Aishwarya Gurumurthy^*, Ashwin Iyer^*, Rohan Kodgule, MD, MBBS^*, Athalee Aguilar^*, Travis Saari^*, Juhi Gupta^*, Cody Hall, MS^*, John S. Runge, PhD^*, Matthew Weiss^*, Marcin P. Cieslik, PhD^* and Russell J. H. Ryan, MD

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI

Kashi Raj Bhattarai, PhD^1,2*, Kelly R. Barnett, PhD^1,2*, Robert J. Mobley, PhD^3,4*, Daniel C. Ferguson, PhD^1,2*, Jonathan D. Diedrich, PhD^1,4*, Brennan P. Bergeron, MS^1,2,5*, Wenjian Yang, PhD^1,2*, Kristine R. Crews, PharmD^1,2*, Wendy Stock, MD⁶, Elisabeth Paietta, PhD^7*, Steven M. Kornblau, MD⁸, Hiroto Inaba, MD, PhD^1,9, Sima Jeha, MD^1,9, Ching-Hon Pui, MD^1,10, Cheng Cheng, PhD^11*, Mary V. Relling, PharmD^1,2, William E. Evans, PharmD^1,2, Jun J. J. Yang, PhD^1,4,5,12 and Daniel Savic, PhD^1,2,5,12

¹Hematological Malignancies Program and Center for Precision Medicine in Leukemia, St. Jude Children's Research Hospital, Memphis, TN
²Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN
³Hematological Malignancies Program and Center for Precision Medicine in Leukemia, St. Jude Children’s Research Hospital, Memphis, TN
⁴Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, TN
⁵Graduate School of Biomedical Sciences, St. Jude Children's Research Hospital, Memphis, TN
⁶Comprehensive Cancer Center, University of Chicago Medicine, Chicago, IL
⁷Albert Einstein College of Medicine, New York, NY
⁸Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁹Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN
¹⁰Department of Oncology, St. Jude Children's Rsch./Hosp., Memphis, TN
¹¹Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
¹²Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN

Sarah Spoeck^*, Nadine Kinz^*, Andreas Villunger^* and Verena Labi, PhD^*

Medical University of Innsbruck, Innsbruck, Austria

Andrew Takeda^*, Jaewoong Lee, PhD^*, Tim Wartewig, MD, PhD, Alberto Bigogno^*, David Fonseca Arce^* and Markus Müschen, MD

Center of Molecular and Cellular Oncology and Department of Immunobiology, Yale University, New Haven, CT

Gisele Olinto Libanio Rodrigues, PhD^1*, Wenqing Li, PhD^1*, Julie Hixon^2*, Hila Winer, PhD^1*, Tu Chun Hsu, DVM^3*, Timothy Gower^3*, Sarah Cramer, DVM, PhD^4*, Caroline Andrews, MVD, PhD^5* and Scott Durum, PhD^1*

¹National Cancer Institute, National Institutes of Health, Frederick, MD
²Cytokines and Immunity Section, Center for Cancer Research, National Cancer Institute, Frederick
³NIH, Frederick
⁴StageBio, Frederick
⁵Charles River Laboratories, Frederick

Kentaro Yamaguchi, MD^1,2*, Junji Koya, MD, PhD^1*, Kota Mizuno, MD^1,2*, Kota Yoshifuji, MD, PhD^1*, Yuta Ito^1,3*, Mitsuhiro Yuasa, MD^1,4*, Yuki Saito, MD, PhD^1,5*, Mariko Tabata, MD^1,6*, Sumito Shingaki, MD, PhD^1*, Yasunori Kogure, MD, PhD^1*, Kazutaka Nakashima, MD^7*, Koichi Ohshima, MD, PhD^7* and Keisuke Kataoka, MD, PhD^1,2

¹Division of Molecular Oncology, National Cancer Center Research Institute, Tokyo, Japan
²Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
³Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
⁴Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
⁵Department of Gastroenterology, Keio University School of Medicine, Tokyo, Japan
⁶Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
⁷Department of Pathology, Kurume University School of Medicine, Kurume, Japan

Rafael Renatino-Canevarolo, PhD^1*, Mark B. Meads, PhD^2*, Maria L. Coelho Siqueira Silva, MSc^1*, Praneeth Reddy Sudalagunta, PhD^1*, Christopher Cubitt, PhD^3*, Gabriel De Avila, BS^4*, Raghunandan Reddy Alugubelli, MS^2*, Amit Kulkarni, PhD^5*, Qi Zhang, PhD^5*, Oliver Hampton, PhD^5*, Rachid C. Baz, MD⁶, Kenneth H. Shain, MD, PhD² and Ariosto Siqueira Silva, PhD^1*

¹Department of Cancer Physiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
²Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
³Cancer PK/PD Core, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
⁴Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
⁵M2GEN, Tampa, FL
⁶Department of Malignant Hematology, Moffitt cancer center and research institute, tampa, FL

Alasdair Duguid^1*, Camille Malouf^1*, Vasiliki Symeonidou^1*, Christina Halsey² and Katrin Ottersbach^1*

¹Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom
²Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom

Sankalp Srivastava, MS^1*, Jie Jiang, PhD^2*, Gretchen Seim^3*, Jagannath Misra, PhD^4*, Utpal Dave, MD⁵, Reuben Kapur, PhD¹, Jiehao Zhou, MD^2*, Jing Fan, PhD^3*, Ronald Wek, PhD^4* and Ji Zhang, PhD¹

¹Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN
²Indiana University, Indianapolis, IN
³Morgridge Institute for Research, University of Wisconsin-Madison, Madison, WI
⁴Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN
⁵Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN

Moritz Bewarder, MD^1*, Michelle Elbert^1*, Konstantinos Christofyllakis, MD^1*, Kristina Heyne, Ph.D.^1*, Gabi Carbon^1*, Natalie Fadle^1*, Evi Regitz^1*, Maximilian Kiefer, MD^1*, Igor Age Kos, MD^1*, Joerg Thomas Bittenbring, MD^1*, Frank Neumann, Ph.D.^1*, Falko Fend, MD^2*, Irina Bonzheim, Ph.D.^2* and Lorenz Thurner, MD¹

¹Department of Hematology, Oncology, Rheumatology and Clinical Immunology, Saarland University Medical Center, Homburg, Germany
²Department of Pathology and Neuropathology, University Hospital Tuebingen, Tuebingen, Germany

Sonia Debek, MSc, BA^1,2*, Dorota Komar, PhD^2,3*, Filip Garbicz^1,4*, Aleksandra Matrejek, MSc^2*, Michał Pawlak, PhD^2*, Ewa Jabłońska, PhD^2*, Maciej Szydlowski, PhD^2*, Magdalena Skrzypczak, PhD^2*, Sylwia Radomska, MSc^5*, Daniela Bellarosa, PhD^6*, Nazli Serin, MSc^7*, Malgorzata Bajor, PhD^8,9*, Bjoern Chapuy, MD, PhD^10,11 and Przemyslaw Juszczynski, MD, PhD^2*

¹Postgraduate School of Molecular Medicine, Medical University of Warsaw, Warsaw, Poland
²Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland
³Centre for Omic Sciences (COS), Eurecat, Centre Tecnològic de Catalunya, Reus, Spain
⁴Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Warszawa, Mazowieckie, Poland
⁵Department of Molecular Biology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland
⁶Experimental and Translational Oncology Department, Menarini Ricerche S.p.A., Pomezia (rome), AL, Italy
⁷Department of Hematology and Medical Oncology, University of Medical Center Göttingen, Göttingen, Germany
⁸Department of Clinical Immunology, Medical University of Warsaw, Warsaw, Poland
⁹Laboratory of Immunology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland
¹⁰Department of Hematology, Oncology and Tumor Immunology, Charité University Medical Center Berlin, Berlin, Germany
¹¹Department of Hematology and Medical Oncology, University of Medical Center Göttingen, Goettingen, Germany

Joana R Costa, PhD^1*, David O'Connor, MD^2,3*, Nurkaiyisah Anuar, MSc^4*, Sunniyat Rahman, PhD MBiochem^1,5*, Nivedita Singh, PhD^6*, Zhaodong China, PhD^7*, Tanya Rapoz-D’Silva, BSc, MSc^1*, Yang Li, PhD^1*, Kent Fung, PhD^1*, Sara Hyseni^1*, Stephen Henderson, PhD^8*, George Morrow^9*, Yanping Guo, DPhil^9*, Javier Herrero, PhD^8*, Richard Jenner, PhD^10*, Dennis Keppei, Ph.D.^4*, A. Thomas Look, MD⁷ and Marc R. Mansour, MD^1,11,12*

¹UCL Cancer Institute, Department of Haematology, University College London, London, United Kingdom
²Department of Haematology, Great Ormond Street Hospital for Children, London, United Kingdom
³UCL Cancer Institute, Department of Haematology, University College London, London, ENG, United Kingdom
⁴Cancer Science Institute of Singapore, Singapore, Singapore
⁵Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia
⁶Laboratory for Molecular Cell Biology (LMCB), University College London, London, United Kingdom
⁷Dana-Farber Cancer Institute, Department of Pediatric Oncology, Harvard Medical School, Boston, MA
⁸Cancer Institute, Bill Lyons Informatics Centre, University College London, London, United Kingdom
⁹UCL Cancer Institute, Flow Cytometry Translational Technology Platform, University College London, London, United Kingdom
¹⁰UCL Cancer Institute, Department of Cancer Biology, University College London, London, United Kingdom
¹¹University College London Hospitals NHS Foundation Trust, London, United Kingdom
¹²Great Ormond Street Institute of Child Health, University College London, London, ENG, United Kingdom

Taylor J Chen, BS^1*, Cory Seth Bridges, BS^2*, Monica Puppi, M.S.^2* and Daniel Lacorazza, PhD³

¹Texas Children’s Hospital Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX
²Texas Children’s Hospital. Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX
³Texas Children’s Hospital, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX

Evan Healy, PhD^1,2*, Rachel McCole, PhD^1*, Craig Monger, PhD^1*, James Nolan^3,4*, Eric Conway, PhD^1*, Gerard Brien, PhD^1*, Cheng Wang, PhD^1*, Hannah K Neikes^5*, Frances Potjewyd, PhD^6*, Michiel Vermeulen, PhD^7*, Aoibhinn Mooney^8*, Richard Flavin, MD, PhD, FRCPath^9*, Elisabeth Vandenberghe, MD, PhD³, Lindsey I James, PhD^10* and Adrian P Bracken, PhD^1*

¹Trinity College Dublin, Smurfit Institute of Genetics, Dublin, Ireland
²Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Clayton, Victoria, Australia
³St James' Hospital, Department of Haematology, Dublin, Ireland
⁴Trinity College Dublin, Smurfit Institute of Genetics, Limeirck, Ireland
⁵Faculty of Science, Radboud Institute for Molecular Life Sciences, Department of Molecular Biology, Nijmegen, Netherlands
⁶UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Chapel Hill, NC
⁷Radboud Institute for Molecular Life Sciences, Oncode Institute, Department of Molecular Biology, Faculty of Science, Nijmegen, Netherlands
⁸St James' Hospital, Department of Histopathology, Dublin, Ireland
⁹St James's Hospital, Dublin, Ireland
¹⁰School of Medicine, Lineberger Comprehensive Cancer Center, Chapel Hill, NC

Advaita Maria Dick, MSc^1*, Erika Tsingos, Dr.^2* and Baubak Bajoghli, Dr.^3*

¹University Hospital Tuebingen, Tuebingen, AL, Germany
²Leiden University, Leiden, Netherlands
³Department of Hematology, Oncology, Clinical Immunology, University Hospital Tuebingen, Tuebingen, Germany