-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

653.O1.6 653. Myeloma and Plasma Cell Dyscrasias: Prospective Therapeutic Trials: Bispecific Monoclonal Antibodies in Myeloma

Symposia: Myeloma and Plasma Cell Dyscrasias: Prospective Therapeutic Trials Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, clinical trials, adult, Biological therapies, Translational Research, Bispecific Antibody Therapy, Clinical Research, Plasma Cell Disorders, drug development, Diseases, Therapies, Immunotherapy, Lymphoid Malignancies, Adverse Events, Study Population, Human, Minimal Residual Disease
Saturday, December 10, 2022: 12:00 PM-1:30 PM
R02-R05 (Ernest N. Morial Convention Center)
Moderators:
Urvi A Shah, MD, Memorial Sloan Kettering Cancer Center and Sarah Larson, MD, UCLA
Disclosures:
Shah: Sanofi: Consultancy; Bristol Myers Squibb: Consultancy, Research Funding; Janssen: Consultancy, Research Funding.
Selected presentations with new information on efficacy and safety, from studies using bispecific antibodies in patients with multiple myeloma.
12:00 PM

Ajai Chari1*, Cyrille Touzeau2*, Carolina Schinke3, Monique C. Minnema, MD, PhD4, Jesus Berdeja, MD5, Albert Oriol6*, Niels WCJ Van De Donk, MD7, Paula Rodriguez Otero8*, Elham Askari9*, Maria-Victoria Mateos, MD10, Luciano J. Megala Costa, MD, PhD11, Jo Caers, PhD12, Leo Rasche, MD13*, Amrita Y. Krishnan, MD, FACP14, Deeksha Vishwamitra15*, Xuewen Ma15*, Xiang Qin15*, Katharine S. Gries, PhD, PharmD16*, Michela Campagna17*, Tara Masterson15*, Brandi Hilder15*, Jaszianne Tolbert15, Thomas Renaud18*, Jenna D. Goldberg18*, Christoph Heuck15*, Jesús San-Miguel, MD, PhD19 and Philippe Moreau, MD20*

1Mount Sinai School of Medicine, New York, NY
2Centre Hospitalier Universitaire de Nantes, Nantes, France
3Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR
4University Medical Center Utrecht, Utrecht, Netherlands
5Sarah Cannon Research Institute, Nashville, TN
6Hospital Germans Trias I Pujol, Barcelona, Spain
7Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
8University of Navarra, Pamplona, Spain
9Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain
10University Hospital of Salamanca/IBSAL/CIC, Salamanca, Spain
11University of Alabama at Birmingham, Birmingham, AL
12University of Liege, Liege, Belgium
13University Hospital of Würzburg, Würzburg, Germany
14City of Hope Comprehensive Cancer Center, Duarte, CA
15Janssen Research & Development, Spring House, PA
16Janssen Global Services, Raritan, NJ
17Janssen-Cilag, Madrid, Spain
18Janssen Research & Development, Raritan, NJ
19Universidad de Navarra, Pamplona, Spain
20University Hospital Hôtel-Dieu, Nantes, France

12:15 PM

Noopur Raje, MD1, Nizar Jacques Bahlis, MD2, Caitlin Costello, MD3, Bhagirathbhai Dholaria, MBBS4, Melhem Solh, MD5, Moshe Yair Levy, MD6, Michael H Tomasson, MD7*, Michael A. Damore, PhD8*, Sibo Jiang, PhD9*, Cynthia Basu, PhD10*, Athanasia Skoura, PhD11*, Edward M Chan, MD12*, Suzanne Trudel13, Andrzej Jakubowiak, MD, PhD14*, Michael P Chu, MD15*, Cristina J. Gasparetto, MD16, Andrew P. Dalovisio, MD17, Michael Sebag, MD, PhD18 and Alexander M Lesokhin, MD19

1Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA
2Arnie Charbonneau Cancer Research Institute, University of Calgary, Calgary, AB, Canada
3Moores Cancer Center, University of California San Diego, La Jolla, CA
4Vanderbilt University Medical Center and Vanderbilt- Ingram Cancer Center, Nashville, TN
5Blood and Marrow Transplant Group of Georgia, Northside Hospital, Atlanta, GA
6Department of Medical Oncology, Baylor Scott and White Health, Dallas, TX
7Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA
8Oncology Research and Development, Pfizer, San Diego, CA
9Early Clinical Development, Pfizer Inc, San Diego, CA
10Early Clinical Development, Pfizer, San Diego, CA
11Early Clinical Development, Pfizer, Collegeville, PA
12Oncology Research and Development, Pfizer, South San Francisco, CA
13Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
14Department of Medicine, University of Chicago Medical Center, Chicago, IL
15Cross Cancer Institute, Edmonton, AB, Canada
16Department of Medicine, Duke University Cancer Institute, Durham, NC
17Department of Hematology and Oncology, Ochsner Health, Jefferson, LA
18Cedars Cancer Center, McGill University Health Centre, Montreal, QC, Canada
19Division of Hematology and Oncology, Memorial Sloan Kettering Cancer Center/Weill Cornell Medical College, New York, NY

12:30 PM

Nizar Jacques Bahlis, MD1, Michael H. Tomasson, MD2, Mohamad Mohty, MD PhD3, Ruben Niesvizky, MD4, Ajay K. Nooka, MD, MPH, FACP5, Salomon Manier, MD, PhD6, Christopher Maisel, MD7, Yogesh Jethava, MD8*, Joaquin Martinez-Lopez, MD, PhD9*, H Miles Prince, MD10, Bertrand Arnulf11*, Paula Rodriguez Otero12*, Guenther Koehne, MD, PhD13, Cyrille Touzeau14*, Noopur Raje, MD15, Shinsuke Iida, MD, PhD16, Marc-Steffen Raab17*, Eric Leip, PhD18*, Sharon Sullivan, PhD19*, Umberto Conte, PharmD20*, Andrea Viqueira, MD21* and Alexander M Lesokhin, MD22

1Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada
2Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA
3Sorbonne University, Hôpital Saint-Antoine, and INSERM UMRs938, Paris, France
4Division of Hematology & Medical Oncology, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY
5Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA
6CHU de Lille, Lille, France
7Baylor University Medical Center, Dallas, TX
8Indiana Blood & Marrow Transplantation, Indianapolis, IN
9Hospital Universitario 12 de Octubre, Madrid, Spain
10Epworth Healthcare, Melbourne, Australia
11Hôpital Saint-Louis, Paris, France
12Clinica Universidad de Navarra, Pamplona, Spain
13Blood and Marrow Transplant Program, Miami Cancer Institute, Baptist Health, Miami, FL
14Centre Hospitalier Universitaire (CHU) de Nantes, INSERM, Université de Nantes, Nantes, France
15Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA
16Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
17Heidelberg Myeloma Center, Department of Hematology/Oncology, Heidelberg University Hospital, Heidelberg, Germany
18Pfizer Inc., Cambridge, MA
19Pfizer Inc, Cambridge, MA
20Pfizer Inc, New York, NY
21Pfizer SLU, Madrid, Spain
22Division of Hematology and Oncology, Memorial Sloan Kettering Cancer Center/Weill Cornell Medical College, New York, NY

12:45 PM

Emma Searle1*, Hang Quach2, Sandy W. Wong, MD3, Luciano J. Megala Costa, MD, PhD4, Cyrille Hulin5*, Wojciech Janowski6*, Jesus Berdeja, MD7, Sébastien Anguille8*, Jeffrey V. Matous, MD9, Cyrille Touzeau10*, Anne-Sophie Michallet, MD, PhD11*, Marla Husnik12*, Deeksha Vishwamitra13*, Zhuolu Niu14*, Julie Larsen15*, Lingling Chen13*, Jenna D. Goldberg16*, Rakesh Popat17* and Andrew Spencer18

1The University of Manchester, Manchester, United Kingdom
2University of Melbourne, St. Vincent’s Hospital Melbourne, Melbourne, VIC, Australia
3UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA
4University of Alabama at Birmingham Hospital, Vestavia, AL
5Hôpital Haut Leveque, University Hospital, Pessac, France
6Calvary Mater Newcastle, Waratah, NSW, Australia
7Sarah Cannon Research Institute, Nashville, TN
8Vaccine and Infectious Disease Institute, University of Antwerp, Edegem, Belgium, Center for Cell Therapy and Regenerative Medicine, Antwerp University Hospital, Edegem, Belgium
9Colorado Blood Cancer Institute, Denver, CO
10Centre Hospitalier Universitaire de Nantes, Nantes, France
11Centre Hospitalier Lyon Sud, Hospices Civils, LYON, France
12Janssen Research & Development, San Diego, CA
13Janssen Research & Development, Spring House, PA
14Janssen Research & Development, Shanghai, China
15Janssen Research & Development, Los Angeles, CA
16Janssen Research & Development, Raritan, NJ
17University College London Hospitals NHS Foundation Trust, London, United Kingdom
18Monash University, Melbourne, Australia

1:00 PM

Carmelo Carlo-Stella, MD, PhD1, Rita Mazza, MD2*, Salomon Manier, MD, PhD3, Thierry Facon3*, Sung-Soo Yoon, MD, PhD4,5, Youngil Koh, MD, PhD5*, Simon J Harrison, MD6,7, Jeremy Er, MD8,9*, Antonio Pinto, MD10*, Francesco Volzone, MD10*, Giulia Perrone, MD11*, Paolo Corradini, MD11, Titouan Cazaubiel, MD12*, Cyrille Hulin12*, Cyrille Touzeau13*, Philippe Moreau, MD14*, Enrique M. Ocio15, Carmen Maria Montes Gaisan, MD15*, Rakesh Popat, MD, PhD16*, Sarah Leong, MD16*, Fritz Offner, MD, PhD17, Paula Rodriguez Otero18*, Ana Alfonso-Pierola, MD, PhD19*, Ann-Marie E Bröske20*, Iryna Dekhtiarenko, PhD21*, Hans-Joachim Helms, PhD22*, Sara Belli, PhD22*, Eva Rossmann, MD, PhD22*, Tanja Fauti, PhD21*, Jan Eckmann20*, Tom Moore, MD20*, Meike Schneider, MD22*, Wolfgang Jacob, PhD20*, Martin Weisser, MD, PhD20*, Martin Hutchings, MD, PhD23* and Caroline Hasselbalch Riley, MD, PhD23*

1Department of Oncology and Hematology, Humanitas University and IRCCS Humanitas Research Hospital, Milan, Italy
2Humanitas University and IRCCS Humanitas Research Hospital, Milan, Italy
3CHU de Lille, Lille, France
4Seoul National University College of Medicine, Seoul, Korea, Republic of (South)
5Seoul National University Hospital, Seoul, Korea, Republic of (South)
6Clinical Haematology, Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, VIC, Australia
7Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia
8The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia
9Department of Clinical Haematology, Peter MacCallum Cancer Center and Royal Melbourne Hospital, Melbourne, Australia
10Istituto Nazionale dei Tumori “Fondazione G Pascale”, IRCCS, Napoli, Italy
11IRCCS Istituto Nazionale dei Tumori, Milan, Italy
12CHU de Bordeaux, Bordeaux, France
13Centre Hospitalier Universitaire (CHU) de Nantes, INSERM, Université de Nantes, Nantes, France
14CHU de Nantes, Nantes, France
15Hospital Universitario Marques de Valdecilla (IDIVAL), Universidad de Cantabria, Santander, Spain
16University College London Hospitals NHS Foundation Trust, London, United Kingdom
17Universitair Ziekenhuis Gent, Gent, Belgium
18Clinica Universidad de Navarra, Navarra, Spain
19Department of Hematology, Clinica Universidad de Navarra, Navarra, Spain
20Roche Pharma Research and Early Development, Roche Innovation Center Munich, Penzberg, Germany
21Roche Pharma Research and Early Development, Roche Innovation Center Zurich, Zurich, Switzerland
22Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland
23Rigshospitalet, Copenhagen, Denmark

1:15 PM

Sandy W. Wong, MD1, Noffar Bar, MD2, Laura Paris, MD3*, Craig C Hofmeister, MD4, Markus Hansson, MD5*, Armando Santoro, MD6,7*, Maria-Victoria Mateos, MD8, Paula Rodríguez-Otero, MD, PhD9*, Johan Lund, MD10*, Cristina Encinas, MD11*, Andrew J. Yee, MD12, Albert Oriol, MD13*, Claudio Cerchione, MD14, Javier de la Rubia, MD15*, Barbara Ferstl, MD16*, Kristina Carlson, MD17, Paz Ribas, MD18*, Arancha Bermúdez, MD19*, Isaac W. Boss, PhD20*, Allison Gaudy, PhD21*, Shaoyi Li, PhD22*, Kevin Hsu, PharmD23*, Colin D. Godwin, MD, MPhil24, Michael R. Burgess, MD, PhD25, Jesús San-Miguel, MD, PhD26 and Luciano J. Megala Costa, MD, PhD27

1Division of Hematology/Oncology, University of California San Francisco, San Francisco, CA
2Section of Hematology, Department of Medicine, Yale University School of Medicine, New Haven, CT
3Hematology Unit, ASST Papa Giovanni XXIII, Bergamo, Italy
4Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA
5Skåne University Hospital, Lund, Sweden
6Department of Biomedical Sciences, Humanitas University, Milan, Italy
7IRCCS Humanitas Research Hospital - Humanitas Cancer Center Rozzano, Milan, Italy
8Department of Hematology, and Center for Cancer Research, University Hospital of Salamanca, Salamanca, Spain
9Department of Hematology, Clínica Universidad de Navarra, Pamplona, Spain
10Haematology Center, Karolinska University Hospital, Stockholm, Sweden
11Hematology Department, Hospital General Universitario Gregorio Marañón, IiSGM, Madrid, Spain
12Massachusetts General Hospital Cancer Center, Boston, MA
13Institut Josep Carreras and Institut Catala d’Oncologia, Hospital Germans Trias i Pujol, Barcelona, Spain
14Hematology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola (FC), Italy
15Hematology Department, University Hospital La Fe, Valencia, Spain
16Department of Internal Medicine 5, Hematology and Oncology, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
17Department of Hematology, Uppsala University Hospital, Uppsala, Uppsala Laen, Sweden
18Department of Hematology, Hospital Universitario Dr Peset Aleixandre, Valencia, Spain
19Hospital Universitario Marqués de Valdecilla (IDIVAL), Santander, Spain
20Translational Research, Bristol Myers Squibb, Seattle, WA
21Clinical Pharmacology and Pharmacometrics, Bristol Myers Squibb, Summit, NJ
22Biostatistics, Bristol Myers Squibb, Berkley Heights, NJ
23Early Clinical Development, Bristol Myers Squibb, Summit, NJ
24Early Clinical Development, Bristol Myers Squibb, Seattle, WA
25Early Clinical Development, Bristol Myers Squibb, Princeton, NJ
26Applied Medical Research, Clínica Universidad de Navarra, Pamplona, Spain
27University of Alabama at Birmingham Hospital, Vestavia, AL

*signifies non-member of ASH