Raghda T Fouda^1*, Srideshikan Sargur Madabushi, PhD², Hemendra Ghimire^2*, Amr M H Abdelhamid^2,3,4*, Ji Eun Lim, PhD^2*, Paresh Vishwasrao, MSc^2*, Stacy B Kiven, BIS^5*, Jamison Brooks, PhD^2,6*, Darren Zuro, PhD^2,7*, Joseph Rosenthal, MD^8*, Chandan Guha, MBBS^9*, Susanta Hui, PhD^2* and Kalpna Gupta, PhD^5,10,11

¹Department of Medicine, Division of Hematology/Oncology, University of California, Irvine, Orange, CA
²Department of Radiation Oncology, City of Hope National Medical Center, Duarte, CA
³Radiation Oncology Section, Department of Medicine and Surgery, Perugia University and General Hospital, Perugia, Italy
⁴Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt
⁵Department of Medicine, Division of Hematology/Oncology, University of California, Irvine, Irvine, CA
⁶Department of Radiation Oncology, Mayo Clinic, Rochester, MN
⁷Department of Radiation Oncology, University of Oklahoma HSC, Oklahoma City, OK, USA, Oklahoma City
⁸Pediatric Hematology/Oncology, City of Hope, Duarte, CA
⁹Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY
¹⁰Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis
¹¹SCIRE, Long Beach VA Medical Center, Long Beach, CA

Ernestine Amos-Abanyie, MPhil^1*, Chithra Palani, PhD², Alana Smith, MS^1*, Qingqing Gu, MD, PhD^1*, Ugochi Ogu, MD^3*, Daniel Johnson, PhD^4*, Umapathy N Siddaramappa, PhD⁵, Betty S. Pace, MD² and Athena Starlard-Davenport, PhD¹

¹Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN
²Department of Pediatrics, Division of Hematology/Oncology, Augusta University, Augusta, GA
³College of Medicine, University of Tennessee Health Science Center, Regional One Health Diggs-Kraus Comprehensive Sickle Cell Center, University of Tennessee Health Science Center, Memphis, TN
⁴Molecular Bioinformatics Core, University of Tennessee Health Science Center, Memphis, TN
⁵Department of Medicine, Division of Hematology/Oncology, Augusta University, Augusta, GA

Yankai Zhang, PhD¹, Celeste K. Kanne^1*, Britney N. Hernandez^1*, Michael J. Lacagnina, PhD^2*, Peter M. Grace, PhD^2*, Mark J. Burish, MD, PhD^3* and Vivien A. Sheehan, MD, PhD¹

¹Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
²The University of Texas MD Anderson Cancer Center, Houston, TX
³The University of Texas Health Science Center, Houston, TX

Aithanh Nguyen^1*, Joseph P Juliette^2*, Alison Wong^3*, Elena Aronovich, PhD^4*, Maya Abdullah^3*, Julia Nguyen^5*, Fuad Abdulla^3*, Chunsheng Chen, PhD^5*, Iryna A Khasabova, PhD^2*, John D Belcher, PhD⁵, Gregory M. Vercellotti, MD⁶, Donald Simone, PhD^2* and Joan D Beckman, MD, PhD⁷

¹Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN
²Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN
³University of Minnesota, Minneapolis, MN
⁴Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN
⁵Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN
⁶Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN
⁷Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota Twin Cities, Minneapolis, MN

Scott A. Peslak, MD, PhD^1,2, Eugene Khandros, MD, PhD², Peng Huang, PhD^2*, Aoi Wakabayashi, BS^2,3, Talla Abbas, BS^1,2*, Osheiza Y. Abdulmalik, DVM^2*, Cheryl A. Keller, PhD^4,5*, Ross C. Hardison, PhD^5*, Junwei Shi, PhD^6* and Gerd A. Blobel, MD, PhD²

¹Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
²Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA
³University of Pennsylvania, Philadelphia, PA
⁴Genomics Research Incubator, Pennsylvania State University, University Park, PA
⁵Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA
⁶Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

Christos Varelas, MD, MSc^1*, Efthymia Vlachaki, MBBS^2*, Filippos Klonizakis, MD^3*, Despoina Pantelidou, MD, PhD^4*, Fani Minti^5*, Michael D. Diamantidis, MD, PhD, MSc⁶, Nikolaos Sampanis^7*, Ioanna Giatagantzidou^8*, Despoina Papadopoulou, MD^4*, Evdoxia Koravou^9*, Ioanna Christodoulou^5*, Evaggelia Zarkada^5*, Tasoula Touloumenidou^10*, Apostolia Papalexandri^9*, Ioanna Sakellari^11*, George Vassilopoulos, MD, PhD¹², Robert Brodsky, MD¹³ and Eleni Gavriilaki, MD, PhD¹⁴

¹Hematology Department - HCT Unit, George Papanikolaou Hospital, Thessaloniki, Greece
²Adults Thalassemia Unit, Hippokration Hospital, Thessaloníki Thalassemia Therapy and Sickle Cell Disease Unit, Thessaloniki, Greece
³Adults Thalassemia Unit, Hippokration Hospital, Thessaloníki Thalassemia Therapy and Sickle Cell Disease Unit, Thessaloniki, AL, Greece
⁴Thalassemia and Sickle Cell Disease Unit, AHEPA University Hospital, Thessaloniki, Thessaloniki, Greece
⁵Aristotle University of Thessaloniki, Thessaloniki, Greece
⁶Thalassemia and Sickle Cell Disease Unit, General Hospital of Larissa, Larissa, Greece
⁷General Hospital of Trikala, Trikals
⁸AHEPA Hospital, Thessaloniki, Greece
⁹Department of Hematology and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
¹⁰Hematology Department and HCT Unit, George Papanikolaou General Hospital, Thessaloniki, Greece
¹¹Hematology Department and HCT Unit, George Papanikolaou General Hospital, THESSALONIKI, AL, Greece
¹²Cell and Gene Therapy Group, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
¹³Division of Hematology, Department of Medicine, Johns Hopkins University, Baltimore, MD
¹⁴2nd Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece

Adeola O Adebayo Michael, PhD¹, Paul Dawson, PhD^2*, Saul Karpen, MD, PhD^2* and David R. Archer, PhD³

¹Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, GA
²Department of Pediatrics - Gastroenterology, Hepatology & Nutrition, Emory University School of Medicine, Emory University, Atlanta
³Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, GA

Maureen Lundt, MSc^1*, Nancy Asomaning, MS^1*, Ingrid Frey, RN, BSN, MS^1*, Xunde Wang, PhD^1*, Anna Conrey, NP^1*, Julia Z Xu, MD, MS², Quan Li, PhD^3*, Emily B Dunkelberger, PhD^3*, Neal Jeffries, PhD^4*, William Eaton, MD⁵ and Swee Lay Thein, MBBS, DSc, FRCP, FRCPath, MRCP, MRCPath¹

¹Sickle Cell Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
²Department of Medicine, University of Pittsburgh, Pittsburgh, PA
³National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD
⁴Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
⁵National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD

Daniela Pinheiro Leonardo, BSc, MSc^1*, Myriam Salazar-Terreros, PhD, MSc^1*, Stephan Menzel, MD, PhD^2*, Carolina Lanaro, BSc, PhD^1*, Dulcinéia Martins de Albuquerque, BSc, PhD^1*, Sara T Olalla Saad, MD, Ph.D.¹, Kleber Yotsumoto Fertrin, MD, PhD³ and Fernando Ferreira Costa, M.D., Ph.D.¹

¹Hematology and Hemotherapy Center, University of Campinas - UNICAMP, Campinas, Brazil
²School of Cancer & Pharmaceutical Sciences, King’s College London Faculty of Life Sciences and Medicine, London, United Kingdom
³Division of Hematology, Department of Medicine, University of Washington, Seattle, WA

Kailyn Lowder^1*, Nirupama Ramadas, PhD^1*, Rafal Pawlinski, PhD² and Erica Sparkenbaugh, PhD¹

¹Blood Research Center, Division of Hematology, University of North Carolina Chapel Hill, Chapel Hill, NC
²Blood Research Center, Division of Hematology, University of North Carolina, Chapel Hill, NC

Enrica Federti^1*, Iana Iatcenko^1*, Alessandra Ghigo^2*, Alessandro Mattè^1*, Veronica Riccardi^1*, Immacolata Andolfo, PhD^3*, Angela Siciliano^1*, Filippo Mazzi^1*, Manuela Stella^4*, Luigi Robbiano^5*, Valeria Pinto^6*, Achille Iolascon, MD, PhD³, Gian Luca Forni^6* and Lucia De Franceschi, MD⁷

¹University of Verona and AOUI Verona, Verona, Italy
²University of Torino, Torino, Italy
³Department of Molecular Medicine and Medical Biotechnology, CEINGE - Biotecnologie Avanzate, University Federico II of Naples, Naples, Italy
⁴Department of Internal Medicine, Pharmacology & Toxicology Unit, University of Genoa, Genova, Italy
⁵Department of Health Sciences, University of Genoa, Genova, Italy
⁶Center for Congenital Anemias, Galliera Hospital, Genoa, Italy
⁷University of Verona and AOUI Verona, Chapel Hill, NC

Raghda T Fouda, MD, PhD^1*, Hemanth M Cherukury, MS¹, Stacy B Kiven, BSc^1*, Natalie Garcia, BS^1*, Donovan A Argueta, PhD², Kalpna Gupta, PhD^1,3,4 and John D Roberts, MD⁵

¹Department of Medicine, Division of Hematology/Oncology, University of California, Irvine, Irvine, CA
²Department of Medicine, Division of Hematology/Oncology, University of California, Irvine, Los Angeles, CA
³Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis
⁴SCIRE, Long Beach VA Medical Center, Long Beach, CA
⁵Yale University, New Haven, CT

Daniel Diatlov^1,2*, Arlette Bohorquez, PhD^3*, Melanie Jackson, MBBS, DCH^4*, Melina Cheong, RN(EC), BScN, MN^4*, Walter H.A. Kahr, MD, PhD, FRCPC^2,4, Kevin H.M. Kuo, MD, MSc, FRCPC⁵, Melanie Kirby -Allen, MBBS^6* and Christoph Licht, MD, FRCP^2,7*

¹Institute of Medical Science, University of Toronto, Toronto, ON, Canada
²Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada
³Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada
⁴Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada
⁵Division of Medical Oncology and Hematology, Department of Medicine, University Health Network, Toronto, ON, Canada
⁶Division of Haematology/Oncology, The Hospital for Sick Children (SickKids) / The University of Toronto, Toronto, Canada, Toronto, ON, Canada
⁷Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada

Stevan P. Tofovic, PhD^1*, Edwin K. Jackson, PhD^1*, Lynda L Ihrig, BS^2*, Stephanie Mutchler, PhD^3* and Enrico M. Novelli, MD, MS²

¹Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA
²Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA
³Department of Medicine, Division of Renal-Electrolyte, University of Pittsburgh, Pittsburgh, PA

Chithra D Palani, PhD^1,2, Xingguo Zhu, PhD^1,2, Manickam Alagar, Ph.D^1,2*, Otis C Attucks, PhD^3* and Betty S. Pace, MD^2,4

¹Department of Pediatrics, Augusta University, Augusta, GA
²Georgia Cancer Center, Augusta University, Augusta, GA
³vTv Therapeutics Inc., High Point, NC
⁴Department of Pediatrics, Division of Hematology/Oncology, Augusta University, Augusta, GA

Emily Vistica-Sampino, MD¹, Anna D Chorzalska, PhD^2*, Dennis M Bonal, MSc, BSc^3*, John Morgan, PhD^4*, Lisa Nguyen^5*, Anaelena Rodriguez^6*, Rishi Lulla, MD, MS^7* and Patrycja M Dubielecka, PhD⁸

¹Rhode Island Hospital/Brown University, Providence, RI
²Signal Transduction Lab, Division of Hematology-Oncology,, Rhode Island Hospital and Warren Alpert Medical School at Brown University, Providence, RI
³Signal Transduction Lab, Division of Hematology-Oncology, Rhode Island Hospital and Warren Alpert Medical School at Brown University, Douglas, MA
⁴Division of Hematology/Oncology, Rhode Island Hospital, Providence
⁵Brown University Medical School/Rhode Island Hospital, Providence
⁶Signal Transduction Lab, Division of Hematology/Oncology, Warren Alpert Medical School at Brown University and Rhode Island Hospital, Providence, RI
⁷Warren Alpert Medical School of Brown University/Rhode Island Hospital, Providence
⁸Division of Hematology-Oncology, Warren Alpert Medical School of Brown University/Rhode Island Hospital, Providence, RI

Timothy Quang, PhD^1*, Julia Z Xu, MD, MS², Ingrid Frey, RN, BSN, MS^3*, Kathryn Jaroszynski, BS^4*, Elise M. Berning, BS^5*, Anna Conrey, NP^3*, Ruth Pierre Charles, DSc, PA-C^3*, Brian Y Hill, MS^4*, Neal Jeffries, PhD^6*, Swee Lay Thein, MBBS, DSc, FRCP, FRCPath, MRCP, MRCPath³ and Bruce J. Tromberg, PhD^7*

¹National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD
²Department of Medicine, University of Pittsburgh, Pittsburgh, PA
³Sickle Cell Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
⁴National Institute of Child Health and Human Development, National Institutes of Health, Bethesda
⁵National Institute of Child Health and Human Development, National Institutes of Health, BETHESDA, MD
⁶National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
⁷National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD

Svetlana Didichenko^1*, Alexey Navdaev, PhD^1*, Moritz Saxenhofer, PhD^2*, Stefanie Graeter, PhD^2*, Alexander Schaub, PhD^2*, Alicia Rovo, MD³, Gregory J Kato, MD^4,5,6,7 and Bronwyn Kingwell, PhD^8*

¹CSL Behring AG, Bern, Switzerland
²Research and Development, CSL Behring AG, Bern, Switzerland
³Department of Hematology and Central Hematology Laboratory, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland
⁴University of Pittsburgh Physicians, Tilghman, MD
⁵Clinical Research & Development, CSL Behring, King of Prussia
⁶Hematology and Oncology/Department of Medicine, University of Mississippi Medical Center, Jackson, MS
⁷University of Pittsburgh Physicians, Pittsburgh, PA
⁸CSL Limited, Parkville, Australia