Sophia Adamia, PhD^1,2, Daisuke Ogiya, MD, PhD^3*, Evdoxia Hatjiharissi^4*, Michael P. Chu, MD⁵, Zuzana Chyra^6,7*, Kenneth Wen^8*, Yu-Tzu Tai, PhD^9,10, David M. Dorfman, MD, PhD^11,12, Teru Hideshima, MD, PhD^9,13 and Kenneth C. Anderson, MD^1,9,14

¹The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
²Institute of Medical and Public Health Research, Ilia State University, Tbilisi, Georgia
³Department of Hematology/Oncology, Tokai University School of Medicine, Isehara, Japan
⁴First Department of Internal Medicine, Division of Haematology, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
⁵Department of Oncology, Cross Cancer Institute, Edmonton, AB, Canada
⁶Department of Hematooncology, University Hospital of Ostrava; Masaryk University, Ostrava, Czech Republic
⁷Department of Internal Studies, University of Ostrava, Ostrava, Czech Republic
⁸Department of Medical Oncology, Jerome Lipper Multiple Myeloma Center, LeBow Institute for Myeloma Therapeutics, Dana-Farber Cancer Institute, Boston, MA
⁹Harvard Medical School, Boston, MA
¹⁰The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Boston, MA
¹¹Department of Pathology, Brigham and Women's Hospital, Boston, MA
¹²Harvard Medical School, Boston
¹³Department of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
¹⁴Dana-Farber Cancer Institute, Boston, MA

Simon Steiger^1,2,3*, Raphael Lutz, MD^2,4,5*, Nina Prokoph, PhD^2,6*, Subarna Palit, PhD^7,8*, Stephan M Tirier, PhD^1*, Philipp Reichert, PhD^2*, Anja Baumann^6*, Nadine Hefner, MSc^2*, Sabrina Schumacher^1*, Dominik Vonficht, MSc^3,4,5*, Florian Grünschläger, MSc^3,4,5*, Alexandra M Poos, PhD^2,6*, Lukas John, MD^2,6*, Laleh Haghverdi, PhD^8*, Jan-Philipp Mallm, PhD^1,9*, Elias K Mai, MD^2*, Mirco Friedrich^2,10*, Katharina Kriegsmann, MD^2*, Mohamed H.S. Awwad, PhD^2*, Anna Jauch, PhD^11*, Uta Bertsch, MD^2,12*, Diana Tichy, PhD^13*, Carsten Müller-Tidow, MD^2,12*, Roland Schroers, MD^14*, Hans Salwender, M.D.^15*, Britta Besemer, MD^16*, Roland Fenk, MD^17*, Katja C. Weisel, MD¹⁸, Hartmut Goldschmidt, MD^2,12, Stefanie Huhn, PhD^2*, Michael Hundemer, MD^2*, Karsten Rippe, PhD^1*, Simon Haas, PhD^4,7,8,19,20*, Niels Weinhold, PhD^2* and Marc S Raab, MD^2,6*

¹Division of Chromatin Networks, German Cancer Research Center (DKFZ) and BioQuant, Heidelberg, Germany
²Department of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany
³Faculty of Biosciences, Heidelberg University, Heidelberg, Germany
⁴Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany
⁵Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany
⁶Clinical Cooperation Unit (CCU) Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany
⁷Berlin Institute of Health (BIH), Charité – Universitätsmedizin Berlin, Berlin, Germany
⁸Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center in the Helmholtz Association, Berlin, Germany
⁹Single Cell Open Lab, German Cancer Research Center (DKFZ) and BioQuant, Heidelberg, Germany
¹⁰German Cancer Research Center (DKFZ), Heidelberg, Germany
¹¹Institute of Human Genetics, Heidelberg University Hospital, Heidelberg, Germany
¹²National Center for Tumor Diseases (NCT), Heidelberg, Germany
¹³Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany
¹⁴Medizinische Universitätsklinik Ruhr-Universität-Bochum, Knappschaftskrankenhaus, Bochum, Germany
¹⁵Asklepios Tumorzentrum Hamburg, AK Altona and AK St. Georg, Hamburg, Germany
¹⁶Medical Clinic II, University Tuebingen, Tuebingen, Germany
¹⁷Department of Hematology, Oncology and Clinical Immunology, University of Duesseldorf, Duesseldorf, Germany
¹⁸Department of Oncology, Hematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
¹⁹Department of Hematology, Oncology and Cancer Immunology, Charité – Universitätsmedizin Berlin, Berlin, Germany
²⁰German Cancer Consortium (DKTK), Heidelberg, Germany

Shuichiro Takahashi^1*, Simone A Minnie, PhD^1*, Samuel RW Legg^1*, Christine R Schmidt^1*, Kathleen S Ensbey^1*, Damian J. Green, MD^2,3 and Geoffrey R Hill, MD^1,3

¹Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA
²Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
³Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA

Bachisio Ziccheddu, PhD^1*, Benjamin Diamond, MD², Kylee H Maclachlan, MBBCh, PhD³, Justin Taylor, MD⁴, Eileen M Boyle, MD, MSc⁵, Juan E. Arango Ossa^6*, Jahn Jacob^2*, Maurizio Affer^2*, Tulasigeri M Totiger, PhD^2*, David Coffey, MD¹, Justin Watts, MD⁷, Sydney X. Lu, MD, PhD⁸, Niccolo Bolli, MD^9,10, Kelly L Bolton, MD¹¹, Jae H Park, MD¹², Heather Landau, MD¹³, Karuna Ganesh, MBBChir, MA, PhD^14*, Andrew McPherson^15*, Mikkael A. Sekeres, MD⁴, Alexander M Lesokhin, MD³, David J. Chung, MD, PhD¹³, Yanming Zhang, MD¹⁶, Caleb Ho, MD¹⁶, Mikhail Roshal, MD¹⁷, Jeffrey W. Tyner¹⁸, Stephen D Nimer, MD¹⁹, Elli Papaemmanuil, PhD²⁰, Saad Usmani, MD²¹, Gareth J. Morgan, MD⁵, Ola Landgren, MD²² and Francesco Maura, MD²

¹Myeloma Service, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
²Myeloma Division, Sylvester Comprehensive Cancer Center, University of Miami, Miami
³Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁴University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL
⁵Myeloma Research Program, Perlmutter Cancer Center, NYU Langone Health, New York, NY
⁶Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York
⁷Sylvester Comprehensive Cancer Center, University of Miami, Coral Gables, FL
⁸Division of Hematology, Dept. of Medicine, Stanford University, Stanford, CA
⁹Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy
¹⁰Hematology & BMT Unit, Fondazione IRCCS Ospedale Maggiore Policlinico di Milano, University of Milan, Milan, Italy
¹¹Department of Medicine, Division of Oncology, Section of Stem Cell Biology, Washington University School of Medicine, Saint Louis, MO, Washington University In St Louis, St Louis, MO
¹²Memorial Sloan-Kettering Cancer Ctr., New York, NY
¹³Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁴Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁵Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁶Department of Pathology, Memorial Sloan Kettering Cancer Center, New York
¹⁷Department of Pathology and Laboratory Medicine, Hematopathology Service, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁸Division of Hematology & Medical Oncology, Oregon Health & Science University, Portland, OR
¹⁹Sylvester Comprehensive Cancer Center, University of Miami, Miami
²⁰Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
²¹Myeloma Service, Memorial Sloan Kettering Cancer Center, New York
²²Myeloma Division, Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL

Jan Eckmann^1*, Tanja Fauti, PhD^2*, Aintzane Zabaleta, PhD^3*, Laura Blanco^3*, Sahar Kassem^4*, Nadege Carrié^4*, Stefan Lorenz^1*, Alejandro Carpy^1*, Tony Christopeit^1*, Georg Fertig^1*, Luise Bernasconi^5*, Marlene Biehl^2*, Sarah Diggelmann^2*, Melanie Knobloch^2*, Maud Mayoux^6*, Charles Dumontet^7*, Bruno Paiva^3*, Ludovic Martinet^4*, Stéphane Leclair^1*, Wei Xu^2*, Christian Klein, PhD⁸ and Pablo Umaña²

¹Roche Innovation Center Munich, Roche Diagnostics GmbH, Penzberg, Germany
²Roche Innovation Center Zurich, Roche Glycart AG, Schlieren, Switzerland
³University of Navarra, IDISNA, CIBERONC, Clínica Universidad de Navarra, Centro de Investigación Médica Aplicada, Pamplona, Spain
⁴Centre De Rechecrche En Cancérologie De Toulouse De Inserm U1037, Toulouse, France
⁵Lonza, Bern, Switzerland
⁶University of Zurich, Institute of Experimental Immunology, Zurich, Switzerland
⁷University of Lyon/Hospices Civils de Lyon, Cancer Research Center of Lyon (CRCL), Pierre-Bénite Cedex, France
⁸Roche Innovation Center Zurich, Schlieren, Switzerland

Paola Neri, MD, PhD¹, Sungwoo Ahn, PhD^1*, Holly Lee, MD¹, Noemie Leblay, PhD^1*, Mirco Friedrich^2*, Ranjan Maity, PhD^1*, Rémi Tilmont, MD^1*, Elie Barakat, MSc^1*, Marc S Raab, MD^2* and Nizar Jacques Bahlis, MD¹

¹Arnie Charbonneau Cancer Research Institute, University of Calgary, Calgary, AB, Canada
²German Cancer Research Center, Heidelberg, Germany