-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

616.O1.6 616. Acute Myeloid Leukemias: Investigational Therapies, Excluding Transplantation and Cellular Immunotherapies: Relapsed/Refractory AML

Symposia: Acute Myeloid Leukemias: Investigational Therapies, Excluding Transplantation and Cellular Immunotherapies Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, clinical trials, Biological therapies, Antibody Therapy, Acute Myeloid Malignancies, AML, adult, Non-Biological therapies, Clinical Research, Chemotherapy, Combination therapy, drug development, pediatric, Diseases, Therapies, Immunotherapy, Adverse Events, Monoclonal Antibody Therapy, Myeloid Malignancies, Radiation Therapy, Study Population, Human, Minimal Residual Disease
Saturday, December 10, 2022: 9:30 AM-11:00 AM
220-222 (Ernest N. Morial Convention Center)
Moderators:
Jonathan M Gerber, MD, Umass Medical School and Catherine Lai, MD, MPH, University of Pennsylvania
Disclosures:
Lai: Jazz Pharma: Speakers Bureau; Astellas: Speakers Bureau; Jazz Pharma: Consultancy; Jazz Pharma: Research Funding; Genentech: Consultancy; Novartis: Consultancy; Abbvie: Consultancy; Taiho: Consultancy; Pfizer: Consultancy; PDS Biotechnology: Consultancy; Macrogenics: Consultancy; Astellas: Consultancy; Daiichi Sankyo: Consultancy.
This session will focus on investigational therapies for relapsed/refractory AML, including novel agents and novel therapeutic combinations.
9:30 AM

Naval Daver, MD1, Jayastu Senapati, MD, MBBS, DM1*, Abhishek Maiti, MBBS2, Sanam Loghavi, MD3, Tapan M. Kadia, MD4, Courtney D. DiNardo, MD, MSCE1, Naveen Pemmaraju, MD1, Elias Jabbour, MD1, Guillermo Montalban-Bravo, MD1, Guilin Tang, MD, PhD3*, Koji Sasaki, MD1, Gautam Borthakur, MD1, Musa Yilmaz, MD4, Joie Alvarez, BSN1*, Sherry A. Pierce, BSN, BA1*, Graciela M. Nogueras González, MPH5*, Jing Ning6*, Ghayas C. Issa, MD7,8, Michael Andreeff, MD, PhD1, Hussein A Abbas, MD, PhD1, Farhad Ravandi, MD1, Guillermo Garcia-Manero, MD9 and Hagop Kantarjian, MD10

1Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
2Department of Leukemia, The University of Texas Health Science Center At Houston, Houston, TX
3Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
4Department of Leukemia, MD Anderson Cancer Center, Houston, TX
5Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
6department of biostatics, The University of Texas, M.D. Anderson Cancer Center, Houston, TX
7Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
8Department of Leukemia, Universit Y of Texas At Houston, Houston, TX
9Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
10Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

9:45 AM

Naval Daver, MD1, Pau Montesinos, PhD, MD2*, Ahmed Aribi, MD3, Giovanni Marconi, MD4, Jessica K. Altman, MD5, Eunice S. Wang, MD6, Gail J. Roboz, MD7, Patrick W. Burke, MD8, Gianluca Gaidano, MD, PhD9, Roland B. Walter, MD, PhD, MS10, Xavier Thomas, MD, PhD11, Deepa Jeyakumar, MD12, Daniel J. DeAngelo, MD, PhD13, Harry P. Erba, MD, PhD14, Elisabetta Todisco, MD, PhD15*, Kebede H. Begna, MD16, Anjali Advani, MD17, Lauris Gastaud, MD18*, Adolfo De La Fuente, MD19*, Antonio Curti, MD, PhD20, Lourdes M. Mendez, MD, PhD21, Paresh Vyas, DPhil, FRCP, FRCPath, MRCP, MRCPath22, Nicolas Boissel, MD, PhD23, Norbert Vey, MD24, Christian Recher, MD, PhD25, Thomas Longval, MD26*, Uwe Platzbecker, MD27, Silke Kapp-Schwoerer, MD28*, Christoph Schliemann, MD29*, Marina Konopleva, MD, PhD1, Laura Torres, MD2*, David A. Sallman, MD30, Guido Marcucci, MD31, Naveen Pemmaraju, MD1, Giovanni Martinelli, MD32, Hagop Kantarjian, MD33, Callum M Sloss, PhD34, Kara E Malcolm, RN34*, Patrick A Zweidler-McKay, MD, PhD34 and Kendra Sweet, MD30

1Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
2Hematology Department, Hospital Universitario i Politecnico La Fe Valencia, Valencia, Spain
3Department of Hematology/HCT, City of Hope National Medical Center, Duarte, CA
4IRCCS Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori” - IRST, Bologna, Italy
5Northwestern University, Chicago, IL
6Leukemia Service, Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY
7Division of Hematology and Oncology, Weill Cornell Medicine and The New York-Presbyterian Hospital, New York, NY
8Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI
9Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy
10Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA
11Department of Hematology, Hospices Civils de Lyon, Lyon-Sud Hospital, Lyon, France
12Division of Hematology/Oncology, UC Irvine Medical Center, Orange, CA
13Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
14Hematologic Malignancies Clinic, Duke University Blood Cancer Center, Durham, NC
15IEO, European Institute of Oncology IRCCS, Milan, Milan, Italy
16Divison of Hematology, Mayo Clinic, Rochester, MN
17Taussig Cancer Institute / Leukemia Program, Cleveland Clinic, Cleveland, OH
18Centre Antoine Lacassagne, Nice Cedex 2, France
19MD Anderson Cancer Center, Madrid, ESP
20IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy
21Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA, Boston, MA
22Department of Clinical Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
23Hospital St. Louis, Paris, France
24Institut Paoli-Calmettes, Aix-Marseille University, UM 105, Centre de Recherche en Cancérologie de Marseille (CRCM), Inserm, U1068, CNRS UMR7258, Marseille, France
25Institut Universitaire du Cancer de Toulouse Oncopole, CHU de Toulouse and Université de Toulouse III, Toulouse, France
26Laboratoire hématologie, APHP Hopital Saint Antoine, Paris, France
27Medical Clinical and Policlinic 1, Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany
28Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
29Department of Hematology, Oncolog and Pneumology, University of Münster, Münster, Germany
30Department of Hematology and Oncology, Moffitt Cancer Center, Tampa, FL
31Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA
32IRCCS Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori", Meldola, Italy
33Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
34ImmunoGen, Inc., Waltham, MA

10:00 AM

Ghayas C. Issa, MD1, Ibrahim Aldoss, MD2, John F. DiPersio, MD, PhD3, Branko Cuglievan, MD4*, Richard M. Stone, MD5, Martha L. Arellano, MD6, Michael J. Thirman, MD7, Manish R. Patel, MD8, David Dickens, MD9*, Shalini Shenoy, MD10, Neerav Shukla, MD11*, Galit Rosen, MD12, Rebecca G. Bagley, MA12*, Michael L. Meyers, MD, PhD12*, Kate Madigan, MD12*, Peter Ordentlich, PhD12*, Yu Gu, PhD12*, Steven Smith, PhD12*, Gerard M. McGeehan, PhD12* and Eytan Stein, MD13

1Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
2City of Hope, Duarte, CA
3Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO
4Division of Pediatric Hematology Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
5Center for Leukemia, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
6Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA
7Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL
8Florida Cancer Specialists/Sarah Cannon Research Institute, Sarasota, FL
9Division of Pediatric Hematology and Oncology, University of Iowa, Iowa City, IA
10Department of Pediatrics, Washington University School of Medicine, Saint Louis, MO
11Department of Pediatrics, Memorial Sloan Kettering Cancer Center Pediatric Hematology/Oncology (PD), New York, NY
12Syndax Pharmaceuticals, Inc., Waltham, MA
13Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY

10:15 AM

Harry P. Erba, MD, PhD1, Amir T. Fathi, MD2,3, Ghayas C. Issa, MD4, Jessica K. Altman, MD5, Pau Montesinos, MD, PhD6*, Mrinal M. M. Patnaik, MD7, James M. Foran, MD8, Stephane De Botton, MD, PhD9*, Maria R. Baer, MD10, Gary J. Schiller, MD11, Roland B. Walter, MD, PhD, MS12, Marina Kremyanskaya, MD, PhD13, Kristen M. Pettit14, Stephen A Strickland, MD, MSCI15, Blake Tomkinson, PhD, MBA16*, Marilyn Tabachri, RN, BSN16*, Mollie Leoni, MD16*, Stephen Dale, MD16* and Eunice S. Wang, MD17

1Leukemia Program, Duke University Medical Center, Durham, NC
2Director of Leukemia Program, Massachusetts General Hospital, Boston, MA
3Associate Professor of Medicine, Harvard Medical School, Boston, MA
4Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
5Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
6Hospital Universitari i Politècnic La Fe, Instituto de Investigación Sanitaria La Fe (IISLAFE), Valencia, Spain
7Division of Hematology, Mayo Clinic, Rochester, MN
8Division of Hematology/Oncology and Blood and Marrow Transplanation and Cellular Therapy, Mayo Clinic, Jacksonville, FL
9Department of Haematology, Institut Gustave Roussy, Villejuif, France
10University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD
11David Geffen School of Medicine at UCLA, Los Angeles, CA
12Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA
13Tisch Cancer Institute, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY
14Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI
15Vanderbilt-Ingram Cancer Center, Nashville, TN
16Kura Oncology, Boston, MA
17Leukemia Service, Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY

10:30 AM

Sameem Abedin, MD1, Guru Subramanian Guru Murthy, MBBS2, Aniko Szabo, PhD3*, Mehdi Hamadani, MD4, Laura C. Michaelis, MD5, Karen Carlson, MD, PhD1, Lyndsey Runaas, MD1*, Katelyn Gauger6*, Avinash G Desai, MD7, Mary M Chen, MD8, Alexandra M. Harrington, MD, MT(ASCP)4 and Ehab L. Atallah, MD1

1Division of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI
2Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI
3Division of Biostatistics, Institute of Health & Equity, Medical College of Wisconsin, Milwaukee, WI
4Medical College of Wisconsin, Milwaukee, WI
5Division of Hematology/Oncology, Department of Medicine, The Medical College of Wisconsin Inc., Milwaukee, WI
6Division of Hematology/Oncology, Medical College of Wisconsin, Milwaukee
7Actinium Pharmaceuticals, New York, NY
8Actinium Pharmaceuticals, Inc., New York, MD

10:45 AM

Soheil Meshinchi, M.D., Ph.D.1, Lane Miller, MD, MSc2*, Stephanie Massaro, MD, MPH3*, Robin Williams, MD, MS4, Elizabeth Krieger, MD5, Melinda Pauly, MD6,7, Catherine Nelson, DO8, Deepa Bhojwani, MD9, Rebecca Johnson, MD10*, Terzah M. Horton, MD, PhD11, Hamayun Imran, MD, MSc12, Wen-I Chang, MD13*, Philip Neff, MD14*, Matthew Kutny, MD15*, Raul C. Ribeiro, MD16, Felipe Bautista, MD17*, Terri Guinipero, MD18*, Kate Murray19*, Alex Butte19* and Arturo Molina, MD19

1Fred Hutchinson Cancer Center, Seattle, WA
2Children's Minnesota, Minneapolis, MN
3Yale University School of Medicine, New Haven, CT
4University of Minnesota Masonic Children’s Hospital, Minneapolis, MN
5Virginia Commonwealth University Health System, Richmond, VA
6Emory University School of Medicine, Atlanta, GA
7Emory University, Atlanta, GA
8Sanford Children's Hospital, Sioux Falls, SD
9Children's Hospital of Los Angeles, Los Angeles, CA
10Mary Bridge Children’s Hospital, Tacoma
11Baylor College of Medicine, Houston, TX
12University of South Alabama, Mobile, AL
13Hasbro Children’s Hospital, Providence, RI
14Dell Children’s Hospital, Austin, TX
15University of Alabama Birmingham, Birmingham, AL
16St. Jude Children's Research Hospital, Memphis, TN
17Novant Health Hemby Children’s Hospital, Charlotte, NC
18Nationwide Children's Hospital, Columbus, OH
19Sutro Biopharma, South San Francisco, CA

*signifies non-member of ASH