64th ASH Annual Meeting and Exposition: 701. Experimental Transplantation: Basic and Translational: Novel Mechanisms of Acute and Chronic Graft-versus-Host Disease

Symposia: Experimental Transplantation: Basic and Translational Oral and Poster Abstracts
Oral

Research, Biological therapies, Translational Research, Checkpoint Inhibitor, GVHD, drug development, Diseases, Immune Disorders, immune mechanism, immunology, Therapies, Adverse Events, Biological Processes, pathogenesis, Transplantation

391-392 (Ernest N. Morial Convention Center)

Moderators:

Ellen Fraint, MD, Children's Hospital at Montefiore and Motoko Koyama, MD, PhD, Fred Hutchinson Cancer Research Center

Disclosures:

No relevant conflicts of interest to declare.

This session includes the novel mechanisms of acute and chronic graft-versus-host disease utilizing pre-clinical models.

9:30 AM

475

Donor-Derived Amphiregulin Drives CD4⁺ T Cell Expansion and Promotes Tissue Pathology after Experimental Allogeneic BMT

Takahiro Ito, MD¹^*, Shuichiro Takashima, MD, PhD^1,2^*, Marco Calafiore, PhD²^*, Ya-Yuan Fu, PhD²^*, Anastasiya Egorova¹^*, Jason Kuttiyara²^*, Winston Chang¹^*, Paola Vinci, PhD²^*, Viktor Arnhold, MD¹^*, Dietmar Zaiss, PhD³^* and Alan M. Hanash, MD^4,5

¹Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
²Memorial Sloan Kettering Cancer Center, New York, NY
³University Hospital Regensburg, Regensburg, Germany
⁴Department of Medicine, Weill Cornell Medical College, New York, NY
⁵Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY

9:45 AM

476

Microbial Bile Acid Metabolism Shapes Effector T Cell Responses during Inflammation in Mouse and Human

Sarah Lindner, MD¹^*, Oriana Miltiadous, MD²^*, Ruben J Ramos³^*, Anqi Dai, MS¹^*, Anastasia Kousa, PhD¹^*, Gabriel K Armijo¹^*, Romina Ghale¹^*, Chi L Nguyen¹^*, Jenny Paredes Sanchez, PhD¹^*, Teng Fei, PhD⁴^*, John W Frame V⁵^*, Sebastien Monette, DMV, MVSc⁶^*, Emily Fontana¹^*, John Slingerland⁷^*, Ying Taur, MD, MHP⁵^*, Marina D Burgos da Silva, PhD¹^*, Kate A Markey, MBBS, PhD, FRACP, MPH⁸, Jonathan U Peled, MD, PhD⁹, Melody Smith, MD, MS¹⁰, Sergio A Giralt, MD⁹, Miguel-Angel Perales, MD¹¹, Justin R Cross, PhD³^*, Clarissa Campbell, PhD¹²^* and Marcel R M van den Brink, MD, PhD¹¹

¹Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, NY
²Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York
³Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Infectious Disease Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁶Center of Comparative Medicine and Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
⁷Memorial Sloan Kettering Cancer Center, New York, NY
⁸Fred Hutch Cancer Center, Seattle, WA
⁹Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁰Division of Blood and Marrow Transplantation and Cellular Therapy, Department of Medicine, Stanford University School of Medicine, Stanford, CA
¹¹Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
¹²CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria

10:00 AM

477

Endothelial Cells Activate Alloreactive CD4⁺ T Cells to Initiate Acute Graft-Versus-Host Disease

Haroon Shaikh, PhD¹^*, Juan Gamboa Vargas^1,2^*, Zeinab Mokhtari, PhD^1,3^*, Josefina Peña Mosca, MSc^1,2^*, Joern Pezoldt, PhD^4,5^*, Hermann Einsele, MD⁶, Jochen Huehn, PhD⁴^* and Andreas Beilhack, MD¹^*

¹Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany
²Graduate School of Life Sciences, Julius-Maximilians University, Würzburg, Germany
³Glaxosmithkline Gmbh & co. kg, Heidelberg, Germany
⁴Helmholtz Centre for Infection Research, Braunschweig, Germany
⁵Laboratory of Systems Biology and Genetics, Institute of Bioengineering and Swiss Institute of Bioinformatics, Lausanne, Switzerland
⁶Department of Internal Medicine II, University Hospital Wuerzburg, Wuerzburg, Germany

10:15 AM

478

Calcineurin Inhibitors Inhibit Tolerance Induction By Suppressing Terminal Differentiation of Donor Exhausted T Cells after Allogeneic SCT

Hajime Senjo, M.D.¹, Daigo Hashimoto, MD¹, Shinpei Kubota, M.D., Ph.D.²^*, Yuki Tanaka, Ph.D.²^*, Shinpei Harada³^*, Kazuki Yoneda, M.D.¹^*, Zixuan Zhang¹^*, Xuanzhong Chen¹^*, Ryo Kikuchi, M.D.¹^*, Yuta Hasegawa, M.D., Ph.D.¹^*, Hiroyuki Ohigashi, M.D., Ph.D.¹^*, Takahide Ara, M.D., Ph.D.¹^*, Yoshinori Hasegawa, Ph.D.⁴^*, Masaaki Murakami, V.M.D., Ph.D.²^* and Takanori Teshima, M.D., Ph.D.¹

¹Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan
²Molecular Psychoneuroimmunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
³Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo City, Japan
⁴Department of Applied Genomics, Kazusa DNA Research Institute, Chiba, Japan

10:30 AM

479

The DNA-Sensor AIM2 Promotes BCR-Activated B Cells in Chronic Graft-Versus-Host-Disease

Jonathan Visentin, PharmD, PhD^1,2,3, Wei Jia, MD, PhD³^*, Jonathan C Poe, PhD³^*, Hsuan Su, MS³^*, Sofian Christina, BS³^*, Rachel A. DiCioccio, BS³^*, Itaevia Curry-Chisolm³^*, Fahmin Basher, MD, PhD³, Sonali Bracken, MD, PhD³^*, Vincent T Ho, MD⁴^*, Vanja Sisirak, PhD¹^*, Mitchell E. Horwitz, MD^3,5, Nelson J. Chao, MD, MBA^3,5 and Stefanie Sarantopoulos, MD, PhD^3,5

¹CNRS, ImmunoConcEpT, UMR5164, Bordeaux University, Bordeaux, France
²Department of Immunology and Immunogenetics, CHU de Bordeaux, Bordeaux, France
³Division of Hematological Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC
⁴Dana-Farber Cancer Institute, Boston, MA
⁵Duke Cancer Institute, Duke University Medical Center, Durham, NC

10:45 AM

480

Attenuation of Graft-Versus-Host-Disease Via Genetic or Pharmacologic Inhibition of the RNA Splicing Factor RBM39

Jessie Bourcier, MD¹^*, Simon J. Hogg, PhD^2,3^*, Caroline Erickson, B.S³^*, Michael E Singer, B.S.³^*, Steven Tittley, BSc³^*, Takahiro Ito, MD⁴^*, Anastasiya Egorova⁴^*, Jason Kuttiyara⁵^*, Alan M. Hanash, MD^6,7,8, Omar Abdel-Wahab, MD^4,9 and Sydney X. Lu, MD, PhD^10,11

¹Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, Neew York, NY
²Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia
³Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Memorial Sloan Kettering Cancer Center, New York, NY
⁶Department of Medicine, Weill Cornell Medical College, New York, NY
⁷Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁸Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁹Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁰Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Stanford, CA
¹¹Division of Hematology, Dept. of Medicine, Stanford University, Stanford, CA

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^*signifies non-member of ASH

701.O2.6 701. Experimental Transplantation: Basic and Translational: Novel Mechanisms of Acute and Chronic Graft-versus-Host Disease