-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

615.O1.6 615. Acute Myeloid Leukemias: Commercially Available Therapies, Excluding Transplantation and Cellular Immunotherapies: New Approaches to Combination Chemotherapy and Venetoclax Plus Hypomethylating Agent Therapy in AML

Symposia: Acute Myeloid Leukemias: Commercially Available Therapies, Excluding Transplantation and Cellular Immunotherapies Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, clinical trials, Acute Myeloid Malignancies, AML, Biological therapies, Antibody Therapy, adult, Non-Biological therapies, elderly, Clinical Practice (Health Services and Quality), assays, Clinical Research, Chemotherapy, Combination therapy, Diseases, Therapies, therapy sequence, real-world evidence, Adverse Events, Myeloid Malignancies, Monoclonal Antibody Therapy, Technology and Procedures, Study Population, Human, profiling, Minimal Residual Disease
Saturday, December 10, 2022: 2:00 PM-3:30 PM
Great Hall BC (Ernest N. Morial Convention Center)
Moderators:
Hetty E. Carraway, MD, MBA, Cleveland Clinic and Akriti G Jain, MD, H. Lee Moffitt Cancer Center and Research Institute
Disclosures:
Carraway: BMS: Consultancy, Honoraria, Speakers Bureau; CTI Biopharma: Consultancy, Membership on an entity's Board of Directors or advisory committees; Jazz: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Stemline: Speakers Bureau; Novartis: Honoraria, Speakers Bureau; Gilead: Consultancy, Membership on an entity's Board of Directors or advisory committees; AbbVie: Other: DSMB; Syndax: Other: DSMB; Takeda: Other: DSMB.
This session includes six abstracts illustrating advances in intensive chemotherapy and venetoclax and hypomethylating agent-based strategies in newly diagnosed and and relapsed/refractory AML.
2:00 PM

Christoph Röllig, MD, MSC1*, Björn Steffen, MD2*, Christoph Schliemann, MD3*, Jan-Henrik Mikesch, PD, MD3*, Nael Alakel, MD4*, Regina Herbst, MD5*, Mathias Haenel, MD6*, Richard Noppeney, MD7*, Maher Hanoun, MD, PhD8*, Martin Kaufmann, MD9, Zdenek Racil, MD10*, Kerstin Schäfer-Eckart11*, Tim Sauer, MD12*, Andreas Neubauer, MD13, Claudia D. Baldus, MD14*, Jolana Mertova15*, Edgar Jost16*, Dirk Niemann, MD17*, Jan Novak18*, Stefan W. Krause, MD19*, Sebastian Scholl, MD20*, Andreas Hochhaus21, Gerhard Held, Professor Dr22*, Tomáš Szotkowski, MD, PhD23*, Christoph Schmid, MD24*, Andreas Rank, MD25*, Lars Fransecky, MD26*, Michael Kramer, MSc27*, Frank Fiebig28*, Annett Haake28*, Friedrich Stoelzel, MD29, Johannes Schetelig, MD, MSc30, Jan Moritz Middeke, MD29*, Uwe Platzbecker, MD31*, Christian Thiede, MD27, Carsten Müller-Tidow, MD12*, Wolfgang E. Berdel, MD32, Hubert Serve, MD2, Gerhard Ehninger, MD33, Jiří Mayer, MD34 and Martin Bornhaeuser, MD35

1Universitätsklinikum Carl Gustav Carus, Dresden, Germany
2Department of Medicine II, Hematology/Oncology, Goethe University Hospital, Frankfurt, Germany
3Department of Hematology, Oncolog and Pneumology, University of Münster, Münster, Germany
4University Hospital TU Dresden, Germany, Dresden, Germany
5Klinikum Chemnitz, Chemnitz, DEU
6Medizinische Klinik III, Klinikum Chemnitz, Chemnitz, Germany
7Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany
8Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany
9Medical Centre, Robert-Bosch-Hospital,, Stuttgart, Germany
10Masaryk University Hospital Brno, Brno, CZE
11Department of Internal Medicine V, Nuremberg Hospital North, Paracelsus Medical University, Nuremberg, Germany
12Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany
13Klinik für Innere Medizin, Schwerpunkt Hämatologie, Onkologie und Immunologie, Philipps University, Marburg, Germany
14Department of Internal Medicine II, University Hospital Schleswig-Holstein, Kiel, Kiel, Germany
15UHKT, Prague, Czech Republic
16University Hospital Aachen, Germany, Aachen, Germany
17Department of Hematology/Oncology and Palliative Medicine, Ev. Stift St. Martin, Koblenz, Germany
18University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles U, Prague, CZE
19University Hospital Erlangen, Germany, Erlangen, Germany
20University Hospital Jena, Jena, Germany
21Department of Internal Medicine 2, Hematology and Oncology, Jena University Hospital, Jena, Germany
22Department of Internal Medicine I, Westpfalz-Klinikum, Kaiserslautern, Germany
23Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic
24Department of Haematology and Oncology, University Hospital and Medical Faculty Augsburg, Augsburg, Germany
25Klinikum Augsburg, Augsburg, DEU
26Department of Internal Medicine II, University Hospital Schleswig-Holstein, Kiel, Germany
27Department of Internal Medicine I, University Hospital Dresden, Dresden, Germany
28Universitätsklinikum Dresden, Dresden, Germany
29Department of Internal Medicine I, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany
30Department of Internal Medicine I, TU Dresden, Dresden, Saxony, Germany
31Department for Hematology, Cell Therapy and Hemostaseology, University of Leipzig Medical Center, Leipzig, Germany
32Department of Medicine A, Hematology and Oncology, University Hospital Muenster, Muenster, Germany
33Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus der TU Dresden, Dresden, Germany
34Department of Internal Medicine Hematology and Oncology, University Hospital Brno and Masaryk University, Brno, Czech Republic
35Universitatsklinikum Cad GustavCarus an der Technischen Universltat Dresden, Dresden, Ferscherstrabo 74, Germany

2:15 PM

Nigel H. Russell, MD1, Charlotte Wilhelm-Benartzi, PhD2*, Steve Knapper, BMBCh3, Leona M Batten2*, Joanna Canham2*, Emily L Hinson, PhD2*, Ulrik Malthe Overgaard, MD4*, Amanda Gilkes5*, Jad Othman, MBBS6, Nicola Potter, PhD6*, Richard Dillon, MA PhD MRCP FRCPath6, Priyanka Mehta7*, Panagiotis Kottaridis, MD, PhD8*, Jamie Cavenagh, MD, PhD9*, Claire Hemmaway, MD10*, Claire Arnold, MD11*, Sylvie D Freeman, MBChB, MRCP, FRCPath12 and Mike Dennis, MD, MRCP, FRCPath13

1Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
2Centre for Trials Research, Cardiff University, Cardiff, United Kingdom
3Cardiff University School of Medicine, Cardiff, United Kingdom
4Copenhagen University Hospital, Denmark, Denmark
5Cardiff University, Cardiff, GBR
6Department of Medical and Molecular Genetics, King's College London, London, United Kingdom
7The University of Bristol and Weston NHS Trust, Bristol, United Kingdom
8University College London Hospital NHS Foundation Trust, London, GBR
9Department of Haematology, St Bartholomew's Hospital, London, United Kingdom
10Auckland City Hospital, Auckland, New Zealand
11Belfast City Hospital, Belfast, United Kingdom
12Centre for Clinical Haematology, University Hospitals Birmingham, Birmingham, United Kingdom
13Haematology, The Christie NHS Foundation Trust, Manchester, United Kingdom

2:30 PM

Keith W. Pratz, MD1, Brian A. Jonas, MD, PhD2, Vinod A. Pullarkat, MD3*, Michael J. Thirman, MD4, Jacqueline S. Garcia, MD5, Walter Fiedler, MD6, Kazuhito Yamamoto, MD, PhD7, Jianxiang Wang, MD8, Sung-Soo Yoon, MD, PhD9, Ofir Wolach, MD10*, Jun-Ho Jang, MD11*, Su-Peng Yeh, MD12*, Grace Ku, MD13, Ying Zhou, PhD14*, Brenda Chyla, PhD14, Jalaja Potluri, MD14 and Courtney D. DiNardo, MD, MSCE15

1Division of Hematology and Oncology, Abramson Cancer Center University of Pennsylvania, Philadelphia, PA
2Department of Internal Medicine, Division of Malignant Hematology, Transplantation and Cellular Therapy, University of California Davis School of Medicine, Sacramento, CA
3Department of Hematology and Hematopoietic Cell Transplantation and Gehr Family Center for Leukemia Research, City of Hope Comprehensive Cancer Center, Duarte, CA
4Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL
5Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
6Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, University Cancer Center Hamburg, University Hospital Eppendorf, Hamburg, Germany
7Aichi Cancer Center, Nagoya, Japan
8Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
9Division of Hematology/Medical Oncology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South)
10Rabin Medical Center, Petah Tikva, Israel
11Division of Hematology-Oncology, Samsung Medical Center, Seoul, Korea, Republic of (South)
12China Medical University Hospital, Taichung, Taiwan
13Genentech, South San Francisco, CA
14AbbVie Inc., North Chicago, IL
15Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

2:45 PM

Sylvie D Freeman, MBChB, MRCP, FRCPath1, Abin Thomas2*, Ian Thomas2*, Paresh Vyas, DPhil, FRCP, FRCPath, MRCP, MRCPath3, Amanda Gilkes4*, Marlen Metzner, MSc3*, Niels Asger Jakobsen, BM BCh MRCP5*, Alison Kennedy, MSc6*, Amy Moore7*, Nuria Marquez Almuina8*, Sarah Burns8*, Sophie King8*, Georgia M. Andrew, BSc9*, Kathleen M.E. Gallagher, PhD10*, Rob Sellar, FRCPath, MBBChir11*, Paul Cahalin, MA MRCP FRCPath12*, Duruta Weber13*, Mike Dennis, MD, MRCP, FRCPath14, Priyanka Mehta15*, Steve Knapper, BMBCh16 and Nigel H. Russell, MD17

1Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom
2Centre for Trials Research, Cardiff University, Cardiff, United Kingdom
3MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
4Cardiff University, Cardiff, GBR
5Oxford Centre for Haematology, NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom
6Wellcome - MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
7University of Oxford, Oxford, United Kingdom
8Cardiff University, Cardiff, United Kingdom
9Laboratory of Myeloid Malignancies, National Heart Lung and Blood Institute, Bethesda, MD
10Cellular Immunotherapy Program, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA
11University College London, London, United Kingdom
12Blackpool Teaching Hospitals NHS Foundation Trust, Blackpool, United Kingdom
13Odense Universitetshospital, Odense, DNK
14Haematology, The Christie NHS Foundation Trust, Manchester, United Kingdom
15The University of Bristol and Weston NHS Trust, Bristol, United Kingdom
16Cardiff University School of Medicine, Cardiff, United Kingdom
17Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom

3:00 PM

Sai Prasad Desikan, MD1*, Marina Konopleva, MD, PhD1, Koichi Takahashi, MD, PhD2, Curtis A Lachowiez, MD3*, Sanam Loghavi, MD4, Lian-Chun Xiao5*, Tapan M. Kadia, MD1, Naval Daver, MD1, Nicholas Short, MD2, Koji Sasaki, MD1, Gautam Borthakur, MD1, Ghayas C. Issa, MD1, Abhishek Maiti, MBBS6, Kelly S. Chien, MD1, Yesid Alvarado, MD1, Guillermo Montalban-Bravo, MD1, Lucia Masarova, MD1, Musa Yilmaz, MD7, Michael Andreeff, MD, PhD1, Elias Jabbour, MD1, Guillermo Garcia-Manero, MD8, Steven M. Kornblau, MD1, Farhad Ravandi, MD1, Hagop Kantarjian, MD9 and Courtney D. DiNardo, MD, MSCE1

1Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
2Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
3Department of Medicine, Oregon Health and Science University, Portland, OR
4Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
5Department of Biostatistics, The University of Texas M.D. Anderson Cancer Center, Houston
6Department of Leukemia, The University of Texas Health Science Center At Houston, Houston, TX
7Department of Leukemia, MD Anderson Cancer Center, Houston, TX
8Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
9Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

3:15 PM

Christophe Willekens, MD1*, Samy Chraibi, MD2*, Justine Decroocq, MD, PhD3*, Benjamin Carpentier, MD4*, Delphine Lebon, MD5*, Sarah Bonnet, MD6*, Nicolas Gauthier, MD7*, Arnaud Pagès8*, Matteo Dragani, MD1*, Sabine Khalife-Hachem, MD1*, Jean-Baptiste Micol, MD1, Florence Pasquier, MD, PhD1*, Stefan Wickenhauser, MD2*, Véronique Saada, PharmD9*, Véronique Vergé, MD10*, Ahmadreza Arbab9*, Christophe Marzac, MD9*, Laurent Pascal, MD, PhD4*, Damien Roos-Weil, MD, PhD7*, Eric Jourdan, MD2*, Didier Bouscary, MD, PhD3* and Stéphane de Botton, MD, PhD1*

1Département d’Hématologie, Gustave Roussy, Université Paris-Saclay, Villejuif, France
2Service d’Hématologie, Centre Hospitalier Universitaire de Nîmes, Nîmes, France
3Service d’Hématologie, Centre Hospitalier Universitaire Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France
4Service d’Hématologie, Groupement des Hôpitaux de l'Institut Catholique de Lille, Lille, France
5Service d’Hématologie, Centre Hospitalier Universitaire Amiens – Picardie, Amiens, France
6Service d’Hématologie, Centre Hospitalier Universitaire de Montpellier, Montpellier, France
7Service d’Hématologie, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France
8Biostatistique et Epidémiologie, CESP Inserm U1018, Gustave Roussy, Université Paris-Saclay, Villejuif, France
9Département de Biologie et Pathologie Médicales, Gustave Roussy, Université Paris-Saclay, Villejuif, France
10Département de Biologie et Pathologie Médicales, Gustave Roussy/Université Paris-Saclay, Villejuif, France

*signifies non-member of ASH