Georgina Gener-Ricos^1*, Fadi Haddad, MD^1*, Koji Sasaki, MD¹, Ghayas C. Issa, MD², Jeffrey Skinner, MHA^1*, Koichi Takahashi, MD, PhD³, Lucia Masarova, MD¹, Jan A. Burger, MD, PhD¹, Gautam Borthakur, MD¹, Prithviraj Bose, MD⁴, Guillermo Garcia-Manero, MD⁵, Elias Jabbour, MD¹ and Hagop Kantarjian, MD⁶

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, Universit Y of Texas At Houston, Houston, TX
³Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁴The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Jorge E. Cortes, MD¹, Michael W. Deininger, MD, PhD², Elza Lomaia, MD, PhD^3*, Beatriz Moiraghi, MD^4*, Maria Undurraga Sutton^5*, Carolina Pavlovsky^6*, Charles Chuah, MD^7*, Tomasz Sacha, MD, PhD^8*, Jeffrey H. Lipton, MD, PhD⁹, James McCloskey, MD^10*, Andreas Hochhaus¹¹, Philippe Rousselot, MD, PhD^12*, Gianantonio Rosti^13*, Hugues de Lavallade, MD^14*, Christine Rojas, MD^15*, Anna Turkina, MD^16*, Lori Maness, MD¹⁷, Moshe Talpaz, MD¹⁸, Michael Mauro, MD¹⁹, Vickie Lu, PhD^20*, Alexander Vorog, MD^20* and Jane F. Apperley, FRCP, FRCPath, MB²¹

¹Georgia Cancer Center, Augusta, GA
²Versiti Blood Research Institute, Milwaukee, WI
³Almazov National Medical Research Centre, St. Petersburg, Russian Federation
⁴Hospital Jose Maria Ramos Mejia, Buenos Aires, Argentina
⁵Hospital del Salvador, Santiago, Chile
⁶Fundaleu, Buenos Aires, Argentina
⁷Singapore General Hospital, Duke-NUS Medical School, Singapore, Singapore
⁸Jagiellonian University Hospital, Kraków, Poland
⁹Princess Margaret Cancer Centre, Toronto, ON, Canada
¹⁰John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ
¹¹Universitätsklinikum Jena, Jena, Germany
¹²Centre Hospitalier de Versailles University de Versailles Saint-Quentin-en-Yvelines, Paris, France
¹³IRST/IRCCS “Dino Amadori,”, Meldola (FC), Ravenna, Italy
¹⁴King's College Hospital NHS Foundation, London, United Kingdom
¹⁵Centro de Investigaciones Clinicas Vina del Mar, Valparaíso, Chile
¹⁶National Medical Research Center for Hematology, Moscow, Russian Federation (Russia), Moscow, Russian Federation
¹⁷University of Nebraska Medical Center, Omaha, NE
¹⁸Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI
¹⁹Memorial Sloan Kettering, New York, NY
²⁰Takeda Development Center Americas, Inc., Lexington, MA
²¹Imperial College London, London, United Kingdom

Ekaterina Yu. Chelysheva, MD, PhD^1*, Anna Turkina, MD^2*, Jane F. Apperley, FRCP, FRCPath, MB³, Mohamed A Yassin, MBBS, MSC, CABM, MSC, FACP⁴, Delphine Rea, MD, PhD⁵, Franck E. Nicolini, MD, PhD⁶, Daniela Barraco^7*, Konstantin Kotlyarchuk^8*, Khamida Kazakbaeva, MD^9*, Sukhrob Saliev^9*, Adi Shacham, MD^10*, Dong-Wook Kim, M.D., Ph.D.¹¹, Salam Al-Kindi, MD^12*, Penka Ganeva^13*, Roman Shmakov, MD, PhD^14*, Jennifer Byrne, PhD, FRCPath^15*, Harry Robertson^16*, Cerrano Marco, MD^17*, Evgenia Polushkina^14*, Malgorzata Monika Trawinska, MD^18* and Elisabetta Abruzzese, MD¹⁹

¹National Medical Research Center for Hematology, Moscow, AZ
²National Medical Research Center for Hematology, Moscow, Russian Federation (Russia), Moscow, Russian Federation
³Centre for Haematology, Imperial College London at the Hammersmith Hospital, London, ENG, United Kingdom
⁴Department of Medical Oncology/ Hematology Section, National Centre For Cancer Care & Research, Doha, Qatar
⁵Université de Paris, Hematology department, Saint-Louis hospital, APHP, Paris, France
⁶Centre Hospitalier Lyon Sud, LYON Cedex 03, France
⁷Local Health Authority of the Seven Lakes Hospital of Circolo, Varese, Italy
⁸SI 'Institute of Blood Pathology and Transfusion Medicine UAMS, Lviv, Ukraine
⁹Research Institute of Hematology and Blood Transfusion MOH of Uzbekistan, Tashkent, Uzbekistan
¹⁰Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
¹¹Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
¹²Department of Haematology, Sultan Qaboos University, Muscat, Oman
¹³Department of hematology, Specilaized Hospital for Active Treatment of Hematological Diseases, Sofia, BGR
¹⁴National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russian Federation
¹⁵Centre for Clinical Haematology, Nottingham University Hospitals NHS Trust, Nottingham, ENG, United Kingdom
¹⁶Imperial College Healthcare NHS Trust, London, United Kingdom
¹⁷Division of Hematology, A.O.U. Città della Salute e della Scienza di Torino, Turin, Italy
¹⁸Hematology, S. Eugenio Hospital, Tor Vergata University, ASL Roma2, Rome, Italy
¹⁹Hematology, S. Eugenio Hospital, Tor Vergata University, ASL Roma2, Roma, I, Italy

Andreas Burchert, MD¹, Susanne Saussele, MD ², Christian Michel, MD^3*, Stephan K Metzelder, MD^4*, Andreas Hochhaus, MD⁵, Norbert Gattermann, MD⁶, Martina Crysandt, MD^7*, Philippe Schafhausen, MD^8*, Matthias Bormann, MD^9*, Markus P. Radsak, MD^10*, Agnès Guerci-Bresler, MD, PhD^11*, Thomas Illmer, MD¹², Maria E Goebeler, MD^13*, Peter Herhaus, MD^14*, Lino L. Teichmann, MD^15*, Georg-Nikolaus Franke, MD^16*, Fabian Lang, MD^17*, Stefan W. Krause, MD^18*, Robert Möhle, MD¹⁹, Martine Klausmann, MD²⁰, Frank Stegelmann, MD²¹, Christoph Lutz, MD^22*, Gabriel Etienne, MD, PhD^23*, Andrea Stoltefuß, MD^24*, Joachim R Göthert, MD²⁵, Thomas Ernst, MD⁵, Andreas Neubauer, MD²⁶, Rüdiger Hehlmann, MD²⁷, Behnaz Aminossadati^28*, Michael Wittenberg, PhD^29*, Markus Pfirrmann, PhD^30*, Carmen Schade-Brittinger^31*, Philipp le Coutre, MD³² and Franck E. Nicolini, MD, PhD³³

¹Department of Hematology and Oncology, University Hospital Giessen and Marburg, Marburg, Germany
²III. Medizinische Klinik für Hämatologie und Onkologie, Universitätsmedizin Mannheim, Mannheim, Germany
³Department of Hematology, Oncology and Immunology, University hospital Gießen and Marburg, Marburg, Germany
⁴Dep. of Internal Medicine, Hematology, Oncology and Immunology, Philipps University Marburg and University Hospital Giessen and Marburg, Campus Marburg, Marburg, Germany
⁵Hematology/Oncology, Jena University Hospital, Jena, Germany
⁶Department of Hematology, Oncology and Clinical Immunology, Heinrich Heine University, Düsseldorf, Germany
⁷Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, University Hospital RWTH Aachen, Aachen, Germany
⁸University Medical Center of Hamburg-Eppendorf, Hamburg, Germany
⁹Klinikum Bremen Mitte, Bremen, Germany
¹⁰Department of Internal Medicine III, University Medical Center, Johannes Gutenberg-University of Mainz, Mainz, Germany
¹¹Service d'Hématologie, Centre Hospitalier Universtaire Brabois, Vandoeuvre-lès-Nancy, France
¹²Group Practice for Hematology and Oncology, Dresden, Germany
¹³Leitung CCC Trial Office, Würzburg, Germany
¹⁴Internal Medicine III, School of Medicine, Klinikum rechts der Isar, Technische Universität München, München, Germany
¹⁵Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen Bonn Cologne Düsseldorf, Germany
¹⁶Department for Hematology, Cell Therapy and Hemostaseology, University of Leipzig Medical Center, Leipzig, Germany
¹⁷Dept. of Medicine, Hematology and Oncology, Goethe University Frankfurt, University Hospital, Frankfurt, Germany
¹⁸University Hospital Erlangen, Germany, Erlangen, Germany
¹⁹Department of Hematology and Oncology, University of Tübingen, Tübingen, Germany
²⁰Practice for Hematology, Oncology, and Gastroenterology, Aschaffenburg, Germany
²¹Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
²²Praxis for Hematology and Oncology, Koblenz, Germany
²³Groupe Fi-LMC, Institut Bergonié, Bordeaux, France
²⁴Evangelisches Krankenhaus Hamm, Hamm, Germany
²⁵Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
²⁶Klinik für Innere Medizin, Schwerpunkt Hämatologie, Onkologie und Immunologie, Philipps University, Marburg, Germany
²⁷Universität Heidelberg and ELN-Foundation, Heidelberg, Germany
²⁸KKS, Philipps University Marburg, Marburg, Germany
²⁹KKS, Philipps University Marburg, Marburg, AL, DEU
³⁰IBE, Ludwig-Maximilians-Universität, München, Germany
³¹KKS Marburg, Philipps University Marburg, Marburg, Germany
³²Department of Hematology, Oncology and Tumor Immunology, Charité Campus Mitte, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Berlin, Germany
³³Centre Hospitalier Lyon Sud, LYON Cedex 03, France

Giovanni Zambrotta^1,2*, Sarit Assouline³, Franck E. Nicolini, MD, PhD⁴, Elisabetta Abruzzese, MD⁵, Maria Cristina Miggiano, MD^6*, Chiara Elena, MD^7*, Alberto Alvarez-Larran, MD, PhD^8*, Ana Triguero^8*, Alessandra Iurlo, MD, PhD^9*, Cristina Bucelli, MD^10*, Francesca Lunghi, MD^11*, Isabella Capodanno, MD^12*, Margherita Maffioli, MD^13*, Sara Galimberti, MD^14*, Giovanni Caocci, MD^15*, Fabio Stagno, MD, PhD¹⁶, Susanne Saussele, MD ¹⁷, Carmen Fava, MD, PhD¹⁸, Philipp le Coutre, MD¹⁹, Massimiliano Bonifacio, MD^20*, Veronica Guglielmana^1,2*, Federica Colombo^1,2*, Laura Antolini, PhD^1* and Carlo Gambacorti-Passerini, MD^1,2

¹Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy
²Hematology Division and Bone Marrow Unit, San Gerardo Hospital, Monza, Italy
³Department of Medicine and Oncology, Jewish General Hospital, McGill University, Montreal, Montreal, QC, Canada
⁴Hématologie clinique & INSEM U1052, Centre Léon Bérard, Lyon, France
⁵Hematology, S. Eugenio Hospital, Tor Vergata University, ASL Roma2, Roma, I, Italy
⁶Hematology Department, San Bortolo Hospital, Azienda ULSS8 "Berica" di Vicenza, Vicenza, Italy
⁷Department of Hematology Oncology, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
⁸Hematology Department, Hospital Clínic, Barcelona, Spain
⁹Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy
¹⁰Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy
¹¹Department of Onco-Haematology - Haematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute and Vita-Salute Hospital, Milano, Italy
¹²Hematology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy
¹³Hematology, Ospedale di Circolo e Fondazione Macchi, University of Insubria, ASST Sette Laghi, Varese, Italy
¹⁴Section of Hematology, Department of Clinical and Experimental Medicine, University of Pisa, Azienda ospedaliera Pisana, Pisa, Italy
¹⁵Hematology Unit, Cagliari University, Businco Hospital, Cagliari, Italy
¹⁶Division of Hematology and Bone Marrow Transplantation Unit, A.O.U. "Policlinico-Vittorio Emanuele", University of Catania, Catania, Italy
¹⁷Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany
¹⁸Hematology Division, A.O. Ordine Mauriziano di Torino, Torino, Italy, Turin, Italy
¹⁹Department of Hematology, Oncology and Tumor Immunology, Charité Campus Mitte, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Berlin, Germany
²⁰Department of Medicine, Section of Hematology, University of Verona, Verona, Italy

Catherine E. Sobieski, MD^1*, Victoria A. Vardell, MD¹ and Srinivas K. Tantravahi, MBBS²

¹Department of Internal Medicine, University of Utah, Salt Lake City, UT
²Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT