Shinya Yamada, MD^1,2*, Masayuki Kubo, MD^1*, Eriko Hamada, MD^1*, Kenki Saito, MD^1*, Masaki Hayakawa, MD, PhD^1*, Hidesaku Asakura, MD, PhD^2* and Masanori Matsumoto, MD³

¹Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Japan
²Department of Hematology, Kanazawa University Hospital, Kanazawa, Japan
³Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Nara, Japan

Andrew Siedlecki^1*, Imad Al-Dakkak^2*, Katerina Anokhina^2*, Nicole Isbel^3*, Véronique Frémeaux-Bacchi, MD^4*, Rodney Gilbert^5*, Laurence Greenbaum, MD, PhD^6*, Gema Ariceta^7*, Gianluigi Ardissino^8*, Franz Schaefer^9*, Eric Rondeau^10* and Christoph Licht, MD, FRCP^11*

¹Brigham and Women's Hospital, Boston, MA
²Alexion, AstraZeneca Rare Disease, Boston, MA
³Department of Nephrology, Princess Alexandra Hospital, Brisbane, Australia
⁴Laboratory of Immunology, Hôpital Européen Georges Pompidou, Paris, France; INSERM UMR S1138, Paris, France
⁵University of Southampton, Southampton, GBR
⁶Division of Pediatric Nephrology, Emory University School of Medicine and Children’s Healthcare of Atlanta, Atlanta, GA
⁷Hospital Universitari Vall D' Hebron, Barcelona, BA, ESP
⁸Centro per la Cura e lo Studio della Sindrome Emolitico-Uremica, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
⁹Division of Pediatric Nephrology, Heidelberg University Hospital, Heidelberg, Germany
¹⁰APHP.6, Sorbonne Université, Paris, FRA
¹¹Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada

Sriya Gunawardena, MD^1*, Angela Hu, MD^1*, Laurel A. Menapace, MD², Hikaru Okada, MD, PhD^1*, Beverly Accomando, MS^1* and Julie Lin, MD^1*

¹Sanofi, Cambridge, MA
²Rare Blood Disorder Therapeutic Area, Sanofi, Cambridge, MA

Darko Antic, PhD^1,2*, Natasa Milic^3*, Thomas Chatzikonstantinou^4,5*, Lydia Scarfo, MD^6*, Vladimir Otasevic, MD^2*, Nina Rajovic^3*, David Allsup^7*, Alejandro Alonso Cabrero^8*, Martin Andres^9*, Monica Baile Gonzales^10*, Antonella Capasso^11*, Rosa Collado^12,13*, Raul Cordoba, MD, PhD¹⁴, Carolina Cuéllar-García^15*, Juan Gonzalo Correa^16*, Lorenzo De Paoli^17*, Maria Rosaria De Paolis^18*, Giovanni Del Poeta, MD^19*, Maria Dimou²⁰, Michael Doubek, MD, PhD^21,22, Maria Efstathopoulou^23*, Shaimaa El-Ashwah^24*, Alicia Enrico^25*, Blanca Espinet, PhD^26*, Lucia Farina^27*, Angela Ferrari^28*, Myriam Foglietta^29*, Alberto Lopez-Garcia^14*, Jose A. Garcia-Marco³⁰, Rocío García-Serra^12,13*, Massimo Gentile, MD^31*, Eva Gimeno^26*, Maria Gomes da Silva^32*, Odit Gutwein^33,34*, Yervand Hakobyan^35*, Yair Herishanu^36*, José Ángel Hernández-Rivas^37*, Tobias Herold, MD³⁸, Gilad Itchaki^39*, Ozren Jaksic, MD, PhD⁴⁰, Ann Janssens, MD, PhD^41*, Оlga B. Kalashnikova^42*, Elżbieta Kalicińska^43*, Arnon P. Kater, MD, PhD⁴⁴, Sabina Kersting, MD, PhD^45*, Maya Koren-Michowitz, MD^34,46, Jorge Labrador Gomez^47*, Deepesh Lad^48*, Luca Laurenti, MD^49,50*, Alberto Fresa, MD^49,51*, Mark-David Levin⁵², Carlota Mayor Bastida^8,53*, Lara Malerba^54*, Roberto Marasca, MD⁵⁵, Monia Marchetti^56*, Juan Marquet^57*, Biljana Mihaljevic^1,2*, Ivana Milosevic^58*, Fatima Mirás^59*, Marta Morawska^60,61*, Marina Motta, MD^62*, Talha Munir, MBBS, MRCP, FRCPath, PhD^63*, Roberta Murru, MD^64*, Raquel Nunes^65*, Jacopo Olivieri^66*, Miguel Arturo Pavlovsky⁶⁷, Inga S. Piskunova^68*, Viola Maria Popov^69*, Francesca Maria Quaglia^70*, Giulia Quaresmini^71*, Gianluigi Reda, MD^72*, Gian Matteo Rigolin^73*, Amit Shrestha^74*, Martin Šimkovič^75*, Svetlana Smirnova^68*, Martin Špaček^76*, Paolo Sportoletti, MD^77*, Oana Stanca^78*, Niki Stavroyianni^79*, Doreen Te Raa^80*, Kristina Tomic^2*, Sanne Tonino^81*, Livio Trentin⁸², Ellen Van Der Spek^83*, Michel van Gelder⁸⁴, Marzia Varettoni, MD^85*, Andrea Visentin, MD, PhD^82*, Candida Vitale^86*, Vojin Vukovic^2*, Ewa Wasik-Szczepanek^87*, Tomasz Wróbel⁸⁸, Lucrecia Yanez San Segundo⁸⁹, Mohamed A Yassin, MBBS, MSC, CABM, MSC, FACP⁹⁰, Marta Coscia^91*, Alessandro Rambaldi, MD⁷¹, Emili Montserrat^16*, Robin Foà^92*, Antonio Cuneo^73*, Marc Carrier, MD, MSc⁹³, Paolo Ghia, MD, PhD⁹⁴ and Kostas Stamatopoulos, MD⁴

¹Faculty of Medicine, University of Belgrade, Belgrade, Serbia
²Lymphoma Center, Clinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia
³Department of Medical Statistics and Informatics, Medical Faculty, University of Belgrade, Belgrade, Serbia
⁴Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece
⁵Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
⁶Università Vita-salute San Raffaele and IRCC Ospedale San Raffaele, Milan, Italy
⁷Centre for Atherothrombosis and Metabolic Disease, Hull York Medical School, Hull, ENG, United Kingdom
⁸Haematology department, Hospital Universitario de La Princesa, Madrid, Spain
⁹Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
¹⁰Hematology Department. University Hospital of Salamanca-IBSAL, Salamanca, Spain
¹¹IRCCS Ospedale San Raffaele, Milano, Italy
¹²Department of Hematology, Hospital General Universitario, Valencia, Spain
¹³Fundación de Investigación del Hospital General Universitario, Valencia, Spain
¹⁴Department of Hematology, Health Research Institute IIS-FJD, Fundacion Jimenez Diaz University Hospital, Madrid, Spain
¹⁵Hematology Unit Terrassa Hospital, Terrasa, Spain
¹⁶Hospital Clínic de Barcelona, Barcelona, Spain
¹⁷Division of Internal Medicine, Hematology Unit, ASL Vercelli, Vercelli, Italy
¹⁸UOC Ematologia PO Vito Fazzi Lecce, Lecce, Italy
¹⁹Hematology, Department of Biomedicine, University Tor Vergata Roma, Italy, Rome, Italy
²⁰1st Internal Medicine Department, Propaedeutic, Hematology Clinical Trial Unit, National and Kapodistrian University of Athens, Athens, Greece
²¹Department of Internal Medicine - Hematology and Oncology, Medical Faculty MU and University Hospital Brno, Brno, Czech Republic
²²Department of Internal Medicine - Hematology and Oncology, University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic
²³Department of Haematology Athens Medical Center-Psychikon Branch, Athens, Greece
²⁴Clinical Hematology Unit, Oncology Center, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt
²⁵Hospital Italiano La Plata, La Plata, Argentina
²⁶Department of Hematology, Hospital del Mar, Barcelona, Spain
²⁷Hematology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
²⁸Hematology Unit, Azienda Unità Sanitaria Locale – IRCCS, Reggio Emilia, Italy
²⁹SC Ematologia, AO S. Croce e Carle, Cuneo, Italy
³⁰Hematology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Majadahonda, Spain
³¹Hematology Unit AO Cosenza, Cosenza, Italy
³²Department of Hematology, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal
³³Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
³⁴Department of Hematology, Shamir Medical Center, Zerifin, Israel
³⁵Hematology Center after Prof. Yeolyan MH RA, Yerevan, Armenia
³⁶Tel-Aviv Sourasky Medical Center and Sackler School of Medicine, Tel Aviv University, Tel-Aviv, ISR
³⁷Department of Hematology, Infanta Leonor University Hospital, Madrid, Spain
³⁸Laboratory for Leukemia Diagnostics, Department of Medicine III, Ludwig-maximilians-Universitaet (LMU), Munich, Bavaria, Germany
³⁹Division of Hematology, Rabin Medical Center, Petah Tikva, and the Sackler School of Medicine, Tel-Aviv University, Petah Tikva, Israel
⁴⁰Division of Hematolog, Dubrava University Hospital, Zagreb, Croatia
⁴¹Department of Hematology, Universitaire Ziekenhuizen Leuven, Leuven, Belgium
⁴²Federal State Budgetary Educational Institution of Higher Education Academician I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russian Federation, St. Petersburg, Russian Federation
⁴³Department and Clinic of Hematology, Blood Neoplasms and Bone Marrow Transplantation Wroclaw Medical University, Pasteura Street 4, 50-367 Wrocław, Poland
⁴⁴Dept of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands
⁴⁵Department of Hematology, Haga Teaching Hospital, The Hague, Netherlands
⁴⁶Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
⁴⁷Hematology Department, Unit Research, Complejo Asistencial Universitario de Burgos, Burgos, Spain
⁴⁸Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
⁴⁹Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, Rome, Italy
⁵⁰Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy
⁵¹Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
⁵²Department of Internal Medicine, Albert Schweitzer hospital, Dordrecht, Netherlands
⁵³Spanish Society of Haematology and hemotherapy (SEHH: Sociedad Española de Hematología y hemoterapia), Madrid, Spain
⁵⁴Hematology and Stem Cell Transplant Center Marche Nord Hospital, Pesaro, Italy
⁵⁵Dept of Medical Sciences, Section of Hematology, University of Modena and Reggio Emilia, Modena, Italy
⁵⁶Hematology Unit & TMO Center, AO SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy
⁵⁷Hematology Department Ramón y Cajal University Hospital, Madrid, Spain
⁵⁸University of Novi Sad, Faculty of Medicine, Clinical Centre of Vojvodina, Novi Sad, Serbia
⁵⁹Hematology Department Hospital Universitario 12 de Octubre, Madrid, Spain
⁶⁰Experimental Hematooncology Department, Medical University of Lublin, Lublin, Poland
⁶¹Hematology Department, St. John's Cancer Center, Lublin, Poland
⁶²S.C. Ematologia ASST Spedali Civili, Brescia, Italy
⁶³Consultant Haematologist, St James's Hospital, Leeds, United Kingdom
⁶⁴Hematology and Stem Cell Transplantation Unit, Ospedale Oncologico A. Businco, ARNAS G. Brotzu, Cagliari, Italy
⁶⁵Hematology Department, Portuguese Institute of Oncology, Lisbon, Portugal
⁶⁶Hematology Clinic, ASUFC, Udine, Italy
⁶⁷FUNDALEU, Clinical research center Buenos Aires, Buenos Aires, Argentina
⁶⁸Consultative Hematology Department with a Day Hospital for Intensive High-Dose Chemotherapy, National Research Center for Hematology, Moscow, Russian Federation
⁶⁹Hematology Department Colentina Clinical Hospital, Bucharest, Romania
⁷⁰Department of Medicine, Section of Hematology, University of Verona, Verona, Italy
⁷¹Hematology, ASST Papa Giovanni XXIII, Bergamo, Italy
⁷²Hematology unit, Hematology Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico of Milan, Milan, Italy
⁷³St. Anna University Hospital, Ferrara, Italy
⁷⁴Hematology Unit, Nepal Cancer Hospital & Research Center, Lalitpur, Nepal
⁷⁵4th Department of Internal Medicine – Haematology, Faculty of Medicine in Hradec Králové, University Hospital and Charles University in Prague, Hradec Kralove, Czech Republic
⁷⁶1st Department of Medicine - Hematology, First Faculty of Medicine, Charles University and General Hospital in Prague, Prague, Czech Republic
⁷⁷Department of Medicine and Surgery, Institute of Hematology and Center for Hemato-Oncological Research, Ospedale S. Maria della Misericordia, Perugia, Italy
⁷⁸"Carol Davila" University of Medicine and Pharmacy - Hematology Department from Coltea Clinical Hospital, Bucharest, Romania
⁷⁹Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
⁸⁰Department of hematology, Gelderse Vallei Ede, Ede, Netherlands
⁸¹Dept of Hematology, Lymmcare, Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands
⁸²Hematology and Clinical Immunology Unit, Department of Medicine, University of Padova, Padova, Italy
⁸³Rijnstate hospital, department of internal medicine Arnhem, Arnhem, Netherlands
⁸⁴Dept internal medicine, Maastricht University Medical Center, Maastricht, Netherlands
⁸⁵Division of Hematology Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
⁸⁶Division of Hematology, A.O.U. Cittàdella Salute e dellaScienza di Torino and Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, TX, Italy
⁸⁷Dept. Hematooncology and Bone Marrow Transplantation Medical University in Lublin, Lublin, Poland
⁸⁸Department and Clinic of Hematology, Blood Neoplasms and Bone Marrow Transplantation Wroclaw Medical University, Wroclaw, Poland
⁸⁹University Hospital and Research Institute of Marqués de Valdecilla (IDIVAL), Santander, Spain
⁹⁰Department of Medical Oncology/ Hematology Section, National Centre For Cancer Care & Research, Doha, Qatar
⁹¹Division of Hematology, A.O.U. Cittàdella Salute e dellaScienza di Torino and Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy
⁹²Hematology, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy
⁹³Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada
⁹⁴Universita' Vita-Salute San Raffaele C.F. 97187560152, Milano, MI, Italy

Jihyun Moon, PhD^1*, Jamey Kain, PhD^2*, Fernando C. Fervenza, MD PhD^3*, Stephen B Erickson, MD^4*, Prince Singh, MBBS, FASN, FACP^5*, Shahrzad Tehranian, MD^6*, Craig B. Langman, MD^7*, Ramy Hanna, MD^8*, Paul Brakeman, MD, PhD^9*, Christopher C. Dvorak, MD¹⁰, Shaun David Lawicki, MBBS^11*, Amita Sharma, MD^12*, Jooeun Lim, PhD^1*, Sujatha Venkataramani, PhD^1*, Mike Ero, MT, CLS, MBA^1* and Bradley Lewis, MD¹

¹Machaon Diagnostics, Inc., Berkeley, CA
²Machaon Diagnostics, Inc., Oakland, CA
³Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN
⁴Mayo Clinic, Rochester, MN
⁵St. Luke's Health, Duluth, MN
⁶UPMC McKeesport, McKeesport, PA
⁷Northwestern University, Chicago, IL
⁸University of California, Irvine, Orange, CA
⁹UCSF Benioff Children's Hospitals, San Francisco
¹⁰Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, Benioff Children's Hospital, San Francisco, CA
¹¹Louisiana State University Health Sciences Center, New Orleans, LA
¹²Massachusetts General Hospital, Boston, MA

Adrián Montaño, Biotechnologist, PhD^1,2*, Ana Marco, MD, PhD^3*, Francisco José López-Jaime, MD^1*, Ihosvany Fernandez-Bello, BSPharm, PhD^1*, Faustino García-Candel, MD, PhD^4*, Miguel Blanquer Blanquer, MD, PhD⁵, Manuel Isidro Muñoz-Pérez, MD^1* and Pascual Marco-Vera, MD, PhD^3,6*

¹Hospital Universitario Regional de Málaga-IBIMA, Málaga, Spain
²University of Salamanca, Salamanca, Spain
³Hospital General Universitario de Alicante-ISABIAL, Alicante, Spain
⁴Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain
⁵Hospital Clínico Universitario Virgen De La Arrixaca, Murcia, Murcia, Spain
⁶Department of Clinical Medicine, Miguel Hernández University, Alicante, Spain

Christoph Gasteyger^1*, Miguel G Uriol-Rivera^2*, Ana I Ávila^3*, Robert S Makar, MD, PhD⁴, Frank R Ernst^5*, John N Booth III^5*, Angels Comas^6*, Ching Lum, PharmD^7*, Ioannis Tomazos^7*, Yan Wang^7* and Pavan K. Bendapudi, MD^4,8,9

¹Alexion, AstraZeneca Rare Disease, Zurich, MA, Switzerland
²Glomerular Diseases Unit, Son Espases University Hospital, Palma de Mallorca, Spain
³Nephrology Department, Dr Peset University Hospital, Valencia, Spain
⁴Harvard Medical School, Boston, MA
⁵Real-World Evidence and Late Phase Research, CTI Clinical Trial & Consulting Services, Covington, KY
⁶Alexion, AstraZeneca Rare Disease, Barcelona, Spain
⁷Alexion, AstraZeneca Rare Disease, Boston, MA
⁸Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Boston, MA
⁹Division of Hematology and Blood Transfusion Service, Massachusetts General Hospital, Cambridge, MA

Sherri Huang, MD^1*, Ashley Perry, MD^1*, Carlos Sanchez Parra, MD^2*, Adriana Gonzalez Torriente^1*, Haider Ghumman^1*, Shaun Charkowick^1*, Joshua Colon^1*, Mckenzi Heide^1*, Michael Jaglal, MD³, Rahul Mhaskar, PhD MPH^1* and Juan Felipe Rico, MD⁴

¹University of South Florida Morsani College of Medicine, Tampa, FL
²Texas Children's Hospital, Houston, TX
³Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁴Department of Pediatrics, Division of Hematology & Oncology, University of South Florida Morsani College of Medicine, Tampa, FL

Patrick Van Dreden, PhD¹, Evangelos Terpos, MD, PhD^2,3, Marianna Politou, MD^4*, Meletios A. Dimopoulos, MD³, Matthieu Grusse^5* and Grigorios T. Gerotziafas^6,7,8*

¹Clinical Research department, Stago, Gennevilliers, France
²National and Kapodistrian University of Athens, Athens, Greece
³Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece
⁴Laboratory of Hematology and Blood Bank Unit, “Aretaieio” Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece
⁵Clinical Research department, Diagnostica Stago, Gennevilliers, France
⁶Institut Universitaire de Cancérologie, Sorbonne University, Paris, France
⁷Service d'Hématologie Biologique Hôpital Tenon, Paris, France, Paris, France
⁸INSERM U938, Faculté de Médecine Pierre et Marie Curie, Université Paris VI,, Paris, France

Oleg Pikovsky, MD^1*, Keren Biham Rochwerger, MD^2*, Kayed Al-Athamen, MD^3*, Offer Erez, MD^4*, Svetlana Daichman, PhD^5*, Zvi H Perry, MD PhD^6* and Anat Rabinovich, MD^7*

¹Transfusion Medicine Institute, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheba, Israel
²Pediatrics A Ward, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel, Beersheba, Israel
³Hematology Institute, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheba, Israel
⁴Department of Obstetrics and Gynecology, Emek Medical Center, Afula, Israel, Afula, Israel
⁵Industrial Management, Sami Shamoon College of Engineering, Beer Sheva, Israel, Beersheba, Israel
⁶Surgery A Ward, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel, Beersheba, Israel
⁷Thrombosis and Hemostasis Unit, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheba, Israel