Robert F. Sidonio, Jr., MD, MSc¹, Anan Lu^2*, Sarah Hale, PhD, MS^3*, Jorge Caicedo, MD^4*, Michael Bullano, PharmD, MS^3* and Shan Xing, PharmD, PhD^4*

¹Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
²Charles River Associates, Boston, MA
³Takeda Development Center Americas, Inc., Lexington, MA
⁴Takeda Pharmaceuticals U.S.A., Inc., Lexington, MA

Huacong Cai, MD^1*, Xinxin Cao, MD^2*, Shujie Wang, MD^3*, Yongqiang Zhao, MD^3*, Jian Li, MD³ and Tie-nan Zhu, MD^3*

¹Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, AL, China
²Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, CA, China
³Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Rezan Abdul-Kadir^1*, Ahmad Tarawah^2*, Naveen Shridhar^3* and Roshni Kulkarni, MD⁴

¹Department of Obstetrics and Gynaecology, University College London, London, United Kingdom
²King Salman Medical City Al Madinah, Madinah, Saudi Arabia
³Rare Disease Global Medical Affairs, Novo Nordisk Service Centre India Private Ltd, Bangalore, India
⁴Michigan State University, Okemos, MI

Eliska Ceznerova, MSc^1*, Jirina Kaufmanova, MSc^2*, Marek Havlicek, MSc^1*, Ondrej Pastva, PhD^1*, Alzbeta Hlavackova, PhD^1*, Roman Kotlin, PhD¹ and Jiri Suttnar, PhD^1*

¹Department of Biochemistry, Institute of Hematology and Blood Transfusion, Prague, Czech Republic
²Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague, Czech Republic

Ahmad Al-Huniti, MD¹, Alexis Katherine Kuhn, PharmD, RPh^2*, Linda Marshall, Pharm.D., R.Ph.^3*, Dawn Rusk, R.N.^4*, Rajiv K. Pruthi, M.B.B.S^5,6,7 and Asmaa Ferdjallah, MD^8*

¹Division of Pediatric Hematology and Oncology, Mayo Clinic, Rochester, MN
²Department of Pharmacy. Mayo Clinic Hospital- Rochester, Rochester, MN
³Department of Pharmacy, Mayo Clinic, Rochester, Rochester, MN
⁴Department of Nursing, Mayo Clinic, Rochester, MN
⁵Division of Hematopathology, Special Coagulation Laboratory, Mayo Clinic, Rochester, MN
⁶Mayo Comprehensive Hemophilia Center, Mayo Clinic, Rochester, MN
⁷Division of Hematology, Mayo Clinic, Rochester, MN
⁸Division of Pediatric Hematology and Oncology, Mayo Clinic, Rochester, MN, USA, Rochester, MN

Brian Hu, MS, PhD^1*, Martin Chandler, BS^1*, Matthew Manuel, MS, PhD^1*, Jorge Caicedo, MD^2*, Michael Denne, PharmD², Bruce Ewenstein, MD, PhD², Ali Mokdad, MD, PhD, MBA^2*, Shan Xing, PharmD, PhD^2* and Michael Recht, MD, PhD, MBA^1,3

¹American Thrombosis and Hemostasis Network, Rochester, NY
²Takeda Pharmaceuticals U.S.A., Inc., Lexington, MA
³Yale University School of Medicine, Rochester, CT

Hidekazu Nishikii, MD, PhD¹, Nobuaki Suzuki, MD^2*, Ryota Kobayashi^3*, Narumi Mizuno^3*, Ryoto Ozaki^3* and Midori Shima, MD, PhD⁴

¹Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
²Department of Transfusion Medicine, Nagoya University Hospital, Nagoya, Japan
³Chugai Pharmaceutical Co., Ltd., Tokyo, Japan
⁴Thrombosis and Hemostasis Research Center, Nara Medical University, Kashihara, Japan

Gili Kenet, MD^1,2, Ampaiwan Chuansumrit, MD^3*, Tadashi Matsushita, MD, PhD⁴, Guy Young, MD⁵, Vandana Yadav^6*, Marek Zak, MD, PhD^7* and Christoph Male, MD^8*

¹The Amalia Biron Thrombosis Research Institute, Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel
²Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
³Mahidol University, Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand
⁴Nagoya University Hospital, Nagoya, Japan
⁵Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA
⁶Novo Nordisk Service Centre India Private Ltd, Bangalore, India
⁷Novo Nordisk A/S, Søborg, Denmark
⁸Department of Paediatrics, Medical University of Vienna, Vienna, Austria

Jill M. Johnsen, MD^1,2, Sarah Ruuska^3*, Peter A. Kouides, MD⁴ and Barbara Konkle^5,6

¹Bloodworks NW, Seattle, WA
²Department of Medicine, University of Washington, Seattle, WA
³Washington Center for Bleeding Disorders, Seattle, WA
⁴Department of Medicine, Mary M. Gooley Hemophilia Center, Rochester, NY
⁵Division of Hematology, University of Washington School of Medicine, Seattle, WA
⁶Washington Institute for Coagulation, Washington Center for Bleeding Disorders, Seattle, WA

Ihosvany Fernandez-Bello, BSPharm, PhD^1*, Jose Manuel Calvo-Villas^2*, Ana Marco, MD, PhD^3*, Sonia Herrero-Martín, MD, PhD^4*, Laura Entrena Ureña, MD^5*, Adrián Montaño, Biotechnologist, PhD^1,6*, Francisco José López-Jaime, MD^1*, Bolivar Luis Diaz Jordan, MD^7*, Covadonga Garcia Diaz, MD^8*, Sergio Jurado Herrera, MD^9*, Noelia Pérez González, MD, PhD^10*, Faustino García-Candel, MD, PhD^11*, Miguel Blanquer Blanquer, MD, PhD¹² and Pascual Marco-Vera, MD, PhD^3,13*

¹Hospital Universitario Regional de Málaga-IBIMA, Málaga, Spain
²Hospital Universitario Miguel Servet, Zaragoza, Spain
³Hospital General Universitario de Alicante-ISABIAL, Alicante, Spain
⁴Hospital Universitario de Guadalajara, Guadalajara, Spain
⁵Hospital Universitario Virgen de las Nieves, Granada, AL, Spain
⁶University of Salamanca, Salamanca, Spain
⁷Hospital General de Valdepeñas, Valdepeñas, Spain
⁸Hematology Department, Hospital Universitario de Burgos, Burgos, Spain
⁹Hospital Universitario Torrecárdenas, Almeria, Spain
¹⁰Hospital Universitario Torrecárdenas, Almería, Spain
¹¹Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain
¹²Hospital Clínico Universitario Virgen De La Arrixaca, Murcia, Murcia, Spain
¹³Department of Clinical Medicine, Miguel Hernández University, Alicante, Spain

Amy D. Shapiro, MD¹, Aby Abraham, MD, DM^2*, Silvia Linari^3*, Jesper Skov Neergaard^4*, Jan Odgaard-Jensen^4*, Jay Jay Thaung Zaw^4* and Huyen Tran, MBBS^5*

¹Indiana Hemophilia & Thrombosis Center, Indianapolis, IN
²Department of Haematology, Christian Medical College, Vellore, Tamil Nadu, India
³Center for Bleeding Disorders and Coagulation, Department of Oncology, Careggi University Hospital, Florence, Italy
⁴Novo Nordisk A/S, Søborg, Denmark
⁵Haemophilia Treatment Centre, The Alfred Hospital, Melbourne, Australia

Steven R. Lentz, MD, PhD¹, Pratima Chowdary, MBBS, MRCP, FRCPATH^2*, Francisco Jose Lopez Jaime, MD^3*, Johnny Mahlangu, MD⁴, Irina Matytsina^5*, Anne Louise Nielsen^5* and Jerzy Windyga, MD, PHD^6*

¹Department of Internal Medicine, University of Iowa, Iowa City, IA
²Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free Hospital, London, United Kingdom
³Hospital Universitario Regional de Málaga, Málaga, Spain
⁴National Health Laboratory Service and Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa
⁵Novo Nordisk A/S, Søborg, Denmark
⁶Department of Hemostasis Disorders and Internal Medicine, Institute of Hematology and Transfusion Medicine, Warsaw, Poland

Tomasz Urasinski, MD, PhD^1*, Klaudia Paczoska, MD^1*, Wanda Badowska, PhD^2*, Halina Bobrowska, MD^3*, Lucja Dakowicz, MD^4*, Grzegorz Dobaczewski^5*, Elzbieta Latos-Grazynska, MD, PhD^6*, Grazyna Karolczyk⁷, Anna Klukowska, MD, PhD^8*, Andrzej Koltan, MD^9*, Magdalena Wojdalska, MD^10*, Pawel Laguna, MD, PhD^8*, Maciej Niedzwiecki, MD^11*, Danuta Pietrys^12*, Julia Radon-Proskura^13*, Monika Radwanska, MD^14*, Iwona Ruranska, MD^15*, Tomasz Szczepanski, MD, PhD^16,17, Dariusz Wasinski, MD^18*, Irena Woznica-Karczmarz, MD^19* and Tomasz Ociepa, MD, PhD^1*

¹Department of Pediatrics, Hemato-Oncology and Gastroenterology, Pomeranian Medical University, Szczecin, Poland
²Department of Pediatric Oncology and Hematology, School of Medicine, University of Warmia Mazury in Olsztyn, Olsztyn, POL
³Wielkopolska Child Health Center, Poznań, Poland
⁴Department of Pediatric Oncology and Hematology, Medical University of Bialystok, Białystok, Poland
⁵Department of Bone Marrow Transplantation, Pediatric Oncology and Hematology, Wroclaw Medical University, Wrocław, POL
⁶Department of Bone Marrow Transplantation, Pediatric Oncology and Hematology, Wroclaw Medical University, Wrocław, Poland
⁷II Department of Pediatrics, Collegium Medicum, Jan Kochanowski University, Kielce, Poland
⁸Department of Pediatric Oncology, Hematology and Transplantation, Medical University of Warsaw, Warszawa, Poland
⁹Department of Pediatrics, Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, POL
¹⁰Department of Pediatrics, Oncology and Hematology, Medical University of Lodz, Łódź, Poland
¹¹Department of Pediatrics, Hematology and Oncology, Medical University of Gdansk, Gdansk, Poland
¹²Department of Pediatric Oncology and Hematology, Collegium Medicum, Jagiellonian University, Kraków, Poland
¹³Department of Pediatrics, Hematology and Oncology, Medical University of Gdansk, Gdańsk, Poland
¹⁴Department of Pediatric Oncology and Hematology, College of Medical Sciences, University of Rzeszow, Rzeszów, Poland
¹⁵Department of Pediatrics, Hematology and Oncology, Medical University of Silesia, Katowice, Poland
¹⁶Medical University of Silesia, Katowice, Poland
¹⁷Department of Pediatrics Hematology and Oncology in Zabrze, Medical University of Silesia, Zabrze, Poland
¹⁸Department of Pediatric Hematology and Oncology, Collegium Medicum, University of Zielona Gora, Zielona Góra, Poland
¹⁹Department of Transfusion Medicine, Medical University of Lublin, Lublin, Poland

Koichiro Yoneyama^*, Mizuki Fukazawa-Shinotsuka^* and Tomohisa Saito, PhD^*

Chugai Pharmaceutical Co., Ltd., Tokyo, Japan

Midori Shima, MD, PhD¹, Hideyuki Takedani, MD, PhD^2*, Kaoru Kitsukawa, MD, PhD^3*, Masashi Taki, MD, PhD^4*, Akira Ishiguro, MD, PhD^5*, Azusa Nagao, MD, MSc^6*, Daisuke Nosaka, BS^7*, Yui Kyogoku, BA^7*, Keisuke Iwasaki, MPH^7* and Keiji Nogami, MD^1*

¹Nara Medical University, Nara, Japan
²IMSUT Hospital, The University of Tokyo, Tokyo, Japan
³Chiba University Hospital, Chiba, Japan
⁴Department of Pediatrics, St. Marianna University School of Medicine, Yokohama, Japan
⁵National Center for Child Health and Development, Tokyo, Japan
⁶Department of Blood Coagulation, Ogikubo Hospital, Tokyo, Japan
⁷Chugai Pharmaceutical Co., Ltd., Tokyo, Japan

Michael Recht, MD, PhD, MBA^1,2, Nabil Daoud, MA^1*, Lucy Lee, PharmD, MPH^3*, Paul Morton, BSc^3* and Leslie J. Raffini, MD, MSCE⁴

¹American Thrombosis and Hemostasis Network, Rochester, NY
²Yale University School of Medicine, New Haven, CT
³Genentech, Inc., South San Francisco, CA
⁴Children's Hospital of Philadelphia, Philadelphia, PA

Ho Jun Lee, MD^1*, Aditi Parikh, MD^2*, Sanjay Ahuja, MD³ and Lalitha V Nayak, MD¹

¹University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH
²Pediatric Genetics, Case Western Reserve University / UH Rainbow Babies and Children's Hospital, Cleveland, OH
³Division of Pediatric Hematology & Oncology, Rainbow Babies and Children's Hospital, Cleveland, OH

Lucy Z Kornblith^1*, Bindhya Sadhanandhan^2*, Sreepriya Arun^2*, Rebecca Long^3*, Alicia J Johnson^4*, Jamie Noll^5*, CN Ramchand^6*, John K Olynyk^3* and David H Farrell, PhD^7*

¹University of California, San Francisco, San Francisco, CA
²Theragen Biologics Pvt Ltd, Chennai, India
³Edith Cowan University, Joondalup, Western Australia, Australia
⁴Oregon Health & Science University, Portland, OR
⁵Jamie Noll, Pharm.D. LLC, The Villages, FL
⁶MagGenome Pvt Ltd, Chennai, India
⁷Department of Surgery, Oregon Health & Science University, Portland, OR

Martin Chandler, BS^1*, Jessica Charlet, PhD, MSc, BSc^2*, Thomas Moulton, MD² and Michael Recht, MD, PhD, MBA^1,3

¹American Thrombosis and Hemostasis Network, Rochester, NY
²Bayer, Whippany, NJ
³Yale University School of Medicine, New Haven, CT

Brooke Sadler, PhD¹, Pamela A Christopherson^2*, Crystal L Perry^3*, Daniel B. Bellissimo, PhD^4*, Sandra L Haberichter, PhD⁵, Gabe Haller, PhD^6*, Lilian Antunes, PhD^1*, Veronica H Flood, MD⁷, Jorge Di Paola, MD⁸, Robert R Montgomery, MD⁹ and The Zimmerman Program Investigators^10*

¹Pediatrics, Washington University School of Medicine, Saint Louis, MO
²Blood Center of WI Blood Research Institute, Milwaukee, WI
³Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI
⁴OB/GYN and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, Magee Women's Hospital, Pittsburgh, PA
⁵Blood Research Institute and Diagnostic Laboratories, Versiti, Milwaukee, WI
⁶Departments of Neurosurgery, Neurology and Genetics, Washington University, St Louis, MO
⁷Pediatric Hematology, Medical College of Wisconsin, Milwaukee, WI
⁸Department of Pediatrics, Washington University School of Medicine in St. Louis, Saint Louis, MO
⁹Blood Research Institute, Milwaukee, WI
¹⁰Medical College of Wisconsin, Milwaukee, WI

Craig M. Kessler, MD¹ and Andreas Tiede, MD²

¹Georgetown University School of Medicine, Washington
²Clinic for Haematology, Haemostaseology, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany

Zhengping Li, MBBS^1*, Man-Chiu Poon, MD², Guoqing Liu^3*, Zekun Li, MD^4*, Jie Sun^4* and Runhui Wu, MD, PhD^5*

¹Hematology Department, Beijing Children's Hospital, Capital Medical University, Beijing, AL, China
²Foothills Hospital, Calgary, AB, Canada
³Hemophilia Comprehensive Care Center, Beijing Children's Hospital, Capital Medical University, Beijing, China
⁴Beijing Children's Hospital, Capital Medical University, Beijing, China
⁵Department of Hematology, National Center for Children's Health, Beijing Children's Hospital, Beijing, China

Ellen Cusano, MD¹, Haowei Linda Sun, MD, MHSc, FRCPC², M Dawn Goodyear, MD¹, Man-Chiu Poon, MD¹, Douglas Seal, MD, FRCPC^3*, R Scott McClure, MD^4* and Natalia Rydz, MD¹

¹Department of Medicine, Division of Hematology and Hematological Malignancies, University of Calgary, Calgary, AB, Canada
²Department of Medicine, University of Alberta, Division of Hematology, Edmonton, AB, Canada
³Department of Anesthesia and Pain Medicine, University of Calgary, Calgary, AB, Canada
⁴Libin Cardiovascular Institute, Department of Cardiac Sciences, University of Calgary, Calgary, AB, Canada

Anjali Sharathkumar, MD, MS¹, Yanrong Jiang, MBBS, MRCP^2,3*, Hwai Jing Hiew, MD, FRCPath^3,4*, Athanasios Siadimas, MSc^5*, Francis Nissen, MD, PhD^5*, Gillian Hanson, ND^6*, Emily Cibelli, PhD^6*, Katya Moreno, MD^5*, Johnny Wharton, PhD^3* and Angela C. Weyand, MD⁷

¹Carver College of Medicine, University of Iowa, Iowa City, IA
²University College London Hospitals NHS Foundation Trust, London, United Kingdom
³Roche Products Ltd., Welwyn Garden City, United Kingdom
⁴University Hospital Southampton NHS Trust, Southampton, United Kingdom
⁵F. Hoffmann-La Roche Ltd., Basel, Switzerland
⁶PicnicHealth, San Francisco, CA
⁷University of Michigan, Ann Arbor, MI

Hitan Patel, MB. ChB^1*, Miranda Norton, PhD^2* and Magdalena D. Lewandowska, MD³

¹Bio Products Laboratory, Ltd., Elstree, United Kingdom
²Bio Products Laboratory. Ltd., Elstree, United Kingdom
³Indiana Hemophilia & Thrombosis Center, Indianapolis, IN