64th ASH Annual Meeting and Exposition: 701. Experimental Transplantation: Basic and Translational: Novel Translational Approaches in Transplantation

Symposia: Experimental Transplantation: Basic and Translational Oral and Poster Abstracts
Oral

Research, Biological therapies, Antibody Therapy, autoimmune disorders, Acute Myeloid Malignancies, AML, Fundamental Science, adult, Translational Research, CHIP, hematopoiesis, GVHD, drug development, Diseases, Immune Disorders, immune mechanism, immunology, Therapies, Immunotherapy, Biological Processes, Myeloid Malignancies, Technology and Procedures, Study Population, Human, Transplantation, Animal model

208-210 (Ernest N. Morial Convention Center)

Moderators:

Federico Simonetta, MD, PhD, and Daisuke Araki, MD, National Institutes of Health

Disclosures:

No relevant conflicts of interest to declare.

This oral session includes novel translational research in transplantation-conditioning, biomarker, prophylaxis and treatment of graft-versus-host disease.

4:30 PM

649

Targeted Deletion of Activated T Cells with a Single Dose of Anti-CD137-Antibody Drug Conjugate Protects Against Acute Gvhd (AGVHD) and Promotes Tolerogenic T Cell Reconstitution after Haplo-Identical Hematopoietic Stem Cell Transplantation (HSCT)

Ulrike Gerdemann, MD^1,2, Jennifer Lane, DVM¹^*, Kyle Kimler^1,3^*, Leanne Lanieri, MS⁴^*, Lisa Olson, PhD⁴^*, Leslie S. Kean, MD, PhD^1,2 and Victor Tkachev, PhD^1,2

¹Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston
²Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston
³Broad Institute of MIT and Harvard, Cambridge
⁴Magenta Therapeutics, Cambridge, MA

4:45 PM

650

Fully Myeloablative Antibody-Drug Conjugates Condition for Hematopoietic Stem Cell Transplantation and Provide Durable Antileukemia Benefit

Stephen P. Persaud, MD, PhD¹, Aditya R. Yelamali²^*, Julie K. Ritchey³^* and John F. DiPersio, MD, PhD³

¹Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO
²Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO
³Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO

5:00 PM

651

Clonal Dynamics after Haematopoietic Stem Cell Transplantation Using Genome-Wide Somatic Mutations

Michael Spencer Chapman, MBBS^1,2^*, C. Matthias Wilk, MD³^*, Steffen Boettcher³^*, Emily Mitchell^2,4,5^*, Kevin J Dawson, PhD¹^*, Larisa V. Kovtonyuk, PhD³^*, Jan Müller, MD³^*, Nicholas Williams, PhD⁵^*, Jyoti Nangalia, MBBChir⁵, Markus G Manz³ and Peter J. Campbell¹^*

¹Wellcome Sanger Institute, Cambridge, United Kingdom
²University of Cambridge, Department of Haematology, Cambridge, United Kingdom
³University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich, Zurich, Switzerland
⁴University of Cambridge, Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom
⁵Wellcome Sanger Institute, Hinxton, United Kingdom

5:15 PM

652

Chronic Graft Versus Host Disease Detected By Tissue-Specific Cell-Free DNA Methylation Biomarkers

Batia Avni¹^*, Daniel Neiman²^*, Elior Shaked²^*, Sigal Grisariu Greenzaid¹^*, Mona Kuzli³^*, Andrea Fracchia³^*, Polina Stepensky¹^*, Tsila Zuckerman, MD⁴, Ahinoam Lev-Sagie⁵^*, Ilana Fox-Fisher²^*, Sheina Piyanzin²^*, Joshua Moss²^*, Benjamin Glaser⁵^*, Ruth Shemer²^* and Yuval Dor²^*

¹Department of Bone Marrow Transplantation & Cancer Immunotherapy, Hadassah Medical Center and Faculty of Medicine, Hebrew University, Jerusalem, Israel
²Faculty of Medicine, Hebrew University, Jerusalem, Israel
³Department of Bone Marrow Transplantation, Hadassah Medical Center and Faculty of Medicine, Hebrew University, Jerusalem, Israel
⁴Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel
⁵Hadassah Medical Center and Faculty of Medicine, Hebrew University, Jerusalem, Israel

5:30 PM

653

Graft Versus Leukaemia (GvL): Identification & Characterisation of Alloreactive Antigens and Cognate T Cell Responses in Acute Myeloid Leukemia

Connor Sweeney¹^*, Gerda Mickute²^*, Kinam Gupta³^*, Marlen Metzner, MSc⁴^*, Batchimeg Usukhbayar, PhD⁴^*, Maria Chiara Barbanti⁵^*, Gavinda Sangha⁶^*, Ronjon Chakraverty, BMBS, PhD^7,8^*, Persephone Borrow¹^*, Nicola Ternette⁹^*, Ane Ogbe¹⁰^*, Maria Aggelakopoulou¹¹^* and Paresh Vyas¹²^*

¹University of Oxford, Oxford, GBR
²Weatherall Institute fo Molecular Medicine, University of Oxford, MRC Molecular Haematology Unit, Oxford, United Kingdom
³Unviersity of Oxford, MRC Molecular Haematology Unit Weatherall Institute of Molecular Medicine, Oxford, United Kingdom
⁴MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
⁵University of Oxford, MRC Molecular Haematology Unit Weatherall Institute of Molecular Medicine, Oxford, United Kingdom
⁶University of Oxford and Oxford University Hospitals NHS Foundation Trust, MRC Molecular Haematology Unit and Department of Haematology O, Oxford, GBR
⁷Department of Haematology, Cancer and Haematology Centre, Churchill Hospital, Headington, Oxford, United Kingdom
⁸MRC Weatherall Institute of Molecular Medicine, University of Oxford., Oxford, United Kingdom
⁹University of Oxford, Nuffield Department of Medicine, Oxford, United Kingdom
¹⁰Unviersity of Oxford, Nuffield Department of Medicine, Oxford, United Kingdom
¹¹University of Oxford, Nuffield Department of medicine, Oxford, United Kingdom
¹²Weatherall Institute of Molecular medicine University of Oxford and Oxford University Hospitals NHS Trust, MRC Molecular Haematology Unit and Dept of Haematology, Oxford, United Kingdom

5:45 PM

654

Chimeric Antigen Receptor Engineering of Mesenchymal Stromal Cells (CAR-MSC) Enhance Immunosuppression and Outcomes in Graft Versus Host Disease (GvHD) Preclinical Models

Olivia Sirpilla, BS^1,2,3,4, Reona Leo Sakemura, MD, PhD^3,4,5, Mehrdad Hefazi, M.D.^3,4,6, James H. Girsch^1,3,4,7^*, Truc Huynh³^*, Michelle J. Cox, Ph.D.^3,4, Kendall J. Schick^2,3,4,8^*, Claudia Manriquez-Roman^1,3,4,7, Ismail Can, PhD^1,3,4,9, Kun Yun^1,3,4,7, Carli M. Stewart, BS^1,2,3,4, Ekene J. Ogbodo, Ph.D.^3,4^*, Elizabeth L. Siegler, Ph.D.^3,4^* and Saad S. Kenderian, MD^{3,4,7,10,11,12,13,14,15,16,17,18}

¹Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN
²Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN
³T Cell Engineering, Mayo Clinic, Rochester, MN
⁴Division of Hematology, Mayo Clinic, Rochester, MN
⁵Mayo Clinic, Rochester, MN
⁶Mayo Clinic, Rochester
⁷Department of Molecular Medicine, Mayo Clinic, Rochester, MN
⁸Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN
⁹Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN
¹⁰Division of Hematology and Bone Marrow Transplantation, Mayo Clinic, Rochester, MN
¹¹Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA
¹²Department of Immunology, Mayo Clinic, Rochester, MN
¹³Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN
¹⁴Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN
¹⁵Translational Research Program, Abramson Family Research Cancer Institute, University of Pennsylvania, Philadelphia, PA
¹⁶T Cell Engineering, Division of Hematology, Department of Molecular Medicine and Department of Immunology, Mayo Clinic, Rochester, MN
¹⁷Division of Hematology and Bone Marrow Transplantation, Department of Medicine, Mayo Clinic, Rochester, MN
¹⁸Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine, Philadelphia, PA

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701.O1.6 701. Experimental Transplantation: Basic and Translational: Novel Translational Approaches in Transplantation