Aditi Dey^1*, Richard J. Burt, MBBS PhD^2,3*, Emily A. Cutler, MSc^4*, Hermione E. Allen, MSc^4*, Ashish Dhir, PhD^5*, Kristina Kirschner, PhD^6* and Adele K. Fielding, MBBS, PhD⁷

¹UCL, London, United Kingdom
²Imperial College, London, United Kingdom
³The Francis Crick Institute, London, United Kingdom
⁴UCL Cancer Institute, London, United Kingdom
⁵University of Edinburgh, Edinburgh, United Kingdom
⁶CRUK Beatson Institute, Bearsden, United Kingdom
⁷Cancer Institute, University College London, London, United Kingdom

Benjamin Rodems, MS^1*, Sonali Sharma, PhD^1*, Takashi Ito, PhD^2*, Craig T Jordan, PhD³, Michael W. Becker, MD⁴, Laura M. Calvi, MD⁵, John M. Ashton, Ph.D^1* and Jeevisha Bajaj, PhD¹

¹Department of Biomedical Genetics, Wilmot Cancer Institute, University of Rochester, Rochester, NY
²Department of Bioscience and Technology, Graduate School of Bioscience and Technology, Fukui Prefectural University, Fukui, Japan
³Division of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO
⁴Wilmot Cancer Institute, Division of Hematology and Oncology, University of Rochester Medical Center, Rochester, NY
⁵Wilmot Cancer Institute, Division of Endocrinology and Metabolism, University of Rochester Medical Center, Rochester, NY

Kristin Komnick, MPH^1*, Phuong T Le^2*, Jennifer May^3*, Joseph Raasch^4*, Clifford J Rosen, MD^5,6,7* and Karen-Sue B Carlson, MD, PhD^1,8

¹Blood Research Institute, Versiti, Milwaukee, WI
²Main Health Institute for Research, Scarborough, ME
³Blood Research Institute, Milwaukee, WI
⁴Wisconsin Lutheran College, Milwaukee, WI
⁵Maine Health Institute for Research, Scarborough, ME
⁶Tufts University, Boston, MA
⁷Harvard Medical Center, Boston, MA
⁸Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI

Kristina Mott^1*, Margret Droste^2*, Lukas J. Weiß, MD^2* and Harald Schulze, PhD³

¹Institute of Experimental Biomedicine, Chair I, University Hospital Würzburg, WüRzburg, Germany
²Institute of Experimental Biomedicine, Chair I, University Hospital Würzburg, Würzburg, Germany
³Institute of Experimental Biomedicine, Chair I, Universitaetsklinikum Wuerzburg, Wuerzburg, Germany

Ioanna Mosialou, PhD^1,2*, Abdullah M Ali, PhD³, Rachel Adams^4*, Adam Corper^4*, Catherine M Woods^5*, Xiaomin Fan^5*, Azra Raza, MD^6,7 and Stavroula Kousteni, PhD⁸

¹Columbia University Irving Medical Center, New York, NY
²Department of Physiology and Cellular Biophysics, Columbia University Medical Center, New York, NY
³Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY
⁴AvantGen Inc, San Diego
⁵Avantgen Inc, San Diego
⁶Columbia Presbyterian, New York, NY
⁷Myelodysplastic Syndrome Center, Columbia University Medical Center, New York, NY
⁸Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY

Zhengqing Xu^1,2,3*, Yue Li^1,2,3*, Yujin Huang^1,2,3*, Yahui Liu^1,2,3*, Kailin Xu^1,2,3*, Jianlin Qiao, PhD^1,2,3 and Lingyu Zeng^1,2,3*

¹Key Laboratory of Bone Marrow Stem Cell, Xuzhou, China
²Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China
³Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China

Vaishali Bhardwaj, PhD¹, Shahrzad Jalali, PhD¹, Jose C. Villasboas, MD², Zhi-Zhang Yang, MD¹, Xinyi Tang, MD, PhD^1*, Prithviraj Mukherjee, Ph.D^1*, Patrizia Mondello, MD, PhD, MSc¹, Hyojin Kim, PhD^1*, Rekha Mudappathi^3*, Junwen Wang, PhD^3*, Jordan E. Krull¹, Kerstin Wenzl, PhD¹, Anne J. Novak, PhD¹ and Stephen M. Ansell, MD, PhD¹

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN
³Mayo Clinic, Scottsdale, AZ

Jennifer Rivière^1*, Mark van der Garde^2*, Judith S. Hecker^1,3*, Michèle C. Buck^1*, Florian Bassermann^1,3,4*, Mareike Verbeek^1* and Katharina S. Goetze^2,3,4

¹Department of Internal Medicine III, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany
²Department of Medicine III, Klinikum rechts der Isar, Technical University Munich (TUM), Munich, Germany
³Partner site Munich, German Cancer Consortium (DKTK), Heidelberg, Germany
⁴Bavarian Center for Cancer Research (BZKF), Munich, Germany

Natividad Alquezar-Artieda^1*, Jennie Roberts^2*, Daniela Kužílková, PhD^3*, Katerina Hlozkova, PhD^4*, Alena Pecinova^5*, Petr Pecina^6*, Martina Zwyrtkova^7*, Eliska Potuckova^8*, Daniel Kavan^9*, Ivana Hermanova^10*, Marketa Zaliova¹¹, Petr Novak^9*, Tomas Mracek^6*, Daniel A Tennant, PhD^12*, Jan Trka¹³ and Julia Starkova, PhD^11*

¹CLIP - Childhood Leukemia Investigation Prague, Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University, Prague, AL, Czech Republic
²Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, GBR
³CLIP - Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
⁴CLIP - Childhood Leukemia Investigation Prague, Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic
⁵Department of Bioenergetics, Institute of Physiology, Czech Academy of Science, Prague, Czech Republic
⁶Department of Bioenergetics, Institute of Physiology of the Czech Academy of Sci, Prague, CZE
⁷CLIP - Childhood Leukemia Investigation Prague. Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University Prague and University Hospital Motol, Prague, CZE
⁸CLIP - Childhood Leukemia Investigation Prague. Department of Paediatric Haematology and Oncology,, Second Faculty of Medicine, Charles University, Prague, Czech Republic
⁹Institute of Microbiology, Academy of Science, Prague, Czech Republic
¹⁰CLIP - Childhood Leukemia Investigation Prague, Department of Pediatric Hematology and Oncology, Second Faculty of Medicine. Charles University, Prague, CZE
¹¹CLIP - Childhood Leukemia Investigation Prague, Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
¹²Hypoxia and Metabolism Group, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom
¹³CLIP - Childhood Leukaemia Investigation Prague, Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic

Andrew L Young, MD, PhD¹, Hannah C Davis^2*, David H Spencer, MD, PhD², Timothy J. Ley, MD³, Stephen T Oh, MD, PhD⁴, Matthew J Walter, MD² and Grant A Challen, PhD⁵

¹Department of Medicine, Division of Oncology, Washington University School of Medicine In St. Louis, Saint Louis, MO
²Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO
³Department of Medicine, Division of Oncology, Section of Stem Cell Biology, Washington University School of Medicine, St. Louis, MO
⁴Department of Medicine, Division of Hematology, Washington University School of Medicine, St. Louis, MO
⁵Division of Oncology, Washington University School of Medicine, St. Louis, MO

Hannah R.S. Fay, BS^1*, Eunice S. Wang, MD^1,2, Marianna Giorgi, BS^2* and Marina Boncek, MS^2*

¹Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY
²Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY