64th ASH Annual Meeting and Exposition: 602. Myeloid Oncogenesis: Basic: Epigenetics and Transcriptional Regulation

Symposia: Myeloid Oncogenesis: Basic Oral and Poster Abstracts
Oral

Research, Fundamental Science, Acquired Marrow Failure Syndromes, Lymphoid Leukemias, Acute Myeloid Malignancies, ALL, AML, apoptosis, Bone Marrow Failure Syndromes, Inherited Marrow Failure Syndromes, Translational Research, Aplastic Anemia, Diversity, Equity, and Inclusion (DEI) , Hemoglobinopathies, hematopoiesis, pediatric, Diseases, immune mechanism, Lymphoid Malignancies, computational biology, Myeloid Malignancies, Biological Processes, Technology and Procedures, molecular biology, Study Population, multi-systemic interactions, Human, pathogenesis, imaging, molecular testing, omics technologies

275-277 (Ernest N. Morial Convention Center)

Moderators:

Peter van Galen, PhD, Brigham and Women's Hospital and Rui Lu, PhD, University of Alabama At Birmingham

Disclosures:

van Galen: ManaT Bio: Consultancy; Immunitas: Honoraria.

Fundamental Research Relating to Epigenetic Regulators and Transcriptional States in Myeloid Oncogenesis.

12:00 PM

529

Systematically Interrogating Downstream Regulation Mechanisms of HOXA9 in MLL-r Leukemia Via Functional Noncoding CRISPR Screens

Chunliang Li, PhD¹, Shaela Wright, MS¹^*, Xuijie Zhao²^*, Shelby Mryncza³^* and Beisi Xu, PhD⁴^*

¹Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN
²Department of Pharmacy and Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN
³Rhodes College, Memphis
⁴Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN

12:15 PM

530

U2AF1 Splicing Factor Mutations Affect RNA Subcellular Compartmentalization in Myeloid Malignancies

Giulia Biancon, PhD¹, Emma Busarello²^*, Mark D Lessard, MS³^*, Edward Courvan, PhD⁴^*, Dahyana Arias Escayola, PhD⁵^*, Jennifer VanOudenhove, PhD¹^*, Veronica Lee⁶^*, Mathew Krick⁶^*, Joerg Bewersdorf, PhD³^*, Karla M Neugebauer, PhD⁵^*, Toma Tebaldi, PhD^2,6^* and Stephanie Halene, MD⁶

¹Section of Hematology, Department of Internal Medicine, Yale University School of Medicine and Yale Cancer Center, New Haven, CT
²University of Trento, Trento, Italy
³Department of Cell Biology, Yale University School of Medicine, New Haven, CT
⁴Department of Biochemistry, University of Colorado, Boulder, CO
⁵Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT
⁶Section of Hematology, Department of Internal Medicine and Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, CT

12:30 PM

531

Single-Cell Pan-Cancer Analysis Reveals Treatment Resistance Stem/Progenitor-like Subpopulation in the High-Risk Pediatric Leukemia

Changya Chen, Ph.D.^1,2^*, Jason Xu, PhD³, Tiffaney L. Vincent⁴^*, Wenbao Yu, PhD^2,5^*, Yang Y Ding, MD⁵, Chia-hui Chen⁵^*, Samuel Kim⁶^*, Elizabeth Li^5,7^*, Shovik Bandyopadhyay, MSTP Candidate⁸^*, Petri Pölönen, PhD⁹, Abdelrahman Elsayed, PhD¹⁰^*, Haley Newman, MD⁴, Brent L. Wood, MD PhD¹¹, Jianzhong Hu, PhD¹²^*, Rawan Shraim, MSc¹³^*, Mignon L. Loh, MD¹⁴, Elizabeth A. Raetz, MD¹⁵, Stephen P. Hunger, MD^16,17, Stanley B. Pounds, PhD¹⁸^*, Jun J. Yang, PhD¹⁹, Charles G. Mullighan, MBBS, MD^20,21, David Frank²²^*, Kathrin M. Bernt, MD^23,24, David T. Teachey, MD²⁵ and Kai Tan, PhD^1,2,26

¹Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
²Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA
³Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
⁴Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
⁵Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA
⁶Immunology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia
⁷Yale School of Medicine, New Haven, CT
⁸Medical Scientist Training Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
⁹Department of Pathology, St. Jude Children's Research Hospital, memphis, TN
¹⁰St. Jude Children's Research Hospital, Memphis
¹¹Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA
¹²Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, TN
¹³Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
¹⁴Department of Pediatrics, Benioff Children's Hospital, University of California San Francisco, San Francisco, CA
¹⁵Division of Pediatric Hematology and Oncology, Stephen D. Hassenfeld Children's Center for Cancer and Blood Disorders, NYU Langone Health, New York, NY
¹⁶Department of Pediatrics, Division of Oncology and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
¹⁷Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
¹⁸Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
¹⁹Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN
²⁰Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, TN
²¹Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
²²Division of Cardiology, Children’s Hospital of Philadelphia, Philadelphia, PA
²³Division of Oncology and Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA
²⁴Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
²⁵Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Rutledge, PA
²⁶Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

12:45 PM

532

Functional Characterization of Cooperating MGA Deletions in RUNX1::RUNX1T1 Acute Myeloid Leukemia

Melvin Edward Thomas III, PhD

Department of Pathology, Saint Jude Children's Research Hospital, Cordova, TN

1:00 PM

533

The Protein Interactomes of CBFB-MYH11 and RUNX1-RUNX1T1 Suggest Different Mechanisms of Action for Initiating Acute Myeloid Leukemia

Ryan B Day, MD, PhD¹, Julia Hickman, BS¹^*, Ziheng Xu, BS²^*, Casey D.S. Katerndahl, PhD¹, Francesca Ferraro, MD, PhD³, Petra Erdmann-Gilmore²^*, R. Reid Townsend, MD, PhD²^* and Timothy J. Ley, MD¹

¹Department of Medicine, Division of Oncology, Section of Stem Cell Biology, Washington University in St. Louis School of Medicine, Saint Louis, MO
²Washington University in St. Louis School of Medicine, Saint Louis, MO
³Department of Medicine, Division of Oncology, Section of Stem Cell Biology, Washington University in St. Louis School of Medicine, SAINT LOUIS, MO

1:15 PM

534

The Role of Quiescence in Acute Myeloid Leukemia Growth

Cecilia Restelli, PhD, DVM¹^*, Giulia De Conti, PhD²^*, Roman Hillje, PhD¹^*, Andrea Polazzi¹^*, Maria Elena Boggio Merlo, PhD¹^*, Giorgio Melloni, PhD³^*, Lucilla Luzi, PhD¹^*, Emanuela Colombo, PhD¹^* and Pier Guiseppe Pelicci, MD^1,4^*

¹Department of Experimental Oncology, European Institute of Oncology (IEO), Milano, Italy
²Netherlands Cancer Institute, Amsterdam, Netherlands
³Harvard Medical School, Boston, MA
⁴European Institute of Oncology (IEO), Department of Oncology and Haemato-Oncology, Milano, Italy

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^*signifies non-member of ASH

602.O1.6 602. Myeloid Oncogenesis: Basic: Epigenetics and Transcriptional Regulation