64th ASH Annual Meeting and Exposition: 602. Myeloid Oncogenesis: Basic: DNA Damage and Genetic Evolution

Symposia: Myeloid Oncogenesis: Basic Oral and Poster Abstracts
Oral

Research, Fundamental Science, Acute Myeloid Malignancies, AML, Translational Research, CHIP, genomics, hematopoiesis, Chronic Myeloid Malignancies, CMML, Diseases, Myeloid Malignancies, Biological Processes, Technology and Procedures, multi-systemic interactions, omics technologies

293-294 (Ernest N. Morial Convention Center)

Moderators:

Daniel Herranz, PharmD, PhD, The Cancer Institute of New Jersey and Claudia Lengerke, MD, University Hospital Tuebingen

Disclosures:

No relevant conflicts of interest to declare.

Fundamental Research Relating to DNA Damage and Genetic Evolution in Myeloid Oncogenesis.

2:45 PM

823

Demonstration That Loss of TET2 Impairs DNA Mismatch Repair Resulting in Clonally Restricted Genomic Instability

Dongxu Jiang, PhD^1,2^*, Feng Pan, PhD³^*, Yihong Guan, PhD¹^*, Xiaorong Gu, PhD¹^*, Naomi Kawashima, MD, PhD^4,5^*, Divya Jyoti Singh, PhD^2,4^*, Danai Dima, MD^1,2, Guangbo Qu, PhD⁶^*, Edward F Greenberg, MD¹, Valeria Visconte, PhD⁴, Omar Mian¹^*, Mingjiang Xu, MD, PhD³, Jaroslaw P. Maciejewski, MD, PhD, FACP¹ and Babal K. Jha, PhD, MPhil, MSc, BSc^1,2^*

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Center for Immunotherapy & Precision Immuno-Oncology, Cleveland Clinic, Lerner Research Institute, Cleveland, OH
³Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX
⁴Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
⁵Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
⁶Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, China

3:00 PM

824

The Long Non-Coding RNA MALAT1 Is Necessary for Hematopoietic Stem and Progenitor Cell Expansion and Preleukemic Myeloproliferation in TET2 Deficient Myeloid Neoplasms

Nana Adjoa Ben-Crentsil¹, Ariel Quintana-Gonzalez, PhD¹^*, Maria E Balasis¹^*, Hannah Newman, BS¹^*, Traci L. Kruer, PhD¹, Lei Sun, PhD¹^*, Christopher Letson, BS¹, Abhishek Dhawan, PhD¹^*, Chetasi Talati, MD¹^*, Meghan Ferrall-Fairbanks, PhD², Alexis Vedder, BS¹^*, Kathy L McGraw, Ph.D.³^*, Rami S. Komrokji¹, Li Ma⁴^* and Eric Padron, MD¹

¹Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL
²J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL
³Center for Cancer Research, National Cancer Institute, Bethesda, MD
⁴The University of Texas MD Anderson Cancer Center, Houston, TX

3:15 PM

825

Genome-Wide CRISPR Screen Reveals Dependency of PPM1D-mutant Cells on DNA Repair

Linda Zhang, BA^1,2, Joanne I. Hsu, MD, PhD^2,3^*, Etienne D. Braekeleer, Ph.D⁴^*, Hidetaka Uryu⁵^*, Elsa Callen-Moreu, PhD⁶^*, Andre Nussenzweig, PhD⁶^*, Koichi Takahashi, MD, PhD^7,8, George S Vassiliou, FRCPath, MRCP, PhD, MBBS⁴ and Margaret A. Goodell, PhD^3,9

¹Translational Biology and Molecular Medicine Graduate Program, Baylor College of Medicine, Houston, TX
²Medical Scientist Training Program, Baylor College of Medicine, Houston
³Translational Biology and Molecular Medicine Graduate Program, Baylor College of Medicine, Houston
⁴University of Cambridge, Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom
⁵Leukemia Department, The UNIVERSITY of TEXAS, M.D. Anderson, Houston, TX
⁶Laboratory of Genome Integrity, NIH NCI, Bethesda
⁷Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁸Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
⁹Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX

3:30 PM

826

Patient-Derived iPSCs Faithfully Represent the Genetic Diversity and Cellular Architecture of Human Acute Myeloid Leukemia

Nataly Cruz Rodriguez¹^*, Andriana G. Kotini, PhD², Saul Carcamo, PhD²^*, Malgorzata Olszewska²^*, Elsa Bernard, PhD³^*, Hanzhi Luo, PhD⁴^*, Michael G Kharas, PhD⁴, Dan Hasson, PhD²^* and Eirini P. Papapetrou, MD, PhD²

¹Icahn School of Medicine at Mount Sinai, New York, NY
²Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
³Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY

3:45 PM

827

Clonal Hematopoiesis Evolves into Dendritic Cell Neoplasm through the Acquisition of UV Mutations in the Skin

Peter van Galen, PhD¹, Gabriel K. Griffin, MD², Christopher A. G. Booth, PhD³, Katsuhiro Togami, MD, PhD³, Sun Sook Chung, PhD³^*, Daniel Ssozi, BA¹^*, Julia A. Verga, BS⁴^*, Juliette M. C. Bouyssou, PhD³^*, Yoke Seng Lee, PhD¹^*, Vignesh Shanmugam, MD⁵^*, Nicole R. LeBoeuf, MD, MPH⁶^*, Elizabeth A. Morgan, MD⁵, Bradley E. Bernstein, MD, PhD⁴^*, Volker Hovestadt, PhD⁴^* and Andrew A. Lane, MD, PhD³

¹Division of Hematology, Brigham and Women's Hospital, Boston, MA
²Department of Pathology, Brigham and Women's Hospital, Newton, MA
³Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁴Dana-Farber Cancer Institute, Broad Institute of MIT and Harvard, Boston, MA
⁵Department of Pathology, Brigham and Women's Hospital, Boston, MA
⁶Department of Dermatology, The Center for Cutaneous Oncology, Brigham & Women’s Hospital/Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

4:00 PM

828

BPDCN MYB Fusions Bind Cell Cycle Gene Promoters, Reactivate Self-Renewal in Progenitor Cells and Induce Myeloid/Dendritic Leukemia

Christopher A. G. Booth, PhD, Juliette M. C. Bouyssou, PhD^*, Katsuhiro Togami, MD, PhD and Andrew A. Lane, MD, PhD

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA

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^*signifies non-member of ASH

602.O3.6 602. Myeloid Oncogenesis: Basic: DNA Damage and Genetic Evolution