Vida Zhang, PhD^*, Joseph Olivera, PhD^*, Richard Coffey, PhD, Elizabeta Nemeth, PhD and Tomas Ganz, MD, PhD

Center for Iron Disorders, UCLA, Los Angeles, CA

Richa Sharma^1*, S. Zebulon Vance^1*, Ada Antypiuk^1*, Deepa Manwani, MD², Quentinn Pearce^3*, James E. Cox, PhD^3*, Xiuli An⁴, Karina Yazdanbakhsh, PhD⁵ and Francesca Vinchi, PhD⁶

¹Iron Research Laboratory, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY
²Division of Pediatric Hematology/Oncology, Department of Pediatrics, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY
³Biochemistry, University of Utah, Salt Lake City, UT
⁴Laboratory of Membrane Biology, New York Blood Center, New York
⁵Laboratory of Complement Biology, New York Blood Center, New York, NY
⁶Iron Research Laboratory, New York Blood Center, New York, NY

Wenbin An, MD^1,2*, Srinivas Aluri^3*, Maayan Levy, MS^2*, Eitan Fibach, PhD^4*, Xiaofan Zhu, MD⁵, Amit Verma, MD⁶ and Yelena Ginzburg, MD⁷

¹Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Tianjin, China
²Icahn School of Medicine at Mount Sinai, New York
³Department of Oncology, Albert Einstein College of Medicine, Bronx, NY
⁴Hematology, Hadassah - Hebrew University Medical Center, Jerusalem, Israel, Jerusalem, ISR
⁵Department of Pediatric Blood Diseases Center, Institute of Hematology & Blood Diseases Hospital, Tianjin, China
⁶Department of Hematology and Medical Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY
⁷Division of Hematology Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY

Eduard J. Van Beers, MD, PhD^1*, Hanny Al-Samkari, MD², Rachael F. Grace, MD³, Wilma Barcellini, MD^4*, Andreas Glenthøj, MD, PhD⁵, Melissa Dibacco, MD^6*, Penelope A. Kosinski, MS^6*, Emily Xu, PhD^6*, Vanessa Beynon, MD^6*, Parija Patel, PharmD, MBA^6*, John B. Porter, MD, FRCP, FRCPath^7* and Kevin H.M. Kuo, MD, MSc, FRCPC⁸

¹Benign Hematology Center, Van Creveldkliniek, University Medical Center Utrecht, University of Utrecht, Utrecht, Netherlands
²Division of Hematology/Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
³Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA
⁴Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
⁵Department of Hematology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
⁶Agios Pharmaceuticals, Inc., Cambridge, MA
⁷Haematology Department, University College London Hospitals, London, United Kingdom
⁸Division of Hematology, Department of Medicine, University of Toronto, Toronto, ON, Canada

Nermi Parrow, PhD¹, Nisha George, PhD^2*, Faris Ali, BS¹, Nadia Wattad, MD^3*, Amaliris Guerra, PhD^4*, Yelena Ginzburg, MD⁵, Stefano Rivella, PhD⁶ and Robert E Fleming, MD^7,8

¹Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO
²Saint Louis University School of Medicine, St Louis
³Saint Louis University School of Medicine, St Louis, MO
⁴Department of Pediatrics, Division of Hematology, The Children’s Hospital of Philadelphia, Philadelphia, PA
⁵Division of Hematology Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
⁶Department of Pediatrics, Division of Hematology, Children’s Hospital of Philadelphia, Philadelphia, PA
⁷Pediatrics, Saint Louis University School of Medicine, University City, MO
⁸Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University, St. Louis, MO

Annie Qiu, B.S.^*, Lin Wang^*, Flavia Dei Zotti, PhD^*, Krystalyn E Hudson, PhD, Eldad A. Hod, MD and Francesca La Carpia, PhD^*

Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY

Koya Ono, MD^1,2*, Tohru Fujiwara, MD, PhD^1,3, Hiroki Shima, PhD^4*, Hironari Nishizawa, MD, PhD^4*, Chie Suzuki, MS^3*, Noriyuki Takahashi^3*, Hiroki Kato, MD, PhD^1*, Koichi Onodera, MD, PhD^1*, Satoshi Ichikawa, MD, PhD^1*, Noriko Fukuhara, MD, PhD⁵, Yasushi Onishi, MD, PhD^1*, Hisayuki Yokoyama, MD, PhD¹, Yukio Nakamura, MD, PhD^6*, Kazuhiko Igarashi, MD, PhD^4* and Hideo Harigae, MD, PhD^1,3

¹Department of Hematology, Tohoku University Graduate School of Medicine, Sendai, Japan
²Division of Hematology, Sendai City Hospital, Sendai, Japan
³Laboratory Diagnostics, Tohoku University Hospital, Sendai, Japan
⁴Department of Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan
⁵Department of Hematology, Tohoku University School of Medicine, Sendai, Japan
⁶Cell Engineering Division, RIKEN BioResource Research Center, Tsukuba, Japan

Amit R. Mehta, MD¹, Myles Wolf, MD, MMsc^2* and Heinz Zoller, MD^3*

¹Duke University - Duke Cancer Institute, Cary, NC
²Division of Nephrology, Duke University School of Medicine, Durham, NC
³Department of Medicine I, Gastroenterology, Hepatology and Endocrinology, Medical University of Innsbruck, Innsbruck, Austria

Andrew J Baldi, MBBS, FRACP, FRCPA^1*, Sant-Rayn Pasricha, MD, PhD^2,3,4, Aaron R Jex^5*, M Imrul Hasan^5,6*, Naomi Jones^5*, Marilou Barrios^7*, Sabine Braat, MSc^5,8*, Jena Hamadani, PhD^6*, Stephen Wilcox^7*, Beverley-Ann Biggs^9* and Rory Bowden^7*

¹Population Health and Immunity, Walter and Eliza Hall Institute of Medical Research, Flemington, VIC, Australia
²Clinical Haematology, Royal Melbourne Hospital & Peter MacCallum Cancer Centre, Parkville, Australia
³Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia
⁴Population Health and Immunity, Walter and Eliza Hall Institute of Medical Research, Fitzroy North, VIC, Australia
⁵Population Health and Immunity, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
⁶International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
⁷Genomics Laboratory, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
⁸Methods and Implementation Support for Clinical and Health Research Hub, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Australia
⁹Doherty Institute of Infection and Immunity, University of Melbourne, Melbourne, Australia

Ling-Hsiang Chuang, PhD^1*, Wentao Sun, MS^2*, Yujie Sun, MD^2* and Bing Han, MD/PhD^3*

¹Department of Epidemiology and Global Health, Umea University, Umea, Sweden
²Vifor Fresenius Kabi (Beijing) Pharmaceutical Consulting Co. Ltd, Beijing, China
³Beijing Union Medical College Hospital, Beijing, China

Vera Hoving^1,2*, Albertine Donker^2,3*, Enrikas Vainorius, MD^4*, Harveen Dhillon Natarajan, PhD^4*, Jenn Lachey, PhD⁴, Simon Cooper, MBBS^4*, Dorine W. Swinkels, MD, PhD^2,5,6* and Saskia Schols^1,2*

¹Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands
²Radboud Expertise Center for Iron Disorders, Radboud University Medical Center, Nijmegen, Netherlands
³Department of Pediatrics, Máxima Medical Center, Veldhoven, Netherlands
⁴Keros Therapeutics, Lexington, MA
⁵Sanquin Blood Bank, Sanquin Diagnostics BV, Amsterdam, Netherlands
⁶Translational Metabolic Laboratory, Radboud University Medical Center, Nijmegen, Netherlands