64th ASH Annual Meeting and Exposition: 506. Bone Marrow Microenvironment: Contribution of Immune Signaling to the Microenvironment

Symposia: Bone Marrow Microenvironment Oral and Poster Abstracts
Oral

Research, Fundamental Science, Acute Myeloid Malignancies, AML, Biological therapies, Bone Marrow Failure Syndromes, Non-Biological therapies, APL, Translational Research, CHIP, genomics, Chemotherapy, Combination therapy, Clinical Research, hematopoiesis, Diseases, immune mechanism, patient-reported outcomes, immunology, Therapies, Immunotherapy, metabolism, computational biology, Myeloid Malignancies, Biological Processes, Pharmacology, Technology and Procedures, molecular biology, Study Population, profiling, Radiation Therapy, Transplantation, Animal model, omics technologies

260-262 (Ernest N. Morial Convention Center)

Moderators:

Tiago C Luis, PhD, Imperial College London and Sandra Pinho, PhD, The University of Illinois at Chicago

Disclosures:

No relevant conflicts of interest to declare.

This session explores the effects of immune cells and inflammation on the bone marrow microenvironment, and in turn, hematopoiesis in normal and diseased models.

12:00 PM

523

M2 Macrophages Drive Resistance to Phagocytosis and Improve Mitochondrial Metabolism in Acute Myeloid Leukemia Facilitating Leukemic Transformation and In Vivo Engraftment

Isabel Weinhaeuser, PhD¹^*, Diego Pereira-Martins, PhD²^*, Luciana Yamamoto de Almeida, PhD³^*, Jacobien R Hilberink, BSc⁴^*, Douglas RA Silveira, MD^5,6^*, Lynn Quek, MBBCh, DPhil, MRCP (UK), FRCPath^5,7,8^*, César Alexander Ortiz, BSc⁹^*, Antonio R. Lucena-Araujo, Prof. PhD¹⁰^*, Nienke Visser¹¹^*, Emanuele Ammatuna, MD. PhD²^*, Gerwin A. Huls, MD, PhD¹², Eduardo M Rego, MD, PhD^{13,14,15,16,17} and Jan Jacob Schuringa, PhD²

¹Experimental Hematology, University Medical Center Groningen, Groningen, AL, Netherlands
²Department of Hematology, Cancer Research Centre Groningen, University Medical Centre Groningen, University of Groningen, Groningen, Netherlands
³University of Sao Paulo, Ribeirao Preto, Brazil
⁴Department of Experimental Hematology, University Medical Center Groningen, Groningen, Netherlands
⁵School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
⁶School of Cancer and Pharmaceutical Sciences, King's College London, London, ENG, United Kingdom
⁷MRC Molecular Haematology Unit and Oxford Biomedical Research Centre, University of Oxford and Oxford University Hospitals, Oxford, United Kingdom
⁸Department of Haematological Medicine, King's College Hospital NHS Foundation Trust, London, United Kingdom
⁹Center of Cell-based Therapy, University of Sao Paulo, Medical School of Ribeirao Preto, RIBEIRAO PRETO, BRA
¹⁰Department of Genetic, Federal University of Pernambuco, Recife - PE, AC, BRA
¹¹Experimental Hematology, University Medical Center Groningen, Groningen, NLD
¹²University Medical Center, University Groningen, Groningen, GZ, Netherlands
¹³Division of Hematology, Transfusion Medicine and Cell Therapy, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
¹⁴Medical Research Laboratory on Molecular Hematology (LIM-31), University of São Paulo, São Paulo, São Paulo, Brazil
¹⁵Center for Cell-based Therapy and Regional Hemotherapy Center, University of Sao Paulo at Ribeirao Preto Medical School, Ribeirao Preto, Sao Paulo, Brazil
¹⁶University of Sao Paulo, Sao Paulo, Brazil
¹⁷University of São Paulo Medical School, Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, Brazil

12:15 PM

524

Neutrophils Regulate Bone Formation Via IL-1b Secretion

Kanako Wakahashi, MD, PhD¹^*, Jiangyan Yu²^*, Andrea Rubio-Ponce¹^*, Stephan Culeman^3,4^*, Brenda Krishacoumar^3,5^*, Carina Scholtysek³^*, Gerhard Krönke³^*, Andreas Schlitzer²^* and Andrés Hidalgo¹

¹Program for Cardiovascular Regeneration, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain
²Quantitative Systems Biology, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany
³Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany
⁴Immunology of Aging, Leibniz Institute on Aging - Fritz Lipmann Institute, Jena, Germany
⁵Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany

12:30 PM

525

Stromal STAT5-Mediated Trophic Activity Regulates Hematopoietic Multipotent Progenitor Niche Factors

Zhengqi Wang, PhD¹, Grace Emmel, MS²^*, Hong Seo Lim, PhD³^*, Astrid Kosters, PhD⁴^*, Eliver Ghosn, PhD⁴, Peng Qiu, PhD⁵^* and Kevin D. Bunting, PhD⁶

¹Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, GA
²School of Biological Sciences, Georgia Institute of Technology, Atlanta
³Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta
⁴Emory Vaccine Center, Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA
⁵Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta
⁶Winship Cancer Institute, Aflac Cancer and Blood Disorders Center of Children’s Healthcare of Atlanta and Department of Pediatrics, Emory University, Atlanta, GA

12:45 PM

526

Bone Marrow Stromal Cell Senescence Induced By Dnmt3a-Mutant Hematopoietic Stem and Progenitor Cells Accelerates Clonal Hematopoiesis and Progression to Leukemia

Jayna J Mistry, PhD^*, Kira A Young, PhD and Jennifer J J Trowbridge, PhD

The Jackson Laboratory, Bar Harbor, ME

1:00 PM

527

Role of Heparan Sulfate 6-O-Endosulfatases in Hematopoiesis

Anna K Whitehead, MS, BS^1,2^* and Xinping Yue, MD, PhD^1,2^*

¹Cardiovascular Center of Excellence, LSU Health Sciences Center, New Orleans, LA
²Department of Physiology, LSU Health Sciences Center, New Orleans, LA

1:15 PM

528

Jagged1⁺ Myeloid-Derived Suppressor Cells Are Required for Recovery of the Hematopoietic Bone Marrow Niche after Myelosuppression

Kostandin V. Pajcini, PhD

Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL

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^*signifies non-member of ASH

506.O2.6 506. Bone Marrow Microenvironment: Contribution of Immune Signaling to the Microenvironment