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503.O2.6 503. Clonal Hematopoiesis, Aging and Inflammation: Insights from Animal Models

Symposia: Clonal Hematopoiesis, Aging and Inflammation Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, Fundamental Science, Acute Myeloid Malignancies, Acquired Marrow Failure Syndromes, autoimmune disorders, AML, adult, CHIP, Translational Research, Bacterial, assays, elderly, hematopoiesis, drug development, Diseases, Immune Disorders, immune mechanism, cell expansion, Infectious Diseases, immunology, metabolism, white blood cell disorders, Myeloid Malignancies, Biological Processes, microbiome, emerging technologies, Technology and Procedures, gene editing, molecular biology, Study Population, Human, pathogenesis, Animal model
Sunday, December 11, 2022: 9:30 AM-11:00 AM
271-273 (Ernest N. Morial Convention Center)
Moderators:
Satish Nandakumar, MBBS, PhD, Albert Einstein College of Medicine and Sheng Shirley Li, PhD, The Jackson Laboratory For Genomic Medicine
Disclosures:
No relevant conflicts of interest to declare.
The abstracts presented in this session utilize data from animal models to advance our mechanistic understanding for age-related clonal expansions and alterations to hematopoietic stem cell function.
9:30 AM
403
A Circulating Microbial Metabolite Drives the Clonal Expansion of Pre-Leukemic Cells

Puneet Agarwal, PhD1, Avery Sampson, BSc1*, Kathleen Hueneman, BSc1*, Kwangmin Choi, PhD1*, Xueheng Zhao, PhD2*, Jessica Galloway-Pena, PhD3*, Kenneth Setchell, PhD2* and Daniel T. Starczynowski, PhD1,4,5

1Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
2Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
3Department of Veterinary Pathobiology, Texas A&M University, College Station, College Station, TX
4Department of Pediatrics, University of Cincinnati, Cincinnati, OH
5University of Cincinnati Cancer Center, Cincinnati, OH
9:45 AM
404
Metformin Treatment Abrogates the Competitive Advantage of Dnmt3a R878H HSPCs By Enhancing DNA Methylation Activity

Mohsen Hosseini1*, Severine Cathelin, PhD1*, Alex Liu1*, Yitong Yang1, Amit Subedi, PhD1, Dhanoop Manikoth Ayyathan, PhD1*, Shraddha Pai, PhD2* and Steven M. Chan, MD, PhD3,4,5

1Princess Margaret Cancer Centre; University Health Network, Toronto, ON, Canada
2Donnelly Centre for Cellular and Biomolecular Research, Toronto, Canada
3Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
4Princess Margaret Cancer Centre, Toronto, ON, Canada
5Department of Medicine, University of Toronto, Toronto, ON, Canada
10:00 AM
405
The Impact of Dnmt3a or Tet2 CH on Alzheimer’s Disease in a Murine Model

Trisha K. Wathan1*, Marcus A. Florez, PhD2,3,4, Josaura V. Fernandez-Sanchez, MD5* and Katherine Y. King, MD, PhD3,4,6

1Department of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, Texas Children's Hospital, Houston, TX
2Department of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, Houston, TX
3Medical Scientist Training Program, Baylor College of Medicine, Houston, TX
4Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX
5Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX
6Division of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, TX
10:15 AM
406
Thrombopoietin Receptor Signaling Promotes the Competitive Advantage of TET2-Mutated Hematopoietic Stem and Progenitor Cells in Clonal Hematopoiesis

Yitong Yang1, Amit Subedi, PhD2 and Steven M. Chan, MD, PhD1,3

1Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
2Princess Margaret Cancer Centre; University Health Network, Toronto, ON, Canada
3Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
10:30 AM
407
Dnmt3a Loss-of-Function Enhances DNA Repair in Proliferative HSCs Under Inflammatory Stress

Christine R Zhang, PhD1, Jason Arand1*, Wentao Han2*, Infencia Xavier Raj1*, Saranajith Dunuwille, PhD3* and Grant A Challen, PhD4

1Division of Oncology, Washington University School of Medicine, St. Louis, MO
2Division of Oncology, Washington University School of Medicine, Saint Louis, MO
3Washington University in St Louis, Saint Louis, MO
4Southwest Tower Room 744, Washington University School of Medicine, St Louis, MO
10:45 AM
408
Inhibition of Hyper-Activated Lysosomes Restores Youthful Properties and Functions in Old Hematopoietic Stem Cells

Tasleem Arif, PhD1*, Jiajing Qiu, PhD2* and Saghi Ghaffari, MD, PhD3

1Department of Cell, Developmental, & Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY
2Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY
3Department of Cell, Developmental and Regenerative Biology, Oncological Sciences, Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY
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*signifies non-member of ASH