-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

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631.O2.6 631. Myeloproliferative Syndromes and Chronic Myeloid Leukemia: Basic and Translational: Molecular Consequences of MPN Driver and Co-mutations Clinically Relevant Abstract

Symposia: Myeloproliferative Syndromes and Chronic Myeloid Leukemia: Basic and Translational Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, Fundamental Science, Bleeding and Clotting, MDS, adult, Translational Research, MPN, Non-Biological therapies, CML, genomics, bioinformatics, Chemotherapy, platelet disorders, Chronic Myeloid Malignancies, hematopoiesis, pediatric, Diseases, immune mechanism, Therapies, immunology, thrombotic disorders, metabolism, computational biology, young adult , Myeloid Malignancies, Biological Processes, emerging technologies, Pharmacology, molecular biology, Technology and Procedures, gene editing, Human, Study Population, profiling, pathogenesis, imaging, Animal model, machine learning, molecular testing, omics technologies, Pathology
Sunday, December 11, 2022: 9:30 AM-11:00 AM
275-277 (Ernest N. Morial Convention Center)
Bridget K Marcellino, MD, PhD, Icahn School of Medicine at Mount Sinai and Rebekka K. Schneider, MD, PhD, Erasmus MC
No relevant conflicts of interest to declare.
In this session, so far unappreciated molecular and phenotypic consequences of MPN driver and co-mutations will be discussed, using murine models and primary patient samples. Transcriptional and metabolic profiling of MPN initiating cells, platelets as well as the bone marrow microenvironment reveal novel mechanisms that drive inflammation and remodelling of the hematopoietic stem cell niche in MPN, and abnormalities in platelet function. The differential effect of type I and type II CALR mutations on the protein structure and chaperone function will be discussed, as well as germline determinants of variation in platelet counts and generation of a new genetically engineered mouse model of histiocytic neoplasms.
9:30 AM

Nicole S Arellano, BA1,2, Jacqueline Gomez2*, Michele Ciboddo, MD2*, Hunter Blaylock2*, Deborah Rodriguez, BA1,2*, Amy K Chen2*, Melissa Gaviria2*, Lulu Allie2*, Alex Rosencrance2,3*, Harrison S Greenbaum2*, Elisa Rumi4*, Oscar Borsani, MD4, Ilaria Carola Casetti, MD, PhD4*, Daniela Pietra, PhD4*, Silvia Catricalá4* and Shannon Elf, PhD1,2

1University of Chicago, The Committee on Cancer Biology, Chicago, IL
2University of Chicago, The Ben May Department for Cancer Research, Chicago, IL
3University of Chicago, Pritzker School of Medicine, Chicago, IL
4Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

9:45 AM

Anna E Marneth, PhD1, Jonas S. Jutzi, MD, PhD1, Chulwoo J. Kim, BA1*, Charles Laurore, BA1*, Anastasia Tishena, BA1*, Frederike Kramer, PhD1, Azucena V. Rocha, BA1*, Mohammed Wazir, MD2*, Lachelle D. Weeks, MD, PhD3,4, Joan How, MD1,4,5, Maximilian F. Stahl, MD6, Marlise R. Luskin, MD4, R. Coleman Lindsley, MD, PhD4*, Olga Pozdnyakova, MD, PhD7*, Timothy A. Graubert, MD8 and Ann Mullally, MD1,4,9

1Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
2Division of General Internal Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, MA
3Center for Prevention of Progression, Dana-Farber Cancer Institute, Boston, MA
4Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
5Department of Medical Oncology, Massachusetts General Hospital, Boston
6Department of Medical Oncology, Dana-Farber Institute, Boston, MA
7Department of Pathology, Brigham and Women's Hospital, Boston, MA
8Massachusetts General Hospital Cancer Center, Charlestown, MA
9Broad Institute, Cambridge, MA

10:00 AM

Rong Li, PhD1,2,3*, Michela Colombo, PhD1,3*, Guanlin Wang, PhD1,3,4,5,6*, Sally-Ann Clark, PhD1*, Antonio Rodriguez-Romera1*, Yiran Meng, PhD1*, Abdullah Khan, PhD1, Wei Xiong Wen1,6*, Nikolaos Sousos, MD, MSc1*, Lauren Murphy1*, Christina Simoglou Karali, PhD1*, Korsuk Sirinukunwattana7*, Jennifer O’Sullivan, MD1*, Ruggiero Norfo, PhD1*, Qian Cheng, PhD1*, Charlotte Brierley, MD, MRCP1*, Joana Carrelha, PhD1*, Zemin Ren, PhD1*, Gabriel A. Rabinovich8*, Vijay A Rathinam, PhD9*, Supat Thongjuea, PhD6*, Daniel Royston, MD PhD10*, Adam J Mead, MD PhD1,10,11 and Bethan Psaila, MD, PhD1,11,12

1Medical Research Council Weatherall Institute of Molecular Medicine and NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
2Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, United Kingdom
3Co-first author, ., United Kingdom
4Shanghai Qi Zhi Institute, Shanghai, China
5Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China
6MRC WIMM Centre for Computational Biology, University of Oxford, Oxford, United Kingdom
7Oxford Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, United Kingdom
8Laboratory of Glycomedicine, Institute of Biology and Experimental Medicine, National Research Council, Buenos Aires, Argentina; Faculty of Exact and Natural Sciences, University of Buenos Aires, Buenos Aires, ARG
9Department of Immunology, University of Connecticut Health School of Medicine, Farmington, CT
10Oxford University Hospitals NHS Trust, Oxford, United Kingdom
11Co-senior author, ., United Kingdom
12MRC Weatherall Institute of Molecular Medicine, University of Oxford; Oxford University Hospitals NHS Trust, Oxford, United Kingdom

10:15 AM

Liesl Butler, MB BS1,2*, Christine Lee, BSc PhD3*, Graham William Magor, BSc1*, Rhiannon Morris, BSc PhD4*, Michael Tallack, MB BS PhD5,6*, Charlene Lam, BSc1*, Adam Ivey, BSc, MSc, PhD7*, Jane Lin, BSc PhD8*, Zihao Deng, BSc1*, Andrew Grigg, MBBS, MD, FRACP, FRCPA9,10*, Jane Mason, MBBS Hons, FRACP, FRCPA11*, Malaika Perchard, MB BS12*, Helen Weston, MBBS, FRACP, FRCPA13*, Nik Cummings, BSc1,14*, Andrew Brooks, BSc PhD15*, Jeffrey J Babon, PhD16*, Andrew J Murphy, BSc PhD17*, Jessica M Salmon, BSc PhD1* and Andrew Charles Perkins, MBBS, PhD, FRACP, FRCPA1,8,18,19

1Australian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia
2Department of Haematology, Alfred Hospital, Melbourne, VIC, Australia
3Diamantina Institute, The University of Queensland, Woolloongabba, AUS
4The Walter and Eliza Hall Institute of Medical Research, Melbourne University, Melbourne, VIC, Australia
5Mater Research Institute - University of Queensland, Brisbane, Australia
6Queensland Medical Laboratories, Brisbane, QLD, Australia
7Molecular Pathology, The Alfred Hospital, Melbourne, VIC, Australia
8Pathology, Alfred Hospital, Melbourne, VIC, Australia
9Department of Haematology, Austin Health, Melbourne, Australia
10Australasian Leukaemia and Lymphoma Group (ALLG), Melbourne, Australia
11Queensland Haemophilia Centre, Cancer Care Services, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia
12Royal Brisbane Women's and Children's Hospital, Brisbane, QLD, Australia
13Haematology Department, Sunshine Coast University Hospital, Sunshione Coast, QLD, Australia
14Pathology, Alfred Health, Melbourne, VIC, Australia
15The University of Queensland, Brisbane, AUS
16The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia
17Haematopoiesis and Leukocyte Biology, Baker Heart and Diabetes Institute, Melbourne, Australia
18Department of Haematology, Alfred Hospital, Melbourne, Australia
19Australasian Leukaemia and Lymphoma Group (ALLG), Richmond, VIC, Australia

10:30 AM

Fan He, PhD1, Angelo BA Laranjeira, PhD1*, Tim Kong, MS1, Katrina Bark, MS2*, Alice Liu, BS2*, Maggie J. Allen, BS1*, Daniel AC Fisher, PhD1*, Mary Fulbright, MS1*, LaYow Yu1*, Nina M. Lasky, RVT, LAT2*, Stephen M. Sykes, PhD3, Angelo D'Alessandro, PhD4, Jorge Di Paola, MD2 and Stephen T Oh, MD, PhD5

1Division of Hematology, Washington University School of Medicine in St. Louis, Saint Louis, MO
2Department of Pediatrics, Washington University School of Medicine in St. Louis, Saint Louis, MO
3Department of Pediatrics, Washington University, Saint Louis, MO
4Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO
5Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO

10:45 AM

Benjamin H Durham, MD1,2, Michael E Singer, B.S.1*, Salima Benbarche, PhD1, Caroline Erickson, B.S.1*, Jahan Rahman, PhD1*, David B. Solit, MD1,3*, Matthew Witkowski, PhD4,5*, Neal Rosen, MD, PhD1*, Omar Abdel-Wahab, MD1,6,7 and Eli L Diamond, MD8*

1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
2Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
3Department of Medicine, Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY
4Perlmutter Cancer Center at NYU Langone Health, New York University, New York, NY
5Pediatrics-Heme/Onc and Bone Marrow Transplantation, University of Colorado Anschutz, Aurora, CO
6Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
7Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
8Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY

*signifies non-member of ASH