64th ASH Annual Meeting and Exposition: 905. Outcomes Research—Lymphoid Malignancies: Outcomes in Childhood Leukemia/Lymphoma

Symposia: Outcomes Research—Lymphoid Malignancies Oral and Poster Abstracts
Oral

Research, Lymphoid Leukemias, ALL, adult, Clinical Practice (Health Services and Quality), epidemiology, Clinical Research, health outcomes research, pediatric, health disparities research, Diseases, real-world evidence, Lymphoid Malignancies, young adult , Adverse Events, survivorship, Study Population, Human

291-292 (Ernest N. Morial Convention Center)

Moderators:

Jenny Ruiz, MD, ARRAY(0x10268784) and Joanna Robles, MD, Duke University School of Medicine

Disclosures:

No relevant conflicts of interest to declare.

This session describes the updates and outcomes in pediatric hematologic malignancies.

2:45 PM

901

The Impact of Cumulative Anesthesia Exposure on Neurocognitive Outcomes in Children with High-Risk Precursor B Acute Lymphoblastic Leukemia: A Multicenter Children’s Oncology Group Study

Sarah Alexander, MD¹, Sumit Gupta, MD, PhD², John Kairalla, PhD³^*, Emily Hibbitts, MS⁴^*, Hannah Weisman⁵^*, Doralina Anghelescu, MD⁶^*, Naomi J Winick, MD⁷, Kevin R. Krull, PhD⁸^*, Wanda L Salzer, MD⁹, Michael J. Burke, MD¹⁰, Lia Gore¹¹, Meenakshi Devidas, PhD, MBA¹², Stephen P. Hunger, MD¹³, Mignon L. Loh, MD¹⁴ and Kristina Hardy¹⁵^*

¹Division of Haematology/Oncology, The Hospital For Sick Children, Toronto, ON, Canada
²Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada
³Department of Biostatistics, University of Florida, Children's Oncology Group, Gainesville, FL
⁴Children's Oncology Group, Gainsville, FL
⁵Children's National Hospital, Washington, DC
⁶Department of Anesthesiology, St. Jude Children's Research Hospital, Memphis, TN
⁷Department of Pediatric Hematology Oncology, University of Texas Southwestern Medical Center, Dallas, TX
⁸Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN
⁹U.S. Army Medical Research and Materiel Command, Olney, MD
¹⁰Department of Pediatrics, The Medical College of Wisconsin Inc., Milwaukee, WI
¹¹Children's Hospital Colorado, University of Colorado, Aurora, CO
¹²Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN
¹³Department of Pediatrics, Division of Oncology and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
¹⁴Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of California Benioff Children’s Hospital, Seattle, WA
¹⁵Childrens National Medical Center, Washington, DC

3:00 PM

902

Epigenetic Age Acceleration and Neurocognitive Function Among Long-Term Survivors of Pediatric Hodgkin Lymphoma: A Report from the St. Jude Lifetime Cohort

AnnaLynn M Williams, PhD, MS¹, Qian Dong, PhD²^*, Nicholas S. Phillips, MD, PhD³^*, Matt J. Ehrhardt, MD, MS⁴, Deokumar Srivastava, PhD⁵^*, Sedigheh Mirzaei Salehabadi, PhD⁶^*, Yutaka Yasui, PhD⁴^*, Kirsten K. Ness, PT, PhD⁴^*, Melissa M. Hudson, MD⁷, Leslie L. Robison, PhD⁴^*, Kevin R. Krull, PhD⁴^* and Zhaoming Wang³^*

¹Wilmot Cancer Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY
²Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN
³St. Jude Children's Research Hospital, Memphis, TN
⁴Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN
⁵Department of Biostatistics, St. Jude Children's Research Hospital, memphis, TN
⁶Department of Biostatistics, St. Jude Children's Research Hospiatl, Memphis, TN
⁷Department of Oncology, Division of Survivorship, St. Jude Children's Research Hospital, Memphis, TN

3:15 PM

903

Poverty during Maintenance and Relapse Risk in Children with Acute Lymphoblastic Leukemia (ALL): A Report from Children’s Oncology Group Study (COG-AALL03N1)

Aman Wadhwa, MD, MSPH¹, Yanjun Chen, MS¹^*, Lindsey Hageman, MPH¹^*, Anna Hoppmann, MD, MPH¹^*, Anne L Angiolillo, MD²^*, David Dickens, MD³^*, Glen Lew, MD⁴, Joseph P. Neglia, MD, MPH⁵^*, Yaddanapudi Ravindranath, MBBS⁶, Arthur K. Ritchey, MD⁷, Amanda Muench Termuhlen, MD⁸^*, Lennie Wong, PhD⁹^*, Wendy Landier, PhD, CRNP¹^* and Smita Bhatia, MD, MPH¹

¹Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL
²Children’s National Health System/George Washington University SMHS, Washington, DC
³Division of Pediatric Hematology and Oncology, University of Iowa, Iowa City, IA
⁴Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Atlanta, GA
⁵University of Minnesota Medical School, Minneapolis, MN
⁶Wayne State University School of Medicine, Children's Hospital of Michigan, Detroit, MI
⁷Children's Hosp. of Pittsburgh of UPMC, Pittsburgh, PA
⁸University of Minnesota, Minneapolis, MN
⁹Department of Population Sciences, City of Hope, Duarte, CA

3:30 PM

904

Severe Adverse Events Associated with Concentrations of High Dose Methotrexate in Pediatric Acute Lymphoblastic Leukemia Patients

Tamara P. Miller, MD^1,2, Nicholas P. DeGroote, MPH³^*, Zachary Taylor⁴^*, Lauren Pommert, MD⁵, Oluwafunbi Awoniyi²^*, Sarah Board⁴^*, Ngozi Ugboh²^*, Vivek Joshi²^*, Allison Weisnicht, MD⁶^*, Nicholas Ambrosino, PharmD⁴^*, Melanie Brooke Bernhardt, MS, PharmD⁷^*, Eric S Schafer, MD⁸^*, Maureen M. O'Brien, MD^9,10, Sharon M. Castellino, MD, MSc^11,12 and Laura B. Ramsey, PhD¹³^*

¹Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Decatur, GA
²Emory University, Atlanta, GA
³Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA
⁴Cincinnati Children's Hospital Medical Center, Cincinnati
⁵University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁶Department of Pediatrics, Baylor College of Medicine, Houston, TX
⁷Baylor College of Medicine, Houston
⁸Baylor College of Medicine, Texas Children's Hospital, Houston, TX
⁹Cincinnati Children's Hospital Medical Center, Cincinnati, OH
¹⁰Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH
¹¹Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Atlanta, GA
¹²Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
¹³Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

3:45 PM

905

Cardiac and Vascular Risks Are the Essential Parameters for Long-Term Surveillance of Lower Risk Childhood Acute Leukemia Survivors

Paul Saultier¹^*, Nour El Riachy²^*, Yves Bertrand, PhD³^*, Marie-Dominique Tabone⁴^*, Guy Leverger⁴^*, Jean-Hugues Dalle, MD, PhD⁵, Andre Baruchel, MD⁴, Cecile Pochon⁶^*, Catherine Paillard⁷^*, Stephane Ducassou⁸^*, Marilyne Poiree⁹^*, Dominique Plantaz¹⁰^*, Justyna Kanold¹¹^*, Virginie Gandemer¹²^*, Nicolas Sirvent¹³^*, Genevieve Plat¹⁴^*, Isabelle Pellier¹⁵^*, Yves Reguerre¹⁶^*, Sandrine Thouvenin¹⁷^*, Audrey Françoise Petit²^*, Pascal Auquier¹^*, Julie Berbis¹⁸^* and Gerard Michel¹^*

¹APHM, Marseille, France
²APHM, MARSEILLE, France
³HCL, Lyon, France
⁴APHP, Paris, France
⁵Pediatric Hematology and Immunology Department, Robert Debré Hospital , GHU APHP Nord - Université Paris Cité, Paris, France
⁶Pediatric Onco-hematology Department, Children’s Hospital, University Hospital of Nancy, Vandoeuvre, France
⁷Pediatric Hematology Department, Hopitaux Universitaires de Strasbourg, Strasbourg, France
⁸Paediatric Oncology Haematology Unit/CEREVANCE/CIC 1401, Inserm CICP, University Hospital of Bordeaux, Bordeaux, France
⁹University Hospital Nice, Nice, France
¹⁰CHU Grenoble, Grenoble, France
¹¹CHU Clermont Ferrand, Clermontferrand, FRA
¹²University Hospital of Rennes, Rennes, France
¹³Montpellier University Hospital, Montpellier, FRA
¹⁴Service d’Hématologie-Immunologie-Oncologie, Hôpital des Enfants - CHU Toulouse, Toulouse, France
¹⁵Pediatric Unit, University Hospital of Angers, Angers, France
¹⁶Pediatric Oncology Department, University Hospital Saint-Denis, Saint-Denis, Reunion
¹⁷CHU Saint Etienne, Saint Etienne, FRA
¹⁸APHM, Marseille, FRA

4:00 PM

906

Comparison of Overall Survival Among Adolescents and Young Adults (AYA) with Newly-Diagnosed Acute Lymphoblastic Leukemia (ALL) Treated with Pediatric-Inspired or Non-Pediatric Inspired Regimens: A Real-World Analysis Using Claims Data

Tarun Bhagnani, MS, BPharm¹^*, Jian J. Zhu, PhD¹^*, David Robert R. Freyer, DO ²^*, Kristen M. O'Dwyer, MD³, Michael E. Roth, MD⁴^*, Julie A. Wolfson, MD, MS⁵, Qian Meng, PhD¹^*, Rui Sammi Tang, PhD¹^* and Robert G. Paglia, RPh, MBA¹^*

¹Servier Pharmaceuticals, Boston, MA
²Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, Los Angeles, CA
³Division of Hematology/Oncology, Department of Medicine, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY
⁴Department of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, TX
⁵Pediatric Hematology-Oncology, Institute for Cancer Outcomes and Survivorship, University of Alabama Birmingham, Birmingham, AL

See more of: Oral and Poster Abstracts

<< Previous Session | Next Session >>

^*signifies non-member of ASH

905.O1.6 905. Outcomes Research—Lymphoid Malignancies: Outcomes in Childhood Leukemia/Lymphoma