-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

634.O2.6 634. Myeloproliferative Syndromes: Clinical and Epidemiological: Novel Therapies and Surrogate Endpoints in ET and PV

Symposia: Myeloproliferative Syndromes: Clinical and Epidemiological Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, clinical trials, Biological therapies, adult, Translational Research, Non-Biological therapies, MPN, epidemiology, elderly, Clinical Research, Chemotherapy, health outcomes research, drug development, Chronic Myeloid Malignancies, patient-reported outcomes, Diseases, Therapies, Immunotherapy, Adverse Events, young adult , Myeloid Malignancies, Pharmacology, Study Population, Human
Monday, December 12, 2022: 10:30 AM-12:00 PM
217-219 (Ernest N. Morial Convention Center)
Moderators:
Mary Frances McMullin, MD, FRCPath, FRCP, Queen's University, Belfast and Jean-Jacques Kiladjian, MD, Hopital Saint-Louis
Disclosures:
McMullin: Novartis: Consultancy, Speakers Bureau; BMS: Consultancy, Research Funding; AOP: Research Funding, Speakers Bureau; CTI: Consultancy; Sierra Oncology: Consultancy; Incyte: Consultancy, Speakers Bureau; Abbvie: Consultancy, Speakers Bureau; Pfizer: Speakers Bureau. Kiladjian: Novartis: Membership on an entity's Board of Directors or advisory committees; Incyte: Membership on an entity's Board of Directors or advisory committees; AbbVie: Membership on an entity's Board of Directors or advisory committees; BMS: Membership on an entity's Board of Directors or advisory committees; AOP Orphan: Membership on an entity's Board of Directors or advisory committees.
In this session results of clinical trials and translational research in ET and PV is presented including some provocative data for correlating outcomes of patients with change in JAK2 V617F allele burden
10:30 AM

Claire N. Harrison, DM1, Jyoti Nangalia, MBBChir2,3,4, Rebecca H. Boucher, BSc, MSc, PhD5*, Aimee Jackson, BSc, MSc5*, Christina Yap, BSc, MSc, PhD5,6*, Jennifer O'Sullivan, MB BCh7,8*, Sonia Fox, BSc9*, Isaak Ailts, MD10*, Amylou C Dueck, PhD11, Holly L. Geyer, MD10*, Ruben Mesa, MD, FACP12, William Dunn, MB Ch.B4*, Eugene Nadezhdin, PhD3*, Natalia Curto-Garcia, MD13*, Anna Green, MD14*, Bridget Wilkins, MD, PhD15*, Jason Coppell, MBBS16*, John Laurie, MB ChB17*, Mamta Garg, MD, FRCP, FRCPath18*, Joanne Ewing, MD, PhD19*, Steve Knapper, BMBCh20, Josephine Crowe, MBBS21*, Ioannis Koutsavlis, MB22*, Anna L Godfrey, BMBCh, PhD23*, Siamak Arami, MD, MRCP, FRCPath24*, Mark W. Drummond, PhD, FRCPath25*, Jennifer Byrne, PhD, FRCPath26*, Fiona J Clark, FRCP, FRCPath27*, Carolyn Mead-Harvey, MS11*, Joanna E Baxter, PhD28*, Mary Frances McMullin, MD, FRCPath, FRCP29 and Adam J Mead, MD PhD8,30

1Dept. of Haematology, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom
2Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
3Wellcome Sanger Institute Hinxton, Cambridgeshire, United Kingdom
4Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom
5Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom
6Clinical Trials and Statistics Unit, The Institute of Cancer Research, London, United Kingdom
7Guy's and St Thomas NHS Foundation Trust, London, United Kingdom
8Medical Research Council Weatherall Institute of Molecular Medicine and NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
9Cancer Research UK, Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom
10Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ
11Department of Quantitative Health Sciences, Mayo Clinic, Scottsdale, AZ
12Mays Cancer Center at UT Health San Antonio, San Antonio, TX
13Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom
14Department of Histopathology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
15Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
16Royal Devon and Exeter Hospital, Exeter, Exeter, United Kingdom
17Worthing Hospital, Worthing, United Kingdom
18University Hospital of Leicester, Leicester, United Kingdom
19University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
20Cardiff University School of Medicine, Cardiff, United Kingdom
21Royal United Hospital, Bath, United Kingdom
22Lothian Health Board, Western General Hospital, Edinburgh, United Kingdom
23Department of Clinical Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom
24London North West University Healthcare NHS Trust, Harrow, GBR
25The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom
26Centre for Clinical Haematology, Nottingham University Hospitals NHS Trust, Nottingham, ENG, United Kingdom
27Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
28Haematology, Cambridge Blood and Stem Cell Biobank NHS-BT Cambridge Centre, Cambridge, United Kingdom
29Centre for Medical Education, Queen's University, Belfast, United Kingdom
30Cancer and Haematology Centre, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom

10:45 AM

Harinder Gill, MD, MBBS, FRCP, FRCPath1, Francesca Palandri, PhD, MD2*, David M Ross, MBBS, PhD, FRACP, FRCPA3*, Tara Cochrane, MBBS4, Courtney Tate, PhD, MBBS, BSc, FRACP, FRCPA5*, Steven W Lane, MD, PhD6, Stephen R Larsen, MBBS PhD FRACP FRCPA7, Aaron T. Gerds, MD, MS8, Anna B. Halpern, MD9, Jake Shortt, FRACP, FRCPA, PhD10, James M. Rossetti, DO11, Kristen M. Pettit12, James Liang, MCBhB, FRACP, FRCPA13*, Adam J Mead, MD PhD14, Monia Marchetti15*, Alessandro M. Vannucchi16, Andrew J Wilson17*, Joachim R Göthert, MD18, Merit Hanna, MBChB FRCPA19*, Francesco Passamonti, MD20*, William S Stevenson, MBBS, PhD, FRACP, FRCPA21, Claire N. Harrison, DM22, Moshe Talpaz, MD23, Nicola Vianelli, MD24* and Hugh Young Rienhoff Jr., MD25

1Department of Medicine, The University of Hong Kong, Hong Kong, Hong Kong
2IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy
3Department of Haematology, Flinders Medical Centre and University, Adelaide, SA, Australia
4Gold Coast University Hospital, Griffith University, Varsity Lakes, QLD, Australia
5Department of Haematology, Gold Coast University Hospital, Southport, Australia
6Cancer Program, Queensland Institute of Medical Research, Brisbane, Australia
7University of Sydney, Sydney, NSW, Australia
8Department of Hematology and Medical Oncology,, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
9Department of Medicine, University of Washington, Seattle, WA
10School of Clinical Sciences at Monash Health, Peter MacCallum Cancer Centre, Clayton, VIC, Australia
11UPMC Hillman Cancer Center, Pittsburgh, PA
12Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI
13Middlemore Hospital, Auckland, New Zealand
14Medical Research Council Weatherall Institute of Molecular Medicine and NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
15Division of Hematology, Hospital Antonio e Biagio and Cesare Arrigo, Alessandria, Italy
16CRIMM, Center of Research and Innovation of Myeloproliferative Neoplasms, University of Florence, Firenze, Italy
17University College London Hospitals NHS Foundation Trust, London, United Kingdom
18Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
19Department of Haematology, Waitemata District Health Board, Auckland, New Zealand
20Hematology, Università Degli Studi Dell'Insubria, Varese, VA, Italy
21Department of Haematology, Royal North Shore Hospital, Sydney, NSW, Australia
22Guy's and St Thomas' NHS Foundation Trust, London, ENG, United Kingdom
23University of Michigan Comprehensive Cancer Center, Ann Arbor, MI
24Department of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology L. e A. Seragnoli, Hematology, Bologna, Italy
25Imago BioSciences, San Carlos, CA

11:00 AM

Paola Guglielmelli, MD, PhD1, Barbara Mora2*, Francesca Gesullo, BSci3*, Francesco Mannelli, MD3*, Giuseppe Gaetano Loscocco, MD3*, Leonardo Signori, PhD3*, Chiara Pessina, PhD4*, Fabiana Pancani, PhD3*, Ilaria Colugnat, PhD4*, Raffaela Aquila, BiSc student5*, Elena Nacca, PhD6*, Paolo Cicogna, MD3*, Francesco Passamonti, MD7* and Alessandro Vannucchi, MD3

1CRIMM, Center of Research and Innovation of Myeloproliferative Neoplasms, University of Florence, AOU Careggi, Florence, Italy
2University of Sette Laghi, VARESE, AL, ITA
3CRIMM, Center Research and Innovation of Myeloproliferative Neoplasms, University of Florence, AOU Careggi, Florence, Italy
4Ospedale di Circolo, ASST Sette Laghi, Lab.Cytogenetics and Molec Biol, Varese, Italy
5University of Florence, Florence, Italy
6CRIMM, Center Research and Innovation of Myeloproliferative Neoplasms, AOU Careggi, Florence, Italy
7Division of Hematology, University Hospital Ospedale di Circolo e Fondazione Macchi - ASST Sette Laghi, University of Insubria, Varese, VA, Italy

11:15 AM

Steffen Koschmieder1,2,3, Susanne Isfort1,2,3*, Florian H. Heidel4,5*, Andreas Hochhaus5, Heiko Becker6, Philipp J. Jost7*, Philippe Schafhausen, MD8*, Martin Griesshammer9*, Denise Wolleschak10*, Mathias Haenel, MD11*, Joachim R Göthert, MD12, Lino L. Teichmann, MD13,14*, Katja Sockel, MD15*, Markus P. Radsak, MD16*, Andreas Reiter, MD17, Konstanze Döhner, MD18, Sebastian Balleisen19*, Nadja Jaekel20*, Nikolas von Bubnoff21*, Frank Stegelmann, MD18, Deniz Gezer1,2*, Maike Kortmann2,22*, Julia Frank23*, Martin Hellmich23* and Tim H. Brümmendorf, MD1,2

1Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany
2Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany
3Shared first authorship, Aachen, Germany
4Hematology, Oncology, Stem Cell Transplantation and Palliative Care, Internal Medicine C, University Medicine Greifswald, Greifswald, Germany
5Department of Hematology and Oncology, Jena University Hospital, Jena, Germany
6Department of Hematology, Oncology, and Stem-Cell Transplantation, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany
7Medical Department III, Hematology and Oncology, and Center for Translational Cancer Research, Translatum, Technical University of Munich, Munich, Germany
8University Medical Center of Hamburg-Eppendorf, Hamburg, Germany
9University Clinic for Hematology, Oncology, Haemostaseology and Palliative Care, Johannes Wesling Medical Center, Minden, University of Bochum, Minden, Germany
10Department of Hematology/Oncology, Otto-von-Guericke University Medical Center Magdeburg, Magdeburg, Germany
11Department of Internal Medicine III, Chemnitz Hospital, Chemnitz, Germany
12Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
13Department of Medicine III, University Hospital Bonn, Bonn, Germany
14Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen Bonn Cologne Düsseldorf, Germany
15Department of Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany
16Department of Internal Medicine III, University Medical Center, Johannes Gutenberg-University of Mainz, Mainz, Germany
17Department of Hematology and Oncology, University Medical Centre Mannheim, Mannheim, Germany
18Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
19Department for Hematology and Medical Oncology and Palliative Medicine, Sana-Kliniken Duisburg, Duisburg, Germany
20University Clinic and Outpatient Clinic for Internal Medicine IV, University Hospital Halle (Saale), Halle/ Saale, Germany
21Department of Hematology and Oncology, University Hospital Schleswig-Holstein, Luebeck, Germany
22Center for Translational & Clinical Research (CTC-A), RWTH Aachen University, Faculty of Medicine, Aachen, Germany
23Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany

11:30 AM

Trine A. Knudsen, MD1*, Dennis Lund Hansen, MD, PhD2*, Lukas Frans Ocias, MD, PhD2*, Ole Weis Bjerrum, MD, DMSc3*, Mette Brabrand, MD2*, Sarah F. Christensen, PhD1*, Christina Schjellerup S. Eickhardt-Dalbøge, MD1*, Christina Ellervik, PhD4,5,6,7,8*, Daniel El Fassi, MD3,9*, Mikael Frederiksen, MD10*, Lasse Kjær, PhD1*, Thomas Kielsgaard Kristensen11*, Torben A. Kruse12*, Morten Kranker Larsen, MSc1*, Torben Mourits-Andersen, MD13*, Ulrik Malthe Overgaard, MD3*, Marianne Tang Severinsen, MD, PhD14*, Vibe Skov, PhD1*, Anders Lindholm Sørensen, MD1*, Jesper Stentoft, MD, PhD15*, Jørn Starklint, MD16*, Karin de Stricker, MD11*, Mads Thomassen, PhD12*, Thomas S. Larsen, MD, PhD2* and Hans Carl Hasselbalch, MD1,9

1Department of Hematology, Zealand University Hospital, Roskilde, Denmark
2Department of Hematology, Odense University Hospital, Odense, Denmark
3Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
4Department of Data and Data Support, Region Zealand, Sorø, Denmark
5Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
6Department of Production, Research, and Innovation, Region Zealand, Sorø, Denmark
7Department of Laboratory Medicine, Boston Children's Hospital, Boston, MA
8Department of Pathology, Harvard Medical School, Boston, MA
9Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
10Department of Hematology, Hospital of Southern Jutland, Aabenraa, Denmark
11Department of Pathology, Odense University Hospital, Odense, Denmark
12Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
13Department of Hematology, Hospital of South West Jutland, Esbjerg, Denmark
14Department of Hematology, Aalborg University Hospital, Aalborg, Denmark
15Department of Hematology, Aarhus University Hospital, Aarhus, Denmark
16Department of Hematology, Hospital of West Jutland, Holstebro, Denmark

11:45 AM

Tiziano Barbui, MD1*, Alessandro M. Vannucchi, MD2*, Valerio De Stefano, MD3*, Arianna Masciulli, PhD1*, Alessandra Carobbio, MSc1*, Arianna Ghirardi, PhD1*, Greta Carioli, PhD1*, Elena Rossi, MD, PhD3*, Fabio Ciceri, MD4*, Massimiliano Bonifacio, MD5*, Alessandra Iurlo, MD, PhD6*, Francesca Palandri, PhD, MD7*, Giulia Benevolo, MD8*, Fabrizio Pane, MD9,10, Alessandra Ricco, MD11*, Giuseppe Carli, MD12*, Marianna Caramella, MD13*, Davide Rapezzi, MD14*, Caterina Musolino, MD15*, Sergio Siragusa, MD16, Elisa Rumi, MD17,18*, Andrea Patriarca, MD19*, Nicola Cascavilla, MD20, Barbara Mora, MD21*, Emma Cacciola, MD22, Carmela Mannarelli, PhD23*, Giuseppe Gaetano Loscocco, MD2*, Paola Guglielmelli, MD, PhD2, Francesca Gesullo, BSci24*, Silvia Betti, MD, PhD3*, Francesca Lunghi, MD25*, Luigi Scaffidi, MD5*, Cristina Bucelli, MD26*, Nicola Vianelli, MD27*, Marta Bellini, MD28*, Maria Chiara Finazzi29,30*, Giovanni Tognoni, MD31* and Alessandro Rambaldi, MD28,29

1FROM Research Foundation Ospedale di Bergamo, Bergamo, Italy
2CRIMM, Center for Research and Innovation of Myeloproliferative Neoplasms, AOU Careggi, University of Florence, Florence, Italy
3Section of Hematology, Department of Radiological and Hematological Sciences, Catholic University, Fondazione Policlinico A Gemelli, IRCCS, Rome, Italy
4Università Vita-Salute San Raffaele and Istituto di Ricovero e Cura a Carattere Scientifico Ospedale San Raffaele, Department of Onco-Hematology, Milano, Italy
5Department of Medicine, Section of Hematology, University of Verona and Azienda Ospedaliera Universitaria Integrata, Verona, Italy
6Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
7IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy
8Hematology Division , Città della Salute e della Scienza Hospital, TORINO, TO, Italy
9Azienda Ospedaliera Universitaria Federico II, Naples, Italy
10Università degli Studi di Napoli, Federico II, Italy
11Hematology and Stem Cell Transplantation Unit, AOUC Policlinico, Bari, Italy
12Hematology Department, Ospedale San Bortolo, Vicenza, Italy
13Department of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy
14S.C. Ematologia, ASO S. Croce e Carle, Cuneo, Italy
15Divisione di Ematologia - Policlinico Universitario, Messina, Italy
16Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PRO.MI.SE), University of Palermo, Palermo, Italy
17Department of Molecular Medicine, University of Pavia, Pavia, Italy
18Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
19Azienda Ospedaliero Universitaria Maggiore della Carità di Novara SCDU Ematologia, Novara, Italy
20Division of Hematology, IRCCS Casa Sollievo Della Sofferenza Hospital, San Giovanni Rotondo, Italy
21Hematology, University Hospital "Ospedale di Circolo e Fondazione Macchi" - ASST Sette Laghi, University of Insubria, Varese, Italy
22Hemostasis/Hematology Unit, Department of Medical, Surgical and Advance Technologies Sciences "G..F. Ingrassia", University of Catania, Catania, Italy
23CRIMM, Center of Research and Innovation of Myeloproliferative Neoplasms, University of Florence, AOU Careggi, Florence, Italy;, Florence, Italy
24CRIMM, Center Research and Innovation of Myeloproliferative Neoplasms, University of Florence, AOU Careggi, Florence, Italy;, Florence, Italy
25Department of Onco-Haematology - Haematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute and Vita-Salute Hospital, Milano, Italy
26Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy
27IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy
28Department of Oncology-Hematology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy
29Department of Oncology and Hematology, University of Milan, Milan, Italy
30Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Italy
31Istituto di Ricerche Farmacologiche "Mario Negri", IRCCS, Milano, Italy

*signifies non-member of ASH