Jad Othman, MBBS^1,2, Nicola Potter, PhD^2*, Katya Mokretar^3*, David Taussig, MD, PhD^4*, Anjum Khan^5*, Pramila Krishnamurthy, MD^6*, Anne-Louise Latif^7*, Paul Cahalin, MA MRCP FRCPath^8*, James Aries^9*, Mariam Amer^10*, Edward Belsham, FRCPath, MB^11*, Eibhlin Conneally, MB, PhD, MRCP, FRCPath¹², Charles Craddock¹³, Dominic Culligan^14*, Mike Dennis, MD, MRCP, FRCPath¹⁵, Caroline Duncan, FRPATH, MBBS, MRCP,^16*, Caroline Furness^17*, Paraskevi Gkreka, MD, PhD^18*, Katherine Hodgson^19*, Wendy Ingram^20*, Andrew King^21*, Panagiotis Kottaridis, MD, PhD^22*, Mary Frances McMullin, MD, FRCPath, FRCP²³, Unmesh Mohite^24*, Loretta Ngu^25*, Katharine Patrick^26*, Tom Rider^27*, Wing Roberts^28*, Marianne Tang Severinsen, MD, PhD^29*, Neill Storrar, MBBChir^30*, Tom Taylor^31*, Nigel H. Russell, MD¹ and Richard Dillon, MA PhD MRCP FRCPath^1,32

¹Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
²Department of Medical and Molecular Genetics, King's College London, London, United Kingdom
³Cancer Genetics, Viapath, London, ENG, GBR
⁴The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom
⁵St James's Institute of Oncology, The Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
⁶King’s College Hospital, London, United Kingdom
⁷Department of Haematology, Queen Elizabeth University Hospital, Glasgow, United Kingdom
⁸Blackpool Teaching Hospitals NHS Foundation Trust, Blackpool, United Kingdom
⁹Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
¹⁰University Hospital Southampton, Southampton, United Kingdom
¹¹Portsmouth Hospitals NHS Trust, Portsmouth, United Kingdom
¹²Haematology, St. James' Hospital, Dublin, Ireland
¹³Centre for Clinical Haematology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
¹⁴Dep. of Haematology, Aberdeen Royal Infirmary, Aberdeen, CA, United Kingdom
¹⁵Haematology, The Christie NHS Foundation Trust, Manchester, United Kingdom
¹⁶Raigmore Hospita, Inverness, United Kingdom
¹⁷Royal Marsden Hospital, London, United Kingdom
¹⁸Princess Royal University Hospital, London, United Kingdom
¹⁹University Hospital Leicester, Leicester, United Kingdom
²⁰Department of Haematology, University Hospital Wales, Cardiff, United Kingdom
²¹Addenbrooke's Hospital, Cambridge, United Kingdom
²²University College London Hospital NHS Foundation Trust, London, GBR
²³Centre for Medical Education, Queen's University, Belfast, United Kingdom
²⁴Singleton Hospital, Swansea, GBR
²⁵Royal Devon & Exeter NHS Foundation Trust, Exeter, United Kingdom
²⁶Sheffield Childrens NHS Foundation Trust, Sheffield, United Kingdom
²⁷The Royal Sussex County Hospital, Brighton, United Kingdom
²⁸Great North Children's Hospital, Newcastle Upon Tyne, United Kingdom
²⁹Aalborg University Hospital, Aalborg, Denmark
³⁰Department of Haematology, NHS Lothian, Edinburgh, United Kingdom
³¹Nottingham University Hospital, Nottingham, United Kingdom
³²Department of Medical and Molecular Genetics, King's College London, London, ENG, United Kingdom

Pengcheng Shi^1*, Xi Jia^2*, Naying Liao^3*, Yin Changxin^4*, Huan Li^1*, Xuejie Jiang, MD^5*, Guopan Yu, MD^5*, Jieyu Ye^5*, Hong Qu^6*, Yu Zhan^7*, Chunju Wen^8*, Yu Zhang^5* and Qifa Liu, MD⁹

¹Department of Hematology, Nanfang Hospital, Southern medical University, Guangzhou, China
²Nanfang Hospital, Southern medical University, Guangzhou, AL, China
³Nanfang Hospital, Southern medical University, Guangzhou, China
⁴nanfang hospital, southern mediacl university, guangzhou, China
⁵Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
⁶Department of Hematology,, Panyu,Guangzhou, Guangdong, China, Pan Yu Central Hospital, Guangzhou, China
⁷gaungzhou twelfth people's hospital, guangzhou, China
⁸ganzhou people's hospital, ganzhou, China
⁹Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China

Nicholas Short, MD¹, Courtney D. DiNardo, MD, MSCE², Naval Daver, MD², Walid Macaron, MD, MSc^2*, Musa Yilmaz, MD³, Gautam Borthakur, MD², Guillermo Montalban-Bravo, MD², Guillermo Garcia-Manero, MD⁴, Ghayas C. Issa, MD², Koji Sasaki, MD², Philip A. Thompson, MBBS², Jan A. Burger, MD, PhD¹, Abhishek Maiti, MBBS², Yesid Alvarado, MD², Monica Kwari, BSN², Ricardo Delumpa, BSN^2*, Jennifer Thankachan^2*, Ejiroghene Mayor, BSN, RN^2*, Christopher Loiselle, BS^2*, Anna Milton^2*, Glenda Banks^2*, Tapan M. Kadia, MD³, Marina Konopleva, MD, PhD¹, Hagop Kantarjian, MD⁵ and Farhad Ravandi, MD²

¹Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Hartmut Döhner, MD¹, Daniela Weber, MSc^2*, Julia Krzykalla, PhD^3*, Walter Fiedler, MD⁴, Michael W.M. Kühn, MD^5*, Thomas Schroeder^6*, Karin Mayer, MD^7*, Michael Lübbert, MD⁸, Mohammad Wattad, MD⁹, Katharina Götze^10*, Lars Fransecky, MD^11*, Elisabeth Koller, MD^12*, Gerald Wulf, MD^13*, Jan Schleicher, MD^14*, Mark Ringhoffer, MD^15*, Richard Greil, MD¹⁶, Bernd Hertenstein, MD^17*, Jürgen Krauter, MD, PhD^18*, Uwe M. Martens, MD¹⁹, David Nachbaur, MD^20*, Maisun Abu Samra, M.D.^21*, Sigrid Machherndl-Spandl, MD^22*, Nadezda Basara, MD²³, Claudia Leis^2*, Anika Schrade, PhD^1*, Silke Kapp-Schwoerer, MD^1*, Lars Bullinger, MD²⁴, Felicitas R. Thol, MD²⁵, Michael Heuser, MD²⁵, Peter Paschka, MD¹, Verena I. Gaidzik, MD¹, Maral Saadati, PhD^26*, Axel Benner^27*, Richard F. Schlenk, MD^2,28, Konstanze Döhner, MD²⁹ and Arnold Ganser, MD^30*

¹Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
²Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany
³Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany
⁴Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, University Cancer Center Hamburg, University Hospital Eppendorf, Hamburg, Germany
⁵Department of Hematology, Oncology and Pneumology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany
⁶Department of Hematology, Oncology and Clinical Immunology, University Hospital Düsseldorf, Medical Faculty, Düsseldorf, Germany
⁷Department of Internal Medicine III, University Hospital of Bonn, Bonn, Germany
⁸Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, Freiburg, Germany
⁹Kliniken Essen Sued, Essen, Germany
¹⁰Department of Internal Medicine III, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany
¹¹Department of Internal Medicine II, University Hospital Schleswig-Holstein, Kiel, Germany
¹²3rd Medical Department for Hematology and Oncology, Hanusch Hospital, Vienna, Austria
¹³Department of Hematology and Oncology, Georg-August-University of Göttingen, Göttingen, Germany
¹⁴Department of Hematology and Oncology, Katharinenhospital Stuttgart, Stuttgart, Germany
¹⁵Department of Internal Medicine III, Municipal Hospital of Karlsruhe, Karlsruhe, Germany
¹⁶3rd Medical Department, Paracelsus Medical University, Salzburg Cancer Research Institute-CCCIT and Cancer Cluster Salzburg, Salzburg, Austria
¹⁷Klinikum Bremen Mitte, Bremen, Germany
¹⁸Department of Internal Medicine III, Städtisches Klinikum Braunschweig, Braunschweig, Germany
¹⁹Department of Internal Medicine III, SLK-Clinics Heilbronn, Heilbronn, Germany
²⁰University Hospital for Internal Medicine V, Haematology and Oncology, Innsbruck Medical University, Innsbruck, Austria
²¹University of Gießen, Gießen, Germany
²²Ordensklinikum Linz Elisabethinen, Linz, Austria
²³Medizinische Klinik I, Malteser Krankenhaus St. Franziskus-Hospital, Flensburg, Germany
²⁴Department of Hematology, Oncology and Tumorimmunology (Campus Virchow-Klinikum), Charite University Berlin, Berlin, Germany
²⁵Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
²⁶Saadati Solutions, Ladenburg, Germany
²⁷Division of Biostatistics, German Cancer Research Center, Heidelberg, Germany
²⁸National Center of Tumor Diseases, Heidelberg, Heidelberg, Germany
²⁹Division of Hematology and Oncology, University Hospital Ulm, Ulm, Germany
³⁰Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hanover, Germany

Huaiyu Wang, MD¹, Shu Chen^1*, Xiaojuan Zhang^1*, Xinhua Lu^1*, Sha Gong^1*, David Wald, PhD, MD^2*, Haitao Zhang, MD^1* and Jing Li^1*

¹The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
²Case Western Reserve University, Cleveland, OH

Eytan Stein, MD¹, Sheng F Cai, MD, PhD², Ying Huang, MS, MA^3*, Andrew Dunbar, MD⁴, Maria R. Baer, MD⁵, Wendy Stock, MD⁶, Tibor Kovacsovics, MD⁷, William G. Blum, MD⁸, Gary J. Schiller, MD⁹, Rebecca L. Olin, MD¹⁰, James M. Foran, MD¹¹, Mark R. Litzow, MD¹², Tara L. Lin, MD¹³, Prapti A. Patel, MD^14*, Matthew C. Foster, MD¹⁵, Michael M. Boyiadzis, MD¹⁶, Robert H. Collins, M.D.¹⁷, Jordan Chervin^18*, Abigail B. Shoben, PhD^19*, Jo-Anne Vergilio, MD^20*, Nyla A. Heerema, PhD²¹, Leonard Rosenberg, PhD RPh^22*, Timothy Chen, PhD^23*, Ashley O. Yocum, PhD^24*, Franchesca Druggan, MSc^25*, Sonja Marcus, MPH^26*, Mona Stefanos^19*, Molly Martycz^19*, Brian J. Druker²⁷, Alice S. Mims, MD³, Uma Borate, MD²⁸, Amy Burd, PhD²⁹, John C. Byrd, MD³⁰ and Ross L. Levine, MD³¹

¹Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
²Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
³Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH
⁴Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁵University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD
⁶University of Chicago, Chicago, IL
⁷Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
⁸Department of Hematology and Oncology, Winship Cancer Institute of Emory University, Atlanta, GA
⁹David Geffen School of Medicine at UCLA, Los Angeles, CA
¹⁰University of California, San Francisco, San Francisco, CA
¹¹Division of Hematology/Oncology and Blood and Marrow Transplanation and Cellular Therapy, Mayo Clinic, Jacksonville, FL
¹²Division of Hematology, Mayo Clinic, Rochester, MN
¹³University of Kansas, Westwood, KS
¹⁴Division of Hematologic Malignancies, University of Texas Southwestern Medical Center, Dallas, TX
¹⁵Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC
¹⁶Univ. of Pittsburgh Cancer Inst., Pittsburgh, PA
¹⁷Division of Hematology/Oncology, Department of Internal Medicine, University of Texas Southwestern, Dallas, TX
¹⁸Memorial Sloan Kettering Cancer Center, New York, NY
¹⁹The Ohio State University Comprehensive Cancer Center, Columbus, OH
²⁰Foundation Medicine, Cambridge, MA
²¹Department of Pathology, The Ohio State University, Columbus, OH
²²Leukemia & Lymphoma Society, Mount Laurel, NJ
²³Department of Internal Medicine, Division of Hematology, College of Medicine, The Ohio State University, Columbus, OH
²⁴The Leukemia & Lymphoma Society, Rye Brook, NY
²⁵The Ohio State University, Columbus, OH
²⁶Leukemia & Lymphoma Society, Rye Brook, NY
²⁷Knight Cancer Institute, Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, OR
²⁸Division of Hematology, The Ohio State University, Columbus, OH
²⁹The Leukemia & Lymphoma Society, White Plains, NY
³⁰Department of Internal Medicine, University of Cincinnati, Cincinnati, OH
³¹Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY