Hartmut Döhner, MD¹, Dylan M. Marchione, PhD^2*, Sung Choe^2*, Pau Montesinos, MD, PhD^3*, Christian Recher, MD⁴, Susana Vives, PhD^5*, Ewa Zarzycka, MD^6*, Jianxiang Wang^7*, Claudio Cerchione, MD⁸, Michael Heuser, MD⁹, Rodrigo T. Calado, MD, PhD^10,11, Andre C. Schuh, MD¹², Su-Peng Yeh, MD^13*, Adolfo De La Fuente, MD^14*, Jianan Hui, PhD^2*, Prapti Patel, MD^15*, Diego A. Gianolio, PhD^2*, Scott R. Daigle, MS^2*, Courtney D. DiNardo, MD, MSCE¹⁶ and Stephane De Botton, MD^17*

¹Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany
²Servier Pharmaceuticals, Boston, MA
³Hospital Universitari i Politècnic La Fe, Instituto de Investigación Sanitaria La Fe (IISLAFE), Valencia, Spain
⁴Service d'Hématologie, CHU de Toulouse - Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France
⁵ICO-Hospital Germans Trias i Pujol, Badalona, Spain
⁶Department of Hematology and Transplantology, Medical University, Gdansk, Poland
⁷Institute of Hematology & Hospital of Blood Disease – Peking Union Medical College, Tianjin, China
⁸Hematology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola (FC), Italy
⁹Department for Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
¹⁰Department of Medical Imaging, Hematology and Clinical Oncology, Ribeirão Preto School of Medicine, University of São Paulo, São Paulo, Brazil
¹¹Department of Medical Imaging, Hematology, and Clinical Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil
¹²Princess Margaret Cancer Centre, Toronto, ON, Canada
¹³China Medical University Hospital, Taichung, Taiwan
¹⁴MD Anderson Cancer Center, Madrid, ESP
¹⁵Servier Pharmaceuticals, Boston
¹⁶Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
¹⁷Institut Gustave Roussy, Villejuif, France

Walid Macaron, MD, MSc^1*, Farhad Ravandi, MD¹, Tapan M. Kadia, MD², Courtney D. DiNardo, MD, MSCE¹, Ghayas C. Issa, MD¹, Naval Daver, MD¹, Sa A Wang, MD^3*, Jeffrey L. Jorgensen, MD, PhD^3*, Keyur Patel, MD, PhD^3*, Sanam Loghavi, MD³, Marina Konopleva, MD, PhD⁴, Musa Yilmaz, MD², Elias Jabbour, MD¹, Abhishek Maiti, MBBS⁵, Hussein A Abbas, MD, PhD¹, Elizabeth J Shpall, MD⁶, Uday R Popat, MD⁶, Gheath Alatrash, PhD, DO⁶, Sherry A. Pierce, BSN, BA^1*, Hagop Kantarjian, MD⁷ and Nicholas Short, MD⁴

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, MD Anderson Cancer Center, Houston, TX
³Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, The University of Texas Health Science Center At Houston, Houston, TX
⁶Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Mark J. Levis, MD^1,2, Harry P. Erba, MD, PhD³, Pau Montesinos, PhD, MD^4*, Radovan Vrhovac, MD, PhD^5*, Elzbieta Patkowska^6*, Heeje Kim, M.D., Ph.D.⁷, Pavel Zak, MD, PhD^8*, Po-Nan Wang, MD⁹, Jaime E. Connolly Rohrbach^10*, Ken CN Chang, PhD^11*, James Hanyok, PharmD^10*, Li Liu^10*, Yasser Mostafa Kamel, MD^11*, Arnaud Lesegretain^12*, Jorge E. Cortes, MD¹³, Mikkael A. Sekeres, MD¹⁴, Hervé Dombret, MD PhD¹⁵, Sergio Amadori, MD¹⁶, Jianxiang Wang, MD¹⁷, Richard F. Schlenk, MD¹⁸ and Alexander Perl, MD¹⁹

¹Division of Hematologic Malignancies, Johns Hopkins University, Baltimore, MD
²Director, Adult Leukemia Program, Co-Division Director, Hematologic Malignancies, Professor of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine, Baltimore, MD
³Leukemia Program, Duke University Medical Center, Durham, NC
⁴Hospital Politecnico Universitario La Fe, Valencia, Spain, Spain
⁵University Hospital Centre Zagreb, Zagreb, HRV
⁶Hematology Department, Institute of Hematology and Transfusion Medicine, Warsaw, Poland
⁷Catholic Hematology Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
⁸Internal Medicine IV – Hematology, University Hospital and Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic
⁹Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan
¹⁰Daiichi Sankyo, Inc, Basking Ridge, NJ
¹¹Daiichi Sankyo, Inc., Basking Ridge, NJ
¹²Daiichi Sankyo Inc., Basking Ridge, NJ
¹³Georgia Cancer Center Augusta University, Augusta, GA
¹⁴University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL
¹⁵Hopital Saint-Louis, Assistance Publique - Hopitaux De Paris (AP-HP), Paris, FRA
¹⁶Tor Vergata Polyclinic Hospital Rome, Rome, RM, Italy
¹⁷Institute of Hematology, CAMS, Tianjin, China
¹⁸National Center of Tumor Diseases, Heidelberg, Heidelberg, Germany
¹⁹Division of Hematology-Oncology/Department of Medicine, University of Pennsylvania, Philadelphia, PA

Pierre Hirsch^1,2*, Jérôme Lambert, MD, PhD^3*, Maxime Bucci^4*, Caroline Deswarte, MSc^5*, Juliette Lambert, MD, PhD^6*, Laurène Fenwarth, MD, MSc^4,7*, Herve Dombret, MD PhD⁸, Nicolas Duployez, PharmD, PhD^4*, Claude Preudhomme, PharmD, PhD⁴, Raphael Itzykson, MD, PhD⁹ and Francois Delhommeau, PharmD-PhD^2,5*

¹Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France, Paris, France
²APHP, Hôpital Saint Antoine, Laboratoire d'hématologie Biologique, Paris, France, Paris, France
³Biostatistics Department, Hôpital Saint Louis, APHP, Paris, France
⁴Laboratory of Hematology, CHU Lille, Lille, France
⁵Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, AP-HP, Hôpital Saint-Antoine, Paris, France
⁶Hôpital de Versailles, Le Chesnay, France
⁷University of Lille, Lille, France
⁸Hopital Saint-Louis, Assistance Publique - Hopitaux De Paris (AP-HP), Paris, FRA
⁹Department of Hematology, Hôpital Saint-Louis, Paris, France

Alberto Hernández Sánchez, MD^1,2*, Teresa González, PhD^2,3*, Marta Anna Sobas, MD, PhD^4*, Eric Sträng, PhD^5*, Castellani Gastone, PhD^6*, María Abáigar^3,7*, Peter JM Valk, PhD⁸, Angela Villaverde Ramiro^2,3*, Axel Benner^9*, Klaus H Metzeler, MD¹⁰, Jesse M. Tettero^11*, Joaquín Martínez-López, MD, PhD^12*, Marta Pratcorona, MD^13*, Javier Martinez Elicegui^2,3*, Ken I Mills, BSc, PhD, FRCPath¹⁴, Christian Thiede, MD¹⁵, Guillermo Sanz, MD, PhD^16,17, Konstanze Döhner, MD¹⁸, Michael Heuser, MD¹⁹, Torsten Haferlach, MD²⁰, Amin T. Turki, MD²¹, Dirk Reinhardt, MD²², Renate Schulze-Rath^23*, Martje Barbus, PhD^24*, Jesús María Hernández-Rivas, MD, PhD^1,2,3, Brian Huntly, MB ChB, FRCPath, FMedSci, PhD²⁵, Gert Ossenkoppele, MD²⁶, Hartmut Döhner, MD²⁷ and Lars Bullinger, MD²⁸

¹Hematology Department, University Hospital of Salamanca, Salamanca, Spain
²Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain
³Cancer Research Center of Salamanca (USAL-CSIC), Salamanca, Spain
⁴Wroclaw Medical University, Wroclaw, Poland
⁵Charité Universitätsmedizin Berlin, Berlin, Germany
⁶DIMES, University of Bologna, Bologna, Italy
⁷Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain
⁸Department of Hematology, Erasmus University Medical Center Cancer Institute, Rotterdam, Netherlands
⁹Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany
¹⁰University of Leipzig, Germany, Leipzig, Germany
¹¹Department of Hematology, Amsterdam University Medical Center location Vrije Universiteit Amsterdam, Amsterdam, Netherlands
¹²Hospital Universitario 12 de Octubre, Madrid, Spain
¹³Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
¹⁴Queen's University Belfast, Belfast, United Kingdom
¹⁵University of Technics Dresden Medical Dept., Dresden, Germany
¹⁶CIBERONC, Instituto de Salud Carlos III, Madrid, Spain
¹⁷Hospital Universitario y Politécnico La Fe, Valencia, Spain
¹⁸Division of Hematology and Oncology, University Hospital Ulm, Ulm, Germany
¹⁹Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
²⁰MLL Munich Leukemia Laboratory, Munich, Germany
²¹Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany
²²Department of Pediatrics III, University Hospital Essen, University Duisburg-Essen, Essen, Germany
²³Bayer AG, Pharmaceuticals Division, Berlin, Berlin, Germany
²⁴AbbVie Deutschland GmbH & Co KG, Wiesbaden, DEU
²⁵Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, ENG, United Kingdom
²⁶Amsterdam University Medical Center, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, Netherlands
²⁷Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
²⁸Department of Hematology, Oncology, and Tumor Immunology, Charité – Universitätsmedizin Berlin, Berlin, Germany

Sandra Huber, PhD^*, Constance Baer, PhD, Stephan Hutter, PhD^*, Frank Dicker, PhD, Manja Meggendorfer, PhD, Christian Pohlkamp, MD^*, Wolfgang Kern, MD, Torsten Haferlach, MD, Claudia Haferlach, MD and Gregor Hoermann, MD, PhD

MLL Munich Leukemia Laboratory, Munich, Germany