Hideki Makishima, MD, PhD¹, Ryunosuke Saiki^2*, Yasuhito Nannya, M.D., Ph.D.^2,3, Sophia C. Korotev^4*, Carmelo Gurnari, MD^5,6, June Takeda, MD^1*, Yukihide Momozawa, DVM, Ph.D^7*, Steve Best, PhD^8*, Pramila Krishnamurthy, MD^9*, Tetsuichi Yoshizato, MD, PhD^2,10, Yoshiko Atsuta^11,12*, Yusuke Shiozawa, MD, PhD^13,14*, Yuka Iijima-Yamashita, PhD^15*, Kenichi Yoshida^2,16, Yuichi Shiraishi, PhD^17*, Yasunobu Nagata, MD, PhD^2*, Nobuyuki Kakiuchi, MD, PhD^2*, Makoto Onizuka, MD, PhD¹⁸, Kenichi Chiba, PhD^19*, Hiroko Tanaka, B.A.^20*, Ayana Kon, MD, PhD^2*, Yotaro Ochi, MD, PhD^21*, Masahiro Marshall Nakagawa, MD, PhD², Rurika Okuda, MSc, BS^13*, Takuto Mori, MD^2*, Akinori Yoda, PhD^13*, Hidehiro Itonaga, MD, PhD²², Yasushi Miyazaki, MD²³, Masashi Sanada, MD, PhD¹⁵, Takayuki Ishikawa²⁴, Shigeru Chiba, MD, PhD²⁵, Hisashi Tsurumi, MD, PhD²⁶, Senji Kasahara²⁷, Carsten Müller-Tidow, MD^28*, Akifumi Takaori-Kondo, MD, PhD²⁹, Kazuma Ohyashiki, MD, PhD³⁰, Toru Kiguchi, MD, PhD^31*, Fumihiko Matsuda, MD, PhD^32*, Joop H. Jansen, PhD³³, Chantana Polprasert, MD^34*, Piers Blombery, MBBS³⁵, Yoichiro Kamatani, MD, Ph.D^36*, Satoru Miyano, PhD^20*, Luca Malcovati, MD³⁷, Torsten Haferlach, MD³⁸, Michiaki Kubo, MD, Ph.D^39*, Mario Cazzola, MD⁴⁰, Austin Kulasekararaj, MD, MBBS, FRCPath, MRCP⁴¹, Lucy A. Godley, MD, PhD⁴², Jaroslaw P. Maciejewski, MD, PhD, FACP⁴³ and Seishi Ogawa, MD, PhD^10,13,44

¹Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, KYO, Japan
²Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
³Department of Hematology/Oncology, IMSUT Hospital, The University of Tokyo, Tokyo, Japan
⁴Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL
⁵Department of Biomedicine and Prevention, Ph.D. in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome Tor Vergata, Rome, Italy
⁶Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
⁷Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
⁸King's College Hospital, London, United Kingdom
⁹King's College Hospital NHS Foundation Trust, London, United Kingdom
¹⁰Center for Hematology and Regenerative Medicine, Department of Medicine (MedH), Karolinska Institutet, Huddinge, Sweden
¹¹The Japanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan
¹²Department of Registry Science for Transplant and Cellular Therapy, Aichi Medical University School of Medicine, Nagakute, Japan
¹³Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto City, Japan
¹⁴Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan
¹⁵Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
¹⁶Wellcome Trust Sanger Institute, Hinxton, United Kingdom
¹⁷Laboratory of Sequence Data Analysis, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
¹⁸Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan
¹⁹Center for Cancer Genomics and Advanced Therapeutics, National Cancer Center Research Institute, Tokyo, Japan
²⁰M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan
²¹Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, HYO, Japan
²²Department of Hematology, Nagasaki University Hospital, Nagasaki city, NSK, Japan
²³Department of Hematology, Atomic Bomb Disease Institute, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan
²⁴Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan
²⁵Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
²⁶Hematology, Gifu University Graduate School of Medicine, Gifu, Japan
²⁷Department of Hematology, Gifu Pharmaceutical University, Gifu, Japan
²⁸Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany
²⁹Department of Hematology, Kyoto University, Kyoto, Japan
³⁰Department of Advanced Cellular Therapy, Tokyo Medical University, Tokyo, Japan
³¹Department of Hematology, Chugoku Central Hospital, Fukuyama, HIR, Japan
³²Kyoto University Graduate School of Medicine, Kyoto, JPN
³³Radboud Institute Molecular Studies, Radboud University Medical Center, Nijmegen, Netherlands
³⁴Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand
³⁵Peter MacCallum Cancer Centre, Peter Maccallum Cancer Centre, East Melbourne, VIC, Australia
³⁶Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
³⁷Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Pavia, Italy
³⁸MLL Munich Leukemia Laboratory, Munich, Germany
³⁹Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan
⁴⁰University of Pavia, University of Pavia, Pavia, Italy
⁴¹King’s College Hospital, National Institute for Health and Care Research/Wellcome King’s Clinical Research Facility, London, ENG, United Kingdom
⁴²University of Chicago Medical Center, Chicago, IL
⁴³Translational Hematology and Oncology Research, Cleveland Clinic Foundation/ Taussig Cancer Institute, Cleveland, OH
⁴⁴Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan

Martina Sarchi, MD^1,2*, Courtnee A Clough, Ph.D^1,3, Anna Gallì, PhD^4*, Gabriele Todisco, MD^2*, J. Philip Creamer, PhD^1*, Luca Malcovati, MD^2,4 and Sergei Doulatov, PhD^1,5,6

¹Division of Hematology, University of Washington, Seattle, WA
²Department of Molecular Medicine, University of Pavia, Pavia, Italy
³Molecular and Cellular Biology Program, University of Washington, Seattle, WA
⁴Department of Hematology Oncology, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy
⁵Department of Genome Sciences, University of Washington, Seattle, WA
⁶Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA

Kristian Gurashi^1*, Yu-Hung Wang, MD^1,2*, Tim C.P Somervaille, PhD FRCP FRCPath^3,4, Kiran Batta, PhD^1* and Daniel H Wiseman, PhD, MB, ChB, MRCP, FRCPath^1,5*

¹Division of Cancer Sciences, The University of Manchester, Manchester, United Kingdom
²Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
³Haematology Department, The Christie Hospital NHS Foundation Trust, Manchester, United Kingdom
⁴Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United Kingdom
⁵Haematology, The Christie Hospital NHS Foundation Trust, Manchester, United Kingdom

David Rombaut^1,2,3*, Carine Lefevre, PhD^1,4*, Batoul Farhat, PhD^1,2*, Sabrina Bondu, PharmD, PhD^1*, Anne Letessier, PhD^1*, Auriane Lesieur-Pasquier, PharmD^1,2*, Daisy Castillo-Guzman, PhD^5*, Marjorie Leduc, PhD^6*, Emilie-Fleur Gautier, PhD^6*, Virginie Chesnais, PhD^1*, Alice Rousseau^1*, Ismael Boussaid, PharmD, PhD^1,2*, Sarah Battault^1,2*, Alexandre Houy^7*, Didier Bouscary, MD, PhD^1,8*, Lise Willems, MD, PhD^1,8*, Nicolas Chapuis, PharmD, PhD^1,9*, Sophie Park, MD, PhD¹⁰, Sophie Raynaud, MD, PhD^11*, Thomas Cluzeau, MD, PhD¹², Emmanuelle Clappier, PharmD, PhD^13*, Pierre Fenaux¹⁴, Lionel Ades¹⁵, Eric Solary, MD PhD¹⁶, Raphael Margueron, PhD^17*, Michel Wassef, PhD^17*, Olivier Kosmider, MD, PhD^1,9*, Samar Alsafadi, PhD^7*, Nathalie Droin, PhD^18*, Angelos Constantinou, PhD^19*, Marc-Henri Stern, MD, PhD^7*, Benoit Miotto, PhD^1*, Frederic Chedin, PhD^5* and Michaela Fontenay, MD, PhD^1,2,3,9

¹Université Paris Cité, CNRS, INSERM U1016, Institut Cochin, Paris, France
²Equipe Labellisée Fondation pour la Recherche Médicale, Paris, France
³Laboratoire d'Excellence du Globule Rouge, GR-Ex, Paris, France
⁴Laboratoire d'excellence du Globule Rouge, GR-Ex, Université Paris Cité, Paris, France
⁵Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, CA
⁶Platform Proteom'IC, Université Paris Cité, CNRS, INSERM U1016, Institut Cochin, Paris, France
⁷Institut Curie, PSL Research University, Sorbonne University, INSERM U830, DNA repair and uveal melanoma, Equipe labellisée par la Ligue Nationale contre le Cancer, Paris, France
⁸Assistance Publique-Hôpitaux de Paris.Centre-Université Paris Cité, Hôpital Cochin, Department of Hematology, Paris, France
⁹Assistance Publique-Hôpitaux de Paris.Centre-Université Paris Cité, Hôpital Cochin, Laboratory of Hematology, Paris, France
¹⁰Department of Clinical Hematology, Centre Hospitalo-Universitaire Grenoble Alpes, Grenoble, France
¹¹Université Côte d'Azur, Centre Hospitalier Universitaire, Laboratory of Hematology, Nice, France
¹²Département d'Hématologie Clinique, Université Côte d'Azur, CHU Nice, Nice, Provence Alpes Cote d'Azur, France
¹³Hematology Laboratory, AP-HP, Hôpital Saint-Louis, Paris, France
¹⁴Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France
¹⁵Department of Hematology, Université de Paris, Saint-Louis Hospital, Paris, France
¹⁶Université Paris-Saclay, INSERM U1287, Gustave Roussy Cancer Campus, Villejuif, France
¹⁷Institut Curie, Paris Sciences Lettres Research University, Sorbonne University, INSERM U934, UMR3215, Paris, France
¹⁸Université Paris Saclay, INSERM U1287, Gustave Roussy Cancer Campus, Villejuif, France
¹⁹Institut de Génétique Humaine, Centre National de la Recherche Scientifique, Université de Montpellier, Montpellier, France

Sayantani Sinha, PhD¹, Zhiyan Silvia Liu^2*, Maxwell Bannister^2*, Erica Arriaga-Gomez^1*, Axia Song^1*, Dawei Zong^2*, Martina Sarchi, MD^3,4,5*, Elizabeth Bonner^1*, Victor Corral^2*, Cassandra Leibson^2*, Wannasiri Chiraphapphaiboon^2*, Derek Stirewalt⁶, Joachim Deeg, MD^7,8*, Sumit Rai, PhD^9*, Matthew J Walter, MD¹⁰, Timothy A. Graubert, MD¹¹, Sergei Doulatov, PhD^12,13,14,15, Dang Hai Nguyen, PhD^16,17 and Stanley C Lee, PhD¹

¹Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA
²Department of Pharmacology, University of Minnesota, Minneapolis, MN
³Division of Hematology, University of Washington, Seattle, WA
⁴Department of Molecular Medicine, University of Pavia, Pavia, ITA
⁵Department of Molecular Medicine, University of Pavia, Pavia, Italy
⁶Fred Hutchinson Cancer Center, Seattle
⁷Fred Hutchinson Cancer Center, Seattle, WA
⁸Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, WA
⁹Massachusetts General Hospital Cancer Center, Boston, MA
¹⁰Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO
¹¹Massachusetts General Hospital Cancer Center, Charlestown, MA
¹²Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA
¹³University of Washington School of Medicine, Seattle, WA, USA, Seattle
¹⁴Department of Genome Sciences, University of Washington, Seattle, WA
¹⁵Division of Hematology, University of Washington School of Medicine, Seattle, WA
¹⁶Department of Pharmacology, Molecular and Cellular Biology Bldg, Minneapolis, MN
¹⁷Masonic Cancer Center, University of Minnesota, Minneapolis, MN

Peter Truong^1*, Sylvie Shen, MD, PhD^2*, Swapna Joshi, MSc^1*, Ali Afrasiabi, MSc^3*, Ling Zhong, PhD^4*, Mark J. Raftery, PhD^4*, Jonas Larsson, MD, PhD⁵, Richard B. Lock, PhD^6,7,8*, Carl R. Walkley, PhD^9,10*, Hamid Alinejad Rokny, PhD^3,11,12*, Julie A.I. Thoms^13*, Christopher J. Jolly, PhD^2* and John E. Pimanda, MBBS, FRACP, FRCPA, PhD^1,2,14

¹School of Clinical Medicine, University of New South Wales, Sydney, Australia
²School of Medical Sciences, University of New South Wales, Sydney, Australia
³BioMedical Machine Learning Lab, Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia
⁴Bioanalytical Mass Spectrometry Facility, University of New South Wales, Sydney, Australia
⁵Division of Molecular Medicine and Gene Therapy, Lund Stem Cell Centre, Lund University, Lund, Sweden
⁶School of Women’s and Children’s Health, University of New South Wales, Sydney, Australia
⁷Children’s Cancer Institute, University of New South Wales, Sydney, Australia
⁸University of New South Wales Centre for Childhood Cancer Research, University of New South Wales, Sydney, Australia
⁹St. Vincent's Institute, University of Melbourne, Melbourne, Australia
¹⁰Department of Medicine, University of Melbourne, Melbourne, Australia
¹¹UNSW Data Science Hub, University of New South Wales, Sydney, Australia
¹²Health Data Analytics Program, AI-Enabled Processes Research Centre, Macquarie University, Sydney, Australia
¹³School of Medical Sciences, University of New South Wales, Randwick, Australia
¹⁴Haematology Department, Prince of Wales Hospital, Sydney, Australia