Ola A Elgamal, PhD, BSc¹, Sandip Vibhute, PhD^2*, Blaise Stearns, M.Sc^1*, Susheela Tridandapani, PhD³, Thomas E Goodwin, PhD^4*, Gerard Hilinski, PhD^5*, Chad Bennett, PhD^5*, Jeffrey Patrick, PharmD^5*, Erin Hertlein, PhD¹ and John C. Byrd, MD¹

¹Department of Internal Medicine, University of Cincinnati, Cincinnati, OH
²Medicinal Chemistry Shared Resource, The Ohio State University Comprehensive Cancer Center, Columbus, OH
³Department of Internal Medicine, Division of Hematology, College of Medicine, The Ohio State University, Columbus, OH
⁴Hendrix College, Conway, AR
⁵Drug Development Institute, The Ohio State University Comprehensive Cancer Center, Columbus, OH

Tareq Abuasab, MD¹, Guillermo Garcia-Manero, MD², Nicholas Short, MD³, Yesid Alvarado, MD¹, Ghayas C. Issa, MD¹, Rubiul Islam, MD^1*, Abhishek Maiti, MBBS⁴, Musa Yilmaz, MD⁵, Nitin Jain, MD⁵, Lucia Masarova, MD¹, Steven M. Kornblau, MD¹, Elias Jabbour, MD¹, Naveen Pemmaraju, MD¹, Guillermo Montalban-Bravo, MD¹, Sherry A. Pierce, BSN, BA^1*, Courtney D. DiNardo, MD, MSCE¹, Tapan M. Kadia, MD¹, Naval Daver, MD¹, Marina Konopleva, MD, PhD¹, Hagop Kantarjian, MD⁶ and Farhad Ravandi, MD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, The University of Texas Health Science Center At Houston, Houston, TX
⁵Department of Leukemia, MD Anderson Cancer Center, Houston, TX
⁶Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Christoph Röllig, MD, MSC^1*, Lars Fransecky, MD^2*, Maher Hanoun, MD, PhD^3*, Björn Steffen, MD^4*, Sabrina Kraus, MD^5*, Christoph Schliemann, MD^6*, Annett Haake^7*, Frank Fiebig^7*, Sven Zukunft^8*, Nael Alakel, MD^9*, Jan Moritz Middeke, MD^10*, Martin Bornhaeuser, MD¹¹, Friedrich Stoelzel, MD¹⁰, Johannes Schetelig, MD, MSc¹², Leo Ruhnke^8*, Michael Kramer, MSc^8*, Malte Von Bonin, MD^13*, Maximilian Alexander Röhnert^14*, Uta Oelschlägel, PhD^15*, Claudia D. Baldus, MD^16*, Hubert Serve, MD⁴ and Martin Wermke, MD^17*

¹University Hospital, TU Dresden, Germany, Dresden, Germany
²Department of Internal Medicine II, University Hospital Schleswig-Holstein, Kiel, Germany
³Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany
⁴Department of Medicine II, Hematology/Oncology, Goethe University Hospital, Frankfurt, Germany
⁵Department of Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany
⁶Department of Hematology, Oncolog and Pneumology, University of Münster, Münster, Germany
⁷Universitätsklinikum Dresden, Dresden, Germany
⁸Department of Internal Medicine I, University Hospital Dresden, Dresden, Germany
⁹University Hospital TU Dresden, Germany, Dresden, Germany
¹⁰Department of Internal Medicine I, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany
¹¹Universitatsklinikum Cad GustavCarus an der Technischen Universltat Dresden, Dresden, Ferscherstrabo 74, Germany
¹²Department of Internal Medicine I, TU Dresden, Dresden, Saxony, Germany
¹³Department of Internal Medicine I, University Hospital 'Carl Gustav Carus', TU Dresden, Dresden, Germany
¹⁴Department of Internal Medicine I, University Hospital Carl-Gustav-Carus Dresden, Dresden, Germany
¹⁵Department of Medicine I, University Hospital Carl Gustav Carus Dresden, Dresden, Germany
¹⁶Department of Internal Medicine II, University Hospital Schleswig-Holstein, Kiel, Kiel, Germany
¹⁷Medical Faculty, NCT/UCC Early Clinical Trial Unit, Technical University Dresden, Dresden, Germany

Jake Shortt, FRACP, FRCPA, PhD¹, Pau Montesinos, PhD, MD^2*, Shuh Ying Tan, MBBS^3*, Teng Fong Ng, BSc, MBBS, MRCP⁴, Chun Yew Fong, MBBS, PhD⁵, Paul Cannell, MBBS, FRACP, FRCPA⁶, Rajeev Rajagopal^7*, Sophia Leitch^8*, Peter T. Tan, MBBS^9*, Sundra Ramanathan, FRACP, FRCPA, MBBS^10*, Robin Gasiorowski, MA, FRACP, FRCPA, MBBS¹¹, Douglas Stuart Lenton, FRACP, FRCPA^12*, Tse-Chieh Teh, MBBS, PhD, FRACP, FRCPA^13*, José Antonio Pérez-Simón, MD, PhD¹⁴, Carolyn Grove, MBBS, PhD^15*, Xiaojun Huang^16*, Courtney D. DiNardo, MD, MSCE¹⁷, Katherine Naidu^18*, Joseph Pariseau^18*, Si Cheng^18*, Yu Liu^18*, Melannie Co, MD^18*, Wai Y. Chan, PhD^18*, Haiyi Guo^18* and Andrew H. Wei, MBBS, FRACP, FRCPA, PhD¹⁹

¹Monash University and Monash Health, Melbourne, VIC, Australia
²Hospital Politecnico Universitario La Fe, Valencia, Spain, Spain
³St Vincent’s Hospital Melbourne, Fitzroy, VIC, Australia
⁴Gold Coast University Hospital, Southport, QLD, Australia
⁵Austin Health, Heidelberg, VIC, Australia
⁶Fiona Stanley Hospital, Murdoch, Western Australia, Australia
⁷Middlemore Hospital, Auckland, New Zealand
⁸North Shore Hospital, Auckland, New Zealand
⁹One Clinical Research, Nedlands, Western Australia, Australia
¹⁰The Saint George Hospital-Kogarah, Kogarah, NSW, Australia
¹¹Concord Repatriation General Hospital, Sydney, NSW, Australia
¹²Orange Health Service (Central West Cancer Care Centre), Orange, NSW, Australia
¹³Department of Clinical Haematology, The Alfred Hospital, Prahan, VIC, Australia
¹⁴Hospital Universitario Virgen del Rocío, Instituto de Biomedicina (IBIS / CSIC), Universidad de Sevilla, Sevilla, Spain
¹⁵Linear Clinical Research, PathWest & Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
¹⁶Peking University People’s Hospital, Beijing, China
¹⁷The University of Texas MD Anderson Cancer Center, Houston, TX
¹⁸BeiGene (Shanghai) Co., Ltd., Shanghai, China and BeiGene USA, Inc., San Mateo, CA
¹⁹Department of Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, VIC, Australia

Suman Kambhampati, MD^1*, Christine M. McMahon, MD², Alireza Eghtedar, MD^3*, Daniel A. Pollyea, MD⁴, Stephane de Botton, MD, PhD^5*, Arnaud Pigneux^6*, Mohamad Cherry, MD, MS⁷, Brian J Ball, MD⁸, Gautam Borthakur, MD⁹, Thomas Cluzeau, MD, PhD^10*, Gary J. Schiller, MD¹¹, Beibei Hu, MS^12*, Angela Volkert^12*, Joanie Aasen Gausman, MS, RN^12*, Graeme Hodgson, PhD^12*, David A. Roth, MD¹², Erica D. Warlick, MD¹², Michael J. Kelly, MD^12* and Eytan Stein, MD¹³

¹Sarah Cannon Cancer Institute, HCA Midwest Health, Research Medical Ctr, Kansas City, MO
²Anschutz Medical Campus, Division of Hematology, University of Colorado School of Medicine, Aurora, CO
³Colorado Blood Cancer Institute at Presbyterian/St. Luke's Medical Center, Denver, CO
⁴Anschutz Medical Campus, Division of Hematology, University of Colorado School of Medicine, Denver, CO
⁵Département d’hématologie et Département d’innovation thérapeutique, Gustave Roussy, Villejuif, France
⁶Hôpital Haut Lévêque, CHU de Bordeaux, Bordeaux, France
⁷Atlantic Health System, Carol Simon Cancer Center, Morristown, NJ
⁸City of Hope National Medical Center, Duarte, CA
⁹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
¹⁰Clinical Hematology Department, Centre Hospitalier Universitaire de Nice, Nice, France
¹¹David Geffen School of Medicine at UCLA, Los Angeles, CA
¹²Syros Pharmaceuticals, Inc., Cambridge, MA
¹³Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY

Gary J. Schiller, MD¹, Laura Finn, MD², Mohamed M. Hegazi, MD^3*, Johnnie J. Orozco, MD, PhD⁴, Avinash Desai, MD^5*, Mary M Chen, MD⁶ and Gail J. Roboz, MD⁷

¹UCLA David Geffen School of Medicine, Los Angeles, CA
²Ochsner Medical Center, New Orleans, LA
³James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY
⁴Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
⁵Actinium Pharmaceuticals, Inc., New York, NY
⁶Actinium Pharmaceuticals, Inc., New York, MD
⁷Weill Cornell Medicine and New York-Presbyterian Hospital, New York, NY

Sonia Jaramillo Segura, MD^1*, Maxi Wass, MD^2*, Judith Schaffrath, MD^3*, Kathrin Rieger^4*, Axel Nogai, MD^5*, Mathias Haenel, MD^6*, Regina Herbst, MD^7*, Friedrich Stoelzel, MD⁸, Christoph Röllig, MD, MSc^9*, Edgar Jost^10*, Richard F. Schlenk, MD^11,12, Richard Noppeney, MD^13*, Christian H. Brandts, MD^14*, Utz Krug, MD¹⁵, Katharina S. Goetze¹⁶, Sebastian Buske^17*, Axel Florschütz^18*, Jörg Schubert^19*, Bernhard Opitz^20*, Martin Mohren, MD^21*, Eva Eßeling, MD^22*, Stephan von Witzendorff^23*, Marion Subklewe, MD²⁴, Martin Kaufmann, MD²⁵, Norbert Frickhofen^26*, Christian W Scholz, MD²⁷, Kerstin Schäfer-Eckart^28*, Volker Kunzmann^29*, Martin Schmidt-Hieber^30*, Herbert G. Sayer, MD, PhD³¹, Andreas Rank, MD^32*, Philipp Hemmati^33*, Frank Schueler, MD³⁴, Simone Kowoll^35*, Marina Scheller, PhD^36*, Jörg Steighardt^37*, Bayram Edemir^38*, Lutz Peter Mueller, MD^39*, Irit Gliko-Kabir^40*, Beatrice Ludwig-Kraus^41*, Sabine Edemir^42*, Ella Sorani, PhD^43*, Mascha Binder, MD^44*, Abi Vainstein, MD^40*, Shaul Kadosh^45*, Cora Gromann^37*, Andreas Wienke^46*, Claudia D. Baldus, MD^47*, Uwe Platzbecker, MD⁴⁸, Hubert Serve, MD⁴⁹, Martin Bornhaeuser, MD⁵⁰, Christian Junghanss, MD^51* and Carsten Mueller-Tidow, MD¹¹

¹Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany., Heidelberg, AL, Germany
²Hematology and Oncology, University Hospital of Halle (Saale), Halle (Saale), Germany
³Stem Cell Transplant Unit, Medical Clinic IV, Martin-Luther-University Halle-Wittenberg, Halle, Germany
⁴Klinik für Hämatologie und Onkologie, Charité Universitätsmedizin Berlin - Campus Benjamin Franklin, Berlin, Germany
⁵Division of Hematology and Oncology at Campus Benjamin Franklin (CBF), Charité, Berlin, Germany
⁶Medizinische Klinik III, Klinikum Chemnitz, Chemnitz, Germany
⁷Department of Internal Medicine III, Klinikum Chemnitz, Chemnitz, Germany
⁸Department of Internal Medicine I, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany
⁹Department of Internal Medicine I, University Hospital, Dresden, Germany
¹⁰Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Aachen, Germany
¹¹Department of Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany
¹²German Cancer Research Center, NCT-Trial Center, National Center for Tumor Diseases, Heidelberg, Germany
¹³Klinik für Hämatologie, Universitätsklinikum Essen, Essen, Germany
¹⁴Goethe University Frankfurt, Frankfurt, Germany
¹⁵Department of Medicine III, Hospital Leverkusen, Leverkusen, Germany
¹⁶Department of Medicine III, Klinikum rechts der Isar, Technical University Munich (TUM), Munich, Germany
¹⁷Städtisches Krankenhaus Kiel, Kiel, DEU
¹⁸Hematology, Klinikum Dessau, Dessau, Germany
¹⁹Elblandklinikum, Riesa, Germany, Riesa, Germany
²⁰14. Krankenhaus St. Elisabeth und St. Barbara Medizinische Klinik III Pneumologie/Hämatologie-Onkologie/Palliativmedizin, Halle, Germany., Halle-Saale, Germany
²¹Johanniter Krankenhaus Genthin-Stendal gGmbH, Stendal, DEU
²²Medizinische Klinik A, Universitätsklinikum Münster, Münster, Germany
²³17. GEMEINSCHAFTSKLINIKUM MITTELRHEIN Ev. Stift St. Martin Klinik für Innere Medizin Schwerpunkt Hämatologie / Onkolgie, Koblenz, Germany., Koblenz, Germany
²⁴Department of Medicine III (Hematology/Oncology), LMU University Hospital Munich, Muenchen, Germany
²⁵2nd Department of Internal Medicine, Oncology and Hematology, Robert Bosch Hospital, Stuttgart, Germany
²⁶Innere Medizin III, Horst-Schmidt-Kliniken Wiesbaden, Wiesbaden, Germany., Wiesbaden, Germany
²⁷Department of Hematology and Oncology, Vivantes Klinikum Am Urban, Berlin, Germany
²⁸Klinikum Nürnberg, Nürnberg, Germany
²⁹Universitätsklinikum Wuerzburg, Medizinische Klinik Und Poliklinik II, Wuerzburg, DEU
³⁰Department of Hematology and Oncology, Carl-Thiem-Klinikum, Cottbus, Cottbus., Cottbus, Germany
³¹Klinik für Innere Medizin II, Universitätsklinikum Jena, Jena, Germany
³²Medical Clinic II, University Hospital of Augsburg, Augsburg, Germany
³³Department of Hematology, Oncology and Palliative Care, Klinikum Ernst von Bergmann, Academic Teaching Hospital of Charité University Medical School, 10117 Berlin, Germany., Berlin, Germany
³⁴DRK Krankenhaus Luckenwalde, Luckenwalde, DEU
³⁵30. Coordination Centre for Clinical Trials, Faculty of Medicine, Martin-Luther University Halle-Wittenberg, Halle, Germany, Halle, Germany
³⁶Department of Medicine, Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany
³⁷Coordination Centre for Clinical Trials, Faculty of Medicine, Martin-Luther University Halle-Wittenberg, Halle, Germany, Halle-Saale, Germany
³⁸30. Coordination Centre for Clinical Trials, Faculty of Medicine, Martin-Luther University Halle-Wittenberg, Halle, Germany, Halle-Saale, Germany
³⁹Martin-Luther-Universität Halle-Wittenberg, Town 1, Germany
⁴⁰BioLineRx, Ltd., Modi'In, Israel
⁴¹Central Laboratory, University Hospital Halle, Halle/Saale, Germany., Halle-Saale, Germany
⁴²Department of Internal Medicine IV, Hematology and Oncology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany., Halle-Saale, Germany
⁴³BioLineRx Ltd., Modi'in, Israel
⁴⁴Martin-luther-University Halle-Wittenberg, Halle (saale), DEU
⁴⁵BioLineRx Ltd., Modiin, Israel
⁴⁶Institute of Medical Epidemiology, Biometrics, and Informatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany, Halle-Saale, Germany
⁴⁷Department of Internal Medicine II, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
⁴⁸Medical Clinical and Policlinic 1, Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany
⁴⁹Dept. of Medicine, Hematology and Oncology, Goethe University Frankfurt, University Hospital, Frankfurt, Germany
⁵⁰Department of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany
⁵¹Departement of Medicine III - Hematology, Oncology, and Palliative Care, University of Rostock, Rostock, Germany

Andrew H Wei^1,2,3, Harry J Iland, MBBS FRACP FRCPA MHGSA^4,5, John Reynolds, PhD^6*, Sun Loo, MBBS, FRACP, FRCPA^1,3, Chong Chyn Chua, MBBS, FRACP, FRCPA^2,3,7, David Westerman^1,8, Ing S Tiong, FRACP, FRCPA, MPhil⁸, Adam Ivey, BSc, MSc, PhD^9*, Piers Blombery, MBBS^1,10, Natasha S Anstee, PhD^3*, Rachel M Koldej, PhD^11,12*, David J. Curtis, MBBS, PhD^2,13, David Kipp, MBBS, BMedSc, FRCPA, FRACP¹³, David Ritchie, MB ChB, PhD^1,11, David M Ross, MBBS, PhD, FRACP, FRCPA^14*, Amanda Souza^15*, Jenny Collins^15*, Ashish Bajel, MBBS, DM¹, Carolyn Grove, MBBS, PhD^16*, Paula Marlton, MD¹⁷, Andrew W Roberts, MBBS, PhD^1,18, Naveen Pemmaraju, MD¹⁹, Keyur P. Patel, MBBS, PhD²⁰, Sanam Loghavi, MD²⁰, Marina Konopleva, MD, PhD¹⁹, Naval Daver, MD¹⁹ and Courtney D. DiNardo, MD, MSCE¹⁹

¹Department of Clinical Haematology, Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, VIC, Australia
²Department of Haematology, The Alfred Hospital and Monash University, Melbourne, VIC, Australia
³The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia
⁴University of Sydney, Sydney, Australia
⁵Institute of Haematology, Royal Prince Alfred Hospital, Sydney, Australia
⁶Department of Haematology, The Alfred Hospital and Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia
⁷Department of Haematology, The Northern Health, Rosanna, VIC, Australia
⁸Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
⁹Molecular Pathology, The Alfred Hospital, Melbourne, VIC, Australia
¹⁰Peter MacCallum Cancer Centre, Peter Maccallum Cancer Centre, East Melbourne, VIC, Australia
¹¹ACRF Translational Research Laboratory, Royal Melbourne Hospital, Parkville, VIC, Australia
¹²Department of Medicine (RMH), The University of Melbourne, Parkville, VIC, Australia
¹³Australian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia
¹⁴Royal Adelaide Hospital and SA Pathology, Adelaide, Australia
¹⁵Australasian Leukaemia & Lymphoma Group, Melbourne, Australia
¹⁶Department of Haematology, Sir Charles Gairdner Hospital & PathWest, Nedlands, Australia
¹⁷Princess Alexandra Hospital and the University of Queensland, Brisbane, QLD, Australia
¹⁸The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia
¹⁹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²⁰Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX

Emmanuel Almanza Huante, MD, MDN¹, Hagop Kantarjian, MD², Kelly S. Chien, MD¹, Courtney D. DiNardo, MD, MSCE¹, Nicholas Short, MD³, Abhishek Maiti, MBBS⁴, Guillermo Montalban-Bravo, MD¹, Naval Daver, MD¹, Jitesh D. Kawedia, BPharm^5*, Kayleigh Bowie, BSN, RN^6*, Sherry A. Pierce, BSN, BA^1*, Farhad Ravandi, MD¹, Marina Konopleva, MD^7*, Guillermo Garcia-Manero, MD⁸ and Tapan M. Kadia, MD⁹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, The University of Texas Health Science Center At Houston, Houston, TX
⁵Division of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Leukemia, The University of Texas. MD Anderson Cancer Center, Houston, TX
⁷Hematology/Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY
⁸Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
⁹Department of Leukemia, MD Anderson Cancer Center, Houston, TX

Yannan Jia^1,2*, Lina Han, PhD¹, Cassandra L Ramage^1*, Connie C. Weng^1*, Lei Yang^1*, Simona Colla, PhD^1*, Helen Ma^1*, Weiguo Zhang, MD, PhD¹, Michael Andreeff, MD, PhD³, Naval Daver, MD³, Nitin Jain, MD⁴, Naveen Pemmaraju, MD³, Kapil N. Bhalla, MD³, Satu Mustjoki, MD, PhD^5,6,7, Peiyi Zhang, MS^8*, Guangrong Zheng, PhD^8*, Daohong Zhou, PhD^9*, Qi Zhang, PhD^1* and Marina Konopleva, MD, PhD¹

¹Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston, TX
²Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, MD Anderson Cancer Center, Houston, TX
⁵Translational Immunology Research program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland
⁶iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
⁷Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
⁸Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL
⁹University of Texas Health Science Center at San Antonio, San Antonio

Huafeng Wang, M.D.^1,2,3,4*, Yiyi Yao, B.S.^1,2*, Liping Mao, M.D.^1,2*, Yinjun Lou, MD, PhD^1,2,4*, Yanling Ren, M.D.^1,2*, Xingnong Ye, M.D.^1,2*, Min Yang, M.D.^1,2*, Liya Ma, M.D.^1,2*, Yi Zhang, M.D.^1,2*, Yile Zhou, M.D.^1,2*, Xin Huang, Ph.D.^1,2,3,4*, Yungui Wang, Ph.D.^1,2,3,4*, Huan Xu, B.S.^1,2*, Hongyan Tong, MD, PhD^1,2,3,4*, Hong-hu Zhu, M.D., Ph.D.^1,2,3,4* and Jie Jin, PhD^1,2,3,4

¹Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
²Zhejiang Provincial Key Laboratory of Hematopoietic Malignancy, Zhejiang University, Hangzhou, China
³Zhejiang University Cancer Center, Hangzhou, China
⁴Zhejiang Provincial Clinical Research Center for Hematological Disorders, Hangzhou, China

Ola A Elgamal, PhD, BSc¹, James R Lerma^1*, Allison Mullaney, DVM^2*, Emily Stahl^3*, Blaise Stearns, M.Sc^1*, Andrew Orry, PhD^4*, Polo Chun-Hung Lam, PhD^4*, Ruben Abagyan, PhD^4*, Alexei Pushechnikov, PhD^5*, Nikolay Savchuk, PhD^5*, Volodymyr Kysil, PhD^5*, Hovhannes Gukasyan, PhD^5*, Iain Dukes, DPhil^5*, Oleg Mitkin, PhD^6*, Ruben Karapetian^6*, Alexei Riakhovskii, PhD^6*, Elena Bulanova, PhD^6*, Vladislav Parchinsky^6*, Alexandre Ivachtchenko, PhD^6*, Sharyn Baker, PharmD PhD⁷, Erin Hertlein, PhD¹ and John C. Byrd, MD¹

¹Department of Internal Medicine, University of Cincinnati, Cincinnati, OH
²Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH
³Experimental Hematology Laboratory, The Ohio State University, Columbus, OH
⁴MolSoft LLC, San Diego
⁵Eilean Therapeutics, Philadelphia
⁶ChemDiv Inc, San Diego
⁷Division of Pharmaceutics and Pharmacology, College of Pharmacy, Comprehensive Cancer Center, The Ohio State University, Columbus

Inge Van Der Werf, PhD^1,2,3*, Kathleen Steel, BA^4*, Phoebe Mondala, BS^5*, Larissa Balaian, PhD^6*, Jacqueline Cloos, Prof^7*, Gertjan J.L. Kaspers, Prof. MD, PhD⁸, James La Clair, PhD^9*, Peggy Wentworth, PhD^10*, Kathleen Fisch, PhD^11*, Leslie Crews, PhD¹², Thomas Whisenant, PhD^11*, Michael Burkart, PhD^9*, Mary Donohoe, PhD^6* and Catriona Jamieson, MD, PhD¹³

¹Dept. of Hematology, Amsterdam University Medical Center, VU University Medical Center, Cancer Center, Amsterdam, Netherlands
²Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
³Division of Regenerative Medicine, University of California, San Diego, Amsterdam, Netherlands
⁴Department of Medicine, Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA
⁵Division of Regenerative Medicine, University of California, San Diego, La Jolla, CA
⁶Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center and Sanford Stem Cell Clinical Center, University of California San Diego, La Jolla, CA
⁷Department of Hematology, Amsterdam UMC, location VUmc, Cancer Center Amsterdam, Amsterdam, Netherlands
⁸Dutch Childhood Oncology Group (DCOG), Utrecht, Netherlands
⁹Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA
¹⁰Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA
¹¹Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, CA
¹²Division of Regenerative Medicine, UCSD, La Jolla, CA
¹³Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center and Sanford Stem Cell Clinical Center, University of California, San Diego, La Jolla, CA

Larissa Balaian, PhD^1*, Mary Donohoe, PhD^2*, Phoebe Mondala, BS^3*, George F. Widhopf II, PhD⁴, Emanuela M. Ghia, PhD⁴, Edward D. Ball, MD^5*, Anna Kulidjian, MD^6*, Inge Van Der Werf, MSc⁷, Thomas J. Kipps, MD, PhD⁸ and Catriona Jamieson, MD, PhD^8,9,10

¹Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center and Sanford Stem Cell Clinical Center, University of California San Diego, La Jolla, CA
²Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA
³Division of Regenerative Medicine, University of California, San Diego, La Jolla, CA
⁴Center for Novel Therapeutics, Moores Cancer Center, University of California, San Diego, La Jolla, CA
⁵UCSD Moores Cancer Center, La Jolla
⁶University of California, San Diego, La Jolla, CA
⁷Cancer Center Amsterdam, Department of Hematology, Amsterdam UMC, Voorschoten, Netherlands
⁸Moores Cancer Center, University of California, San Diego, La Jolla, CA
⁹Sanford Stem Cell Clinical Center, University California, San Diego, La Jolla, CA
¹⁰Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center and Sanford Stem Cell Clinical Center, University of California, San Diego, La Jolla, CA

Andrius Zucenka, MD^1,2*, Lukas Kevličius, MD^2*, Linas Davainis, MD^2*, Birutė Davainienė, MD^2*, Kazimieras Maneikis, MD^2*, Regina Pileckytė, MD, PhD^1,2*, Dominika Vasilevska^1*, Igoris Trociukas, MD^2*, Vilmantė Vaitekėnaitė, MD^2* and Laimonas Griškevičius, MD, PhD^1,2*

¹Faculty of Medicine, Institute of Clinical Medicine, Vilnius University, Vilnius, Lithuania
²Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania

Ioannis Mantzaris, MD, MS¹, Mendel Goldfinger, MD², David Levitz, MD¹, Kateryna Fedorov, MD¹, Karen Fehn, RN, BSN^1*, Nicole Chambers, ANP/FNP^3*, Anne Munoz, RN^1*, Aradhika Dhawan^1*, Joel Victor^1*, Nishi Shah, MD, MPH¹, Aditi Shastri, MD¹, Noah Kornblum, MD^1*, R. Alejandro Sica, MD¹, Kira Gritsman, MD, PhD⁴, Dennis Cooper, MD¹, Mimi Kim, Sc.D^5*, Evripidis Gavathiotis, CPA, PhD, BSc^6*, Marina Konopleva, MD, PhD⁶, Amit Verma, MD⁴, Eric J. Feldman, MD^1* and Ulrich G. Steidl, MD, PhD⁶

¹Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY
²Oncology, Montefiore Medical Center/ Albert Einstein College of Medicine, Bronx, NY
³Oncology, Montefiore Medical Center Center for Cancer Care, Bronx, NY
⁴Department of Oncology, Montefiore Medical Center/ Albert Einstein College of Medicine, Bronx, NY
⁵Department of Epidemiology & Population Health (Biostatistics), Albert Einstein College of Medicine, Bronx, NY
⁶Albert Einstein College of Medicine, Bronx, NY

Chong Chyn Chua, MBBS, FRACP, FRCPA^1,2,3,4, Natasha S Anstee, PhD^3,5*, Anoop Kumar Enjeti, MBBS, FRCPA, MD, MRCP^2,6, Devendra Hiwase, MD, MBBS, PhD, FRACP, FRCPA⁷, Paula Marlton, MD^2,8, Ashish Bajel, MBBS, DM^2,9, Shuh Ying Tan, MBBS^2,10*, Edward S. Morris, BMBS, DM^2,11, Chun-Kei-Kris Ma, BSc(Med), MBBS, PhD, FRACP, FRCPA^2,12*, Carolyn Grove, MBBS, PhD^2,13*, Julian Cooney, MBBS, FRACP, FRCPA^2,14, Ashanka Beligaswatte, MBBS, FRACP, FRCPA^2,15*, Rachel M Koldej, PhD^16,17*, Stephen B Ting, MBBS, FRACP, FRCPA, PhD^2,18*, Travis Perera, MB ChB, FRACP, FRCPA^2,19*, Amanda Johnston, MBBS, FRACP, FRCPA^2,12, John Reynolds, PhD^2,5*, David Ritchie, MB ChB, PhD^2,16,20,21 and Andrew H Wei, MBBS, PhD^2,3,5,9

¹Department of Haematology, The Alfred Hospital and Monash University, Melbourne, VIC, Australia
²Australasian Leukaemia and Lymphoma Group (ALLG), Melbourne, VIC, Australia
³The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia
⁴Northern Hospital, Melbourne, VIC, Australia
⁵The Alfred Hospital and Monash University, Melbourne, VIC, Australia
⁶Department of Haematology, Calvary Mater Hospital, Waratah, NSW, Australia
⁷Department of Haematology, Royal Adelaide Hospital, Adelaide, SA, Australia
⁸Princess Alexandra Hospital and the University of Queensland, Brisbane, QLD, Australia
⁹Department of Clinical Haematology, Peter MacCallum Cancer Centre and the Royal Melbourne Hospital, Melbourne, VIC, Australia
¹⁰St. Vincent’s Hospital Melbourne, Fitzroy, VIC, Australia
¹¹Townsville Cancer Centre, Townsville, QLD, Australia
¹²Department of Haematology, Westmead Hospital, Sydney, NSW, Australia
¹³Department of Haematology, Sir Charles Gairdner Hospital & PathWest, Nedlands, Australia
¹⁴Department of Haematology, Fiona Stanley Hospital, Perth, Australia
¹⁵Department of Haematology, Flinders Medical Centre, Adelaide, Australia
¹⁶ACRF Translational Research Laboratory, Royal Melbourne Hospital, Parkville, VIC, Australia
¹⁷Department of Medicine (RMH), The University of Melbourne, Parkville, VIC, Australia
¹⁸Department of Haematology, Eastern Health and Monash University, Melbourne, VIC, Australia
¹⁹Wellington Blood and Cancer Centre, Wellington, New Zealand
²⁰Department of Clinical Haematology, Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, VIC, Australia
²¹Department of Medicine, The University of Melbourne, Parkville, VIC, Australia

Sung-Soo Yoon, MD, PhD¹, Dong-Yeop Shin, M.D., Ph.D.^2*, Je-Hwan Lee, MD, PhD³, Jun Ho Jang, MD, PhD⁴, June-Won Cheong⁵, Ho-Jin Shin^6*, Jeong-Ok Lee, MD Ph.D.⁷, Yunsuk Choi, MD., Ph.D.^3*, Joseph Clarey, MBBS FRACP FRCPA^8*, Jeejin Im^9*, Suntae Kim, Ph.D.^9*, Ky-Youb Nam, PhD^9*, Kyu-Tae Kim, PhD.^9*, June Han, Ph.D.^9*, Jeong Hyeok Yoon, PhD.^9*, Bao Nguyen^10*, Li Li, MD., PhD.^10* and Donald Small, MD., PhD.¹¹

¹Division of Hematology/Medical Oncology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South)
²Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South)
³Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of (South)
⁴Division of Hematology-Oncology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of (South)
⁵Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, Seoul, KOR
⁶Department of Internal Medicine, Pusan National University Hospital, Busan, Korea, Republic of (South)
⁷Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea, Republic of (South)
⁸ICON caner centre, North Mackay, Australia
⁹Pharos iBio Co., Ltd., Anyang, Korea, Republic of (South)
¹⁰Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD
¹¹Department of Oncology and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD

Antonia V. Bennett, PhD^1*, Xianming Tan, PhD^2*, Matthew C. Foster, MD^3*, Daniel R. Richardson, MD, MSc, MA⁴, Ashley L. Bryant, PhD, RN, OCN, FAAN⁵, William A. Wood, MD, MPH⁶, Ashley O. Yocum, PhD^7*, Alice S. Mims, MD⁸, Uma Borate, MD⁹ and Amy Burd, PhD¹⁰

¹Department of Health Policy and Management, University of North Carolina, Chapel Hill, NC
²Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC
³Division of Hematology/Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC
⁴Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC
⁵School of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, NC
⁶Division of Hematology/Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC
⁷The Leukemia & Lymphoma Society, Rye Brook, NY
⁸Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH
⁹Division of Hematology, The Ohio State University, Columbus, OH
¹⁰The Leukemia & Lymphoma Society, White Plains, NY

Sae Ishimaru, MD^1*, Gwenaëlle Gueguen, MD^2*, Seth E. Karol, MD³, Francisco J. Bautista Sirvent, MD, PhD^4,5*, Valeria Ceolin, MD^4,6*, Bianca F. Goemans, MD, PhD⁴, Marlous Bakker^4*, Laura Di Laurenzio, PhD^7*, Jennifer Lukin^7*, Harm Van Tinteren, PhD^4*, Gauri B. Sunkersett, DO^8*, Maika Onishi, MD, MAS⁹, Kristina Unnebrink, PhD^10*, Dirk Reinhardt, MD¹¹, Gwen L Nichols, MD⁷, E. Anders Kolb, MD¹² and C. Michel Zwaan, Prof. MD, PhD^4,13*

¹Princess Máxima Center for Pediatric Oncology, Utrecht, AL, Netherlands
²Department of Childhood and Adolescent Oncology, Institute Gustave Roussy, Villejuif, France
³Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN
⁴Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
⁵ITCC consortium, Paris, France
⁶Regina Margherita Children's Hospital, University of Turin, Turin, Italy
⁷The Leukemia & Lymphoma Society, Rye Brook, NY
⁸Abbvie, South San Francisco, FL
⁹Genentech, Inc., South San Francisco, CA
¹⁰AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany
¹¹Department of Pediatric Hematology and Oncology, University Hospital Essen, Essen, Germany
¹²Nemours Center for Cancer and Blood Disorders, Nemours Children's Health, Wilmington, DE
¹³Department of Pediatric Oncology/Hematology, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands

Naval Daver, MD¹, Takayuki Ikezoe, MD, PhD², Justin Watts, MD³, Naoko Hosono, MD⁴, Yoshiaki Ogawa, MD^5*, Yasushi Miyazaki, MD⁶, Harry P. Erba, MD, PhD⁷, John Affinito, MD^8*, Emily Brooks, PhD^8*, Ken Eguchi, PhD^9*, Hongliang Cai, PhD^8*, Bo Xu, PhD^8*, Jay Stoudemire, PhD^8*, Matthew Hitron, MD^8*, Akinobu Watanabe^8*, Philip Komarnitsky, MD, PhD^8* and Junichiro Yuda, MD, PhD^10*

¹The University of Texas M.D. Anderson Cancer Center, Houston
²Department of Hematology, Fukushima Medical University Hospital, Fukushima, Japan
³Sylvester Comprehensive Cancer Center, University of Miami, Coral Gables, FL
⁴University of Fukui, Fukui, Japan
⁵Department of Hematology /Oncology, Tokai University School of Medicine, Isehara, Japan
⁶Nagasaki University, Nagasaki, Japan
⁷Duke University, Durham, NC
⁸Sumitomo Pharma Oncology, Cambridge, MA
⁹Sumitomo Pharma Co., Ltd., Osaka, OSA, Japan
¹⁰Department of Hematology, National Cancer Center Hospital East, Kashiwa, Japan