Valentino Conter, MD^1*, Maria Grazia Valsecchi, PhD^2*, Gunnar Cario, MD, PhD^3*, Martin Zimmermann, PhD^4*, Andishe Attarbaschi, MD^5*, Jan Stary, MD^6,7*, Felix Niggli, MD^8*, Luciano Dalla Pozza, MD^9*, Sarah Elitzur, MD^10*, Daniela Silvestri, Dr^11*, Franco Locatelli, Prof., MD, PhD¹², Anja Moericke, MD^13*, Gernot Engstler, MD^14*, Petr Smisek, MD^6*, Nicole Bodmer, MD^15*, Draga Barbaric, MBBS FRACP^16*, Shai Izraeli, MD¹⁷, Carmelo Rizzari^18*, Joachim Boos, MD^19*, Barbara Buldini^20*, Claudia Lanvers-Kaminsky, PhD^21*, Giovanni Cazzaniga, PhD²², Bernd Gruhn^23*, Andrea Biondi, MD, PhD²⁴ and Martin Schrappe, MD¹³

¹Pediatric Hematology-Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, MBBM Foundation, Monza, Italy
²Bicocca Bioinformatics, Biostatistics and Bioimaging Centre, Department of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy
³Universitätsklinikum Schleswig-Holstein, Kiel, Germany
⁴Department of Pediatric Hematology and Oncology, Hannover Medical School (MHH), Hannover, Germany
⁵St. Anna Children's Hospital, Vienna, Austria
⁶Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
⁷Dept. of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
⁸University Children's Hospital, Zurich, Switzerland, CHE
⁹Cancer Centre for Children, Children’s Medical Research Institute (CMRI), Westmead, NSW, Australia
¹⁰Pediatric Hematology and Oncology, Schneider Children's Medical Center and Tel Aviv University, Tel Aviv, Israel
¹¹Bicocca Center of Bioinformatics, Biostatstics and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy
¹²Department of Pediatric Hematology and Oncology, IRCCS Ospedale Pediatrico Bambino Gesù Rome, Catholic University of the Sacred Heart, Rome, Italy
¹³Department of Pediatrics I, Pediatric Hematology/Oncology, ALL-BFM Study Group, Christian Albrechts University Kiel and University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
¹⁴St Anna Children's Hospital, Medical University of Vienna, Vienna, Austria
¹⁵University Children's Hospital Zürich, Zürich, Switzerland
¹⁶Kids Cancer Centre, Sydney Children’s Hospital Randwick, Randwick, Australia
¹⁷Department of Pediatric Hematology Oncology, Schneider Children Medical Center of Israel, Petach Tikva, Israel
¹⁸Pediatric Hematology-Oncology Unit, University of Milano-Bicocca, MBBM Foundation, San Gerardo Hospital, Monza, Italy
¹⁹Department of Pediatric Hematology and Oncology, University Childrens’ Hospital of Münster, Münster, Germany
²⁰University of Padua, Padua, It, Italy
²¹Paediatric Haematology and Oncology, University Hospital of Muenster, Muenster, NRW, DEU
²²Dept. of Pediatrics / Medical Genetics and Tettamanti Research Center, University of Milano-Bicocca, Fondazione MBBM / San Gerardo Hospital, Monza, Italy
²³Department of Pediatrics, Jena University Hospital, Jena, Germany
²⁴Department of Medicine, University of Milano-Bicocca, Monza, Italy

Nicolas Boissel, MD, PhD^1,2, Francoise Huguet, MD^3*, Thibaut Leguay, MD^4*, Hunault-Berger Mathilde, MD, PhD^5*, Carlos Graux^6*, Yves Chalandon, MD⁷, Eric Delabesse, MD, PhD^8*, Yosr Hicheri, MD^9*, Patrice Chevallier, MD¹⁰, Marie Balsat^11*, Cedric Pastoret, MD, PhD^12*, Martine Escoffre-Barbe, MD^13*, Florence Pasquier, MD, PhD^14*, Jean-Pierre Marolleau, MD, PhD¹⁵, Anne Thiebaut-Bertrand^16*, Anne Huynh^17*, Nathalie Dhedin, MD^18*, Emilie Lemasle, MD^19*, Caroline Bonmati, MD^20*, Sébastien Maury^21*, Gaëlle Guillerm, MD^22*, Anna Berceanu, MD^23*, Urs Schanz, MD²⁴, Thomas Cluzeau, MD, PhD²⁵, Pascal Turlure, MD^26*, Philippe Rousselot, MD, PhD^27*, Bernard J. M. De Prijck, MD^28*, Nathalie Grardel, MD^29*, Marie C Bene, PharmD, DPhil^30*, Marine Lafage, MD^31*, Norbert Ifrah, MD PhD³², Veronique Lheritier^33*, Vahid Asnafi, MD, PhD^34,35*, Emmanuelle Clappier, PharmD, PhD^36* and Herve Dombret, MD PhD^37,38

¹St-Louis Hospital, APHP, Adolescent and Young Adult Hematology Department, Paris, France
²URP-3518, Saint-Louis Research Insitute, Université Paris Cité, Paris, France
³Department of Hematology, Institut Universitaire du Cancer-Oncopole CHU de Toulouse, Toulouse, France
⁴Hematology Clinic, Bordeaux University Hospital, Pessac, France
⁵department of hematology, CHU Angers, Angers, ML, France
⁶Université Catholique de Louvain, CHU UCL Namur (Godinne), Yvoir, Belgium
⁷Geneva University Hospitals, Geneva, Switzerland
⁸FRA
⁹Departement d'Hematologie, Institut Paoli-Calmettes, MARSEILLE, France
¹⁰Hematology Department, Nantes University Hospital, Nantes, France
¹¹Service Hematologie, Centre Hospitalier Lyon Sud, Lyon, France
¹²INSERM U1236 /Hematology Laboratory, University Hospital of Rennes, RENNES, FRA
¹³Hôpital de Pontchaillou, Centre Hospitalier Universitaire de Rennes, Rennes, France
¹⁴Gustave Roussy, Département clinique d'hématologie, INSERM UMR1170, Villejuif, FRA
¹⁵Hematology Department, Amiens University Hospital, Amiens, France
¹⁶Department of Hematology, CHU-Grenoble Onco-Hematologie, Grenoble, France
¹⁷Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France
¹⁸St-Louis Hospital, APHP, Adolescents and Young Adults Hematology Department, Paris, France
¹⁹Hematology Department, Henri-Becquerel Cancer Center, Rouen, France
²⁰Service D'Hématologie, Centre Hospitalier Universitaire De Nancy, Nancy, FRA
²¹Service d’Hématologie clinique, Hôpitaux universitaires Henri-Mondor (AP-HP), Créteil, FRA
²²Department of Hematology, Brest University Hospital, Brest, France
²³Clinical Hematology, Besançon University Hospital, Besançon, France
²⁴Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland
²⁵Département d'Hématologie Clinique, Université Côte d'Azur, CHU Nice, Nice, Provence Alpes Cote d'Azur, France
²⁶Department of Clinical Hematology, Limoges University Hospital, Limoges, France
²⁷Hematology Department, Centre Hospitalier de Versailles, LE CHESNAY CEDEX, France
²⁸CHU Sart Tilman, Liege, BEL
²⁹Laboratory of Hematology, Centre Hospitalier Universitaire Lille, Lille, France
³⁰Hematology Biology, Nantes University Hospital, Nantes, France
³¹Department of Genetics, La Timone Hospital, Aix Marseille University, MARSEILLE, France
³²Clinical Hematology, Angers University Hospital, Angers, France
³³Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL), Centre Hospitalier Lyon Sud, Lyon, France
³⁴INSERM U1151, Université Paris Descartes Sorbonne Cité, Paris, France
³⁵Laboratory of Onco-Hematology, Necker University Hospital, Paris, France
³⁶Hematology Laboratory, AP-HP, Hôpital Saint-Louis, Paris, France
³⁷URP-3518, Institut de Recherche Saint-Louis, Université Paris Cité, Paris, France
³⁸Hopital Saint-Louis, Assistance Publique - Hopitaux De Paris (AP-HP), Paris, FRA

Nicola Goekbuget, MD¹, Walter Fiedler, MD², Nael Alakel, MD^3*, Max S. Topp, MD^4*, Maher Hanoun, MD^5*, Björn Steffen, MD^1*, Ralph Wäsch⁶, Andreas Viardot, MD⁷, Kathrin Nachtkamp, MD^8*, Matthias Stelljes, MD^9*, Hendrik Poeck, MD¹⁰, Vladan Vucinic, MD^11*, Boris Böll, MD^12*, Joachim Beck, MD^13*, Lars Fransecky, MD^14*, Knut Wendelin, MD^15*, Folker Schneller, MD^16*, Christoph Faul, MD¹⁷, Veit L Buecklein, MD^18*, Lena Reiser^1*, Monika Brüggemann, MD^19*, Hubert Serve, MD¹ and Stefan Schwartz, M.D.^20*

¹Department of Medicine II, Hematology/Oncology, Goethe University Hospital, Frankfurt, Germany
²Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, University Cancer Center Hamburg, University Hospital Eppendorf, Hamburg, Germany
³University Hospital TU Dresden, Germany, Dresden, Germany
⁴UniversitäTsklinikum WüRzburg, Würzburg, Germany
⁵Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany
⁶Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
⁷Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany
⁸Department of Hematology, Oncology and Clinical Immunology, Universitätsklinik Düsseldorf, Düsseldorf, Germany
⁹University Hospital of Muenster, Muenster, Germany
¹⁰Department of Internal Medicine III, Hematology and Oncology, University Hospital Regensburg, Regensburg, Bavaria, Germany
¹¹Department for Hematology, Cell Therapy and Hemostaseology, University of Leipzig Medical Center, Leipzig, Germany
¹²Hematology/Oncology, University Hospital Cologne, Cologne, NRW, Germany
¹³Universitatsmedizin Mainz, Mainz, Schkeuditz, Germany
¹⁴Department of Internal Medicine II, University Hospital Schleswig-Holstein, Kiel, Germany
¹⁵Paracelsus Medizinische Privatuniversität Nürnberg, Klinik f. Innere Medizin 5, Nuernberg, Germany
¹⁶Medical Department III, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
¹⁷University Hospital Tübingen, Department of Medicine II, Hematology, Oncology, Clinical Immunology and Rheumatology, Tübingen, Germany
¹⁸Department of Medicine III, University Hospital, LMU Munich, Munich, Germany
¹⁹Department of Internal Medicine II, University Hospital Schleswig-Holstein, Kiel, Kiel, Germany
²⁰Hematology, Oncology and Tumor Immunology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

Ruth Wangondu, MD, PhD¹, Emily Ashcraft, MPH^2*, Kathryn G Roberts, PhD³, Cheng Cheng, PhD^2*, Hiroto Inaba, MD, PhD¹ and Charles G. Mullighan, MBBS, MD³

¹Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN
²Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
³Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN

Nicola Goekbuget, MD¹, Andreas Viardot, MD², Björn Steffen, MD^1*, Joachim Hahn, MD^3*, Bernd Spriewald, MD^4*, Sonja Martin, MD^5*, Simon Raffel, MD⁶, Lino L. Teichmann, MD^7*, Arne Trummer, MD^8*, Winfried Alsdorf, MD^9*, Anke Morgner, MD^10*, Stefan Schwartz, M.D.^11*, Matthias Stelljes, Prof. Dr. med.¹², Vladan Vucinic, MD^13*, Nael Alakel, MD^14*, Andrea Stoltefuß, MD^15*, Claudia D. Baldus, MD^16*, Monika Brüggemann, MD^16*, Hubert Serve, MD¹ and Dieter Hoelzer, MD, PhD¹⁷

¹Department of Medicine II, Hematology/Oncology, Goethe University Hospital, Frankfurt, Germany
²Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
³Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany
⁴Med. Klinik 5 / Hämatologie u. Internist. Onkologie, Universität Erlangen-Nürnberg, Erlangen, Germany
⁵Department of Hematology and Oncology, Robert-Bosch-Hospital, Stuttgart, Germany
⁶Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany
⁷Department of Medicine III, University Hospital Bonn, Bonn, Germany
⁸Department of Internal Medicine III, Braunschweig Municipial Hospital, Braunschweig, Germany
⁹Department of Oncology and Hematology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
¹⁰Klinikum Chemnitz, Chemnitz, Germany
¹¹Hematology, Oncology and Tumor Immunology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
¹²Department of Medicine / Hematology and Oncology, University of Muenster, Muenster, Germany
¹³Department for Hematology, Cell Therapy and Hemostaseology, University of Leipzig Medical Center, Leipzig, Germany
¹⁴University Hospital TU Dresden, Germany, Dresden, Germany
¹⁵Evangelisches Krankenhaus Hamm, Hamm, Germany
¹⁶Department of Internal Medicine II, University Hospital Schleswig-Holstein, Kiel, Kiel, Germany
¹⁷Onkologikum Frankfurt, Frankfurt, Germany

Yoshihiro Hatta¹, Atsushi Sato, MD, PhD^2*, Akiko Kada, MPH^3*, Akiko Moriya Saito, MD, PhD^3*, Fumihiko Hayakawa, MD, PhD⁴, Arata Watanabe, MD^5*, Tatsuhiro Sakamoto, MD, PhD^6*, Katsuhiro Miura, MD^7*, Yoshifumi Shimizu, MD^8*, Junya Kanda, MD, PhD⁹, Yasushi Onishi, MD, PhD^10*, Noboru Asada, MD, PhD¹¹, Yasuhiro Okamoto, MD, PhD¹², Chihaya Imai, MD, PhD¹³, Koichi Oshima, MD, PhD^14*, Katsuyoshi Koh, MD^14*, Atsushi Manabe, MD, PhD¹⁵, Keizo Horibe, MD, PhD^3,16*, Hitoshi Kiyoi¹⁷, Itaru Matsumura¹⁸ and Yasushi Miyazaki, MD¹⁹

¹Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
²Department of Hematology and Oncology, Miyagi Children’s Hospital, Sendai, Japan
³Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
⁴Department of Integrated Health Sciences, Division of Cellular and Genetic Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan
⁵Department of Pediatrics, Nakadori General Hospital, Akita, JPN
⁶Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
⁷Division of Hematology and Rheumatology, Department of Medicine, Nihon University, Tokyo, Japan
⁸Department of Hematology, Takarazuka City Hospital, Takarazuka, Japan
⁹Department of Hematology and Oncology, Kyoto University, Kyoto, Japan
¹⁰Department of Hematology, Tohoku University Graduate School of Medicine, Sendai, Japan
¹¹Department of Hematology and Oncology, Okayama University Hospital, Okayama, OKA, Japan
¹²Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
¹³Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
¹⁴Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan
¹⁵Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan
¹⁶Department of Pediatrics, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
¹⁷Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya-shi, Japan
¹⁸Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, Osakasayama, Japan
¹⁹Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan