Claire N. Harrison, DM¹, Jyoti Nangalia, MBBChir^2,3,4, Rebecca H. Boucher, BSc, MSc, PhD^5*, Aimee Jackson, BSc, MSc^5*, Christina Yap, BSc, MSc, PhD^5,6*, Jennifer O'Sullivan, MB BCh^7,8*, Sonia Fox, BSc^9*, Isaak Ailts, MD^10*, Amylou C Dueck, PhD¹¹, Holly L. Geyer, MD^10*, Ruben Mesa, MD, FACP¹², William Dunn, MB Ch.B^4*, Eugene Nadezhdin, PhD^3*, Natalia Curto-Garcia, MD^13*, Anna Green, MD^14*, Bridget Wilkins, MD, PhD^15*, Jason Coppell, MBBS^16*, John Laurie, MB ChB^17*, Mamta Garg, MD, FRCP, FRCPath^18*, Joanne Ewing, MD, PhD^19*, Steve Knapper, BMBCh²⁰, Josephine Crowe, MBBS^21*, Ioannis Koutsavlis, MB^22*, Anna L Godfrey, BMBCh, PhD^23*, Siamak Arami, MD, MRCP, FRCPath^24*, Mark W. Drummond, PhD, FRCPath^25*, Jennifer Byrne, PhD, FRCPath^26*, Fiona J Clark, FRCP, FRCPath^27*, Carolyn Mead-Harvey, MS^11*, Joanna E Baxter, PhD^28*, Mary Frances McMullin, MD, FRCPath, FRCP²⁹ and Adam J Mead, MD PhD^8,30

¹Dept. of Haematology, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom
²Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
³Wellcome Sanger Institute Hinxton, Cambridgeshire, United Kingdom
⁴Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom
⁵Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom
⁶Clinical Trials and Statistics Unit, The Institute of Cancer Research, London, United Kingdom
⁷Guy's and St Thomas NHS Foundation Trust, London, United Kingdom
⁸Medical Research Council Weatherall Institute of Molecular Medicine and NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
⁹Cancer Research UK, Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom
¹⁰Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ
¹¹Department of Quantitative Health Sciences, Mayo Clinic, Scottsdale, AZ
¹²Mays Cancer Center at UT Health San Antonio, San Antonio, TX
¹³Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom
¹⁴Department of Histopathology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
¹⁵Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
¹⁶Royal Devon and Exeter Hospital, Exeter, Exeter, United Kingdom
¹⁷Worthing Hospital, Worthing, United Kingdom
¹⁸University Hospital of Leicester, Leicester, United Kingdom
¹⁹University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
²⁰Cardiff University School of Medicine, Cardiff, United Kingdom
²¹Royal United Hospital, Bath, United Kingdom
²²Lothian Health Board, Western General Hospital, Edinburgh, United Kingdom
²³Department of Clinical Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom
²⁴London North West University Healthcare NHS Trust, Harrow, GBR
²⁵The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom
²⁶Centre for Clinical Haematology, Nottingham University Hospitals NHS Trust, Nottingham, ENG, United Kingdom
²⁷Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
²⁸Haematology, Cambridge Blood and Stem Cell Biobank NHS-BT Cambridge Centre, Cambridge, United Kingdom
²⁹Centre for Medical Education, Queen's University, Belfast, United Kingdom
³⁰Cancer and Haematology Centre, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom

Harinder Gill, MD, MBBS, FRCP, FRCPath¹, Francesca Palandri, PhD, MD^2*, David M Ross, MBBS, PhD, FRACP, FRCPA^3*, Tara Cochrane, MBBS⁴, Courtney Tate, PhD, MBBS, BSc, FRACP, FRCPA^5*, Steven W Lane, MD, PhD⁶, Stephen R Larsen, MBBS PhD FRACP FRCPA⁷, Aaron T. Gerds, MD, MS⁸, Anna B. Halpern, MD⁹, Jake Shortt, FRACP, FRCPA, PhD¹⁰, James M. Rossetti, DO¹¹, Kristen M. Pettit¹², James Liang, MCBhB, FRACP, FRCPA^13*, Adam J Mead, MD PhD¹⁴, Monia Marchetti^15*, Alessandro M. Vannucchi¹⁶, Andrew J Wilson^17*, Joachim R Göthert, MD¹⁸, Merit Hanna, MBChB FRCPA^19*, Francesco Passamonti, MD^20*, William S Stevenson, MBBS, PhD, FRACP, FRCPA²¹, Claire N. Harrison, DM²², Moshe Talpaz, MD²³, Nicola Vianelli, MD^24* and Hugh Young Rienhoff Jr., MD²⁵

¹Department of Medicine, The University of Hong Kong, Hong Kong, Hong Kong
²IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy
³Department of Haematology, Flinders Medical Centre and University, Adelaide, SA, Australia
⁴Gold Coast University Hospital, Griffith University, Varsity Lakes, QLD, Australia
⁵Department of Haematology, Gold Coast University Hospital, Southport, Australia
⁶Cancer Program, Queensland Institute of Medical Research, Brisbane, Australia
⁷University of Sydney, Sydney, NSW, Australia
⁸Department of Hematology and Medical Oncology,, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
⁹Department of Medicine, University of Washington, Seattle, WA
¹⁰School of Clinical Sciences at Monash Health, Peter MacCallum Cancer Centre, Clayton, VIC, Australia
¹¹UPMC Hillman Cancer Center, Pittsburgh, PA
¹²Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI
¹³Middlemore Hospital, Auckland, New Zealand
¹⁴Medical Research Council Weatherall Institute of Molecular Medicine and NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
¹⁵Division of Hematology, Hospital Antonio e Biagio and Cesare Arrigo, Alessandria, Italy
¹⁶CRIMM, Center of Research and Innovation of Myeloproliferative Neoplasms, University of Florence, Firenze, Italy
¹⁷University College London Hospitals NHS Foundation Trust, London, United Kingdom
¹⁸Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
¹⁹Department of Haematology, Waitemata District Health Board, Auckland, New Zealand
²⁰Hematology, Università Degli Studi Dell'Insubria, Varese, VA, Italy
²¹Department of Haematology, Royal North Shore Hospital, Sydney, NSW, Australia
²²Guy's and St Thomas' NHS Foundation Trust, London, ENG, United Kingdom
²³University of Michigan Comprehensive Cancer Center, Ann Arbor, MI
²⁴Department of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology L. e A. Seragnoli, Hematology, Bologna, Italy
²⁵Imago BioSciences, San Carlos, CA

Paola Guglielmelli, MD, PhD¹, Barbara Mora^2*, Francesca Gesullo, BSci^3*, Francesco Mannelli, MD^3*, Giuseppe Gaetano Loscocco, MD^3*, Leonardo Signori, PhD^3*, Chiara Pessina, PhD^4*, Fabiana Pancani, PhD^3*, Ilaria Colugnat, PhD^4*, Raffaela Aquila, BiSc student^5*, Elena Nacca, PhD^6*, Paolo Cicogna, MD^3*, Francesco Passamonti, MD^7* and Alessandro Vannucchi, MD³

¹CRIMM, Center of Research and Innovation of Myeloproliferative Neoplasms, University of Florence, AOU Careggi, Florence, Italy
²University of Sette Laghi, VARESE, AL, ITA
³CRIMM, Center Research and Innovation of Myeloproliferative Neoplasms, University of Florence, AOU Careggi, Florence, Italy
⁴Ospedale di Circolo, ASST Sette Laghi, Lab.Cytogenetics and Molec Biol, Varese, Italy
⁵University of Florence, Florence, Italy
⁶CRIMM, Center Research and Innovation of Myeloproliferative Neoplasms, AOU Careggi, Florence, Italy
⁷Division of Hematology, University Hospital Ospedale di Circolo e Fondazione Macchi - ASST Sette Laghi, University of Insubria, Varese, VA, Italy

Steffen Koschmieder^1,2,3, Susanne Isfort^1,2,3*, Florian H. Heidel^4,5*, Andreas Hochhaus⁵, Heiko Becker⁶, Philipp J. Jost^7*, Philippe Schafhausen, MD^8*, Martin Griesshammer^9*, Denise Wolleschak^10*, Mathias Haenel, MD^11*, Joachim R Göthert, MD¹², Lino L. Teichmann, MD^13,14*, Katja Sockel, MD^15*, Markus P. Radsak, MD^16*, Andreas Reiter, MD¹⁷, Konstanze Döhner, MD¹⁸, Sebastian Balleisen^19*, Nadja Jaekel^20*, Nikolas von Bubnoff^21*, Frank Stegelmann, MD¹⁸, Deniz Gezer^1,2*, Maike Kortmann^2,22*, Julia Frank^23*, Martin Hellmich^23* and Tim H. Brümmendorf, MD^1,2

¹Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany
²Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany
³Shared first authorship, Aachen, Germany
⁴Hematology, Oncology, Stem Cell Transplantation and Palliative Care, Internal Medicine C, University Medicine Greifswald, Greifswald, Germany
⁵Department of Hematology and Oncology, Jena University Hospital, Jena, Germany
⁶Department of Hematology, Oncology, and Stem-Cell Transplantation, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany
⁷Medical Department III, Hematology and Oncology, and Center for Translational Cancer Research, Translatum, Technical University of Munich, Munich, Germany
⁸University Medical Center of Hamburg-Eppendorf, Hamburg, Germany
⁹University Clinic for Hematology, Oncology, Haemostaseology and Palliative Care, Johannes Wesling Medical Center, Minden, University of Bochum, Minden, Germany
¹⁰Department of Hematology/Oncology, Otto-von-Guericke University Medical Center Magdeburg, Magdeburg, Germany
¹¹Department of Internal Medicine III, Chemnitz Hospital, Chemnitz, Germany
¹²Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
¹³Department of Medicine III, University Hospital Bonn, Bonn, Germany
¹⁴Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen Bonn Cologne Düsseldorf, Germany
¹⁵Department of Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany
¹⁶Department of Internal Medicine III, University Medical Center, Johannes Gutenberg-University of Mainz, Mainz, Germany
¹⁷Department of Hematology and Oncology, University Medical Centre Mannheim, Mannheim, Germany
¹⁸Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
¹⁹Department for Hematology and Medical Oncology and Palliative Medicine, Sana-Kliniken Duisburg, Duisburg, Germany
²⁰University Clinic and Outpatient Clinic for Internal Medicine IV, University Hospital Halle (Saale), Halle/ Saale, Germany
²¹Department of Hematology and Oncology, University Hospital Schleswig-Holstein, Luebeck, Germany
²²Center for Translational & Clinical Research (CTC-A), RWTH Aachen University, Faculty of Medicine, Aachen, Germany
²³Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany

Trine A. Knudsen, MD^1*, Dennis Lund Hansen, MD, PhD^2*, Lukas Frans Ocias, MD, PhD^2*, Ole Weis Bjerrum, MD, DMSc^3*, Mette Brabrand, MD^2*, Sarah F. Christensen, PhD^1*, Christina Schjellerup S. Eickhardt-Dalbøge, MD^1*, Christina Ellervik, PhD^4,5,6,7,8*, Daniel El Fassi, MD^3,9*, Mikael Frederiksen, MD^10*, Lasse Kjær, PhD^1*, Thomas Kielsgaard Kristensen^11*, Torben A. Kruse^12*, Morten Kranker Larsen, MSc^1*, Torben Mourits-Andersen, MD^13*, Ulrik Malthe Overgaard, MD^3*, Marianne Tang Severinsen, MD, PhD^14*, Vibe Skov, PhD^1*, Anders Lindholm Sørensen, MD^1*, Jesper Stentoft, MD, PhD^15*, Jørn Starklint, MD^16*, Karin de Stricker, MD^11*, Mads Thomassen, PhD^12*, Thomas S. Larsen, MD, PhD^2* and Hans Carl Hasselbalch, MD^1,9

¹Department of Hematology, Zealand University Hospital, Roskilde, Denmark
²Department of Hematology, Odense University Hospital, Odense, Denmark
³Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
⁴Department of Data and Data Support, Region Zealand, Sorø, Denmark
⁵Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
⁶Department of Production, Research, and Innovation, Region Zealand, Sorø, Denmark
⁷Department of Laboratory Medicine, Boston Children's Hospital, Boston, MA
⁸Department of Pathology, Harvard Medical School, Boston, MA
⁹Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
¹⁰Department of Hematology, Hospital of Southern Jutland, Aabenraa, Denmark
¹¹Department of Pathology, Odense University Hospital, Odense, Denmark
¹²Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
¹³Department of Hematology, Hospital of South West Jutland, Esbjerg, Denmark
¹⁴Department of Hematology, Aalborg University Hospital, Aalborg, Denmark
¹⁵Department of Hematology, Aarhus University Hospital, Aarhus, Denmark
¹⁶Department of Hematology, Hospital of West Jutland, Holstebro, Denmark

Tiziano Barbui, MD^1*, Alessandro M. Vannucchi, MD^2*, Valerio De Stefano, MD^3*, Arianna Masciulli, PhD^1*, Alessandra Carobbio, MSc^1*, Arianna Ghirardi, PhD^1*, Greta Carioli, PhD^1*, Elena Rossi, MD, PhD^3*, Fabio Ciceri, MD^4*, Massimiliano Bonifacio, MD^5*, Alessandra Iurlo, MD, PhD^6*, Francesca Palandri, PhD, MD^7*, Giulia Benevolo, MD^8*, Fabrizio Pane, MD^9,10, Alessandra Ricco, MD^11*, Giuseppe Carli, MD^12*, Marianna Caramella, MD^13*, Davide Rapezzi, MD^14*, Caterina Musolino, MD^15*, Sergio Siragusa, MD¹⁶, Elisa Rumi, MD^17,18*, Andrea Patriarca, MD^19*, Nicola Cascavilla, MD²⁰, Barbara Mora, MD^21*, Emma Cacciola, MD²², Carmela Mannarelli, PhD^23*, Giuseppe Gaetano Loscocco, MD^2*, Paola Guglielmelli, MD, PhD², Francesca Gesullo, BSci^24*, Silvia Betti, MD, PhD^3*, Francesca Lunghi, MD^25*, Luigi Scaffidi, MD^5*, Cristina Bucelli, MD^26*, Nicola Vianelli, MD^27*, Marta Bellini, MD^28*, Maria Chiara Finazzi^29,30*, Giovanni Tognoni, MD^31* and Alessandro Rambaldi, MD^28,29

¹FROM Research Foundation Ospedale di Bergamo, Bergamo, Italy
²CRIMM, Center for Research and Innovation of Myeloproliferative Neoplasms, AOU Careggi, University of Florence, Florence, Italy
³Section of Hematology, Department of Radiological and Hematological Sciences, Catholic University, Fondazione Policlinico A Gemelli, IRCCS, Rome, Italy
⁴Università Vita-Salute San Raffaele and Istituto di Ricovero e Cura a Carattere Scientifico Ospedale San Raffaele, Department of Onco-Hematology, Milano, Italy
⁵Department of Medicine, Section of Hematology, University of Verona and Azienda Ospedaliera Universitaria Integrata, Verona, Italy
⁶Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
⁷IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy
⁸Hematology Division , Città della Salute e della Scienza Hospital, TORINO, TO, Italy
⁹Azienda Ospedaliera Universitaria Federico II, Naples, Italy
¹⁰Università degli Studi di Napoli, Federico II, Italy
¹¹Hematology and Stem Cell Transplantation Unit, AOUC Policlinico, Bari, Italy
¹²Hematology Department, Ospedale San Bortolo, Vicenza, Italy
¹³Department of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy
¹⁴S.C. Ematologia, ASO S. Croce e Carle, Cuneo, Italy
¹⁵Divisione di Ematologia - Policlinico Universitario, Messina, Italy
¹⁶Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PRO.MI.SE), University of Palermo, Palermo, Italy
¹⁷Department of Molecular Medicine, University of Pavia, Pavia, Italy
¹⁸Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
¹⁹Azienda Ospedaliero Universitaria Maggiore della Carità di Novara SCDU Ematologia, Novara, Italy
²⁰Division of Hematology, IRCCS Casa Sollievo Della Sofferenza Hospital, San Giovanni Rotondo, Italy
²¹Hematology, University Hospital "Ospedale di Circolo e Fondazione Macchi" - ASST Sette Laghi, University of Insubria, Varese, Italy
²²Hemostasis/Hematology Unit, Department of Medical, Surgical and Advance Technologies Sciences "G..F. Ingrassia", University of Catania, Catania, Italy
²³CRIMM, Center of Research and Innovation of Myeloproliferative Neoplasms, University of Florence, AOU Careggi, Florence, Italy;, Florence, Italy
²⁴CRIMM, Center Research and Innovation of Myeloproliferative Neoplasms, University of Florence, AOU Careggi, Florence, Italy;, Florence, Italy
²⁵Department of Onco-Haematology - Haematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute and Vita-Salute Hospital, Milano, Italy
²⁶Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy
²⁷IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy
²⁸Department of Oncology-Hematology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy
²⁹Department of Oncology and Hematology, University of Milan, Milan, Italy
³⁰Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Italy
³¹Istituto di Ricerche Farmacologiche "Mario Negri", IRCCS, Milano, Italy