-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

701.O2.6 701. Experimental Transplantation: Basic and Translational: Novel Mechanisms of Acute and Chronic Graft-versus-Host Disease

Symposia: Experimental Transplantation: Basic and Translational Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, Biological therapies, Translational Research, Checkpoint Inhibitor, GVHD, drug development, Diseases, Immune Disorders, immune mechanism, immunology, Therapies, Adverse Events, Biological Processes, pathogenesis, Transplantation
Sunday, December 11, 2022: 9:30 AM-11:00 AM
391-392 (Ernest N. Morial Convention Center)
Moderators:
Ellen Fraint, MD, Children's Hospital at Montefiore and Motoko Koyama, MD, PhD, Fred Hutchinson Cancer Research Center
Disclosures:
No relevant conflicts of interest to declare.
This session includes the novel mechanisms of acute and chronic graft-versus-host disease utilizing pre-clinical models.
9:30 AM

Takahiro Ito, MD1*, Shuichiro Takashima, MD, PhD1,2*, Marco Calafiore, PhD2*, Ya-Yuan Fu, PhD2*, Anastasiya Egorova1*, Jason Kuttiyara2*, Winston Chang1*, Paola Vinci, PhD2*, Viktor Arnhold, MD1*, Dietmar Zaiss, PhD3* and Alan M. Hanash, MD4,5

1Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
2Memorial Sloan Kettering Cancer Center, New York, NY
3University Hospital Regensburg, Regensburg, Germany
4Department of Medicine, Weill Cornell Medical College, New York, NY
5Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY

9:45 AM

Sarah Lindner, MD1*, Oriana Miltiadous, MD2*, Ruben J Ramos3*, Anqi Dai, MS1*, Anastasia Kousa, PhD1*, Gabriel K Armijo1*, Romina Ghale1*, Chi L Nguyen1*, Jenny Paredes Sanchez, PhD1*, Teng Fei, PhD4*, John W Frame V5*, Sebastien Monette, DMV, MVSc6*, Emily Fontana1*, John Slingerland7*, Ying Taur, MD, MHP5*, Marina D Burgos da Silva, PhD1*, Kate A Markey, MBBS, PhD, FRACP, MPH8, Jonathan U Peled, MD, PhD9, Melody Smith, MD, MS10, Sergio A Giralt, MD9, Miguel-Angel Perales, MD11, Justin R Cross, PhD3*, Clarissa Campbell, PhD12* and Marcel R M van den Brink, MD, PhD11

1Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, NY
2Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York
3Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, NY
4Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
5Infectious Disease Service, Memorial Sloan Kettering Cancer Center, New York, NY
6Center of Comparative Medicine and Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
7Memorial Sloan Kettering Cancer Center, New York, NY
8Fred Hutch Cancer Center, Seattle, WA
9Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY
10Division of Blood and Marrow Transplantation and Cellular Therapy, Department of Medicine, Stanford University School of Medicine, Stanford, CA
11Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
12CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria

10:00 AM

Haroon Shaikh, PhD1*, Juan Gamboa Vargas1,2*, Zeinab Mokhtari, PhD1,3*, Josefina Peña Mosca, MSc1,2*, Joern Pezoldt, PhD4,5*, Hermann Einsele, MD6, Jochen Huehn, PhD4* and Andreas Beilhack, MD1*

1Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany
2Graduate School of Life Sciences, Julius-Maximilians University, Würzburg, Germany
3Glaxosmithkline Gmbh & co. kg, Heidelberg, Germany
4Helmholtz Centre for Infection Research, Braunschweig, Germany
5Laboratory of Systems Biology and Genetics, Institute of Bioengineering and Swiss Institute of Bioinformatics, Lausanne, Switzerland
6Department of Internal Medicine II, University Hospital Wuerzburg, Wuerzburg, Germany

10:15 AM

Hajime Senjo, M.D.1, Daigo Hashimoto, MD1, Shinpei Kubota, M.D., Ph.D.2*, Yuki Tanaka, Ph.D.2*, Shinpei Harada3*, Kazuki Yoneda, M.D.1*, Zixuan Zhang1*, Xuanzhong Chen1*, Ryo Kikuchi, M.D.1*, Yuta Hasegawa, M.D., Ph.D.1*, Hiroyuki Ohigashi, M.D., Ph.D.1*, Takahide Ara, M.D., Ph.D.1*, Yoshinori Hasegawa, Ph.D.4*, Masaaki Murakami, V.M.D., Ph.D.2* and Takanori Teshima, M.D., Ph.D.1

1Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan
2Molecular Psychoneuroimmunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
3Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo City, Japan
4Department of Applied Genomics, Kazusa DNA Research Institute, Chiba, Japan

10:30 AM

Jonathan Visentin, PharmD, PhD1,2,3, Wei Jia, MD, PhD3*, Jonathan C Poe, PhD3*, Hsuan Su, MS3*, Sofian Christina, BS3*, Rachel A. DiCioccio, BS3*, Itaevia Curry-Chisolm3*, Fahmin Basher, MD, PhD3, Sonali Bracken, MD, PhD3*, Vincent T Ho, MD4*, Vanja Sisirak, PhD1*, Mitchell E. Horwitz, MD3,5, Nelson J. Chao, MD, MBA3,5 and Stefanie Sarantopoulos, MD, PhD3,5

1CNRS, ImmunoConcEpT, UMR5164, Bordeaux University, Bordeaux, France
2Department of Immunology and Immunogenetics, CHU de Bordeaux, Bordeaux, France
3Division of Hematological Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC
4Dana-Farber Cancer Institute, Boston, MA
5Duke Cancer Institute, Duke University Medical Center, Durham, NC

10:45 AM

Jessie Bourcier, MD1*, Simon J. Hogg, PhD2,3*, Caroline Erickson, B.S3*, Michael E Singer, B.S.3*, Steven Tittley, BSc3*, Takahiro Ito, MD4*, Anastasiya Egorova4*, Jason Kuttiyara5*, Alan M. Hanash, MD6,7,8, Omar Abdel-Wahab, MD4,9 and Sydney X. Lu, MD, PhD10,11

1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, Neew York, NY
2Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia
3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
4Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
5Memorial Sloan Kettering Cancer Center, New York, NY
6Department of Medicine, Weill Cornell Medical College, New York, NY
7Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
8Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
9Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
10Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Stanford, CA
11Division of Hematology, Dept. of Medicine, Stanford University, Stanford, CA

*signifies non-member of ASH