David O'Connor, MD^1,2*, Jonas Demeulemeester^3*, Lucia Conde, PhD^4*, Amy A. Kirkwood, MSc^5*, Kent Fung, PhD^6*, Foteini Papaleonidopoulou, MSc^7*, Gianna Bloye, MSci^8*, Nadine Farah, MBBChir, PhD^8*, Sunniyat Rahman, PhD MBiochem^8,9,10*, Jeremy Hancock^11*, Caroline Bateman^12*, Sarah Inglott^1*, Jon Mee^13*, Javier Herrero, PhD^14*, Peter Van Loo^15,16*, Anthony V. Moorman¹⁷, Ajay Vora, MD¹⁸ and Marc R. Mansour, MD^19,20*

¹Department of Haematology, Great Ormond Street Hospital for Children, London, United Kingdom
²UCL Cancer Institute, Department of Haematology, University College London, London, ENG, United Kingdom
³KU Leuven, Leuven, BEL
⁴UCL Cancer Instiute, London, United Kingdom
⁵Cancer Research UK & UCL Cancer Trials Centre, University College London, London, United Kingdom
⁶UCL Cancer Institute, Department of Haematology, University College London, London, United Kingdom
⁷UCL Cancer Institute, London, United Kingdom
⁸UCL Cancer Institute - Department of Haematology, University College London, London, United Kingdom
⁹Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia
¹⁰Peter MacCallum Cancer Centre, Melbourne, Australia
¹¹North Bristol NHS Trust, Bristol, United Kingdom
¹²10The Children's Hospital at Westmead, Sydney, Australia
¹³Cancer Clinical Trials Unit, Birmingham University, Birmingham, United Kingdom
¹⁴Cancer Institute, Bill Lyons Informatics Centre, University College London, London, United Kingdom
¹⁵Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston
¹⁶Francis Crick Institute, London, United Kingdom
¹⁷Wolfson Childhood Cancer Research Centre, Newcastle University, Newcastle, United Kingdom
¹⁸Department of Haematology, The Children's Hospital, London, United Kingdom
¹⁹Cancer Institute, University College London, London, United Kingdom
²⁰Great Ormond Street Institute of Child Health, University College London, London, ENG, United Kingdom

Lauren K. Meyer, MD, PhD¹, Ritu P. Roy^1*, Petri Pölönen, PhD², Abdelrahman Elsayed, PhD^2*, Benjamin J. Huang, MD^1*, Shunsuke Kimura, MD, PhD^3*, Cristina Delgado-Martin, PhD^1*, Tiffaney L. Vincent^4*, Theresa Ryan^4*, Brent L. Wood, MD PhD⁵, Zhiguo Chen, MS^6*, Yu Liu, PhD^2*, Jinghui Zhang, PhD^2*, Terzah M. Horton, MD, PhD⁷, Mignon L. Loh, MD⁸, Meenakshi Devidas, PhD^2*, Elizabeth A. Raetz, MD⁹, Robert J. Hayashi^10*, Stuart S. Winter, MD^11*, Kimberly P. Dunsmore, MD^12*, Stephen P. Hunger, MD⁴, Stanley B. Pounds, PhD^13*, Michelle L. Hermiston, MD, PhD¹, Jun J. Yang, PhD², Charles G. Mullighan, MBBS, MD², David T. Teachey, MD¹⁴ and Adam B. Olshen, PhD^1*

¹University of California, San Francisco, San Francisco, CA
²St. Jude Children's Research Hospital, Memphis, TN
³Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
⁴Children's Hospital of Philadelphia, Philadelphia, PA
⁵Children's Hospital Los Angeles, Los Angeles, CA
⁶University of Florida, Gainesville, FL
⁷Baylor College of Medicine, Houston, TX
⁸Ben Towne Center for Childhood Cancer Research, Seattle Children's Hospital, Seattle, WA
⁹Laura and Isaac Perlmutter Cancer Center, NYU langone Health, New York, NY
¹⁰Washington University, St. Louis Children's Hospital, St. Louis, MO
¹¹Children's Minnesota, Minneapolis, MN
¹²University of Virginia Cancer Center, Barringer, VA
¹³Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
¹⁴Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA

Jason Xu, PhD¹, Changya Chen, Ph.D.^2*, Tiffaney L. Vincent^3*, Petri Pölönen, PhD⁴, Abdelrahman Elsayed, PhD^4*, Jianzhong Hu, PhD^5*, Satoshi Yoshimura^6*, Wenbao Yu, PhD^7*, Chia-hui Chen^7*, Elizabeth Li^8*, Rawan Shraim, MSc^9*, Marieke Lavaert, Ph.D^10*, Haley Newman, MD³, Yang-yang Ding^7*, Anusha Thadi^11*, Kyung Jin Ahn, BS^11*, Jacqueline Peng^11*, Chujie Gong^12*, Yusha Sun^13*, Shovik Bandyopadhyay, MSTP Candidate^14*, David Frank^15*, Mignon L. Loh, MD^16,17, Elizabeth A. Raetz, MD¹⁸, Zhiguo Chen^19*, Brent L. Wood, MD PhD²⁰, Meenakshi Devidas, PhD, MBA²¹, Kimberly P. Dunsmore, MD^22*, Stuart S. Winter, MD^23*, Gang Wu, PhD^24*, Avinash Bhandoola, M.B., B.S., Ph.D.^10*, Stanley B. Pounds, PhD^25*, Stephen P. Hunger, MD²⁶, Jun J. Yang, PhD⁵, Charles G. Mullighan, MBBS, MD²⁷, David T. Teachey, MD²⁸ and Kai Tan, PhD^2,29

¹Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
²Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
³Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
⁴St. Jude Children's Research Hospital, Memphis, TN
⁵Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, TN
⁶Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN
⁷Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA
⁸Yale School of Medicine, New Haven, CT
⁹Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
¹⁰National Institutes of Health, Bethesda, MD
¹¹Children’s Hospital of Philadelphia, Philadelphia, PA
¹²University of Pennsylvania, Philadelphia, PA
¹³Perelman School of Medicine, Medical Scientist Training Program, Philadelphia, PA
¹⁴Graduate Group in Cell & Molecular Biology, University of Pennsylvania, Philadelphia, PA
¹⁵Division of Cardiology, Children’s Hospital of Philadelphia, Philadelphia, PA
¹⁶Division of Hematology, Oncology, BMT, and Cellular Therapies, Seattle Children's Hospital, Seattle, WA
¹⁷The Ben Town Center for Childhood Cancer Research, Seattle Children's Hospital, Seattle, WA
¹⁸Division of Pediatric Hematology and Oncology, Stephen D. Hassenfeld Children's Center for Cancer and Blood Disorders, NYU Langone Health, New York, NY
¹⁹Department of Biostatistics, University of Florida, Gainesville, FL
²⁰Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA
²¹Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN
²²Division of Oncology, University of Virginia Children’s Hospital, Charlottesville, VA
²³Children's Minnesota, Minneapolis, MN
²⁴Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN
²⁵Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
²⁶Department of Pediatrics, Division of Oncology and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
²⁷Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
²⁸Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Rutledge, PA
²⁹Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA

Petri Pölönen, PhD¹, Abdelrahman Elsayed, PhD^2,3*, Danika Di Giacomo, PhD^2*, Lindsey Montefiori, PhD², Shunsuke Kimura, MD, PhD^2*, Jason Myers^4*, Dale Hedges, PhD^4*, Jason Xu, PhD⁵, Yawei Hui, PhD^4*, Zhongshan Cheng, PhD^4*, Yiping Fan, PhD^4*, Ilaria Iacobucci, PhD², Yunchao Chang, PhD^2*, Rawan Shraim, MSc^6*, Meenakshi Devidas, PhD^7*, Stuart S. Winter, MD⁸, Kimberly P. Dunsmore, MD^9,10*, Jun J. J. Yang, PhD¹¹, Tiffaney L. Vincent^12*, Kai Tan, PhD^{13,14,15,16,17,18}, Changya Chen, Ph.D.^14,16*, Haley Newman, MD¹², Mignon L. Loh, MD¹⁹, Elizabeth A. Raetz, MD²⁰, Stephen P. Hunger, MD²¹, Evadnie Rampersaud, PhD^4*, Ti-Cheng Chang, PhD^4*, Gang Wu, PhD^4*, Stanley B. Pounds, PhD^3*, Charles G. Mullighan, MBBS, MD^2,22 and David T. Teachey, MD^5,12,23

¹Department of Pathology, St. Jude Children's Research Hospital, memphis, TN
²Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
³Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
⁴Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN
⁵Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
⁶Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
⁷Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN
⁸Research Institute and Cancer and Blood Disorders Program, Children's Minnesota, Eagan, MN
⁹Division of Oncology, University of Virginia Children’s Hospital, Charlottesville, VA
¹⁰Virginia Tech Carilion School of Medicine, Roanoke, VA
¹¹Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN
¹²Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
¹³Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
¹⁴Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA
¹⁵Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
¹⁶Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
¹⁷Institute for regenerative medicine, University of Pennsylvania, Philadelphia, PA
¹⁸Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, PA
¹⁹Department of Pediatrics, Benioff Children’s Hospital and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA
²⁰Perlmutter Cancer Center and Department of Pediatrics, NYU Langone Health, New York, NY
²¹Department of Pediatrics, Division of Oncology and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
²²Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, TN
²³Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Rutledge, PA

Shawn Lee, MD¹, Wenjian Yang, PhD^1*, Yoshihiro Gocho, MD^2*, August John^2*, Lauren Rowland^2*, Brandon Smart^2*, Hannah Williams, MPH^2*, Dylan Maxwell, MS^2*, Jeremy Hunt, MBA^2*, Wentao Yang, PhD^1*, Kristine R. Crews, PharmD^2*, Kathryn G Roberts, PhD³, Sima Jeha, MD⁴, Cheng Cheng, PhD^5*, Seth E. Karol, MD⁴, Mary V. Relling, PharmD¹, Gary Rosner, ScD^6*, Hiroto Inaba, MD, PhD⁴, Charles G. Mullighan, MBBS, MD³, Ching-Hon Pui, MD⁴, William E. Evans, PharmD¹ and Jun J. Yang, PhD²

¹Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN
²Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, TN
³Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
⁴Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN
⁵Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
⁶Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD

Emily C. Liang, MD¹, Simone E. Dekker, MD, PhD², Jean M.G. Sabile, MD³, Stefan Torelli, MD^4*, Amy Zhang, MPH^5*, Katharine Miller, PhD^5*, Parveen Shiraz, MD⁶, Brandon Hayes-Lattin, MD⁷, Jessica Leonard, MD⁷ and Lori Muffly, MD⁶

¹Department of Medicine, University of Washington, Seattle, WA
²Department of Medicine, Oregon Health & Science University, Portland, OR
³Department of Medicine, Oregon Health and Science University, Portland, OR
⁴Department of Medicine, Stanford University School of Medicine, Stanford, CA
⁵Department of Medicine, Quantitative Sciences Unit, Stanford University School of Medicine, Stanford, CA
⁶Department of Medicine, Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University School of Medicine, Stanford, CA
⁷Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University, Portland, OR