Josh Bennett, BSc^1*, Jennifer Yeung, PhD, BS², Avery Sampson, BSc^3*, Kathleen Hueneman, BSc^3*, Mark Wunderlich, MS^4*, Kwangmin Choi, PhD^3*, Andrew Volk, PhD⁵, Scott B. Hoyt, Ph.D.^6*, Craig J. Thomas, PhD^7,8* and Daniel T. Starczynowski, PhD³

¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²Cincinnati Children's Hospital Medical Center, Cincinnati, KY
³Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁴Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁵Division of Hematology/Oncology, Cincinati Childrens Hospital Medical Center, Cincinnati, OH
⁶Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD
⁷Division of Pre-Clinical Innovation Chemistry Technologies, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD
⁸Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD

Courtney Chambers^1*, Kristen Kurtz, MD^2,3*, Andrew Henry Lewis, PhD⁴, Katharina Wohlan, PhD⁵, Yuen San Chan, PhD^1*, Katerina Cermakova, PhD^1*, Milan Dejmek, PhD^6*, Michal Sala, PhD^6*, Rogelio Aguilar^7*, Mario Loeza Cabrera^1*, Radim Nencka, PhD^6*, H. Daniel Lacorazza, PhD⁸, Rachel E. Rau, MD^9,10 and H. Courtney Hodges, PhD^1,11,12*

¹Department of Molecular and Cellular Biology, Center for Precision Environmental Health, and Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX
²Texas Children's Hospital, Houston, TX
³Department of Pediatrics, Baylor College of Medicine, Houston, TX
⁴Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX
⁵Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston
⁶Institute of Organic Chemistry and Biochemistry, Prague, CZE
⁷Baylor College of Medicine, Houston, TX
⁸Texas Children’s Hospital, Department of Pathology & Immunology, Baylor College of Medicine Texas Children's Hospital, Houston, TX
⁹Texas Children’s Cancer and Hematology Centers, Department of Pediatrics, Texas Childrens Hospital, Houston, TX
¹⁰Department of Pediatrics, Baylor College of Medicine, Houston
¹¹Department of Bioengineering, Rice University, Houston, TX
¹²Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, TX

Vanessa E. Kennedy, MD¹, Cheryl Peretz, MD², Paul Lee, MD, PhD^3*, Brenda Chyla, PhD⁴, Yan Sun, PhD^4*, Monique Dail, PhD^5*, Jason Hill, PhD^6*, Elaine Tran^1*, Andrew Koh^1*, Jessica K. Altman, MD⁷, Naval Daver, MD⁸, Mark J. Levis, MD⁹, James McCloskey, MD^10*, Alexander Perl, MD¹¹ and Catherine Smith, MD¹

¹University of California San Francisco, San Francisco, CA
²Department of Pediatrics and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA
³AbbVie, Inc., North Chicago, IL
⁴AbbVie Inc., North Chicago, IL
⁵Genentech Inc., South San Francisco, CA
⁶Astellas Pharma Global Development, Northbrook, IL
⁷Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
⁸Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁹Division of Hematologic Malignancies, Johns Hopkins University, Baltimore, MD
¹⁰John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ
¹¹Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA

Katherine Knorr, MD, PhD¹, Caroline Erickson, B.S.^2*, Eric Wang, PhD^3*, Jahan Rahman, PhD^2*, Xiaoli Mi, MD^4*, Sydney Lu, MD, PhD^5*, Nina Fox^4*, Alex Penson, PhD^4*, Simon Hogg, PhD^4*, Robert Stanley, MD, PhD^1*, Daichi Inoue, MD, PhD⁶, David Knorr, MD, PhD¹, Jeffrey Ravetch, MD, PhD^7,8* and Omar Abdel-Wahab, MD⁹

¹Memorial Sloan Kettering Cancer Center, New York, NY
²Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
³Human Oncology and Pathogenesis Program, Dept. of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Memorial Sloan Kettering Cancer Center, New York
⁵Stanford University, Stanford
⁶Department of Hematology-Oncology, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe, HYO, Japan
⁷Rockefeller University, New York, NY
⁸Rockefeller University, New York
⁹Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY

Daniel Bergér, MSc^1*, Steffen Dickopf, PhD^2*, Binje Vick, PhD^3*, Katharina Weinlich, BSc^4*, Irmela Jeremias, MD, PhD³, Ulrich Brinkmann, Ph.D.^2* and Christoph Klein, MD PhD⁴

¹Dr. von Hauner Children’s Hospital, Ludwig-Maximilians-Universität, München, Germany
²Roche Pharmaceutical Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, Germany
³Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany
⁴Dr. von Hauner Children’s Hospital, Ludwig-Maximilians-Universität, Munich, Germany

Matteo Bianchi^1*, Christian Reichen^1*, Stefanie Fischer^1*, Yvonne Grübler^1*, Aline Eggenschwiler^1*, Rajlakshmi Marpakwar^1*, Thamar Looser^1*, Patricia Spitzli^1*, Christel Herzog^1*, Denis Villemagne^1*, Yvonne Kaufmann^1*, Alienor Auge^1*, Martin Hänggi^1*, Waleed Ali^1*, Tamara Lekishvili^1*, Teresa Frasconi^1*, Stephan Wullschleger^1*, Christof Zitt^1*, Marco Franchini^1*, Amelie Croset^1*, Randall Watson^1*, Vladimir Kirkin^1*, Ursina Luethi^2*, Adrian Ochsenbein, MD^2*, Carsten Riether, PhD², Daniel Steiner^1*, Nicolas Leupin^1* and Anne Goubier^1*

¹Molecular Partners AG, Zürich-Schlieren, Switzerland
²Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland