Talha Munir, MBBS, MRCP, FRCPath, PhD^1,2,3*, Louise-Rae Cherrill^4*, Nichola Webster^5*, Surita Dalal, PhD^6*, Rebecca H. Boucher, BSc, MSc, PhD^4*, Chhaya Sankhalpara, BSc^7*, Francesca Yates, PhD^4*, Sonia Fox, BSc^4*, Donald Macdonald, MBChB, MD, FRCP, PhD, FCRPath^8*, Christopher Fegan^9*, Alison McCaig, MBChB, FRCPath, PhD, MRCP^10*, Anna Schuh, MD, PhD, FRCP, FRCPath¹¹, Andrew Pettitt, PhD, FRCPath^12*, John G. Gribben, MD, DSc, FRCP, FRCPath, FMedSci¹³, Piers E.M. Patten, FRCP, FRCPath, PhD¹⁴, Stephen Devereux, PhD, FRCP, FRCPath, MRCPath, MB BS^14*, Adrian Bloor, PhD FRCP FRCPath^15*, Christopher P Fox, PhD¹⁶, Francesco Forconi, MD, PhD^17*, Andy C. Rawstron, PhD^6* and Peter Hillmen¹⁸

¹Department of Haematology, St James's University Hospital, Leeds, United Kingdom
²Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom
³Consultant Haematologist, St James's Hospital, Leeds, United Kingdom
⁴Cancer Research UK, Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom
⁵St. James’s University Hospital, Leeds, United Kingdom
⁶HMDS, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
⁷Cancer Research UK, Clinical Trials Unit, University of Birmingham, Birmingham, ENG, United Kingdom
⁸Imperial College Healthcare NHS Trust, London, United Kingdom
⁹University Hospital of Wales, Cardiff, United Kingdom
¹⁰The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom
¹¹Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
¹²Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, United Kingdom
¹³St Bartholomew's Hospital, London, United Kingdom
¹⁴King's College London and King's College Hospital NHS Foundation Trust, London, United Kingdom
¹⁵Haematology, The Christie Hospital NHS Foundation Trust, Manchester, United Kingdom
¹⁶Nottingham University Hospitals NHS Trust, Nottingham, GBR
¹⁷University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
¹⁸Institute of Oncology, St. James's University Hospital, Leeds, United Kingdom

John N. Allan¹, Tanya Siddiqi, MD^2*, Thomas J. Kipps, MD, PhD³, Bryone J. Kuss, MBBS, PhD, FRACP, FRCPA^4*, Xavier C. Badoux, MBBS, FRACP, FRCPA⁵, Jacqueline C. Barrientos, MD, MS^6*, Alessandra Tedeschi^7*, Stephen Opat, FRACP, FRCPA, MBBS^8*, Ian W. Flinn, MD PhD⁹, Eva Gonzalez Barca, MD, PhD^10*, Ryan Jacobs, MD^11*, Edith Szafer-Glusman, PhD^12*, Cathy Zhou, MS^12*, Anita Szoke, MD^12*, William G. Wierda, MD, PhD^13*, Paolo Ghia, MD, PhD¹⁴ and Constantine S. Tam^15*

¹Weill Cornell Medicine, New York, NY
²City of Hope National Medical Center, Duarte
³UC San Diego Moores Cancer Center, San Diego, CA
⁴Flinders University and Medical Center, Bedford Park, SA, Australia
⁵Ministry of Health, Kogarah, NSW, Australia
⁶Mount Sinai Comprehensive Cancer Center, Miami Beach, FL
⁷ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy
⁸Monash University, Clayton, VIC, Australia
⁹Sarah Cannon Research Institute and Tennessee Oncology, Nashville, TN
¹⁰Universitat de Barcelona, Institut Catalá d’Oncologia Hospitalet, Barcelona, Spain
¹¹Levine Cancer Institute, Charlotte, NC
¹²Pharmacyclics LLC, an AbbVie Company, South San Francisco, CA
¹³Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
¹⁴Universita' Vita-Salute San Raffaele C.F. 97187560152, Milano, MI, Italy
¹⁵Peter MacCallum Cancer Centre, Royal Melbourne Hospital, University of Melbourne, Melbourne, VIC, Australia

Carsten U Niemann, MD^1*, Talha Munir, MBBS, MRCP, FRCPath, PhD^2*, Carol Moreno, MD, PhD^3*, Carolyn Owen, MD^4*, George A Follows, MD, PhD^5*, Ohad Benjamini^6*, Ann Janssens, MD, PhD^7*, Mark-David Levin⁸, Anders Österborg^9*, Tadeusz Robak¹⁰, Martin Šimkovič^11*, Sergey Voloshin^12*, Vladimir I. Vorobyev, MD¹³, Munci Yagci, MD^14*, Loic Ysebaert, MD, PhD^15*, Keqin Qi^16*, Qianaya Qi^17*, Lori Parisi^17*, Srimathi Srinivasan^18*, Natasha Schuier^19*, Kurt Baeten^20*, Angela Howes, BSc, PhD²¹, Donne Bennett Caces^17* and Arnon P. Kater, MD, PhD²²

¹Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark
²Consultant Haematologist, St James's Hospital, Leeds, United Kingdom
³Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Josep Carreras Leukaemia Research Institute, Barcelona, Spain
⁴Tom Baker Cancer Centre, Calgary, Canada
⁵Addenbrookes Hospital, Cambridge, United Kingdom
⁶Sheba Medical Center, Ramat Gan, Israel
⁷UZ Leuven Gasthuisberg, LEUVEN, Belgium
⁸Department of Internal Medicine, Albert Schweitzer hospital, Dordrecht, Netherlands
⁹Karolinska University Hospital, Stockholm, Sweden
¹⁰Medical University of Lodz, Copernicus Memorial Hospital, Lodz, Poland
¹¹4th Department of Internal Medicine – Haematology, Faculty of Medicine in Hradec Králové, University Hospital and Charles University in Prague, Hradec Kralove, Czech Republic
¹²Russian Scientific and Research Institute of Hematology and Transfusiology, St Petersburg, Russian Federation
¹³Bone Marrow Transplant, Botkin Hospital, Moscow, Russia
¹⁴Gazi Universitesi Tip Fakultesi, Ankara, Turkey
¹⁵Hematology Department, Institut Universitaire du Cancer Toulouse Oncopole, Toulouse, France
¹⁶Janssen Research & Development, Titusville, NJ
¹⁷Janssen Research & Development, Raritan, NJ
¹⁸Oncology Translational Research, Janssen Research & Development, Lower Gwynedd Township, PA
¹⁹Janssen Research & Development, Dusseldorf, Germany
²⁰Janssen Research & Development, Beerse, Belgium
²¹Janssen Research & Development, Raritan
²²Academic Medical Center, Amsterdam Zuidoost, NH, Netherlands

Talha Munir, MBBS, MRCP, FRCPath, PhD^1,2,3*, Alexandra Pitchford^4*, Adrian Bloor, PhD FRCP FRCPath^5*, Andrew Pettitt, PhD, FRCPath^6*, Piers E.M. Patten, FRCP, FRCPath, PhD⁷, Francesco Forconi, MD, PhD^8*, Anna Schuh, MD, PhD, FRCP, FRCPath⁹, Christopher P Fox, PhD¹⁰, Simona Gatto^11*, Ben Kennedy, MBChB, FRCP, FRCPath^12*, John Gribben^13*, Nicholas Pemberton^14*, Oonagh Sheehy, MB BCh BAO, MRCP, FRCPath^15*, Gavin Preston, MD^16*, Dena Howard^17*, Anna Hockaday^4*, David Cairns, PhD^18*, Sharon Jackson^4*, Natasha Greatorex^4*, Nichola McWhirter^19*, Jane Shingles^19*, Kate Cwynarski, MD^20*, Shankara Paneesha, MD²¹, David Allsup^22*, Andrew Rawstron, PhD^23* and Peter Hillmen^24,25

¹Consultant Haematologist, St James's Hospital, Leeds, United Kingdom
²NCRI CLL Sub-group, Leeds, United Kingdom
³Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom
⁴Leeds Cancer Research UK Clinical Trials Unit, Leeds Institute of Clinical Trials Research, Leeds, United Kingdom
⁵Haematology, The Christie Hospital NHS Foundation Trust, Manchester, United Kingdom
⁶University of Liverpool, Liverpool, United Kingdom
⁷Comprehensive Cancer Centre, King’s College London, London, United Kingdom
⁸School of Cancer Sciences, University of Southampton, Southampton, United Kingdom
⁹Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
¹⁰Nottingham University Hospitals NHS Trust, Nottingham, GBR
¹¹Cardiff and Vale UHB, Cardiff, United Kingdom
¹²Leicester Royal Infirmary, Leicester, United Kingdom
¹³Barts and The London School of Medicine, London, GBR
¹⁴Worcestershire acute Hospital NHS Trust, Worchester, United Kingdom
¹⁵Belfast HSC Trust, Belfast, United Kingdom
¹⁶Department of Haematology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom
¹⁷Roche Products Limited, Welwyn Garden City, United Kingdom
¹⁸Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, ENG, United Kingdom
¹⁹Haematology malignancy and diagnostic service, Leeds, United Kingdom
²⁰University College London Hospitals NHS Foundation Trust, London, United Kingdom
²¹Birmingham Heartlands Hospital, Birmingham, United Kingdom
²²Centre for Atherothrombosis and Metabolic Disease, Hull York Medical School, Hull, ENG, United Kingdom
²³HMDS, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
²⁴Institute of Oncology, St. James's University Hospital, Leeds, United Kingdom
²⁵Section of Experimental Haematology, University of Leeds, Leeds, United Kingdom

Nitin Jain, MD¹, Michael J. Keating, MBBS², Philip A. Thompson, MBBS¹, Alessandra Ferrajoli², Jayastu Senapati, MD, MBBS, DM^1*, Jan A. Burger, MD, PhD¹, Gautam Borthakur, MD¹, Koichi Takahashi, MD, PhD², Zeev E. Estrov, MD¹, Marina Konopleva, MD, PhD¹, Koji Sasaki, MD¹, Tapan M. Kadia, MD³, Naveen Pemmaraju, MD¹, Naval Daver, MD¹, Elias Jabbour, MD¹, Courtney D. DiNardo, MD, MSCE¹, Yesid Alvarado, MD¹, Musa Yilmaz, MD¹, Prithviraj Bose, MD⁴, Maro Ohanian, DO^1*, Rashmi Kanagal-Shamanna, MD⁵, Keyur Patel, MD, PhD^5*, Jeffrey L. Jorgensen, MD, PhD^5*, Sa A Wang, MD^5*, Sameh Nassar, MD^6*, Naveen Garg, MD^6*, Hyunsoo Hwang^7*, Xuemei Wang, MS^7*, Nichole Cruz, RN^1*, Ana Ayala, RN^2*, William Plunkett, PhD⁸, Hagop Kantarjian, MD⁹, Varsha Gandhi, PhD⁸ and William G. Wierda, MD, PhD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
³Department of Leukemia, MD Anderson Cancer Center, Houston, TX
⁴The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
⁸Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX
⁹Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Philip A. Thompson, MBBS¹, Michael J. Keating, MBBS¹, Alessandra Ferrajoli¹, Nitin Jain, MD², Christine B. Peterson, PhD^3*, Naveen Garg, MD^4*, Ana Ayala, RN^1*, Jon A Hernandez^1*, Tapan M. Kadia, MD², Prithviraj Bose, MD⁵, Naveen Pemmaraju, MD⁶, Nicholas Short, MD¹ and William G. Wierda, MD, PhD⁷

¹Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
²Department of Leukemia, MD Anderson Cancer Center, Houston, TX
³Department of Biostatistics, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁴Department of Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷The University of Texas M.D. Anderson Cancer Center, Houston, TX