-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

641.O2.6 641. Chronic Lymphocytic Leukemias: Basic and Translational: Pathogenesis and Transformation

Symposia: Chronic Lymphocytic Leukemias: Basic and Translational Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, Fundamental Science, Lymphoid Leukemias, adult, Antibody Therapy, apoptosis, Translational Research, CLL, Lymphomas, genomics, B Cell lymphoma, Combination therapy, Diseases, immune mechanism, immunology, Therapies, aggressive lymphoma, Lymphoid Malignancies, metabolism, Biological Processes, molecular biology, Technology and Procedures, gene editing, Study Population, Human, pathogenesis, Animal model, omics technologies
Sunday, December 11, 2022: 4:30 PM-6:00 PM
R02-R05 (Ernest N. Morial Convention Center)
Moderators:
Tanja Nicole Hartmann, PhD, Medical Center and Faculty of Medicine, University of Freiburg and Marek Mraz, MD, ARRAY(0xefd2d20)
Disclosures:
Hartmann: AstraZeneca: Research Funding.
4:30 PM

Julieta H. Sepulveda Yanez, MSc1,2*, Edwin Quinten, BSc1*, Marvyn T. Koning, MD1*, Janneke A. Eken, MSc1*, Dietmar Pfeifer, PhD3*, Ruben A.L. De Groen1*, Diego Alvarez Saravia, BSc4*, Andreas Agathangelidis, PhD5*, Cornelis A.M. van Bergen, PhD1*, Kostas Stamatopoulos, MD5,6, Joost S.P. Vermaat, MD, PhD1, Katja Zirlik, MD7, Marcelo Navarrete, MD8, Hassan Jumaa, PhD9* and Hendrik Veelken, MD, PhD 1

1Department of Hematology, Leiden University Medical Center, Leiden, Netherlands
2Centro Austral de Tecnología Genómica, University of Magallanes, Punta Arenas, Chile
3Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, Freiburg, Germany
4Computer Engineering, Magallanes University, Punta Arenas, Chile
5Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece
6Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
7Department of Hematology, Oncology and Stem Cell Transplantation, University of Freiburg Medical Center, Freiburg, Germany
8School of Medicine, University of Magallanes, Punta Arenas, Chile
9Institute of Immunology, University Medical Center Ulm, Ulm, Germany

4:45 PM

Shih-Shih Chen, PhD1, Xiao-Jie Yan, MD PhD1*, Martina Cardillo, PhD1*, Anita Ng1*, Andrew Shih, PhD2*, Gonzalo Blanco1*, Morgan King-Richards, MS1*, Yu-Ju Chen, MS1*, Yasmine Kieso, MSCR1*, Joanna M. Rhodes, MD, MSCE3, Kanti R Rai, MD1 and Nicholas Chiorazzi, MD1

1Karches Center for Oncology Research, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY
2Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute For Medical Research, Manhasset, NY
3Northwell Health Cancer Institute, New Hyde Park, NY

5:00 PM

Erin Michelle Parry, MD, PhD1,2, Romain Guieze, MD, PhD1,3,4*, Ignaty Leshchiner, PhD5,6*, Connor Johnson, BA5*, Eugen Tausch, MD7*, Sameer A. Parikh, MD8, Camilla K Lemvigh, MSc1,9*, Julien Broséus, MD PhD10,11*, Sébastien Hergalant12*, Connor Messer5*, Filippo Utro, PhD13*, Chaya Levovitz, MD, PhD13*, Kahn Rhrissorrakrai, PhD13*, Liang Li5*, Shuqiang Li, PhD5,14*, Geoffrey G Fell15*, Robert A. Redd, MS15*, Ziao Lin, BS5*, Binyamin A. Knisbacher, PhD5*, Christof Schneider, MD16*, Stacey M. Fernandes, BS17*, Julian M. Hess5*, Laura Z. Rassenti, PhD18, Thomas J. Kipps, MD, PhD18, Nitin Jain, MD19, William G. Wierda, MD, PhD20, Florence Cymbalista, MD PhD21*, Pierre Feugier, MD, PhD22*, Neil E. Kay, MD23, Kenneth J Livak, PhD1,14*, Brian P Danysh, PhD5*, Chip Stewart, PhD24*, Donna S. Neuberg, ScD15, Matthew S. Davids, MD1,2, Jennifer R. Brown, MD, PhD1,2, Laxmi Parida, PhD13*, Stephan Stilgenbauer, MD16, Gad Getz, PhD5,25* and Catherine J. Wu, MD1,2,5

1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
2Harvard Medical School, Boston, MA
3EA 7453 (CHELTER), Université Clermont Auvergne, Clermont-Ferrand, France
4Department of Hematology, CHU Clermont Ferrand, Clermont Ferrand, MA, France
5Broad Institute of MIT and Harvard, Cambridge, MA
6Department of Medicine, Boston University School of Medicine, Boston, MA
7Department of Internal Medicine III, Ulm University, Ulm, Germany
8Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN
9Department of Health Technology, Technical University of Denmark, Lyngby, Denmark
10Inserm UMRS1256 Nutrition-Genetique et Exposition aux Risques Environnementaux, University de Lorraine, Nancy, France
11CHRU-Nancy, University of Lorraine, Nancy, France
12Inserm UMRS1256 Nutrition-Genetique et Exposition aux Risques Environnementaux, University de Lorraine, Nancy, AL, FRA
13IBM T.J. Watson Research Center, Yorktown Heights, NY
14Translational Immunogenomics Lab, Dana-Farber Cancer Institute, Boston, MA
15Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
16Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany
17Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA
18Moores Cancer Center, University of California, San Diego, La Jolla, CA
19Department of Leukemia, MD Anderson Cancer Center, Houston, TX
20The University of Texas M.D. Anderson Cancer Center, Houston, TX
21Laboratory of Hematology, APHP, Hôpital Avicenne, Bobigny, France
22CHRU-Nancy, service d'hématologie biologique, pôle laboratoires, University of Lorraine, Nancy, France
23Department of Immunology, Mayo Clinic, Rochester, MN
24Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA
25Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, MA

5:15 PM

Heribert Playa-Albinyana, MSc, BSc1,2,3*, Fabian Arenas, PhD4,5*, Romina Royo6*, Ariadna Giró4,5*, Irene López4,5,7*, Monica Lopez-Guerra, PhD4,5,7*, Sílvia Beà, PhD2,5,7,8*, Elías Campo, PhD MD2,3,7,8, Ferran Nadeu, PhD3,8* and Dolors Colomer, PhD2,3,4,7*

1Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
2University of Barcelona, Barcelona, Spain
3Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain
4Experimental Therapeutics in Lymphoid Malignancies Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
5Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Barcelona, Spain
6Barcelona Supercomputing Center (BSC), Barcelona, Spain
7Hematopathology Section, Pathology Department, Hospital Clinic, Barcelona, Spain
8Molecular Pathology of Lymphoid Neoplasms Group, IDIBAPS, Barcelona, Spain

5:30 PM

Supriya Chakraborty, PhD1*, Giulia Felician, PhD1*, Claudio Martines, MS1*, Alice Bonato, MS1*, Ana Colado, PhD1*, Marija Vujovic, BSci2*, Aleksandar J. Dimovski, MD, PhD2* and Dimitar G Efremov, MD, PhD1

1Molecular Hematology, International Center for Genetic Engineering and Biotechnology, Trieste, Italy
2Research Center for Genetic Engineering and Biotechnology “Georgi D. Efremov”, Macedonian Acadey of Sciences and Arts, Skopje, Macedonia, The former Yugoslav Republic of

5:45 PM

Elisa Ten Hacken, PhD1, Gabriela Brunsting Hoffmann, BS2*, Kayla Cruz3*, Erin Michelle Parry, MD, PhD2, Elizabeth Witten2*, Donna S. Neuberg, ScD4, Gordon J Freeman, PhD5* and Catherine J. Wu, MD3,6,7,8

1Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA
2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
3Harvard Medical School, Boston, MA
4Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
5Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
6Department of Medical Oncology, Dana-Farber Cancer Institute, Inc, Boston, MA
7Broad Institute of MIT and Harvard, Cambridge, MA
8Department of Medicine, Brigham and Women's Hospital, Boston, MA

*signifies non-member of ASH