64th ASH Annual Meeting and Exposition: 901. Health Services and Quality—Non-Malignant Conditions: Level Up! Taking Quality Care to the Next Level in Sickle Cell Disease

Symposia: Health Services and Quality—Non-Malignant Conditions Oral and Poster Abstracts
Oral

Sickle Cell Disease, Research, clinical trials, Clinical Practice (Health Services and Quality), Clinical Research, health outcomes research, Hemoglobinopathies, Diversity, Equity, and Inclusion (DEI) , blood banking, Diseases, patient-reported outcomes, Therapies, Technology and Procedures

New Orleans Theater C (Ernest N. Morial Convention Center)

Moderators:

Alexander A Boucher, MD, University of Minnesota and Meghan Drayton Jackson, DO, Riley Hospital for Children

Disclosures:

Boucher: CSL Behring: Research Funding; Takeda: Research Funding.

Abstracts in this session highlight interventions to improve care quality for patients with sickle cell disease. First, authors will present opportunities for optimization of two foundational components of sickle cell disease care: transfusion therapy and transcranial doppler screening. Second, authors will present interventions to address unique considerations for patients with sickle cell disease with uptake of COVID vaccination, medication adherence, and pain-related disability.

2:45 PM

883

Optimizing the Frequency of Transcranial Doppler (TCD) Exams in Children with Sickle Cell Anemia

Ayobami Olanrewaju, MBBS¹, Zachary Abramson, MD²^*, Jane S Hankins, MD, MS³, Clifford Takemoto⁴^*, M. Beth McCarville, MD⁵^*, Andrew M Heitzer, PhD⁶^*, Guolian Kang, PhD, MS⁷, Victoria Okhomina⁵^* and Winfred C. Wang, MD³

¹Department of Hematology, St Jude Children's Research Hospital, Cordova, TN
²St Jude Children's Research Hospital, Memphis
³Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
⁴Hematology, St. Jude Research Hospital, Memphis, TN
⁵St Jude Children's Research Hospital, Memphis, TN
⁶Department of Psychology, St. Jude Children's Research Hospital, Memphis, TN
⁷Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN

3:00 PM

884

Optimizing Use of Automated Isovolemic Hemodilution Red-Cell Exchange in a Patient Cohort with Sickle Cell Disease: A Quality Improvement Intervention

Kelsey Uminski, MD¹, Iris Perelman, MSc²^*, Alan Tinmouth, MD, FRCPC^2,3^* and Johnathan Mack, MD, FRCPC^2,3^*

¹Division of Hematology, University of Calgary, Calgary, AB, Canada
²Ottawa Hospital Research Institute, Ottawa Hospital Center for Transfusion, Ottawa, ON, Canada
³Division of Hematology, University of Ottawa, Ottawa, ON, Canada

3:15 PM

885

A US-Wide Red Blood Cell Alloantibody Exchange Can Decrease Mortality and Produce Cost Savings in the Care of Alloimmunized Patients with Sickle Cell Disease

George Goshua, MD, MSc¹, Ronald G. Hauser, MD²^*, Chris Tormey, MD³, Ankur Pandya, PhD⁴^* and Jeanne E. Hendrickson, MD⁵

¹Section of Hematology, Yale University School of Medicine, New Haven, CT
²Department of Laboratory Medicine, Yale School of Medicine & VA Connecticut Healthcare System, West Haven, CT
³Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT
⁴Department of Health Policy and Management, Harvard T.H. Chan School of Public Health, Boston
⁵Department of Laboratory Medicine and Pathology, Emory University, Atlanta, GA

3:30 PM

886

Assessing Multi-Level Barriers to Medication Adherence in Youth with Sickle Cell Disease Using Pharmacy-Based Prescription Refill Data

Arlene Smaldone¹^*, Deepa Manwani, MD², Banu Aygun, MD³, Abena Appiah-Kubi, MD, MPH⁴, Kim Smith-Whitley, MD⁵^* and Nancy S. Green, MD⁶

¹Columbia University School of Nursing, New York, NY
²Albert Einstein College of Medicine, The Children’s Hospital at Montefiore, New York, NY
³Pediatric Hematology Oncology and Stem Cell Transplantation, Cohen Children's Medical Center, New Hyde Park, NY
⁴Cohen Children's Medical Center, Northwell Health, New Hyde Park, NY
⁵Global Blood Therapeutics, South San Francisco, CA
⁶Department of Pediatrics, Columbia U. Medical Center Div. of Pediatric Hematology/Oncology/Stem Cell Trans, New York, NY

3:45 PM

887

Increasing COVID-19 Vaccination Rates Amongst Children with Sickle Cell Disease: A Quality Improvement Project

Adam P Yan, MD^1,2^*, Natasha M. Archer, MD^1,2, Dianne Arnold, RN MSN³^*, Eileen Hansbury, MSc, PA-C¹^*, Matthew M. Heeney, MD^1,4, Dave Johnson, MS⁵^*, Erika Lichtman, RN³^*, Heather McMullan, RN¹^*, Lisa Morrissey, RN MPH MSN¹^* and Maya Ilowite, MD^1,2^*

¹Dana-Farber / Boston Children’s Cancer and Blood Disorders Center, Boston, MA
²Harvard Medical School, Boston, MA
³Boston Children's Hospital, Boston, MA
⁴Department of Pediatrics, Harvard Medical School, Boston, MA
⁵Boston Children’s Hospital Program for Patient Safety and Quality, Boston, MA

4:00 PM

888

Preliminary Feasibility and Efficacy of the Balance Program to Reduce Pain-Related Disability in Pediatric Sickle Cell Disease

Megan E. Connolly, PhD^1,2^*, Christina Sharkey, PhD³^*, Sydney M. Forman, BS²^*, Stephanie Merwin, PhD^3,4^*, Deepika S. Darbari, MD^5,6 and Steven J. Hardy, PhD^1,2

¹Departments of Psychiatry & Behavioral Sciences and Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC
²Division of Hematology, Children's National Hospital, Washington, DC
³Division of Hematology, Children's National Hospital, Washington
⁴Departments of Psychiatry & Behavioral Sciences and Pediatrics, George Washington University School of Medicine and Health Sciences, Washington
⁵Pediatrics, The George Washington University School of Medicine, Washington, DC
⁶Center for Cancer and Blood Disorders, Children's National Hospital, Washington, DC

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^*signifies non-member of ASH

901.O1.6 901. Health Services and Quality—Non-Malignant Conditions: Level Up! Taking Quality Care to the Next Level in Sickle Cell Disease