina Gil^12*, Teresa Bernal del Castillo, MD^13*, Juan Miguel Bergua Burgués^14*, Lorenzo Algarra^15*, Mar Tormo¹⁶, Pilar Martinez Sanchez, MD^17*, Elena Soria^18*, Josefina Serrano^8*, Juan Manuel Alonso Dominguez, MD, PhD^19*, Raimundo García-Boyero, MD^20*, Maria Luz Amigo, MD^21*, Pilar Herrera^22*, Maria Jose Sayas^23*, Esperanza Lavilla^24*, Joaquín Martínez-López, MD, PhD^25*, María José Calasanz, PhD^26*, Ramon Garcia-Sanz⁵, Jose A. Perez-Simon, MD, PhD¹⁸, María Teresa Gómez-Casares, MD, PhD^7*, Joaquín Sánchez-Garcia, MD⁸, Eva Barragán^1,10* and Pau Montesinos, MD, PhD^1*

¹Hospital Universitari i Politécnic-IIS La Fe, Valencia, Spain
²Molecular Biology Unit, Hospital Universitari i Politécnic-IIS La Fe, Valencia, Spain
³Spanish National Cancer Research Center (CNIO), Madrid, Spain
⁴CIMA LAB Diagnostics-Universidad de Navarra, Pamplona, Spain, Pamplona, Spain
⁵Hospital Universitario de Salamanca (HUS/IBSAL), CIBERONC and Center for Cancer Research-IBMCC (USAL-CSIC), Salamanca, Spain
⁶Hospital Universitario Virgen del Rocío, Instituto de Biomedicina (IBIS / CSIC / CIBERONC), Universidad de Sevilla, Sevilla, Spain
⁷Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain
⁸IMIBIC, Hematology, Hospital Universitario Reina Sofía, UCO, Cordoba, Spain
⁹Hematology Department, Hospital Universitari i Politécnic-IIS La Fe, Valencia, Spain
¹⁰CIBERONC Instituto de Salud Carlos III, Madrid, Spain
¹¹Hospital Universitari i Politècnic La Fe, Instituto de Investigación Sanitaria La Fe (IISLAFE), Valencia, Spain
¹²Servicio de Hematología Clínica, Hospital General de Alicante, Alicante, Spain
¹³Hospital Universitario Central de Asturias, Instituto Universitario (IUOPA), Instituto de investigación del Principado de Asturias (ISPA),, Oviedo, ESP
¹⁴Hospital San Pedro de Alcántara, Cáceres, Spain
¹⁵Hospital Universitario General de Albacete, Albacete, Spain
¹⁶Hematology Department, Hospital Clínico Universitario-INCLIVA, Valencia, Spain
¹⁷Hematology Department, Hospital Universitario 12 de Octubre, CNIO, Madrid, Spain
¹⁸Hospital Universitario Virgen del Rocío, Instituto de Biomedicina (IBIS / CSIC), Universidad de Sevilla, Sevilla, Spain
¹⁹Hospital Universitario Fundacion Jimenez Diaz - IISFJD-UAM, Madrid, Madrid, Spain
²⁰Hospital Universitario General de Castellón, Castellón de la Plana, Spain
²¹Hospital Universitario Morales Messeguer, Murcia, Spain
²²Hospital Universitario Ramón y Cajal, Madrid, Spain
²³Hospital Universitario Dr. Peset, Valencia, Spain
²⁴Hospital Universitario Lucus Augusti, Lugo, Spain
²⁵Hematology Department, Hospital Universitario 12 de Octubre, CNIO, Complutense University, Madrid, Spain
²⁶CIMA LAB Diagnostics-Universidad de Navarra, IdiSNA: Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain

Francisco Marchi, BS¹, Fernando Sckaff^2*, Xueyuan Cao, PhD^3,4*, Raul C. Ribeiro, MD³, Jeffrey E. Rubnitz, MD^5,6, Stanley B. Pounds, PhD^7* and Jatinder K. Lamba, PhD⁸

¹Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL
²University of Florida, Gainesville
³St. Jude Children's Research Hospital, Memphis, TN
⁴Department of Health Promotion and Disease Prevention, University of Tennessee Health Science Center, Memphis, TN
⁵Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN
⁶St. Jude Children's Hospital, Memphis, TN
⁷Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
⁸UF Health Cancer Center, Gainesville, FL

Norman Salomao^1*, Nabih Maslah, PharmD, PhD^2*, Anouk Giulianelli^3*, Louis Drevon, MD^4*, Lorea Aguinaga^5*, Xiaolian Gu^6*, Bruno Cassinat, PharmD, PhD², Stephane Giraudier, MD, PhD^7*, Pierre Fenaux⁸ and Robin Fahraeus^1*

¹INSERM UMR1131 -Institut de Recherche Saint Louis (IRSL - Hôpital St Louis) - Université de Paris, Paris, France
²INSERM UMR 1131, Institut de Recherche Saint-Louis, Paris, France
³APHP, Paris, France
⁴ApHP, paris, France
⁵APHP, Paris, FRA
⁶Umea University, Umea, Sweden
⁷INSERM UMR 1131, Saint-Louis Research Institute, Paris, France
⁸Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France

Olga Pérez-López^1,2*, Marta Reinoso Segura^3*, Clara B. Calderon Garcia, PhD^4*, Noelia González-Carrasco^5*, María Solé^6*, Eduardo Rodriguez Arboli, MD^7*, Concepción Prats-Martín, MD^8*, Jose González Campos^9*, Jose A. Perez-Simon, MD, PhD¹⁰ and Teresa Caballero, PhD^2,10,11*

¹Hospital Universitario de Jerez de la Frontera, Jerez de la Frontera, Spain
²Department of Hematology, Hospital Universitario Virgen del Rocio; Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla,Spain, Sevilla, Spain
³Department of Hematology, Hospital Universitario Virgen del Rocío, Sevilla, ESP
⁴Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Rocío of Sevilla, Sevilla, Spain
⁵Department of Hematology, Hospital Universitario Virgen Macarena, Sevilla, Spain
⁶Hospital Juan R. Jiménez, Huelva, Spain
⁷Instituto de Biomedicina de Sevilla (IBiS), UCG-Hematología, Hospital Universitario Virgen del Rocío, SEVILLA, Spain
⁸UCG-Hematología, Hospital Universitario Virgen del Rocío, Seville, Spain
⁹UCG-Hematología, Hospital Universitario Virgen del Rocío, Sevilla, Spain
¹⁰Instituto de Biomedicina de Sevilla (IBiS), UGC-Hematología, Hospital Universitario Virgen del Rocío/ CSIC/ CIBERONC, Universidad de Sevilla, Sevilla, Spain
¹¹University of Seville, MADRID, Spain

Joshua Tatarian^1*, Stephen Hyter, PhD^2*, Andrew K. Godwin, PhD^2*, Daniel Farrell, MD^2*, Tara L. Lin, MD³ and Haitham Abdelhakim, MD³

¹University of Kansas School of Medicine, Kansas City, KS
²Department of Pathology & Laboratory Medicine, University of Kansas Cancer Center, Kansas City, KS
³Division of Hematologic Malignancies & Cellular Therapeutics, University of Kansas Cancer Center, Kansas City, KS

Martina Crysandt, MD^1,2,3,4*, Pia Krüger, MD^5*, Steffen Koschmieder^6,7,8, Ingo Kurth, MD^9*, Tim H. Brümmendorf, MD^7,10, Florian Kraft^11* and Edgar Jost^1,12*

¹Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, University Hospital RWTH Aachen, Aachen, Germany
²Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany
³Department of Internal Medicine IV, University Hospital RWTH Aachen, Aachen, Germany
⁴Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen Bonn Cologne Düsseldorf, Germany
⁵Institute for Human Genetics and Genomic Medicine,, University Hospital RWTH Aachen, Aachen, Germany
⁶Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Faculty of Medicine, University Hospital of Aachen, Aachen, Germany
⁷Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany
⁸Department of Medicine (Hematology, Oncology, Hemostaseology, and SCT), RWTH Aachen University, Aachen, Germany
⁹Institute of Human Genetics, University Hospital, Technical University (RWTH) Aachen, Aachen, Germany
¹⁰Department of Hematology and Oncology, Center for Integrated Oncology (CIO), Uniklinik RWTH Aachen, Aachen, Germany
¹¹Institute for Human Genetics and Genomic Medicine, University Hospital RWTH Aachen, Aachen, Germany
¹²Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Aachen, Germany

Andrew J. Menssen, PhD¹, Chad A. Hudson, MD, PhD¹, Todd A. Alonzo, PhD^2,3*, Robert B. Gerbing, MA^2*, Laura Pardo^1,4*, Fan-Chi Hsu, PhD^1*, Loren L. Lott^1*, Fangyan Dai^1*, Keely Ghiradelli^1*, Yi-Cheng Wang, MS^2*, E. Anders Kolb, MD^2,5, Todd M. Cooper, DO⁶, Jessica A. Pollard, MD^7,8, Michael R. Loken, PhD^1*, Richard Aplenc, MD, PhD⁹, Lisa Eidenschink Brodersen, PhD¹ and Soheil Meshinchi, M.D., Ph.D.^2,10

¹Hematologics, Inc., Seattle, WA
²Children's Oncology Group, Monrovia, CA
³Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA
⁴Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
⁵Nemours Center for Cancer and Blood Disorders, Nemours Children's Health, Wilmington, DE
⁶Seattle Children’s Hospital, Cancer and Blood Disorders Center, Seattle, WA
⁷Dana Building 3136, Dana-Farber Cancer Institute, Boston, MA
⁸Harvard Medical School, Boston, MA
⁹Division of Oncology and Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA
¹⁰Fred Hutchinson Cancer Center, Seattle, WA

Leo Ruhnke^1*, Julia Frimmel^1*, Christoph Röllig^2*, Brigitte Mohr^1*, Heidi Altmann^1*, David Poitz^3*, Sven Zukunft^1*, Katrin Schranz^4,5*, Sebastian Vosberg^6*, Karsten Spiekermann⁴, Michael von Bergwelt, Prof. Dr.^7*, Edgar Jost^8*, Sabine Dressler^9*, Kerstin Schäfer-Eckart^9*, Triantafyllos Chavakis^3*, Daniela Aust^10*, Korinna Jöhrens^10*, Gustavo Baretton^10*, Martin Bornhäuser, MD^1*, Philipp A. Greif^4,5, Friedrich Stölzel^1*, Sylvia Herold^10* and Lisa Wagenführ^1*

¹Department of Internal Medicine I, University Hospital Dresden, Dresden, Germany
²Department of Internal Medicine I, Department of Internal Medicine I, University Hospital Dresden, TU Dresden, Dres, Dresden, Germany
³Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Dresden, Dresden, Germany
⁴Department of Medicine III, University Hospital Grosshadern, Ludwig-Maximilians University, Munich, Germany
⁵German Cancer Consortium (DKTK) partner site Munich, Germany and German Cancer Research Center (DKFZ), Heidelberg, Germany
⁶Department of Internal Medicine, Division of Oncology, Medical University of Graz, Graz, Austria
⁷Department of Medicine III, University Hospital, LMU Munich, Munich, Germany
⁸Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Aachen, Germany
⁹Department of Internal Medicine V, Nuremberg Hospital North, Paracelsus Medical University, Nuremberg, Germany
¹⁰Institute of Pathology, University Hospital Dresden, Dresden, Germany

Sebastian Wolf^1,2,3*, Ashok Kumar Jayavelu, PhD^4,5*, Florian Buettner, PhD^1,3*, Gabriela Alexe, PhD^6,7*, Björn Häupl, PhD^1,2,3*, Constanze Schneider, PhD^2,6,7*, Anne C Wilke, MD^1,2,3*, Alena Zindel^1,2,3*, Dominique Jahn^1,2,3*, Bianca Splettstoesser^4*, Julius Christoph Enssle, MD^1,2,3*, Anjali Cremer, MD^1,2,3*, Christoph Röllig^8*, Christian Thiede, MD⁹, Björn Steffen, MD^1,2,3*, Martin Bornhäuser, MD^9,10*, Henning Urlaub, PhD^11*, Kimberly Stegmaier, MD^6,7, Hubert Serve, MD^1,2,3, Matthias Mann, PhD^4* and Thomas Oellerich, MD^1,2,3*

¹German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Frankfurt, Germany
²Department of Medicine II, Hematology and Oncology, University Hospital Frankfurt, Goethe-University, Frankfurt, Germany
³Frankfurt Cancer Institute (FCI), Frankfurt, Germany
⁴Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Munich, Germany
⁵Hopp Children’s Cancer Center, University Hospital Heidelberg, Heidelberg, Germany
⁶Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA
⁷Broad Institute of MIT and Harvard, Cambridge, MA
⁸Department of Internal Medicine I, Department of Internal Medicine I, University Hospital Dresden, TU Dresden, Dres, Dresden, Germany
⁹Department of Internal Medicine I, University Hospital Dresden, Dresden, Germany
¹⁰National Center for Tumor Diseases (NCT), Partner Site Dresden, Dresden, Germany
¹¹Bioanalytical Mass Spectrometry Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany