Valeria Santini, MD, PhD^1*, Uwe Platzbecker, MD², Pierre Fenaux³, Aristoteles Giagounidis, MD⁴, Yasushi Miyazaki, MD⁵, Mikkael A. Sekeres, MD⁶, Zhijian Xiao, MD&PhD^7*, Guillermo Sanz, MD, PhD^8,9, Marlies Van Hoef^10*, Fei Ma^11*, Sabine Hertle^10*, Pedro Marques Ramos, PhD^10* and Amer M. Zeidan, MD¹²

¹University of Florence, Florence, Italy
²University Hospital Leipzig, Leipzig, Germany
³Hôpital Saint-Louis, Paris, France
⁴Marien Hospital, Düsseldorf, Germany
⁵Nagasaki University, Nagasaki, Japan
⁶University of Miami, Miami, FL
⁷Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin, China
⁸CIBERONC, Instituto de Salud Carlos III, Madrid, Spain
⁹Hospital Universitario i Politécnic La Fe, Valencia, Spain
¹⁰Novartis Pharma AG, Basel, Switzerland
¹¹Novartis Pharmaceuticals Corporation, East Hanover, NJ
¹²Department of Internal Medicine, Yale School of Medicine and Yale Cancer Center, New Haven, CT

Yudi Zhang, PhD^1*, Junying Wu^1*, Tiejun Qin^1,2*, Zefeng Xu^1,3*, Shiqiang Qu^1,4*, Lijuan Pan^2,4*, Bing Li^3,4*, Huijun Wang^4,5*, Xin Yan, MD^1*, Jingye Gong^4*, Robert Peter Gale⁶ and Zhijian Xiao, MD&PhD^2,7,8*

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
²MDS and MPN Centre, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
³MDS and MPN Centre, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁴State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁵Hematologic Pathology Centre, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁶Centre for Haematology Research, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom
⁷State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁸Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

Lisa Pleyer, Assoc. Prof., MD, MBI, EMBA^1,2,3*, Marc Vaisband, M.Sc.^1,3,4*, Michael Pfeilstocker, Univ.-Prof., MD, MBA^2,5, Reinhard Stauder, a.o. Univ. Prof., MD, M.Sc.^2,6, Sonja Heibl, MD^2,7*, Heinz Sill, Univ. Prof., MD^2,8*, Michael Girschikofsky, MD^2,9*, Margarete Stampfl-Mattersberger, MD^2,10*, Christoph Tinchon, MD^2,11*, Bernd L. Hartmann, MD^2,12*, Andreas Petzer, Univ. Prof., MD^2,13, Martin Schreder, MD^2,14*, Clemens A. Schmitt, Univ. Prof., MD^2,15,16, Sonia Vallet, MD, PhD^2,17*, Thomas Melchardt, Assoc. Prof., MD, PhD^1,2,3*, Lukas Scagnetti, MD^2,7*, Armin Zebisch, Assoc. Prof., MD^2,8,18*, Sigrid Machherndl-Spandl, MD^2,19*, Dominik Wolf, Univ. Prof., MD^2,20*, Felix Keil, Univ. Prof., MD^2,5*, Jan Hasenauer, Univ. Prof., PhD^4* and Richard Greil, MD^1,3,21

¹Salzburg Cancer Research Institute (SCRI) Center for Clinical Cancer and Immunology Trials (CCCIT), Salzburg, Austria and Cancer Cluster Salzburg (CCS), Salzburg, Austria
²Austrian Group of Medical Tumor Therapy (AGMT) Study Group, Vienna, Austria
³3rd Medical Dept. with Hematology, Medical Oncology, Rheumatology and Infectiology, Paracelsus Medical University, Salzburg, Austria
⁴Life & Medical Sciences Institute, University of Bonn, Bonn, Germany
⁵3rd Medical Department for Haematology and Oncology, Hanusch Hospital, Vienna, Austria
⁶Department of Hematology and Oncology, Comprehensive Cancer Center Innsbruck (CCCI) , Medical University of Innsbruck (MUI), Innsbruck, Austria
⁷4th Medical Dept. of Internal Medicine, Hematology, Internistic Oncology and Palliative Medicine, Klinikum Wels-Grieskirchen GmbH, Wels, Austria
⁸Division of Hematology, Medical University of Graz, Graz, Austria
⁹1st Medical Department, Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz GmbH Elisabethinen, Linz, Austria
¹⁰Department of Internal Medicine 2, Klinik Donaustadt, Vienna, Austria
¹¹Department of Internal Medicine, LKH Hochsteiermark, Leoben, Austria
¹²Department of Internal Medicine II: Oncology, Hematology, Gastroenterology, Infectiology, Feldkirch Academic Teaching Hospital, Rankweil, Austria
¹³Department of Internal Medicine I, Ordensklinikum Linz Barmherzige Schwestern, Linz, Austria
¹⁴1st Department of Internal Medicine, Center for Oncology and Haematology, Wiener Gesundheitsverbund, Klinik Ottakring, Wien, Wien, Austria
¹⁵Department of Internal Medicine 3 – Hematology and Oncology, Kepler University Clinic, Johannes Kepler University, Linz, Austria
¹⁶Charité - University Medical Center, Molecular Cancer Research Center, Berlin, Germany
¹⁷Department of Internal Medicine 2, University Hospital Krems, Karl Landsteiner Private University of Health Sciences, Krems, MA, Austria
¹⁸Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Division of Pharmacology, Medical University of Graz, Graz, Austria
¹⁹Ordensklinikum Linz Elisabethinen, Linz, Austria
²⁰Department for Hematology and Oncology, Comprehensive Cancer Center Innsbruck (CCCI), Medical University of Innsbruck, Innsbruck, Austria
²¹Austrian Group of Medical Tumor Therapy (AGMT) Study Group, Salzburg, Austria

Victoria A. Vardell, MD¹, Douglas J. Peters, MD^1*, Srinivas K. Tantravahi, MBBS² and Ami B. Patel, MD²

¹Department of Internal Medicine, University of Utah, Salt Lake City, UT
²Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT

Ha Nguyen^1*, Koji Sasaki, MD², Farhad Ravandi, MD², Rajyalakshmi Luthra, PhD^3*, Keyur P. Patel, MBBS, PhD³, Sanam Loghavi, MD³, Fatima Zahra Jelloul, MD^3*, Mark Routbort, MD, PhD^4*, Awdesh Kalia^5*, Guillermo Montalban-Bravo, MD², Kelly S. Chien, MD², Peter Hu, PhD^6*, Musa Yilmaz, MD⁷, Carlos E. Bueso-Ramos, MD, PhD⁴, L. Jeffrey Medeiros, MD³, Guillermo Garcia-Manero, MD⁸ and Rashmi Kanagal-Shamanna, MD⁹

¹The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX
⁵MD Anderson Cancer Center, Houston, TX
⁶School of Health Professions, The University of Texas MD Anderson Cancer Center, Houston
⁷Department of Leukemia, MD Anderson Cancer Center, Houston, TX
⁸Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
⁹Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX

Miriam Erlacher, MD, PhD^1,2*, Sebastian Stasik, PhD^3*, Ayami Yoshimi, MD, PhD^4*, Julia-Annabell Georgi, MD^3*, Gudrun Göhring, MD^5*, Martina Rudelius, MD^6*, Irith Baumann, MD^7*, Stephan Schwarz-Furlan, MD^7*, Barbara De Moerloose, MD^8*, Henrik Hasle, MD, PhD⁹, Riccardo Masetti, Prof., MD, PhD^10*, Shlomit Barzilai-Birenboim, MD^11*, Jan Stary, MD^12*, Marcin W. Wlodarski, MD, PhD^4,13, Natalia Rotari, MD^4*, Senthilkumar Ramamoorthy, PhD^4,14*, Dirk Lebrecht, PhD^1*, Peter Noellke, MPH^4*, Brigitte Strahm, MD^15*, Charlotte M. Niemeyer^2,4 and Christian Thiede, MD^3,16

¹Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany
²partner site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
³Department of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany
⁴Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Faculty of Medicine, University of Freiburg, Freiburg, Germany
⁵Department of Human Genetics, Hannover Medical School, Hannover, Germany
⁶Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany
⁷Institute of Pathology Kaufbeuren-Ravensburg, Kaufbeuren, Germany
⁸Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, BEL
⁹Department of Pediatrics, Aarhus University Hospital Skejby, Aarhus, Denmark
¹⁰Pediatric Oncology and Hematology "Lalla Seràgnoli", IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
¹¹Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
¹²Dept. of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
¹³Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
¹⁴Institute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine, University of Freiburg, Freiburg, Germany
¹⁵Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany
¹⁶German Cancer Research Center (DKFZ), Heidelberg, Germany