Annamaria Aprile, PhD¹, Silvia Sighinolfi^1,2*, Laura Cassina, PhD^3*, Mariacarla Panzeri^4*, Mariangela Storto^1*, Stefano Beretta, PhD^1*, Ivan Merelli, PhD^1,5*, Alessandra Boletta, PhD^3* and Giuliana Ferrari, PhD^1,2

¹San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy
²Vita-Salute San Raffaele University, Milan, Italy
³Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy
⁴Advanced Light and Electron Microscopy BioImaging Center (ALEMBIC), IRCCS San Raffaele Scientific Institute, Milan, Italy
⁵Institute for Biomedical Technologies, National Research Council, Segrate, Italy

Kevin H.M. Kuo, MD, MSc, FRCPC^1,2,3, D. Mark Layton, MB, BS^4*, Ashutosh Lal, MD⁵, Hanny Al-Samkari, MD⁶, Penelope A. Kosinski, MS^7*, Bo Tong, PhD^7*, Jeremie H. Estepp, MD⁷, Katrin Uhlig, MD^7* and Elliott P. Vichinsky, MD⁸

¹Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
²Division of Hematology, Department of Medicine, University of Toronto, Toronto, ON, Canada
³Division of Medical Oncology and Hematology, Department of Medicine, University Health Network, Toronto, ON, Canada
⁴Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom
⁵Division of Hematology, UCSF Benioff Children's Hospital Oakland, Oakland, CA
⁶Massachusetts General Hospital, Boston, MA
⁷Agios Pharmaceuticals, Inc., Cambridge, MA
⁸Division of Hematology, UCSF Benioff Children’s Hospital Oakland, Oakland, CA

Elena E. Solomou, MD¹, Polyxeni Delaporta, PhD^2*, Aimilia Mantzou, PhD^3*, Marianna Tzannoudaki^4*, Panagiotis T Diamantopoulos, MD, PhD^5*, Christina Salamaliki, MD^6*, Christina-Nefeli Kontandreopoulou^5*, Athina Vyniou^7*, Foteini Perganti, MD^8*, Ioannis Papassotiriou, PhD³ and Antonis Kattamis, MD⁹

¹Department of Internal Medicine, University of Patras Medical School, Rion, Greece
²Thalassemia Unit, First Department of Pediatrics, ‘Aghia Sophia’ Children’sHospital, National and Kapodistrian University of Athens , Athens, Greece, ATHENS, Greece
³First Department of Pediatrics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece
⁴Department of Pediatrics Aghia Sophia Hopsital, University of Athens Medical School, Athens, Greece
⁵Hematology Unit, First Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece
⁶University of Patras Medical School, Patras, Greece
⁷University of Athens Medical School, Athens, Greece
⁸First Department of Pediatrics, Oncology / Hematology Unit "Aghia Sophia" Children's Hospital, Athens, Greece
⁹Pediatric Hematology Oncology Unit, First Department of Pediatrics, National and Kapodistrian University of Athens, Aghia Sophia Children’s Hospital, Athens, Greece

Rattana Weerasathain, MD^1*, Pokpong Piriyakhuntorn, MD^1*, Adisak Tantiworawit, MD¹, Supawan Buranapin, MD^2*, Chanisa Thonusin, MD, PhD^3,4,5*, Piangrawee Niprapan, MNS^1*, Nonthakorn Hantrakun^1*, Teerachat Punnachet, MD^1*, Thanawat Rattanathammethee, MD^1*, Sasinee Hantrakool, MD^1*, Chatree Chai-Adisaksopha, MD, PhD¹, Ekarat Rattarittamrong, MD^1*, Lalita Norasetthada, MD¹, Nipon Chattipakorn, MD, PhD^3,4,5* and Siriporn C. Chattipakorn, DDS, PhD^4,5,6*

¹Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
²Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
³Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
⁴Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
⁵Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, Thailand
⁶Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand

Jianyun Liao^*, Chaoke Bu^*, Lan He^*, Yuelin He^*, Jujian He^*, Dan Chen^*, Bo Lyu^*, Weiwei Zhang^*, Haoran Tang^*, Xinrui Liu^* and Chunfu Li, MD

Nanfang-Chunfu Children's Institute of Hematology & Oncology, Taixin Hospital, Dongguan, China

Paolo Ricchi, MD, PhD^1*, Laura Pistoia, MSc^2*, Anna Spasiano^3*, Sabrina Armari^4*, Aurelio Maggio, MD⁵, Saveria Campisi, MD^6*, Alessandra Quota^7*, Annamaria Carrà^8*, Riccardo Righi^9*, Antonino Vallone^10*, Ada Riva^11*, Vincenzo Positano^2*, Alessia Pepe, MD, PhD^12*, Filippo Cademartiri, MD, PhD^2* and Antonella Meloni, PhD^2*

¹Unità Operativa Semplice Dipartimentale Malattie Rare del Globulo Rosso, Azienda Ospedaliera di Rilievo Nazionale "A. Cardarelli, Napoli, Italy
²Department of Radiology, Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy
³Unità Operativa Semplice Dipartimentale Malattie Rare del Globulo Rosso, Azienda Ospedaliera di Rilievo Nazionale "A. Cardarelli”, Napoli, Italy
⁴Reparto di Pediatria, Azienda Ospedaliera di Legnago, Legnago (VR), Italy
⁵Ematologia II con Talassemia, Ospedale "V. Cervello", Palermo, Italy
⁶Unità Operativa Semplice Talassemia, Presidio Ospedaliero “Umberto I”, Siracusa, Italy
⁷Servizio di Talassemia., Ospedale "V. Emanuele III", Gela (CL), Italy
⁸Unità Operativa di Pediatria, Ospedale “G. Da Saliceto”, Piacenza, Italy
⁹Diagnostica per Immagini e Radiologia Interventistica, Ospedale del Delta, Lagosanto (FE), Italy
¹⁰Reparto di Radiologia, Azienda Ospedaliera "Garibaldi" Presidio Ospedaliero Nesima, Catania, Italy
¹¹Struttura Complessa di Radiologia, Ospedale “SS. Annunziata” ASL Taranto, Taranto, Italy
¹²Institute of Radiology, Department of Medicine, University of Padua, Padova, Italy

Antonella Meloni, PhD^1*, Laura Pistoia, MSc^1*, Vincenzo Positano^1*, Antonio De Luca^2*, Nicola Martini^1*, Mauro Murgia, MD^3*, Angelica Barone^4*, Maria Grazia Sanna^5*, Sara Gentili^6*, Antonella Massa^7*, Aurelio Maggio, MD⁸, Gianfranco Sinagra^2*, Alessia Pepe, MD, PhD^9* and Filippo Cademartiri, MD, PhD^1*

¹Department of Radiology, Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy
²Cardiovascular Department, University of Trieste, Trieste, Italy
³Centro Provinciale per le Microcitemie, Ospedale San Martino di Oristano, Oristano, Italy
⁴Unità Operativa di Pediatria e Oncoematologia, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
⁵Servizio trasfusionale Aziendale, Azienda Ospedaliero-Universitaria di Sassari, Sassari, Italy
⁶Unità Operativa Immunoematologia e Medicina Trasfusionale, Ospedale "San Donato", Arezzo, Italy
⁷Servizio trasfusionale, Ospedale “Giovanni Paolo II”, Olbia, Italy
⁸Ematologia II con Talassemia, Ospedale "V. Cervello", Palermo, Italy
⁹Institute of Radiology, Department of Medicine, University of Padua, Padova, Italy

Khaled M. Musallam^1*, Louise Lombard^2*, Keely Gilroy^3*, Lydia Vinals^4*, Candice Tam^5* and Maria Rizzo^5*

¹Thalassemia Center, Burjeel Medical City, Abu Dhabi, United Arab Emirates
²Health Economics and Outcomes Research, Agios Pharmaceuticals, Westfield, IN
³Medical Affairs, Agios Pharmaceuticals, Cambridge, MA
⁴Health economics and outcomes research, Cytel Inc., Montreal, Canada
⁵Health Economics and Outcomes Research, Cytel Inc., London, United Kingdom