Jayastu Senapati, MD, MBBS, DM^1*, Elias Jabbour, MD¹, Nicholas Short, MD², Nitin Jain, MD³, Partow Kebriaei, MD⁴, Richard E Champlin, MD⁴, Issa F. Khouri, MD⁴, Elizabeth J Shpall, MD⁴, Patrice Nasnas^5*, Aram Bidikian^1*, Rebecca Garris^1* and Hagop Kantarjian, MD⁶

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
³Department of Leukemia, MD Anderson Cancer Center, Houston, TX
⁴Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Bijal D. Shah, MD¹, Armin Ghobadi, MD², Olalekan O. Oluwole, MBBS³, Aaron C. Logan, MD, PhD⁴, Nicolas Boissel, MD, PhD⁵, Ryan D. Cassaday, MD⁶, Thibaut Leguay, MD^7*, Michael R. Bishop, MD⁸, Max S. Topp, MD^9*, Dimitrios Tzachanis, MD, PhD¹⁰, Kristen M. O'Dwyer, MD¹¹, Martha L. Arellano, MD¹², Yi Lin, MD, PhD¹³, Maria R. Baer, MD¹⁴, Gary J. Schiller, MD¹⁵, Jae H Park, MD¹⁶, Marion Subklewe, MD¹⁷, Mehrdad Abedi, MD¹⁸, Monique C. Minnema, MD, PhD¹⁹, William G. Wierda, MD, PhD²⁰, Daniel J. DeAngelo, MD, PhD²¹, Patrick Stiff, MD²², Deepa Jeyakumar, MD²³, Jinghui Dong, PhD^24*, Sabina Adhikary, PhD^24*, Lang Zhou, PhD^24*, Petra C. Schuberth, PhD^24*, Imi Faghmous, MS, MPH^24*, Behzad Kharabi Masouleh, MD^24* and Roch Houot, MD, PhD^25*

¹Moffitt Cancer Center, Tampa, FL
²Washington University School of Medicine, St. Louis, MO
³Vanderbilt University Cancer Center, Nashville, TN
⁴UCSF Medical Center, San Francisco, CA
⁵Hôpital Saint-Louis, Paris, France
⁶University of Washington, Fred Hutchinson Cancer Research Center, Seattle, WA
⁷Service d'hématologie clinique et thérapie cellulaire Hopital du Haut-Leveque CHU de Bordeaux, Bordeaux, Bordeaux, France
⁸University of Chicago Medicine, Chicago, IL
⁹Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany
¹⁰University of California San Diego, San Diego, CA
¹¹Wilmot Cancer Institute, University of Rochester, Rochester, NY
¹²Winship Cancer Institute, Emory University, Atlanta, GA
¹³Division of Hematology, Mayo Clinic, Rochester, MN
¹⁴Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD
¹⁵David Geffen School of Medicine at UCLA, Los Angeles, CA
¹⁶Memorial Sloan Kettering Cancer Center, New York, NY
¹⁷Ludwig-Maximilians-Universität München, Munich, Germany
¹⁸Davis Comprehensive Cancer Center, University of California, Sacramento, CA
¹⁹on behalf of HOVON/LLPC, University Medical Center Utrecht, Utrecht, Netherlands
²⁰The University of Texas MD Anderson Cancer Center, Houston, TX
²¹Dana-Farber Cancer Institute, Boston, MA
²²Loyola University Chicago Stritch School of Medicine, Maywood, IL
²³Irvine Medical Center, University of California, Orange, CA
²⁴Kite, a Gilead Company, Santa Monica, CA
²⁵CHU Rennes, Univ Rennes, Inserm & EFS, Rennes, France

Annelienke M. van Hulst^1*, Erica L.T. van den Akker, MD, PhD^2*, Emma J. Verwaaijen, MSc¹, Marta Fiocco, Prof. PhD^1,3*, Niki Rensen, MD, PhD^1*, Raphaële R.L. van Litsenburg, MD, PhD^1*, Saskia M.F. Pluijm, PhD^1*, C. Michel Zwaan, Prof. MD, PhD^1*, Hanneke M. Van Santen, MD, PhD^1,4*, Rob Pieters, Prof. MD. PhD¹, Andrea W.M. Evers, Prof. PhD.^5*, Martha A. Grootenhuis, PhD^1* and Marry M. van den Heuvel-Eibrink, MD¹

¹Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
²Pediatric Endocrinology, Erasmus MC- Sophia Children’s Hospital, Rotterdam, Netherlands
³Mathematical Institute, Leiden University, Leiden, Netherlands
⁴Pediatric Endocrinology, Wilhelmina Children’s Hospital/UMC Utrecht, Utrecht, Netherlands
⁵Leiden University Institute of Psychology, Leiden, Netherlands

Shai Shimony, MD^1,2*, Yael Flamand, MS^3*, Yannis K. Valtis, MD⁴, Andrew E. Place, MD, PhD⁵, Lewis B. Silverman, MD⁶, Lynda M. Vrooman, MD⁷, Andrew M. Brunner, MD⁸, Stephen E. Sallan, MD⁷, Richard M. Stone, MD⁹, Martha Wadleigh, MD², Donna S. Neuberg, ScD³, Daniel J DeAngelo, MD, PhD² and Marlise R. Luskin, MD²

¹Rabin Medical Center and Faculty of Medicine, Tel Aviv University, Petah Tikva, ISR
²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
³Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
⁴Brigham and Women's Hospital, Boston, MA
⁵Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA
⁶Dana-Farber Cancer Institute and Boston Children's Hospital, Department of Pediatric Oncology, Boston, MA
⁷Division of Hematology/Oncology, Boston Children’s Hospital, Harvard Medical School, Boston, MA
⁸Division of Hematology/Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
⁹Center for Leukemia, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA

Josephine Anne Lucero, MD¹, Brayan Merchán, MD^2*, Osamah Jamal S. Jarallah, MD³, Aniket Bankar, MBBS, MD, DM¹, Steven M. Chan, MD, PhD⁴, Marta B. Davidson, MD, PhD⁴, Vikas Gupta, MD, FRCP, FRCPath¹, Dawn Maze, MD, FRCPC, MSc¹, Mark D. Minden, MD, PhD¹, Guillaume Richard-Carpentier, MD, FRCPC¹, Aaron D. Schimmer, MD, PhD⁵, Andre C. Schuh, MD⁵, Karen Yee, MD¹ and Hassan Sibai, MBBS, MD^6*

¹Leukemia Program, Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada
²Hematology Department, Hospital del Mar, Barcelona, Catalonia, Spain
³Division of Hematology, Department of Medicine, University of Toronto, Toronto, ON, Canada
⁴Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁵Division of Medical Oncology and Hematology, University Health Network, Toronto, ON, Canada
⁶Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada

Fatima M Khadadah, FRCPC, MBBChir¹, Claire Andrews, MB, FRCPath^2,3, Eshetu G. Atenafu, M.Sc., P.Stat^4*, Andre C. Schuh, MD⁵, Dawn Maze, MD, FRCPC, MSc⁶, Karen Yee, MD⁶, Osamah Jamal S. Jarallah, MD⁷, Mark D. Minden, MD, PhD⁶, Aaron D. Schimmer, MD, PhD⁵, Steven M. Chan, MD, PhD⁸, Vikas Gupta, MD, FRCP, FRCPath⁶, Dennis Dong Hwan Kim, MD, PhD^9* and Hassan Sibai, MBBS, MD^10*

¹Kuwait Cancer Control Centre, Kuwait, Kuwait
²Leukemia Program, Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada
³Haematology, Mater Misericordiae University Hospital, Dublin, Ireland
⁴Department of Biostatistics, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁵Division of Medical Oncology and Hematology, University Health Network, Toronto, ON, Canada
⁶Leukemia Program, Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada
⁷Division of Hematology, Department of Medicine, University of Toronto, Toronto, ON, Canada
⁸Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁹Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, CAN
¹⁰Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada

Martha-Lena Mueller^1*, Torsten Haferlach, MD², Manja Meggendorfer, PhD², Claudia Haferlach, MD² and Wolfgang Kern, MD²

¹MLL Munich Leukemia Laboratory, 81377, Germany
²MLL Munich Leukemia Laboratory, Munich, Germany

Louise Guolla, MD, MSc^1,2*, Sara Breitbart, MN, NP^2,3*, Farid Foroutan, PhD^2,4*, Lehana Thabane, Ph.D.^1,2,5,6* and Sumit Gupta, MD, PhD^7,8,9,10

¹Department of Pediatrics, McMaster University, Hamilton, ON, Canada
²Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, ON, Canada
³Division of Neurosurgery, Hospital for Sick Children, Toronto, ON, Canada
⁴Ted Rogers Centre for Heart Research, University Health Network, University of Toronto, Toronto, ON, Canada
⁵St. Joseph’s Healthcare Hamilton, Hamilton, ON, Canada
⁶Faculty of Health Sciences, University of Johannesburg, Johannesburg, South Africa
⁷Cancer Research Program, Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
⁸Institute for Health Policy, Evaluation and Management, University of Toronto, Toronto, ON, Canada
⁹Faculty of Medicine, University of Toronto, Toronto, ON, Canada
¹⁰Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada

Maria Agustina Perusini, MD¹, Eshetu G. Atenafu, M.Sc., P.Stat^2*, Aniket Bankar, MBBS, MD, DM³, Vikas Gupta, MD, FRCP, FRCPath³, Mark D. Minden, MD, PhD¹, Jad Sibai, MSc^4*, Dawn Maze, MD, FRCPC, MSc³, Marta B. Davidson, MD, PhD⁵, Steven M. Chan, MD, PhD⁵, Fernando Binder, MD^6*, Guillaume Richard-Carpentier, MD, FRCPC³, Salman Alharbi, MD^1*, Claire Andrews, MB, FRCPath⁷, Karen Yee, MD¹, Andre C. Schuh, MD⁶ and Hassan Sibai, MBBS, MD^8*

¹Leukemia Program, Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
²Princess Margaret Cancer Centre, Department of Biostatistics, University Health Network, University of Toronto, Toronto, ON, Canada
³Leukemia Program, Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada
⁴Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁵Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁶Division of Medical Oncology and Hematology, University Health Network, Toronto, ON, Canada
⁷Department of Haematology, St Vincent's University Hospital, Dublin, Ireland
⁸Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada

Emmanuel Almanza Huante, MD, MDN¹, Elias Jabbour, MD¹, Marina Konopleva, MD, PhD¹, Cesar Nunez, MD², Sergej Konoplev, MD, PhD^3*, Nicholas Short, MD⁴, Naveen Pemmaraju, MD¹, Fatima Zahra Jelloul, MD^3*, Guilin Tang, MD, PhD^3*, Hagop Kantarjian, MD⁵ and Nitin Jain, MD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Pediatric Oncology and Patient Care, MD Anderson Cancer Center, Houston, TX
³Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Nienke van Engelen^1*, Merel A. Roest^1*, Freerk van Dijk^1*, Edwin Sonneveld, PhD^1*, Reno Bladergroen^1*, Simon van Reijmersdal^2*, Vincent H.J. van der Velden, PhD^3*, Patricia G. Hoogeveen^4*, W A. Kors, MD^1*, Esme Waanders, PhD^5*, Roland P. Kuiper, PhD^1,5 and Marjolijn C.J. Jongmans, MD, PhD^1,5*

¹Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
²Department of Genetics, Radboud University Medical Center, Nijmegen, Ge, Netherlands
³Department of Immunology, Erasmus Medical Center, University Medical Center, Rotterdam, Netherlands
⁴Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
⁵Department of Genetics, University Medical Center Utrecht, Utrecht, Netherlands

Jayastu Senapati, MD, MBBS, DM^1*, Nicholas Short, MD², Nitin Jain, MD³, Farhad Ravandi, MD¹, Tharakeswara K. Bathala, MBBS MD^4*, Aram Bidikian^1*, Fadi Haddad, MD^1*, Patrice Nasnas^5*, Naval Daver, MD⁶, Tapan M. Kadia, MD³, Rebecca Garris^1*, Monica Kwari, BSN¹, Hagop Kantarjian, MD⁷ and Elias Jabbour, MD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
³Department of Leukemia, MD Anderson Cancer Center, Houston, TX
⁴Abdominal Imaging, University of Texas MD Anderson Cancer Center, Houston
⁵Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶MD Anderson Cancer Center, Houston, TX
⁷Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Varsha Gupta, MBBS¹, Vinit Singh, MD, MBBS², Aasems Jacob, MD^3*, Ravneet Bajwa, MD¹ and Michael J Levitt, MD¹

¹Hematology Oncology, Jersey Shore University Medical Center, Neptune, NJ
²Internal Medicine, Monmouth Medical Center, Ocean, NJ
³Pikeville Medical Center, Pikeville, KY

Salman Alharbi, MD^1*, Maria Agustina Perusini, MD^1,2, Sita Bhella, M.D., MSc^3*, Mark D. Minden, MD, PhD⁴, Dawn Maze, MD, FRCPC, MSc⁴, Vikas Gupta, MD, FRCP, FRCPath⁴, Aaron D. Schimmer, MD, PhD⁴, Andre C. Schuh, MD⁴, Karen Yee, MD⁵, Steven M. Chan, MD, PhD⁶, Aniket Bankar, MBBS, MD, DM⁶, Marta B. Davidson, MD, PhD⁶, Guillaume Richard-Carpentier, MD, FRCPC⁶, Jad Sibai, MSc^7* and Hassan Sibai, MBBS, MD^5*

¹Leukemia Program, Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
²Princess Margaret Cancer Centre, University Health Network University of Toronto, Toronto, Canada, Toronto, ON, Canada
³Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Canada
⁴Division of Medical Oncology and Hematology, University Health Network, Toronto, ON, Canada
⁵Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁶Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁷Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada