64th ASH Annual Meeting and Exposition: 501. Hematopoietic Stem and Progenitor Cells and Hematopoiesis: Basic and Translational: Disease and Aging

Symposia: Hematopoietic Stem and Progenitor Cells and Hematopoiesis: Basic and Translational Oral and Poster Abstracts
Oral

Research, Fundamental Science, Biological therapies, adult, Translational Research, Bone Marrow Failure Syndromes, elderly, Genetic Disorders, Combination therapy, genomics, bioinformatics, drug development, hematopoiesis, pediatric, Diseases, Gene Therapy, cell expansion, neonatal, Therapies, Lymphoid Malignancies, computational biology, young adult , Myeloid Malignancies, Biological Processes, Metabolic Disorders, molecular biology, Technology and Procedures, multi-systemic interactions, Study Population, Human, Transplantation, pathogenesis, imaging, omics technologies

393-396 (Ernest N. Morial Convention Center)

Moderators:

Michael J. Nemeth, PhD, Roswell Park Comprehensive Cancer Center and Senthil Velan Bhoopalan, MBBS, PhD, University of Nevada School of Medicine

Disclosures:

No relevant conflicts of interest to declare.

4:30 PM

924

Dysfunctional Clusterin-Positive Hematopoietic Stem Cells Expand with Aging

Shuhei Koide, PhD¹^*, Motohiko Oshima, PhD²^*, Akira Nishiyama, PhD³^*, Koichi Murakami, MD, PhD^3,4^*, Naoki Itokawa, MD, PhD²^*, Yaeko Nakajima-Takagi, PhD²^*, Zhiqian Zheng²^*, Nozomi Yusa⁵^*, Kazuaki Yokoyama, MD, PhD⁶, Arinobu Tojo, M.D., Ph.D.⁷, Tomohiko Tamura, MD, PhD^3,4 and Atsushi Iwama, MD, PhD²

¹Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
²Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
³Department of Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
⁴Advanced Medical Research Center, Yokohama City University, Kanagawa, Japan
⁵Department of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
⁶Department of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, TKY, Japan
⁷Division of Molecular Therapy, Advanced Clinical Research Center., Tokyo, Japan

4:45 PM

920

Discovery of a New Human Hematopoietic Stem Cell Involved with Aging That Retains Memory of Immune Activation

Andy G.X. Zeng, BSc^1,2, Murtaza S Nagree, PhD¹^*, Alexander Murison, PhD³^*, Isabel Lim¹^*, Sayyam Shah¹^*, Alicia Aguilar-Navarro^1,4^*, Joana Araújo, MD^1,5,6^*, Darrien Parris, B.Sc¹^*, Jessica L McLeod⁷^*, Liqing Jin, MD¹^*, Elvin Wagenblast, PhD^8,9, Eugenia Flores-Figueroa, PhD^1,10^*, John E. Dick, PhD^1,2 and Stephanie Z Xie, PhD¹

¹Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
²Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
³Princess Margaret Cancer Centre, University Health Network, Toronto, ON, CAN
⁴Instituto Mexicano Del Seguro Social, Mexico City, MEX
⁵Faculty of Medicine, University of Porto, Porto, Portugal
⁶Department of Hematology, Centro Hospitalar Universitário de São João, Porto, Portugal
⁷Phillip Orsino Cell Processing Laboratory, Princess Margaret Cancer Centre, Toronto, ON, Canada
⁸Icahn School of Medicine at Mount Sinai, New York, NY
⁹Princess Margaret Cancer Centre, University Health Network, East York, ON, Canada
¹⁰Unidad de Investigación Médica en Enfermedades Oncológicas, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico

5:00 PM

921

Mlkl Mediates Age-Related Attrition of Hematopoietic Stem Cells and Ineffective Hematopoiesis in Myelodysplastic Syndrome

Yuta Yamada¹^*, Masayuki Yamashita, MD, PhD¹^*, Jinjing Yang¹^*, Shin Murai²^*, Kenta Sumiyama³^*, Hiroyasu Nakano²^* and Atsushi Iwama, MD, PhD¹

¹Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
²Department of Biochemistry, Toho University School of Medicine, Tokyo, Japan
³RIKEN Center for Biosystems Dynamics Research, Osaka, Japan

5:15 PM

922

Activated CMPs Act in Concert with the Spleen and Accelerate Hematopoietic Inflation after Transplantation

Takao Yogo, MD¹, Hans Jiro Jiro Becker, MD/PhD²^* and Satoshi Yamazaki, PhD^1,2^*

¹Institute of Medical Science, Division of Stem Cell Biology, The University of Tokyo, Tokyo, Japan
²Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

5:30 PM

923

Lasting Hematopoietic Memory Induced By Gestational Diabetes Contributes to Atherosclerosis Development in Adult Offspring

Vinothini Govindarajah¹^*, Masahide Sakabe¹^*, Samantha Good¹^*, Michael Solomon¹^*, Nong Chen¹^*, Ady Kendler²^*, Mei Xi^1,3^* and Damien Reynaud^1,3

¹Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, OH
³Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH

5:45 PM

919

Mutational Permutations of a Single Amino Acid Exert Divergent Phenotypic Effects in Human, Mice, and Cellular Models of SAMD9L Bone Marrow Failure Disorder

Sushree S Sahoo, PhD^1,2,3, Charnise Goodings-Harris, PhD⁴, Shondra Miller⁵^*, Maria Angeles Lillo Osuna, PhD¹^*, Baranda S Hansen⁵^*, Lei Han, PhD⁶^*, Ti-Cheng Chang, PhD⁷^*, Tim Lammens, PhD, MSc⁸^*, Mattias Hofmans, MD⁹^*, Marta Derecka, PhD¹⁰, Barbara De Moerloose, MD¹¹^* and Marcin W. Wlodarski, MD, PhD²

¹Dept. of Hematology, St. Jude Children's Research Hospital, Memphis, TN
²Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
³Dept. of Hematology, St. Jude Children’s Research Hospital, Memphis, TN
⁴St Jude Children's Research Hospital, Memphis, TN
⁵Center for Advanced Genome Engineering (CAGE), St Jude Children's Research Hospital, Memphis, TN
⁶Department of Hematology, St Jude Children's Research Hospital, Memphis, TN
⁷Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN
⁸Department of Paediatric Haematology-Oncology, Ghent University Hospital Ghent, Belgium, Ghent, Oost-Vlaanderen, Belgium
⁹Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium
¹⁰Dept. of Hematology, St Jude Children's Research Hospital, Memphis, TN
¹¹Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, BEL

See more of: Oral and Poster Abstracts

<< Previous Session | Next Session >>

^*signifies non-member of ASH

501.O2.6 501. Hematopoietic Stem and Progenitor Cells and Hematopoiesis: Basic and Translational: Disease and Aging