Christopher A. Eide^1*, Stephen E. Kurtz, PhD^2,3*, Andy Kaempf^4*, Nicola Long^3*, Sunil K Joshi¹, Tamilla Nechiporuk^1*, Ariane Huang^1*, Charles Dibb^1*, Daniel Bottomly^5*, Shannon K. McWeeney, PhD^5*, Bill H. Chang, MD, PhD⁶, Brian J. Druker¹ and Jeffrey W. Tyner^1,7

¹Knight Cancer Institute, Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, OR
²Knight Cancer Institute, Division of Oncological Sciences, Oregon Health & Science University, Portland, OR
³Knight Cancer Institute, Division of Hematology & Medical Oncology, Oregon Health & Science University, Portland, OR
⁴Biostatistics Shared Resource, Knight Cancer Institute, Oregon Health & Science University, Portland, OR
⁵Knight Cancer Institute, Division of Bioinformatics and Computational Biomedicine, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR
⁶Knight Cancer Institute, Division of Pediatric Hematology and Oncology, Oregon Health & Science University, Portland, OR
⁷Knight Cancer Institute, Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR

Lucille Stuani, Ph.D.^1,2, Astraea Jager, B.S.^1*, Ambrine Sahal, B.S.^2*, Abhishek Koladiya, Ph.D.^1*, Jolanda Sarno, Ph.D.¹, Pablo Domizi, Ph.D.¹, Yuxuan Liu, Ph.D.^1*, Veronique De Mas, PharmD, Ph.D.^2,3*, Christian Recher, MD^2,4, Francois Vergez, DVM, Ph.D.^2,3*, Jean-Emmanuel Sarry, PhD^2* and Kara L. Davis, D.O.¹

¹Department of Pediatrics, Hematology, Oncology, and Stem Cell Transplant and Regenerative Medicine, Stanford University, Stanford, CA
²Centre de Recherches en Cancérologie de Toulouse - CRCT, Inserm - Université de Toulouse Paul Sabatier – CNRS, Toulouse, France
³Laboratoire d'Hématologie, CHU de Toulouse - Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France
⁴Service d'Hématologie, CHU de Toulouse - Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France

Ana Rio-Machin, PhD^1*, Findlay Bewicke-Copley, PhD^2,3, Jiexin Zheng^4*, Pedro Casado Izquierdo, PhD^5*, Juho J. Miettinen, PhD^6*, Naeem Khan, PhD^7*, Jonas Demeulemeester, PhD^8*, Szilvia Krizsán, MD^9*, Christopher Middleton^10*, Sam Benkwitz-Bedford^11*, Joseph Saad, MSc^12*, Amaia Vilas-Zornoza, PhD^13,14,15*, Teresa Ezponda^16,17,18*, William Grey^19,20*, Vincent-Philippe Lavallée, MD^21*, Alexis Nolin-Lapalme^22*, Farideh Miraki-Moud^23*, Janet Matthews^24*, Marianne Grantham^25*, Ryan J Colm^26*, Jonathan Bond, MB, PhD, MRCPI, FRCPath^27,28*, Doriana Di Bella^24*, Krister Wennerberg, PhD^29*, Alun Parsons^30*, Andy G.X. Zeng, BSc³¹, Hannah Armes, PhD^32*, Karina Close^2*, Fadimana Kaya^4*, Kevin Rouault-Pierre, PhD^24*, John G. Gribben, MD, DSc, FRCPath^24,33, Felipe Prosper, MD^34,35,36,37*, James Cavenagh, MD³⁸, John E. Dick, PhD³⁹, Sylvie D Freeman, MBChB, MRCP, FRCPath⁴⁰, Peter Van Loo^41*, Csaba Bödör, PhD^42*, Guy Sauvageau, MD, PhD⁴³, Kimmo Porkka, MD, PhD^44,45,46,47*, Caroline A. Heckman, PhD^30,48, Jun Wang, PhD^2*, Jean-Baptiste Cazier, PhD^49*, David Taussig, MD, PhD^50*, Dominique Bonnet, PhD⁵¹, Pedro Cutillas, PhD^4* and Jude Fitzgibbon, PhD^2*

¹Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, ENG, United Kingdom
²Centre for Cancer Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
³Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
⁴Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
⁵Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
⁶Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland
⁷Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom
⁸Department of Oncology, VIB - KU Leuven Center for Cancer Biology, KU Leuven, Belgium
⁹MTA-SE Momentum Molecular Oncohematology Research Group, Department of Pathology and Cancer Research, Semmelweis University, Budapest, Hungary
¹⁰University of Birmingham, Birmingham, United Kingdom
¹¹Centre for Computational Biology, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom
¹²Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Uusimaa, Finland
¹³Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain
¹⁴Centro de Investigación Médica Aplicada, University of Navarra, Clínica Universidad de Navarra, Pamplona, Spain
¹⁵Hemato-Oncology Program, Cima Universidad de Navarra, Pamplona, Spain
¹⁶Clínica Universidad de Navarra.Centro de Investigación Biomédica en Red de Cáncer, CIBERONC. Foundation For Applied Medical Research, University of Navarra, Pamplona, Spain
¹⁷Centro de Investigación Biomédica en Red de Cáncer, CIBERONC, Madrid, Spain
¹⁸Área de Oncología, Centro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, IDISNA, Pamplona, Spain
¹⁹Department of Biology, York Biomedical Research Institute, University of York, York, United Kingdom
²⁰Haematopoietic Stem Cell Lab, The Francis Crick Institute, London, United Kingdom
²¹Department of Pediatric Hematology Oncology, CHU Sainte-Justine Research Center, Montréal, QC, Canada
²²Institute for Research in Immunology and Cancer, Montreal, Canada
²³Acute Leukaemia Team, Institute of Cancer Research, London, United Kingdom
²⁴Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
²⁵Barts Health NHS Trust, London, United Kingdom
²⁶School of Computer Science, University College Dublin, Dublin, Ireland
²⁷Systems Biology Ireland, University College Dublin, Dublin, Ou, Ireland
²⁸Children's Health Ireland at Crumlin, Dublin, Ireland
²⁹Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark
³⁰Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland
³¹Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
³²Centre for Cancer Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, ENG, United Kingdom
³³Barts Health NHS Trust Barts and The London School of Medicine, Queen Mary University of London, London, United Kingdom
³⁴Advanced Genomics Laboratory, Hemato-Oncology program, Centro de Investigación Médica Aplicada (CIMA), University of Navarra, Pamplona, Spain
³⁵Department of Oncology-Hematology, Centro de Investigación Médica Aplicada (CIMA), Navarra university-IDISNA. Centro de Investigación Biomédica en Red de Cáncer, CIBERONC. Clínica Universidad de Navarra, Pamplona, Navarra, Spain
³⁶Centro de Investigación Biomédica en Red de Cáncer, CIBERONC, Pamplona, Spain
³⁷Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain
³⁸Department of Haemato-Oncology, St Bartholomew's Hospital, Barts Health NHS Trust, London, United Kingdom
³⁹University Health Network, Toronto, ON, Canada
⁴⁰Centre for Clinical Haematology, University Hospitals Birmingham, Birmingham, United Kingdom
⁴¹Francis Crick Institute, London, United Kingdom
⁴²HCEMM-SE Molecular Oncohematology Research Group, Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
⁴³The Leucegene Project at the Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, QC, Canada
⁴⁴Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
⁴⁵Translational Immunology Research program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland
⁴⁶HUS Comprehensive Cancer Center, Hematology Research Unit Helsinki and iCAN Digital Precision Cancer Center Medicine Flagship, University of Helsinki, Helsinki, Finland
⁴⁷Helsinki University Central Hospital Cancer Center, Helsinki, Finland
⁴⁸Institute for Molecular Medicine Finland, Institute For Molecular Medicine Finland FIMM, Helsinki, Finland
⁴⁹Centre for Computational Biology, University of Birmingham, Birmingham, United Kingdom
⁵⁰The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom
⁵¹Hematopoietic Stem Cell Lab, The Francis Crick Institute, London, United Kingdom

Joseph Saad, MSc^1,2*, Samuli Eldfors, PhD^3,4,5,6, Vilma Ikonen, MSc^1*, Bjørn Tore Gjertsen, MD, PhD^7,8*, Mika Kontro, MD, PhD^9,10*, Kimmo Porkka, MD, PhD^11* and Caroline A. Heckman, PhD¹

¹Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland
²Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland
³Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, MA, Finland
⁴Harvard Medical School, Boston, MA
⁵Cancer Center, Massachusetts General Hospital, Charlestown, MA
⁶Department of Medicine, University of Helsinki, Helsinki, Finland
⁷Haukeland University Hospital, Bergen, NOR
⁸Department of Hematology, Institute of Clinical Science, University of Bergen, Bergen, Norway
⁹Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
¹⁰Hematology Research Unit Helsinki, University of Helsinki and Department of Hematology, Helsinki University Hospital Comprehensive Cancer Centre, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
¹¹Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland

Jad Othman, MBBS¹, Richard Dillon, MA PhD MRCP FRCPath¹, Charlotte Wilhelm-Benartzi, PhD^2*, Steve Knapper, BMBCh³, Leona M Batten^2*, Joanna Canham^2*, Emily L Hinson, PhD^2*, William Villiers, PhD^4*, Michelle Kleeman^5*, Amanda Gilkes^6*, Nicola Potter, PhD^1*, Ulrik Malthe Overgaard, MD^7*, Priyanka Mehta^8*, Panos Kottaridis, MD, PhD^9*, Jamie Cavenagh, MD, PhD^10*, Claire Hemmaway, MD^11*, Claire Arnold, MD^12*, Mike Dennis, MD, MRCP, FRCPath¹³ and Nigel H. Russell, MD¹⁴

¹Department of Medical and Molecular Genetics, King's College London, London, United Kingdom
²Centre for Trials Research, Cardiff University, Cardiff, United Kingdom
³Cardiff University School of Medicine, Cardiff, United Kingdom
⁴Department of Medical and Molecular Genetics, King's College London, London, ENG, United Kingdom
⁵Genomics Facility, NIHR Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London, London, United Kingdom
⁶Division of Cancer and Genetics, Cardiff University, Cardiff, United Kingdom
⁷Copenhagen University Hospital, Denmark, Denmark
⁸The University of Bristol and Weston NHS Trust, Bristol, United Kingdom
⁹University College London Hospital NHS Foundation Trust, London, GBR
¹⁰Department of Haematology, St Bartholomew's Hospital, London, United Kingdom
¹¹Auckland City Hospital, Auckland, New Zealand
¹²Belfast City Hospital, Belfast, United Kingdom
¹³Department of Haematology, The Christie, Manchester, GBR
¹⁴Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom

Jatinder K. Lamba, PhD^1,2, Richard J Marrero, PharmD³, Abdelrahman H Elsayed, MSc⁴, Xueyuan Cao, PhD^5*, Huiyun Wu, PhD^6*, Hiroto Inaba, MD, PhD⁷, Susana C. Raimondi, PhD⁸, Ching-Hon Pui, MD⁹, Raul C. Ribeiro, MD¹⁰, Jeffrey E. Rubnitz, MD⁷ and Stanley B. Pounds, PhD^6*

¹Department of Pharmacotherapy and Translational Research, University of Florida, College of Pharmacy, Pharmacotherapy and Translational Re, Gainesville, FL
²UF Health Cancer Center, Gainesville, FL
³Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, GAINESVILLE, FL
⁴Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL
⁵Department of Health Promotion and Disease Prevention, University of Tennessee Health Science Center, Memphis, TN
⁶Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
⁷Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN
⁸Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
⁹Department of Oncology, St. Jude Children's Rsch./Hosp., Memphis, TN
¹⁰St. Jude Children's Research Hospital, Memphis, TN