-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

626.O1.6 626. Aggressive Lymphomas: Prospective Therapeutic Trials: Frontline Treatment of Large B-cell Lymphoma

Symposia: Aggressive Lymphomas: Prospective Therapeutic Trials Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Biological therapies, Research, clinical trials, adult, Bispecific Antibody Therapy, Lymphomas, non-Hodgkin lymphoma, Combination therapy, Clinical Research, B Cell lymphoma, Diseases, Therapies, Immunotherapy, aggressive lymphoma, Adverse Events, Lymphoid Malignancies, Monoclonal Antibody Therapy, Study Population, Human, Transplantation
Monday, December 12, 2022: 10:30 AM-12:00 PM
La Nouvelle Orleans Ballroom C (Ernest N. Morial Convention Center)
Moderators:
Matthew J. Matasar, MD, MS, Memorial Sloan-Kettering Cancer Center/New York Presbyterian and Yazeed Sawalha, MD, The Ohio State University Wexner Medical Center
Disclosures:
Sawalha: TG Therapeutics: Research Funding; Celgene/BMS: Research Funding; BeiGene: Research Funding; Epizyme: Consultancy.
The purpose of this session is to present advances in the treatment of newly diagnosed aggressive B-cell lymphoma including incorporation of targeted therapies, immunotherapy and risk adaptive approaches.
10:30 AM

Monica Balzarotti, MD1*, Umberto Ricardi, MD2*, Michele Spina, MD3, Andrea Evangelista, MSc4*, Alessandra Tucci, MD5*, Federica Cavallo, MD6*, Manuela Zanni, MD7*, Annalisa Arcari, MD8*, Vittorio Ruggero Zilioli, MD9*, Roberto Sartori, MD10*, Francesco Merli, MD11*, Francesca Re, MD12*, Umberto Vitolo, MD13, Maria Assunta Deidda, MD14*, Luca Melis, MD15*, Daniela Dessì, MD16*, Marcello Rodari, MD17*, Armando Santoro, MD18*, Gianluca Gaidano, MD, PhD19, Giovannino Ciccone, MD20*, Stephane Chauvie, PhD21* and Maria Giuseppina Cabras, MD16*

1Department of Hematology, Humanitas Clinical and Research Center IRCCS, Rozzano, Italy
2Radiation Oncology, Department of Oncology, University of Turin, Turin, ITA
3Dept of Medical Oncology, IRCCS CRO Aviano, Aviano (PN), Italy
4Città Della Salute E Della Scienza, Torino, ITA
5Department of Hematology, ASST Spedali Civili, Brescia, Italy
6Division of Hematology , AOU Città della Salute e della Scienza di Torino, Torino, Italy
7Division of Hematology, Azienda Ospedaliera Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy
8Hematology Unit, Ospedale Guglielmo da Saliceto, Piacenza, Italy
9Division of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milan, IT-MI, Italy
10Ospedale di Castelfranco Veneto - Ematologia, Castelfranco Veneto, ITA
11AUSL-IRCCS, Reggio Emilia, Reggio Emilia, Italy
12Hematology and CTMO, Azienda Ospedaliera-Universitaria di Parma, Parma, Italy
13Candiolo Cancer Institute, FPO-IRCCS, Candiolo (Torino), Italy
14Department of Radiotherapy, Regional Oncological Businco Hospital, Cagliari, Italy
15Ospedale Oncologico "A. Businco" Cagliari ·, Nuclear Medicin Unit, Cagliari, Italy
16Division of Hematology, Ospedale Oncologico Armando Businco, Cagliari, Italy
17Nuclear Medicine, IRCCS Humanitas Research Hospital, Milano, Italy
18Humanitas University and IRCCS Humanitas Research Hospital, Humanitas Cancer Center, Milan, Italy
19Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy
20Unit of Clinical Epidemiology, Azienda Ospedaliera e Universitaria Città della Salute e della Scienza and CPO Piemonte, Torino, Italy
21Medical Phyhsics Department, S. Croce Hospital, Cuneo, Italy

10:45 AM

Sirpa Leppa, MD, PhD1, Judit M. Jørgensen, MD, PhD2*, Marja-Liisa Karjalainen-Lindsberg, MD, PhD3*, Klaus Beiske, MD, PhD4*, Mette Pedersen, MD, PhD5*, Kristina Drott, MD, PhD6*, Annika Pasanen, MD, PhD1*, Kristiina Karihtala, MD1*, Susanna Mannisto, MD, PhD1*, Leo Meriranta, MD1*, Bente Wold, MD4*, Marianne Brodtkorb, MD, PhD7*, Unn Merete Fagerli, MD, PhD8*, Thomas S. Larsen, MD, PhD9*, Lars Munksgaard, MD10*, Kaisa Sunela, MD, PhD11*, Øystein Fluge, MD, PhD12*, Sirkku Jyrkkio, MD, PhD13*, Peter de Nully Brown, MD, PhD14* and Harald Holte, MD, PhD4

1University of Helsinki and Helsinki University Hospital, Helsinki, Finland
2Aarhus University Hospital, Aarhus, Denmark
3Helsinki University Hospital, Helsinki, Finland
4Oslo University Hospital, Oslo, Norway
5Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
6Skåne University Hospital, Lund, Sweden
7Department of Oncology, Oslo University Hospital, Oslo, Norway
8St. Olavs Hospital, Trondheim, Norway
9Odense University Hospital, Odense, Denmark
10Roskilde Hospital, Roskilde, Denmark
11Tampere University Hospital, Tampere, Finland
12Haukeland University Hospital, Bergen, Norway
13Turku University Hospital, Turku, Finland
14Department of Haematology, Rigshospitalet, Copenhagen, Denmark

11:00 AM

Andrew J Davies, BSc, BM, FRCP, PhD1*, Louise Stanton, MSc2*, Josh Caddy, BSc2*, Sharon Barrans, PhD3*, Sam Wilding, MSc, PhD4*, Geoff N Saunders, MSc2*, Christoph Mamot, M.D.5,6*, Urban Novak6,7*, Andrew K. McMillan, MD8, Paul A Fields, MD, PhD9, Graham P. Collins, MBBS, MA, MRCP, FRCPath, DPhil10, Richard Stephens11*, Francesco Cucco, PhD12*, Chulin Sha, PhD13*, Moniek Van Hoppe, MSc3*, Reuben M Tooze, PhD3*, Matthew A Care, PhD, MSc, BSc14*, Gareth Griffiths, PhD2*, Anna Schuh, MD, PhD, FRCP, FRCPath15, Ming-Qing Du, PhD12, David R Westhead, D. Phil. M.A.14*, Cathy Burton, MBBChir, MA, MD, FRCPath3* and Peter Johnson, MD, FRCP16

1CRUK Experimental Cancer Medicines Centre, University of Southampton, Southampton, United Kingdom
2Cancer Research UK Southampton Clinical Trials Unit, University of Southampton, Southampton, United Kingdom
3Haematological Malignancy Diagnostic Service, Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
4CRUK Southampton Clinical Trials Unit, University of Southampton, Southampton, United Kingdom
5Medical Oncology, Cantonal Hospital Aarau, Switzerland
6The Swiss Group for Clinical Cancer Research (SAKK), Bern, Switzerland
7Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
8Department of Haematology, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom
9Department of Haematology, Guy's and St. Thomas' NHS Foundation Trust, Kings Health Partners, London, United Kingdom
10Department of Clinical Haematology, Oxford University Hospitals, Oxford, United Kingdom
11Patient Representative, NCRI Consumer Forum, London, United Kingdom
12Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
13Institute of Basic Medicine and Cancer, Chinese Academy of Sciences, Hangzhou, China
14School of Molecular and Cellular Biology and Leeds Institute of Data Analytics, University of Leeds, Leeds, United Kingdom
15Department of Oncology, University of Oxford, Oxford, United Kingdom
16Cancer Research UK Experimental Cancer Medicines Centre UK, Southampton, United Kingdom

11:15 AM

Elisabeth Schorb, MD1*, Lisa Isbell, MD1*, Andrea Kerkhoff, MD2*, Stephan Mathas, MD3*, Friederike Braulke, MD4,5*, Gerlinde Egerer, MD6*, Alexander Roeth, MD7, Simon Christian Schliffke, MD8*, Peter Borchmann9, Uta Brunnberg, MD10*, Frank P. Kroschinsky, MD, MBA11, Robert Möhle, MD12, Andreas Rank, MD13*, Dominique Wellnitz, MD14*, Benjamin Kasenda, MD PhD15*, Lisa Pospiech16*, Julia Wendler, MD16*, Gabriele Ihorst1,17*, Florian Scherer, MD1*, Martina Deckert, MD18*, Elina Henkes, MD19*, Justus Duyster1*, Jürgen Finke, MD, PhD1 and Gerald Illerhaus, MD16

1Department of Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University of Freiburg, Freiburg, Germany
2Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Muenster, Muenster, Germany
3Hematology, Oncology, and Tumor Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany
4Comprehensive Cancer Center, University Medicine of Göttingen, Göttingen, AL, Germany
5Department of Hematology and Medical Oncology, University Medical Center Göttingen, Göttingen, Germany
6Department of Hematology, Oncology and Rheumatology, Heidelberg University, Heidelberg, Germany
7Department of Hematology, University Hospital Essen, Essen, Germany
8Department of Oncology and Hematology, BMT With Section Pneumology, University Cancer Center Hamburg, Hamburg, DEU
9German Hodgkin Study Group (GHSG), Department I of Internal Medicine, University Hospital Cologne, Cologne, Germany
10Department of Medicine 2, Hematology and Oncology, University Hospital Frankfurt, Frankfurt, Germany
11Dresden University Hospital, Dresden, Germany
12Department of Hematology and Oncology, University of Tübingen, Tübingen, Germany
13Medical Clinic II, University Hospital of Augsburg, Augsburg, Germany
14University Hospital of Schleswig-Holstein, Kiel, DEU
15Department of Medical Oncology, University Hospital Basel, Basel, Switzerland
16Department of Hematology, Oncology and Palliative Care, Klinikum Stuttgart, Stuttgart, Germany
17Clinical Trials Unit, Faculty of Medicine and Medical Center, Freiburg, Germany
18Insitute of Neuropathology, Universitätsklinikum Köln, Köln, Germany
19Clinic for Neuroradiology, Klinikum Stuttgart, Freiburg, Germany

11:30 AM

Max S. Topp1, Monica Tani, MD2*, Michael Dickinson, MD3, Nilanjan Ghosh, MD4, Armando Santoro, MD5*, Antonio Pinto, MD6*, Francesc Bosch, MD, PhD7, Christopher P. Fox8*, Armando López-Guillermo, MD, PhD9*, Claudia Carlucci10*, Chun Wu11*, Kathryn Humphrey10*, Pauline Baumlin12*, Martin Barrett10*, Naseer Qayum10* and Franck Morschhauser, MD, PhD13*

1Universitätsklinikum Würzburg, Würzburg, Germany
2Ospedale Santa Maria delle Croci, Ravenna, Italy
3Peter MacCallum Cancer Centre, Royal Melbourne Hospital and The University of Melbourne, Melbourne, Australia
4Levine Cancer Institute/Atrium Health, Charlotte, NC
5Humanitas University and IRCCS Humanitas Research Hospital, Humanitas Cancer Center, Milan, Italy
6Istituto Nazionale Tumori, Fondazione ‘G. Pascale’, IRCCS, Naples, Italy
7Hospital Universitari Vall d’Hebron, Barcelona, Spain
8Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom
9Hospital Clínic de Barcelona, Barcelona, Spain
10Roche Products Ltd, Welwyn Garden City, United Kingdom
11Roche (China) Holding Ltd., Shanghai, China
12F. Hoffmann-La Roche Ltd, Basel, Switzerland
13Hôpital Claude Huriez Univ. Lille, CHU Lille, ULR 7365 - GRITA - Groupe de Recherche sur les formes Injectables et les Technologies Associées and Centre Hospitalier Régional Universitaire de Lille, Lille, France

11:45 AM

Adam J. Olszewski1*, Abraham Avigdor, MD2,3, Sunil Babu, MD4*, Itai Levi5*, Herbert Eradat, MD6, Uri Abadi3,7*, Houston Holmes, MD8*, Matthew McKinney, MD9*, Dariusz Woszczyk10*, Krzysztof Giannopoulos11*, Wojciech Jurczak12, Diana Dunshee13*, Annie Yang13*, Mingzhu Zhou14*, Naseer Qayum15*, Gila Sellam16* and Netanel A. Horowitz17*

1Brown University, Providence, RI
2Sheba Medical Center, Ramat Gan, Israel
3Tel Aviv University, Tel Aviv, Israel
4Fort Wayne Medical Oncology and Hematology, Fort Wayne, IN
5Soroka University Medical Center, Be'er-Sheva, Israel
6University of California, Los Angeles, CA
7Meir Medical Center, Kfar Saba, Israel
8Texas Oncology/Baylor-Sammons Cancer Center, Dallas, TX
9Duke Cancer Institute, Durham, NC
10University of Opole, Provincial Hospital, Opole, Poland
11Medical University of Lublin, Lublin, Poland
12Maria Sklodowska-Curie National Research Institute of Oncology, Krakow, Poland
13Genentech, Inc., South San Francisco, CA
14F. Hoffmann-La Roche, Ltd., Shanghai, China
15Roche Products Ltd, Welwyn Garden City, United Kingdom
16F. Hoffmann-La Roche, Ltd., Basel, Switzerland
17Rambam Healthcare Campus, Technion, Haifa, Israel

*signifies non-member of ASH