Zhenhua Chen, PhD^1*, Keren Zhou^1*, Jianhuang Xue^1,2*, Andrew Small^1*, Gang Xiao, PhD^1,3,4*, Le Xuan Truong Nguyen, PhD^5,6*, Zheng Zhang^1*, Emily Prince^1*, Hengyou Weng^1,7*, Huilin Huang^1,8*, Zhicong Zhao^1,9*, Ying Qing^1*, Chao Shen, PhD^1*, Li Han^1*, Brandon Tan^1*, Wei Li^1*, Rui Su, PhD¹, Hanjun Qin, PhD^10*, Yangchan Li^1,11*, Dong Wu^1*, Zhaohui Gu, PhD^12,13, Vu N Ngo, PhD^1*, Xin He, MD^6,14*, Jianfei Chao^15*, Keith Leung^1*, Kitty Wang^1*, Lei Dong^1*, Xi Qin^1*, Zhenming Cai^1,16*, Yue Sheng, PhD^17,18, Yu Chen^19*, Xiwei Wu, PhD^20*, Bin Zhang, PhD^6,14*, Yanhong Shi^15*, Guido Marcucci, MD^6,14, Zhijian Qian, Ph.D¹⁷, Mingjiang Xu, MD, PhD²¹, Markus Müschen, MD^1,22, Xiaolan Deng^1* and Jianjun Chen, PhD^1,6

¹Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA
²Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China
³Institute of Immunology, School of Medicine, Zhejiang University, Hangzhou, China
⁴Liangzhu Laboratory, Medical Center, Zhejiang University, Hangzhou, China
⁵Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematology Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope, Duarte, CA
⁶Gehr Family Center for Leukemia Research, Medical Center and Comprehensive Cancer Center, City of Hope National Medical Center, Duarte, CA
⁷Guangzhou Laboratory, Guangzhou, China
⁸Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou, China
⁹Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
¹⁰Integrative Genomics Core, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
¹¹Department of Radiation Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
¹²Department of Computational and Quantitative Medicine, Beckman Research Institute of City of Hope, Duarte, CA
¹³Department of Systems Biology, Beckman Research Institute of City of Hope, Duarte, CA
¹⁴Department of Hematological Malignancies Translational Science, Beckman Research Institute of City of Hope, Monrovia, CA
¹⁵Division of Stem Cell Biology Research, Department of Developmental and Stem Cell Biology, Beckman Research Institute of City of Hope, Duarte, CA
¹⁶Department of Immunology, Key Laboratory of Immune Microenvironment and Diseases, Nanjing Medical University, Nanjing, China
¹⁷Department of Medicine and Department of Biochemistry and Molecular Biology, UF Health Cancer Center, University of Florida, Gainesville, FL
¹⁸Department of Hematology, the Second Xiangya Hospital, Central South University, Changsha, China
¹⁹Molecular Instrumentation Center, University of California, Los Angeles, CA
²⁰Intergrative Genomics Core, Beckman Research Institute of City of Hope, Duarte, CA
²¹Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX
²²Center of Molecular and Cellular Oncology and Department of Immunobiology, Yale University, New Haven, CT

Zhilian Jia, PhD^1,2, Zunsong Hu, PhD^3,4, Behzad Damirchi^2,4*, Than Than Han, MS^2,4* and Zhaohui Gu, PhD^2,4

¹Department of Computational and Quantitative Medicine, Beckman Research Institute of City of Hope, Arcadia, CA
²Department of Systems Biology, Beckman Research Institute of City of Hope, Duarte, CA
³Department of Systems Biology, Beckman Research Institute of City of Hope, Baldwin Park, CA
⁴Department of Computational and Quantitative Medicine, Beckman Research Institute of City of Hope, Duarte, CA

Mark Y Chiang, MD¹, Qing Wang, PhD^2*, Carea Mullin^3*, Elizabeth Choe^4*, Nicole Dean^2*, Fatema Akter^3*, Siyi Chen^3*, Ashley Melnick, MSc⁵, Anna McCarter, PhD⁶, Rohan Kodgule, PhD^7*, Raghu Vannam^8*, Christopher J. Ott, PhD⁹ and Russell J. H. Ryan, MD¹⁰

¹Hematology-Oncology, University of Michigan, Ann Arbor, MI
²Department of Internal Medicine, University of Michigan, Ann Arbor
³University of Michigan, Ann Arbor
⁴Biostatistics Department, University of Michigan, Ann Arbor
⁵Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor
⁶Stanford University, Palo Alto
⁷Department of Pathology, University of Michigan, Ann Arbor, MI
⁸Massachussets General Hospital, Cambridge
⁹MGH Cancer Center, Charlestown, MA
¹⁰Department of Pathology, University of Michigan Medical School, Ann Arbor, MI

Ashley Melnick, MSc¹, Anna McCarter, PhD^2,3, Shannon Liang^4*, Nicole Dean^5*, Elizabeth Choe^6*, Nicholas Kunnath^7*, Brian Magnuson, PhD^8*, Karena Lin^9*, Qing Wang, PhD^5*, Surinder Kumar, PhD^10,11*, David Lombard, MD PhD^11,12*, Russell J. H. Ryan, MD¹³, Mats Ljungman, PhD^8* and Mark Y Chiang, MD¹⁴

¹Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor
²University of Michigan, Ann Arbor, MI
³Stanford University, Palo Alto
⁴College of Literature, Science, and Arts, University of Michigan, Ann Arbor, MI
⁵Department of Internal Medicine, University of Michigan, Ann Arbor
⁶Biostatistics Department, University of Michigan, Ann Arbor
⁷Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI
⁸Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor
⁹Cellular and Molecular Biology Program, University of Michigan, Ann Arbor
¹⁰Department of Pathology, University of Michigan, Ann Arbor
¹¹Sylvester Comprehensive Cancer Center, University of Miami, Miami
¹²University of Michigan Health System, Ann Arbor, MI
¹³Department of Pathology, University of Michigan Medical School, Ann Arbor, MI
¹⁴Hematology-Oncology, University of Michigan, Ann Arbor, MI

Giovanni A. Botten^1*, Yuannyu Zhang, PhD^1*, Kseniia Dudnyk^2*, Xin Liu, PhD^1*, Jacob T. Sanders, PhD^3*, Aygun Imanci^4*, Nathalie M. Droin, PhD^4*, Hui Cao^1*, Pranita Kaphle^1*, Kathryn E. Dickerson, MD^1*, Mingyi Chen, MD, PhD^3*, Weina Chen, MD, PhD^3*, Eric Solary, MD PhD⁴, Peter Ly, PhD^3*, Jian Zhou, PhD^2* and Jian Xu, PhD¹

¹Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX
²Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX
³Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX
⁴Université Paris-Saclay, INSERM U1287, Gustave Roussy Cancer Campus, Villejuif, France

Sunniyat Rahman, PhD MBiochem^1,2,3*, Nadine Farah, MBBChir, PhD^1*, Jonas Demeulemeester, PhD^4,5*, Joana R Costa, PhD^6*, Gianna Bloye, MSci^1*, David O'Connor, MD^7,8*, Rachael Pocock, MBBS, BSc, MRCP^1*, Adam Turna^1*, SooWah Lee, MSc^9*, Adele K. Fielding, MBBS, PhD¹, Juliette Roels, PhD^10*, Małgorzata Dawidowska, PhD^11*, Pieter Van Vlierberghe, PhD¹², Suzana Hadjur, PhD^13*, Alejandro Gutierrez, MD¹⁴, Michelle A Kelliher, PhD¹⁵, Simone Riva, MSc BSc^16*, Jim R. Hughes, PhD^17*, James O.J. Davies, MRCP PhD^17*, Peter Van Loo^18*, Mark A. Dawson² and Marc R. Mansour, MD^6,19*

¹UCL Cancer Institute - Department of Haematology, University College London, London, United Kingdom
²Peter MacCallum Cancer Centre, Melbourne, Australia
³Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia
⁴Department of Oncology, VIB - KU Leuven Center for Cancer Biology, KU Leuven, Belgium
⁵The Francis Crick Institute, London, GBR
⁶UCL Cancer Institute, Department of Haematology, University College London, London, United Kingdom
⁷Department of Haematology, Great Ormond Street Hospital for Children, London, United Kingdom
⁸UCL Cancer Institute, Department of Haematology, University College London, London, ENG, United Kingdom
⁹UCL Cancer Institute, London, United Kingdom
¹⁰Department for Biomolecular Medicine, Ghent University, Ghent, Belgium
¹¹Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland
¹²Cancer Research Institute Ghent (CRIG), Ghent, Flanders, Belgium
¹³UCL Cancer Institute, University College London, London, United Kingdom
¹⁴Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, MA
¹⁵Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA
¹⁶MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
¹⁷MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
¹⁸Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston
¹⁹Great Ormond Street Institute of Child Health, University College London, London, ENG, United Kingdom