De Zhou, MD^1,2,3,4*, Xianbo Huang, MD, PhD^1,2,3,4*, Xueying Li^1,2,3,4*, Lixia Zhu^1,2,3,4*, Mixue Xie^1,2,3,4*, Xin Huang, Ph.D.^1,2*, Fang Yu^5*, Juying Wei^1,2,3,4*, Liya Ma, M.D.^1,2,3,4*, Xiudi Yang^1,2,3,4*, Jianai Sun^1,2,3,4*, Li Li^1,2,3,4*, Wanzhuo Xie^1,2,4,6*, Hongyan Tong, MD, PhD^1,2,3,4*, Jie Jin, M.D., Ph.D.^1,2,3,4, Honghu Zhu, MD^1,2,3,4* and Xiujin Ye, MD^1,2,3,4*

¹Zhejiang Provincial Key Laboratory of Hematopoietic Malignancy, Zhejiang University, Hangzhou, Zhejiang, PR China, Hangzhou, China
²Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang, PR China, Hangzhou, China
³Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China, Hangzhou, China
⁴Zhejiang Provincial Clinical Research Center for Hematological Disorders, Hangzhou, China, Hangzhou, China
⁵Department of Pathology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China, Hangzhou, China
⁶Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

Dandan Wang, MD, MS¹, Subramaniam Malarkannan, PhD^2,3,4*, Kasiani C. Myers, MD⁵, Emery H. Bresnick, PhD^6,7,8,9, James Verbsky^10* and Monica Thakar, MD^11,12

¹Versiti, Blood Research Institute, The Medical College of Wisconsin, Milwaukee, WI
²Department of Medicine, Medical College of Wisconsin, Milwaukee, WI
³Blood Research Institute, Versiti, Milwaukee, WI
⁴Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI
⁵Department of Pediatrics, Division of Bone Marrow Transplantation and Immune Deficieny, Cincinnati Children's Hospital, Cincinnati, OH
⁶Wisconsin Blood Cancer Research Institute, Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI
⁷UW-Madison Blood Research Program, Department of Cell and Regenerative Biology; UW Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin - Madison, Madison, WI
⁸Wisconsin Blood Cancer Research Institute, Department of Cell and Regenerative Biology, Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI
⁹University of Wisconsin, Middleton, WI
¹⁰Medical College of Wisconsin, Milwaukee, WI
¹¹Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI
¹²Clinical Research Division, Fred Hutchinson Cancer Research Center, and Department of Pediatrics, University of Washington, Seattle, WA

Ailin Zhao^1*, Xin Wang^1*, Mengshi Hu^2*, Lijuan Chen, PhD^2* and Ting Niu¹

¹Department of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P.R. China, Chengdu, Sichuan, China
²State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center, Chengdu, Sichuan, 610041, P.R. China, Chengdu, Sichuan, China

Ulrich Salzer, MD^1*, Christoph B. Geier, MD, MSc^1*, Maryssa Ellison, BS^2*, Melis Yilmaz, MMSc^2,3*, Caroline von Spee-Mayer, MD^4*, Carsten Speckmann, MD^4,5*, Stephan Ehl, MD, PhD^4,5*, Olaf Neth, MD, PhD^6*, Ana Pilar Garcia Garcia, MD^7,8,9*, Angela Deya Martinez, MD^7,8,9*, Laia Alsina, MD, PhD^7,8,9*, Katja Sockel, MD^10*, Catharina Schuetz, MD, MSc^11,12*, David E. Potts, MMSc^13*, Boglarka Ujhazi, MS^13*, Krisztian Csomos, PhD^13*, Jolan E. Walter, MD, PhD^2,3,14* and Klaus Warnatz, MD^1*

¹Department of Rheumatology and Clinical Immunology, Center for Chronic Immunodeficiency (CCI), University Medical Center Freiburg, Freiburg, Germany
²Division of Allergy and Immunology, Departments of Pediatrics and Medicine, University of South Florida Morsani College of Medicine, St. Petersburg, FL
³Division of Allergy and Immunology, Departments of Pediatrics, Johns Hopkins All Children's Hospital, St. Petersburg, FL
⁴Center of Chronic Immunodeficiency, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
⁵Center for Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany
⁶Paediatric Infectious Diseases, Rheumatology and Immunology Unit, University Hospital Virgen del Rocio, Institute of Biomedicine, Seville, Spain
⁷Clinical Immunology Unit, Hospital Sant Joan de Déu-Hospital Clínic Barcelona, Barcelona, Spain
⁸Clinical Immunology and Primary Immunodeficiencies Unit, Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain
⁹Institut de Recerca Sant Joan de Déu, Barcelona, Spain
¹⁰Medical Clinic and Policlinic I, University Hospital Dresden, TU Dresden, Dresden, Germany
¹¹Department of Pediatrics, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
¹²Universitäts Centrum für Seltene Erkrankungen, University Hospital Carl-Gustav-Carus, Technische Universität Dresden, Dresden, Germany
¹³University of South Florida at Johns Hopkins All Children's Hospital, St. Petersburg, FL
¹⁴Division of Allergy and Immunology, Massachusetts General Hospital for Children, Boston, MA

Moraima Jiménez, MD^1,2*, Sandra Novoa Jáuregui, MD^1*, Candela Fernández-Naval, PhD^3*, Marc Bosch Schips, MD^1*, Sofía Muzio, MD^1*, Víctor Navarro Garcés^4*, Cristina Andrés, PhD^3*, Mónica Martínez-Gallo, PhD^5*, Andrés Antón^3*, Alba Cabirta^1*, Angel Serna, MD^1*, Daniel Medina^2,6*, Soraya Peralta^2,6*, Gemma Pujadas^2,6*, Cristina Hernandez^2,6*, Carlota Pagès, MSc^2,6*, Tomás Pumarola^3*, Mercedes Valentín^1*, David Valcárcel, MD, PhD⁷, Manuel Hernández^8*, Isabel Ruiz-Camps, MD, PhD^9*, Marta Crespo, PhD^2,6*, Juliana Esperalba, PhD^3*, Pau Abrisqueta, MD, PhD^1,2* and Francesc Bosch, MD, PhD^1,2,6

¹Servei d’Hematologia, Vall d’Hebron Hospital Universitari, Experimental Hematology, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain
²Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain
³Department of Microbiology, Vall d’Hebron Hospital Universitari, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain
⁴Oncology Data Science (ODysSey) Group, Vall d’Hebron Institute of Oncology (VHIO), BARCELONA, Spain
⁵Department of Immunology, Vall d’Hebron Hospital Universitari, Vall d’Hebron Research Institute, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain
⁶Experimental Hematology, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain
⁷Hospital Universitari Vall d’Hebron, Barcelona, Spain
⁸Department of Immunology, Vall d’Hebron Hospital Universitari, Vall d’Hebron Research Institute, Vall d’Hebron Barcelona Hospital Campus. Department of Cell Biology, Physiology and Immunology, Autonomous University of Barcelona (UA), Barcelona, Spain
⁹Department of Infectious Diseases, Vall d´Hebron University Hospital, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain

Cilia R. Pothast^1*, Romy C. Dijkland, MSc^1*, Melissa Thaler^2*, Renate S. Hagedoorn, ing.^3*, Michel G.D. Kester^1*, Anne K. Wouters^1*, Pieter S. Hiemstra, PhD^4*, Martijn J. van Hemert, PhD^2*, Stephanie Gras, PhD^5*, J.H. Frederik Falkenburg^1* and Mirjam H.M. Heemskerk¹

¹Department of Hematology, Leiden University Medical Center, Leiden, Netherlands
²Department of Microbiology, Leiden University Medical Center, Leiden, Netherlands
³Department of Hematology, Leiden University Medical Center (LUMC), Leiden, Netherlands
⁴Leiden University Medical Center, Leiden, NLD
⁵Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, Melbourne, Australia

Masashi Nishikubo, MD^1*, Yoshimitsu Shimomura, MD^1*, Ryusuke Yamamoto, MD, PhD^1*, Hayato Maruoka, MHS^2*, Seiko Nasu, AS^2*, Tomomi Nishioka, Diploma^3*, Kenji Sakizono, Diploma^1*, Satoshi Mitsuyuki, MD^1*, Tomoyo Kubo, MD^1*, Naoki Okada, MD^1*, Daishi Nakagawa, MD^1*, Kimimori Kamijo, MD^1*, Hiroharu Imoto, MD^1*, Yuya Nagai, MD, PhD^1*, Nobuhiro Hiramoto, MD^1*, Satoshi Yoshioka, MD, PhD¹, Noboru Yonetani, MD^1*, Tadakazu Kondo, MD, PhD¹ and Takayuki Ishikawa¹

¹Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan
²Department of Clinical Laboratory, Kobe City Medical Center General Hospital, Kobe, Japan
³LSI medience Laboratory, Kobe City Medical Center General Hospital, Kobe, Japan

Tsung-Chih Chen^1,2,3*, Chia-Lang Hsu, Dr^4*, Chi-Yuan Yao, M.D.^2,5*, Yu-Ren Chen^5*, Yueh-Chwen Hsu, PhD^5*, Chein-Jun Kao^5*, Hsin-An Hou, MD, PhD^3*, Wen-Chien Chou, MD, PhD^3,5 and Hwei-Fang Tien, MD, PhD³

¹Division of Hematology/Medical Oncology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
²Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
³Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
⁴Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan
⁵Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan

Rushil Shah^1*, Xanthi-Leda Katopodi, MS^2*, Anthos Christofides, MD^1,3*, Rinku Pal, MS^4*, Ioannis Vlachos, PhD^2,5,6*, Nikolaos Patsoukis, PhD^1* and Vassiliki A Boussiotis, MD, PhD¹

¹Hematology-Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
²Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
³Department of Medicine, Yale University, New Haven, CT
⁴Hematology-Oncology, Beth Israel Deaconess Medical Center, Boston, MA
⁵Broad Institute of MIT and Harvard, Cambridge, MA
⁶Spatial Technologies Unit, Harvard Medical School Initiative for RNA Medicine, Boston, MA