Nancy Arthur, PhD¹, Keegan A Christensen, B.A.^2*, Kathleen Mannino, B.S.^3*, Stephen M. Sykes, PhD⁴, Ashutosh Kumar^5*, Nichole M Helton^6*, Agata Gruszczynska, B.S.^7*, Timothy J. Ley, MD⁸ and Francesca Ferraro, MD, PhD³

¹Washington University in Saint Louis, ST Louis, MO
²Washington University In Saint Louis, St. Louis, MO
³Washinghton University in Saint Louis, Saint Louis, MO
⁴Department of Pediatrics, Washington University, Saint Louis, MO
⁵Washington University in Saint Louis, Saint Louis, MO
⁶Washington University in Saint Louis, St. Louis, MO
⁷Washinghton University in Saint Louis, Saint Louis
⁸Washington University in St. Louis, St Louis, MO

Maryam Ghashghaei^1,2*, Marty Yue^2*, Aaremish Arsalan^2*, Giuseppe Bombaci, PhD^3*, Sandra Spencer Miko, PhD^4*, Haya Shaalan^2*, Glenn Edin^2*, Gregg Morin, PhD^4*, Fabiana Perna, MD, PhD⁵ and Ly P Vu, PhD^2,6

¹Faculty of Pharmaceutical Sciences, University of British Columbia, NORTH VANCOUVER, BC, Canada
²Terry Fox Laboratory, British Columbia Cancer Research Center, Vancouver, BC, Canada
³Department of Medicine, Indiana University Simon Comprehensive Cancer Center, Indianapolis, IN
⁴Genome Sciences Centre, British Columbia Cancer Research Center, Vancouver, BC, Canada
⁵Department of Medicine, Indiana University School of Medicine, Indianapolis, IN
⁶Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada

Rasoul Pourebrahim, MD, PhD^1*, Rafael Heinz Montoya, BS^1*, Lauren B Ostermann^1* and Michael Andreeff, MD, PhD²

¹Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

Angela Maria Savino, Ph.D.^1*, Briana Turner, B.S^2*, Sangmoo Jeong, PhD³, Tanya Schild, PhD^4*, Xuejing Yang, PhD^5*, Hanzhi Luo, PhD^6*, Rachel Chirayil, BS^4*, Quinlan Cullen, BS^4*, Mandy Chan, BS^7*, Grace Han^7*, Kathryn Chang^8*, Sudha Janaki Raman, PhD^9*, Justin R Cross, PhD^10*, Kayvan Keshari, PhD^4* and Michael G Kharas, PhD⁶

¹Università Degli Studi di Milano-Bicocca, Department of Medicine, Milano, Italy
²Department of Radiology and Department of Pharmacology, Memorial Sloan Kettering Cancer Center, New York City, NY
³Institute for NanoBioTehnology, Johns Hopkins University, Baltimore, MD
⁴Department of Radiology, Memorial Sloan Kettering Cancer Center, New York City, NY
⁵Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York City, NY
⁶Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY
⁷Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York City, NY
⁸Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York city, NY
⁹Metabolics Core, Memorial Sloan Kettering Cancer Center, New York City, NY
¹⁰MSKCC, New York

Jonathan M Tsai, MD, PhD^1*, Jacob D Aguirre, PhD^2*, Jared Brown, PhD^3*, Vivian Focht^2*, Yen-Der Li, MD^3*, Georg Kempf, PhD^2*, Lukas Kater, PhD^2*, Pius Galli^2*, Simone Cavadini, PhD^2*, Brittany E Sandoval, MSc^4*, Charles Zou^3*, Justine Rutter^3*, Katherine Donovan, PhD^5*, Quinlan Sievers, MD, PhD⁶, Paul Park^3*, Jevon A. Cutler, PhD^7*, Charlie Hatton^3*, Elizabeth Ener^3*, Micah T Sperling^3*, Mikolaj Slabicki, PhD^6*, Peter G. Miller, MD, PhD⁸, Roger Belizaire, MD, PhD⁹, Adam S. Sperling, MD, PhD¹⁰, Scott A. Armstrong, MD, PhD⁷, Eric S. Fischer, PhD^11*, Nicolas Thomä, PhD^2* and Benjamin L. Ebert, MD, PhD^8,12,13,14

¹Department of Pathology, Brigham and Women's Hospital, Boston, MA
²Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
³Dana-Farber Cancer Institute, Boston
⁴Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
⁵Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA
⁶Broad Institute of Harvard and MIT, Cambridge, MA
⁷Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
⁸Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁹Department of Pathology, Division of Transfusion Medicine, Dana Farber/Brigham & Women's/Massachusetts General Hospital, Boston, MA
¹⁰Division of Hematology, Dana-Farber Cancer Institute, Boston, MA
¹¹Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA
¹²Harvard Medical School, Boston, MA
¹³Howard Hughes Medical Institute, Boston, MA
¹⁴Broad Institute of MIT and Harvard University, Cambridge, MA

Nicole L. Michmerhuizen, PhD¹, Masayuki Umeda, MD^1*, Ilaria Iacobucci, PhD¹, Bright Arthur, MS^1*, Danika Di Giacomo, PhD^1*, Ryan Hiltenbrand, MS^1*, Pablo Portola, BS^1*, Sherif Abdelhamed, PhD¹, Hongling Huang, PhD^2*, Peipei Zhou, PhD^2*, Lingyun Long, PhD^2*, Hao Shi, PhD^2*, Yu Sun, PhD^2*, Evangelia K. Papachristou, PhD^3*, Chandra Chilamakuri, PhD^3*, Clive S. D'Santos, PhD^3*, Hongbo Chi, PhD^2*, Jeffery M. Klco, MD, PhD¹ and Charles G. Mullighan, MBBS, MD¹

¹Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
²Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN
³University of Cambridge, Cambridge, United Kingdom

Umeshkumar M Vekariya, PhD^1*, Katherine Sullivan-Reed, PhD^1*, Monika Toma, PhD^1*, Margaret Nieborowska-Skorska, MD, PhD^1*, Bac Viet Le, PhD^1*, Marie-Christine Caron, PhD^2*, Anna-Mariya Kukuyan, PhD^1*, Paulina Podszywalow-Bartnicka, PhD^3*, Kumaraswamy Chitrala, PhD^1*, Jessica Atkins, BSc^4*, Malgorzata Drzewiecka, PhD^1,5*, Wanjuan Feng, PhD^6*, Joe Chan, PhD^1*, Konstantin Golovine, PhD^1*, Jaroslav Jelinek, MD, PhD^7*, Tomasz Sliwinski, PhD^5*, Jayashri Ghosh, PhD^1*, Ksenia Maslawska-Wasowska, PhD^8*, Reza Nejati, MD^9*, Mariusz A Wasik, MD^9*, Stephen M. Sykes, PhD¹⁰, Katarzyna Piwocka, PhD^3*, Emir Hadzijusufovic, DVM^11,12,13*, Peter Valent, MD¹², Richard Pomerantz, PhD^14*, George Morton, PhD^15*, Wayne Childers, PhD^15*, Huaqing Zhao, MS, PhD^16*, Elisabeth Paietta, PhD¹⁷, Ross L. Levine, MD¹⁸, Martin S. Tallman, MD¹⁹, Hugo F Fernandez, MD^20*, Mark R. Litzow, MD²¹, Gaorav P Gupta, PhD^6*, Jean-Yves Masson, PhD^2* and Tomasz Skorski, MD, PhD⁴

¹Fels Cancer institute For Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA
²CHU de Québec Research Centre (Oncology Division), Laval University Cancer Research Center, Québec City, QC, Canada
³Nencki Institute of Experimental Biology, Warsaw, Poland
⁴Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA
⁵Laboratory of Medical Genetics, University of Lodz, Lodz, Poland
⁶Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
⁷Coriell Institute for Medical Research, Coriell University, Camden, NJ
⁸Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL
⁹Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA
¹⁰Department of Pediatrics, Washington University, Saint Louis, MO
¹¹Department for Companion Animals and Horses, University Clinic for Small Animals, Internal Medicine Small Animals, University of Veterinary Medicine Vienna, Vienna, Austria
¹²Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria
¹³Department of Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
¹⁴Sidney Kimmel Cancer Center, Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA
¹⁵Moulder Center for Drug Discovery, School of Pharmacy, Temple University, Philadelphia, PA
¹⁶Lewis Katz School of Medicine at Temple University, Philadelphia, PA
¹⁷Cancer Center, Montefiore Medical Center, Bronx, NY
¹⁸Department of Medicine and Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁹Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
²⁰Moffitt Malignant Hematology & Cellular Therapy at Memorial Healthcare System, Pembroke Pines
²¹Division of Hematology, Mayo Clinic, Rochester, MN

Yangchan Li^1*, Xiaolan Deng^1*, Lei Dong, PhD², Li Han^1*, Le Xuan Truong Nguyen, PhD^3*, Jianhuang Xue^4*, Zhicong Zhao^4*, Wei Li^1*, Ying Qing^1*, Chao Shen, PhD^1*, Brandon Tan^4*, Zhenhua Chen, PhD^5*, Meilin Xue^4*, Keith Leung^1*, Kitty Wang^1*, Srividya Swaminathan, PhD¹, Ling Li, PhD⁶, Mark Wunderlich, MS^7*, James C Mulloy⁸, Bin Zhang, PhD⁹, David A Horne, PhD^10*, Steve T Rosen, MD¹¹, Guido Marcucci, MD¹², Mingjiang Xu, MD, PhD¹³, Zejuan Li^14*, Minjie Wei^15*, Rui Su, PhD¹⁶ and Jianjun Chen, PhD¹⁶

¹Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA
²Systems Biology, City of Hope, Monrovia, CA
³Division of Hematopoietic Stem Cell and Leukemia Research, City of Hope National Medical Center, South El Monte, CA
⁴City of Hope, Monrovia, CA
⁵Department of Systems Biology, Beckman Research Institute of City of Hope, Arcadia, CA
⁶Department of Hematology/HCT, City of Hope National Medical Center, Duarte, CA
⁷Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁸Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
⁹Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
¹⁰Department of Molecular Medicine, Beckman Research Institute, City of Hope, Duarte, CA
¹¹Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA
¹²Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA
¹³Indiana University School of Medicine, San Antonio, TX
¹⁴Houston Methodist, Houston, TX
¹⁵China Medical University, Shenyang, China
¹⁶Department of Systems Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA

Sarai Dean^1*, Chiharu Ishikawa^2*, Xiaoqin Zhu^2*, Timothy Nixon^2*, Sean Walulik^1*, Michael Wyder^2*, Jessica Jordan^2*, Mark Wunderlich, MS^3*, Daniel T. Starczynowski, PhD⁴, Nathan Salomonis, PhD^5*, Ken Greis, PhD^6* and Andrew Volk, PhD⁴

¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²University of Cincinnati, Cincinnati, OH
³Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁴Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁵Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁶Department of Cancer Biology, University of Cincinnati, Cincinnati

Sapana S Jalnapurkar, PhD¹, Subin S George^1*, Gabrielle Ochoco^1*, Jason Grana^2* and Vikram R Paralkar, MD¹

¹Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA
²Department of Hematology- Oncology, University of Pennsylvania, Philadelphia, PA

Luisa Ladel, MD^1*, Jessica Pham, B.S.^2*, Larissa Balaian, PhD^3*, Kathleen Steel, BA^4*, Isabelle Oliver, BS^5* and Catriona Jamieson, MD, PhD^6,7,8,9,10

¹Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA
²Moores Cancer Center, University of California, San Diego, San Diego
³Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center and Sanford Stem Cell Clinical Center, University of California San Diego, La Jolla, CA
⁴Department of Medicine, Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA
⁵Department of Medicine, Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, CA
⁶Sanford Stem Cell Clinical Center, University California, San Diego, La Jolla, CA
⁷Professor of Medicine, University California, San Diego, La Jolla, CA
⁸CIRM Alpha Stem Cell Clinic, University California, San Diego, La Jolla, CA
⁹Division of Regenerative Medicine, University of California, San Diego, La Jolla, CA
¹⁰Moores Cancer Center, University of California, San Diego, La Jolla, CA

Mayra A. Gonzalez^1*, Jose L. Lopez^2*, Vanessa V. Velazquez^2*, Mariah Perkins^2*, Idaly M. Olivas^3*, Alfonso E. Bencomo³, Andres J. Rubio^2*, Jehu N. Apaflo^4*, Sudip Bajpeyi^4* and Anna M. Eiring^2,3

¹Department of Molecular and Translational Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX
²Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center at El Paso, El Paso, TX
³Department of Molecular and Translational Medicine, Texas Tech University Health Sciences Center at El Paso, El Paso, TX
⁴Department of Kinesiology, Metabolic Nutrition and Exercise Research (MiNER) Laboratory, University of Texas at El Paso, El Paso, TX

Pascal Naef^1,2,3*, Ramin Radpour, PhD^4,5*, Carla Jaeger-Ruckstuhl, PhD^1,2*, Nils Bodmer^1,2*, Gabriela M Baerlocher, Dr. med.^1,6, Hartmut Döhner, MD⁷, Konstanze Döhner, MD⁸, Carsten Riether, PhD^1,2 and Adrian Ochsenbein, MD^1,2*

¹Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland
²Department of Medical Oncology, Inselspital, Bern University Hospital, Bern, Switzerland
³Graduate School of Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland
⁴University of Bern, Department for BioMedical Research (DBMR), Bern, Switzerland
⁵Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
⁶Department of Hematology, Inselspital, Bern University Hospital, Bern, Switzerland
⁷Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
⁸Division of Hematology and Oncology, University Hospital Ulm, Ulm, Germany

Max Petersen^1*, Anna D Chorzalska, PhD^2*, Anaelena Rodriguez^3*, Dennis M Bonal, MSc, BSc^4* and Patrycja M Dubielecka, PhD⁵

¹Signal Transduction Lab, Division of Hematology-Oncology, Rhode Island Hospital and Warren Alpert Medical School at Brown University, Providence, RI
²Signal Transduction Lab, Division of Hematology-Oncology,, Rhode Island Hospital and Warren Alpert Medical School at Brown University, Providence, RI
³Signal Transduction Lab, Division of Hematology/Oncology, Warren Alpert Medical School at Brown University and Rhode Island Hospital, Providence, RI
⁴Signal Transduction Lab, Division of Hematology-Oncology, Rhode Island Hospital and Warren Alpert Medical School at Brown University, Douglas, MA
⁵Division of Hematology-Oncology, Warren Alpert Medical School of Brown University/Rhode Island Hospital, Providence, RI

Anna Stengel, PhD, Manja Meggendorfer, PhD, Wencke Walter, PhD^*, Constance Baer, PhD, Niroshan Nadarajah^*, Stephan Hutter, PhD^*, Wolfgang Kern, MD, Torsten Haferlach, MD and Claudia Haferlach, MD

MLL Munich Leukemia Laboratory, Munich, Germany

Yu Kochi, MD^1*, Yoshikane Kikushige, MD, PhD^2*, Toshihiro Miyamoto, MD, PhD^3,4 and Koichi Akashi, MD, PhD²

¹Graduate School of Medical Sciences, Kyushu University, Fukuoka City, Japan
²Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
³Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
⁴Department of Hematology, Kanazawa University, Kanazawa, Japan

Xiaorong Gu, PhD^1*, Zeinab Albadry M. Zahran, MD^1,2*, Nneha Sakre, PhD^3*, Caroline Schuerger, PhD^4* and Yogenthiran Saunthararajah, MD¹

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt
³Department of Environmental Health and Safety, Stanford University, Stanford, CA
⁴Center of Security and Emerging Technology, Georgetown University, Georgtown, WA

Sipra Panda, DVM¹, Yiqian Wang, BS^2,3*, Lisa Richter⁴, Michelle Becker^4*, Lisa J Garrett, MS^5*, Cecilia Rivas^6*, Lemlem Alemu, BS^7*, Ling Zhao, MD, PhD^8,9*, Paul P. Liu, MD, PhD¹⁰ and R. Katherine Hyde, PhD⁴

¹University Of Nebraska Medical Center, Omaha, NE
²University of Nebraska Medical Center, Omaha, NE
³Guangzhou Medical University, Guangzou, China
⁴Department of Biochemistry and Molecular Biology, and Fred and Pamela Buffet Cancer Center, University of Nebraska Medical Center, Omaha, NE
⁵Transgenic Mouse Core, Bethesda
⁶Transgenic Mouse Core, NIH, Bethesda
⁷Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
⁸Oncogenesis and Development Section/NHGRI, Bethesda, MD
⁹Cleveland Clinic, Cleveland
¹⁰Translational and Functional Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD

Mengdan Liu, BA^1,2, Samuel A Stoner, PhD³, Amanda G Davis, PhD^1,3 and Dong-Er Zhang, PhD^1,3,4

¹School of Biological Sciences, University of California, San Diego, La Jolla, CA
²Moores Cancer Center, University of California, San Diego, SAN DIEGO, CA
³Moores Cancer Center, University of California, San Diego, La Jolla, CA
⁴School of Medicine, University of California, San Diego, La Jolla, CA

Estelle Erkner^1*, Thomas Hentrich^2*, Rahel Fitzel^1*, Hildegard Keppeler^1*, Fulya Korkmaz^1*, Johan Jeong^3*, Julia Schulze-Hentrich^2*, Claudia Lengerke, MD⁴, Dominik Schneidawind^1* and Corina Schneidawind^1*

¹Department of Internal Medicine II, University Hospital Tuebingen, Tuebingen, Germany
²Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tuebingen, Germany
³Merck, South San Francisco, CA
⁴Department of Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tuebingen, Tuebingen, Germany

Ruchika Pokhriyal, PhD, MSc, BSc, Laura Evans, PhD^*, Jillian K O'Neil^* and Julie-Aurore Losman, MD, PhD

Medical Oncology, Dana-Farber Cancer Institute, Boston, MA

Xiaomin Wang^1*, Shuaibing Hou^1*, Tengxiao Guo^1*, Yanjie Lan^1*, Shengnan Yuan^1*, Shuang Yang^1*, Fei Zhao^2*, Yajing Chu, PhD^1*, Cheng Tao, MD, PhD^3* and Weiping Yuan, PhD, MD¹

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem,Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
²State Key Laboratory of Experimental Hematology, National Clinical Research Cent, Tianjin, China
³State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin, China

Nathan Duong, BSc^1,2, Dilshad H. Khan, PhD¹, Geethu Emily Thomas, PhD, MSc, BSc¹, Rose Hurren, BSc^1*, Jong Bok Lee, PhD^3*, Jonathan St-Germain, PhD^1*, Lily Drimmer^1*, Yongran Yan, MSc^1*, Neil MacLean^1*, Marcela Gronda, MSc^1*, Brandon D Brown, MD^4*, Brian Raught, PhD^1*, Andrea Arruda, MSc^3*, Mark D. Minden, MD, PhD¹, Li Zhang, MD, PhD^5*, Steven M. Kornblau, MD⁶, Vito Spadevecchio, B.A^7* and Aaron D. Schimmer, MD, PhD^8,9

¹Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
²Department of Medical Biophysics, University of Toronto, Mississauga, ON, Canada
³University Health Network, Toronto, ON, Canada
⁴Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada
⁶Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Interlinked Therapeutics, LLC, Portland
⁸Division of Medical Oncology and Hematology, University Health Network, Toronto, ON, Canada
⁹Department of Medicine, University of Toronto, Toronto, ON, Canada

Xiaoyu Liu^*, Shaowei Qiu, MD^*, Haiyan Xing, MS^*, Runxia Gu^*, Junli Mou^*, Wanqing Xie^*, Zheng Tian^*, Kejing Tang, BS^*, Qing Rao, MS^*, Min Wang^* and Jianxiang Wang, MD

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

Chuan Chen, MD, PhD^1*, Na Man, PhD^1*, Francesco Tamiro, PhD^1*, Krystal Hossack, BS, MSc^1*, Julio Poveda, MD^2*, Daniel Bilbao, PhD^1,2, Gloria Mas, PhD^1*, Stephanie Duffort, MS^1*, Concepcion Martinez, BS^1*, Hidehiro Itonaga, MD, PhD¹, Fan Liu, PhD^1,3*, Jennifer R Chapman-Fredricks, MD^2* and Stephen D Nimer, MD^1,3,4

¹Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL
²Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL
³Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL
⁴Department of Medicine, University of Miami Miller School of Medicine, Miami, FL

Samuel Taylor, PhD¹, Jacob Stauber^1*, Oliver Bohorquez^1*, Boris Bartholdy, PhD^1*, Emily Schwenger^1*, Abdelbasset A Farahat^2*, Justin Wheat^1*, David W Boykin^2*, Gregory MK Poon^2* and Ulrich G. Steidl, MD, PhD³

¹Albert Einstein College of Medicine, Bronx, NY
²Georgia State University, Atlanta
³Department of Oncology, Montefiore Medical Center/ Albert Einstein College of Medicine, Bronx, NY

Tatsuya Morishima, MD, PhD^1,2*, Koichi Takahashi, MD, PhD^3,4, Desmond Wai Loon Chin, PhD^5*, Kenji Tokunaga, MD^6*, Yuichiro Arima, MD, PhD^7*, Masao Matsuoka, MD, PhD⁶, Toshio Suda, MD, PhD^5,8 and Hitoshi Takizawa, PhD⁹

¹Laboratory of Hematopoietic Stem Cell Engineering, International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan
²Laboratory of Stem Cell Stress, International Research Center for Medical Sciences, Kumamoto University, Kumamoto City, Japan
³Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁴Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
⁶Department of Hematology, Rheumatology and Infectious Diseases, Kumamoto University Hospital, Kumamoto, Japan
⁷Laboratory of Developmental Cardiology, International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan
⁸Laboratory of Stem Cell Regulation, International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan
⁹Laboratory of Stem Cell Stress, International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan

Chenyan Wu^1*, Daryl Boey^2*, Jiezhen Mo, PhD^3*, Sofia Papavasileiou^3*, Johanna Ungerstedt, MD, PhD^4*, Miao Xu, MSc, MD^5*, Gunnar Nilsson, Professor^6* and Joakim S. Dahlin, PhD^3*

¹Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
²Karolinska Institutet and Karolinska University Hospital, Stockholm, SWE
³Karolinska Institutet, Stockholm, Sweden
⁴Karolinska University Hospital, Stockholm, Sweden
⁵Department of Hematology, Qilu Hospital, Shandong University, Jinan, China
⁶Karolinska Institutet, 171 76 Stockholm, SWE

Ziqing Wang^1*, Yan Lv^2*, Erpeng Yang^3*, Yujin Li^4*, Dehao Wang^5*, Yumeng Li^3*, Weiyi LIU^6*, Mingqian Sun^1* and Hu Xiaomei, PhD⁷

¹Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
²China Academy of Chinese Medical Sciences, Beijing, CHN
³Department of Hematology, Xiyuan Hospital, China Academy of Chinese Medical Scie, Beijing, CHN
⁴Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, CHN
⁵Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, AL, CHN
⁶Xiyuan Hospital, China Academy of Chinese Medical Sciences, BEIJING, CHN
⁷XiYuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China

Mojtaba Bakhtiarigheshlaghbakhtiar, MD^1*, Swati S Bhasin, PhD^2,3, Beena E Thomas, Ph.D^2*, Hope L Mumme, BSc^2,4* and Manoj Bhasin, PhD^2,3,5

¹Pediatrics, Emory university, Atlanta, GA
²Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Atlanta, GA
³Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
⁴Department of Pediatrics, Emory school of Medicine, Decatur, GA
⁵Department of Biomedical Informatics, Emory University, Atlanta, GA

Yihan Mei^*, Manling Chen^*, Xiaoyu Liu^*, Runxia Gu^*, Shaowei Qiu, MD^*, Qing Rao, MS^*, Min Wang^* and Jianxiang Wang, MD

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

Hidehiro Itonaga, M.D., Ph.D.^1,2, Adnan K Mookhtiar, BS^3*, Sarah Greenblatt, PhD^4*, Fan Liu, PhD^5*, Concepcion Martinez, BS^4*, Renata Grozovsky, PhD³, Daniel Bilbao, PhD^6,7, Masai Rains^3*, Pierre-Jacques Hamard, PhD⁴, Jun Sun, PhD^4*, Afoma Umeano^8*, Stephanie Duffort, MS^4*, Chuan Chen, MD, PhD^9*, Na Man, PhD^4*, Gloria Mas Martin, PhD^4*, Stephen Schürer, PhD^8* and Stephen D Nimer, MD¹⁰

¹University of Miami, Miller School of Medicine, Sylvester Comprehensive Cancer Center, Miami, FL
²Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan
³Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, FL
⁴Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL
⁵Department of Biochemistry and Molecular Biology & Sylvester Comprehensive Cancer Center, Miami, FL
⁶University of Miami, Miami, FL
⁷Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL
⁸Department of Molecular and Cellular Pharmacology, University of Miami, Miller School of Medicine, Miami, FL
⁹Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medi, Miami, FL
¹⁰Director, Sylvester Comprehensive Cancer Center Professor of Medicine, Biochemistry & Molecular Biology University of Miami Miller School of Medicine, Miami, FL

Yue Feng, BS^1,2, Yulia Jitkova, PhD^1*, Alexander Keszei, PhD^1*, Jonathan St-Germain, PhD^1*, Yongran Yan, MSc^1*, Brian Raught, PhD^1,2*, Mohammad Mazhab-Jafari, PhD^1,2* and Aaron D. Schimmer, MD, PhD^3,4

¹Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
²Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
³Department of Medicine, University of Toronto, Toronto, ON, Canada
⁴Division of Medical Oncology and Hematology, University Health Network, Toronto, ON, Canada