Kira A Young, PhD¹, Jayna J Mistry, PhD^1*, James Chavez, BS^2*, Eric M Pietras, PhD^2,3 and Jennifer J J Trowbridge, PhD¹

¹The Jackson Laboratory, Bar Harbor, ME
²Division of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO
³Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO

Ashwin Kishtagari, MBBS¹, MA Wasay Khan*, MBBS^2*, Yajing Li*, MS^2*, Cosmin Bejan, PhD^3*, Naimisha Marneni, MBBS^2*, Alexander J. Silver, BA⁴, Kelly von Beck, BS⁵, Travis Spaulding, MD⁶, Shannon Stockton, MD^4*, Christina A. Snider, MD⁷, Kelly Pugh, MD⁶, Andrew Sochacki, MD⁸, Dixon Dorand, MD, PhD^6*, Taralynn Mack^9*, Caitlyn Vlasschaert, MD^10*, Brent Ferrell, MD⁶, Yaomin Xu, PhD^11*, Michael R. Savona, MD¹² and Alexander G. Bick, MD, PhD^13*

¹Division of Hematology & Oncology, Vanderbilt Ingram Cancer Center, Franklin, TN
²Vanderbilt University Medical Center, Nashville
³Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN
⁴Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN
⁵Vanderbilt University, Nashville, TN
⁶Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
⁷Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, TN
⁸Department of Medicine and Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN
⁹Vanderbilt University School of Medicine, Nashville
¹⁰Department of Medicine, Queen's University, Kingston, ON, CAN
¹¹Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN
¹²Vanderbilt University School of Medicine, Nashville, TN
¹³Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN

Christopher M Arends^1*, Thomas G Liman, MD^2,3,4,5,6*, Paulina Strzelecka, PhD^1*, Anna Kufner, MD PhD^6*, Shufan Huo, MD^6*, Catarina M Stein, MSc^1*, Sophie Piper, PhD^6,7,8*, Marlon Tilgner^1*, Pia S Sperber, MD^6*, Savvina Dimitriou^1*, Peter Heuschmann, MD^9*, Raphael Hablesreiter, MSc^1*, Christoph Harms, MD^2,4,6*, Lars Bullinger, MD^1,10, Matthias Endres, MD^2,3,4,6* and Frederik Damm, MD^1,10*

¹Department of Hematology, Oncology, and Cancer Immunology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
²Center for Stroke Research Berlin (CSB) with Department of Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany
³German Center for Neurodegenerative Diseases, Berlin, Germany
⁴German Center for Cardiovascular Research, Berlin, Germany
⁵Department of Neurology, Carl von Ossietzky-University, Evangelical Hospital Oldenburg, Oldenburg, Germany
⁶Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany
⁷Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Charité - Universitätsmedizin Berlin, Berlin, Germany
⁸NeuroCure Clinical Research Center, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
⁹University of Wuerzburg, Wuerzburg, Germany
¹⁰German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany

Rohan Kodgule, MD, MBBS^1*, Joshua Robinson^2*, Sridhar Nonavinkere Srivatsan, MS^3*, Cara Lunn Shirai, PhD², Feiyu Du^3*, Tianjiao Wang², Ajay Khanna^3*, Catrina Fronick, BS^4*, Robert Fulton, MS^4*, David H Spencer, MD, PhD³, Matthew J Walter, MD³ and Eric Duncavage, M.D.^2*

¹Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO
²Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO
³Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO
⁴McDonnell Genome Institute, Washington University School of Medicine, Saint Louis, MO

Michael D Ashby, MD^1*, Natasha S Anstee, PhD^1,2*, Tongted Das, PhD^1*, Ing S Tiong, FRACP, FRCPA, MPhil^1,3, Sun Loo, MBBS, FRACP, FRCPA¹, Andrew Spencer¹ and Andrew H. Wei, MBBS, FRACP, FRCPA, PhD^1,2,4

¹The Alfred Hospital and Monash University, Melbourne, VIC, Australia
²The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia
³Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
⁴Department of Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, VIC, Australia

Anne Sonnenschein, Ph.D.^1*, Elle Moore^1*, Christine Lo, Ph.D.^1*, Peter Kang, M.D.^1*, Timothy J Taxter, M.D.^1*, Brett Mahon, M.D.^2* and Duane C Hassane, Ph.D.³

¹Tempus Labs, Inc., Chicago, IL
²Tempus Labs, Inc, Chicago, IL
³Tempus Labs, Inc., New York, NY

Masahiro Marshall Nakagawa, MD, PhD¹, Ryosaku Inagaki, MSc^1,2*, Yutaka Kuroda, MD, PhD^3*, Yasuhito Nannya, M.D., Ph.D.¹, Lanying Zhao, MD, PhD^1*, Yotaro Ochi, MD, PhD^1*, June Takeda, MD^1*, Qi Xingxing, PhD^1*, Akinori Yoda, PhD^4*, Ayana Kon, MD, PhD^1*, Nobuyuki Kakiuchi, MD, PhD^1*, Hideki Makishima, MD, PhD¹, Shuichi Matsuda, MD, PhD^3* and Seishi Ogawa, MD, PhD^1,5,6

¹Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
²DSP Cancer Institute, Sumitomo Dainippon Pharma Co., Ltd., Osaka, Japan
³Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⁴Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto City, Japan
⁵Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto, Japan
⁶Center for Hematology and Regenerative Medicine, Department of Medicine (MedH), Karolinska Institutet, Huddinge, Sweden

Matthew T. Jenkins, BS^1,2*, Timothy J Scott, BS^3*, Lindsey N Guerin, BS^4*, Alana M Franceski, BS^5*, Yunli E Chu, BS^6*, Pawan Bhat, BS⁷, Chad R. Potts, BS^8*, Robert S. Welner, PhD^5*, Emily Hodges, PhD^9,10* and Brent Ferrell, MD¹¹

¹Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN
²Department of Pharmacology, Vanderbilt University, Nashville, TN
³Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, TN
⁴Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN
⁵Division of Hematology/Oncology, University of Alabama At Birmingham, Birmingham, AL
⁶Program in Cancer Biology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN
⁷Program in Cancer Biology, School of Medicine, Vanderbilt University, Nashville, TN
⁸Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN
⁹Department of Biochemistry, Vanderbilt University Medical Center, Nashville, TN
¹⁰Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN
¹¹Department of Medicine, Vanderbilt University Medical Center, Nashville, TN

Alexander J. Silver, BA¹, Donovan J. Brown, BS^1*, Maria P. Arrate, BS^1*, Yu Wang, PhD^2*, Melissa A. Fischer, MSc, PhD¹, Pawan Bhat, BS¹, J. Brett Heimlich, MD, PhD^1*, Alexander G. Bick, MD, PhD^3*, P. Brent Ferrell, MD^4,5*, Yaomin Xu, PhD^2* and Michael R. Savona, MD^4,5

¹Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
²Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN
³Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
⁴Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
⁵Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN

Zhuoer Xie, MD, MS¹, Alexandra Smith, MS^2*, Rami S. Komrokji³, Najla Al Ali, MS⁴, Anand Ashwin Patel, MD⁵, Caner Saygin, MD⁶, Amer M. Zeidan, MD⁷, Jan Philipp Bewersdorf, MD⁸, Ashwin Kishtagari, MBBS⁹, Joshua F. Zeidner, MD¹⁰, Catherine C. Coombs, MD¹¹, Yazan F. Madanat, MD¹², James M. Foran, MD¹³, Talha Badar, MD¹⁴, Pinkal Desai, MD, MPH¹⁵, Charlton Tsai, MD^15*, Elizabeth A. Griffiths, MD¹⁶, Monzr M. Al Malki, MD¹⁷, Idoroenyi Amanam, MD¹⁷, Catherine Lai, MD, MPH¹⁸, Joachim Deeg, MD^19*, Lionel Ades²⁰, Cecilia Arana Yi, MD, MSHS²¹, Afaf Osman, MD²², Shira Dinner, MD²³, Yasmin Abaza, MD²³, Namrata Chandhok, MD^24*, Deborah Soong, MD^24*, Justin Taylor, MD²⁵, Andrew M. Brunner, MD²⁶, Hetty E. Carraway, MD, MBA²⁷, Abhay Singh, MD, MPH²⁸, Susan M. Geyer, PhD^29*, Eric Padron, MD³⁰, Mrinal M. M. Patnaik, MD, MBBS³¹, Michael R. Savona, MD³² and Aref Al-Kali, MD³¹

¹Division of Hematology, Mayo Clinic, Lutz, FL
²Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN
³H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
⁴Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
⁵Department of Medicine, Section of Hematology/Oncology, University of Chicago Medical Center, Chicago, IL
⁶Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL
⁷Department of Internal Medicine, Yale School of Medicine and Yale Cancer Center, New Haven, CT
⁸Department of Medicine; Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁹Department of Internal Medicine, Division of Hematology, Vanderbilt University School of Medicine; Ingram Cancer Center, Nashville, TN
¹⁰UNC - Lineberger Comprehensive Cancer Center, Chapel Hill, NC
¹¹Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC
¹²Division of Hematology/Oncology, Department of Internal Medicine, University of Texas Southwestern, Dallas, TX
¹³Division of Hematology/Oncology and Blood and Marrow Transplanation and Cellular Therapy, Mayo Clinic, Jacksonville, FL
¹⁴Division of Hematology and Oncology, Mayo Clinic Florida, Jacksonville, FL
¹⁵Division of Hematology and Oncology, Weill Cornell Medicine and The New York-Presbyterian Hospital, New York, NY
¹⁶Roswell Park Comprehensive Cancer Center, Buffalo, NY
¹⁷Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA
¹⁸University of Pennsylvania Perelman Center for Advanced Medicine, Philadelphia, PA
¹⁹Fred Hutchinson Cancer Center, Seattle, WA
²⁰Department of Hematology, Université de Paris, Saint-Louis Hospital, Paris, France
²¹Mayo Clinic, Phoenix, AZ
²²Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
²³Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL
²⁴Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
²⁵University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL
²⁶Mass General Cancer Center, Massachusetts General Hospital, Boston, MA
²⁷Department of Hematology and Medical Oncology, Taussig Cancer institute, Leukemia Program, Cleveland Clinic, Cleveland, OH
²⁸Department of Hematology and Medical Oncology, Taussig Cancer Institute, Leukemia Program, Cleveland Clinic Foundation, Cleveland, OH
²⁹Alliance Statistics and Data Management Center, Mayo Clinic, Rochester, MN
³⁰Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL
³¹Division of Hematology, Mayo Clinic, Rochester, MN
³²Vanderbilt University School of Medicine, Nashville, TN

Pawan Bhat, BS¹, J. Brett Heimlich, MD, PhD^2*, Alyssa Parker, BS^3*, Matthew T. Jenkins, BS^4*, Chad R. Potts, BS^2*, Jessica Ulloa, BS^2*, Alexander J. Silver, BA⁵, Donovan J. Brown, BS^2*, Peter van Galen, PhD⁶, Michael R. Savona, MD⁷, Alexander G. Bick, MD, PhD^3* and Brent Ferrell, MD²

¹Program in Cancer Biology, School of Medicine, Vanderbilt University, Nashville, TN
²Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
³Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
⁴Department of Pharmacology, Vanderbilt University, Nashville, TN
⁵Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN
⁶Massachusetts General Hospital, Boston, MA
⁷Vanderbilt-Ingram Cancer Center, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN

Zhuoer Xie, MD, MS¹, Kristen McCullough, PharmD², Terra L. Lasho, PhD³, Jenna A. Fernandez, PhD^3*, Christy Finke, BS^3*, Michelle Renee Amundson^3*, Betsy Laplant, MS^4*, Abhishek A. Mangaonkar, MBBS³, Naseema Gangat, MBBS³, Kaaren K. Reichard, MD^5*, Michelle A Elliott, MD³, Thomas E. Witzig, MD³ and Mrinal M. M. Patnaik, MD, MBBS³

¹Division of Hematology, Mayo Clinic, Lutz, FL
²Division of Pharmacology, Mayo Clinic, Rochester, MN
³Division of Hematology, Mayo Clinic, Rochester, MN
⁴Division of Clinical Trials & Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN
⁵Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN