64th ASH Annual Meeting and Exposition: 501. Hematopoietic Stem and Progenitor Cells and Hematopoiesis: Basic and Translational: Basic and Developmental

Symposia: Hematopoietic Stem and Progenitor Cells and Hematopoiesis: Basic and Translational Oral and Poster Abstracts
Oral

Research, Fundamental Science, Translational Research, genomics, hematopoiesis, immune mechanism, cell expansion, Therapies, immunology, metabolism, Biological Processes, molecular biology, Technology and Procedures, multi-systemic interactions, omics technologies

252-254 (Ernest N. Morial Convention Center)

Moderators:

Sushree S Sahoo, PhD, St. Jude Children's Research Hospital and Miguel Ganuza Fernandez, PhD, John Vane Science Centre

Disclosures:

No relevant conflicts of interest to declare.

2:45 PM

817

Unveiling the Biological Role of Peripheral Blood Human Circulating Hematopoietic Stem and Progenitor Cells

Pamela Quaranta¹^*, Luca Basso-Ricci, MSc¹^*, Raisa Jofra Hernández, MSc¹^*, Matteo Maria Naldini, MD¹^*, Matteo Barcella, PhD¹^*, Guido Pacini, PhD¹^*, Carlo Pietrasanta, MD^2,3^*, Lorenza Pugni, MD^2,3^*, Giulia Pais¹^*, Fabrizio Benedicenti¹^*, Francesca Dionisio, MSc¹^*, Stefania Giannelli, PhD¹^*, Ilaria Monti, MSc¹^*, Silvia Darin⁴^*, Graziano Barera, MD⁵^*, Francesca Tucci, MD⁴^*, Francesca Ferrua, MD, PhD⁴^*, Valeria Calbi, MD, PhD⁴^*, Marco Ometti, MD, PhD⁶^*, Bernhard Gentner, MD, PhD¹, Raffaella Di Micco, PhD¹^*, Eugenio Montini, PhD¹^*, Andrea Calabria, PhD¹^*, Ivan Merelli, PhD¹^*, Fabio Mosca, MD^2,3^*, Maria Ester Bernardo, MD, PhD^1,4^*, Maria Pia Cicalese, MD^1,4^*, Alessandro Aiuti, MD, PhD^1,4 and Serena Scala, PhD¹^*

¹San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), San Raffaele Scientific Institute, Milan, Italy
²Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
³Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
⁴Pediatric Immunohematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy
⁵Pediatric Department, San Raffaele Scientific Institute, Milan, Italy
⁶Orthopaedic Unit, San Raffaele Scientific Institute, Milan, Italy

3:00 PM

818

GAS6 Promotes Robust Expansion of Human Hematopoietic Stem and Progenitor Cells with High Serial Engraftment Activity

Harinad B Maganti, PhD¹^*, Javed Manesia, PhD², Tanvir Hasan¹^*, Chelasea Mcgregor, MSc¹^*, Roya Pasha, MSc³^*, David Allan, MD⁴^*, Julie Audet, PhD⁵^* and Nicolas Pineault, PhD¹

¹Canadian Blood Services, Ottawa, ON, Canada
²STEMCELL Technologies, Vancouver, BC, CAN
³Canadian blood service, Ottawa, Canada
⁴Canadian Blood Services, Ottawa, Canada
⁵University of Toronto Institute of Biomaterials & Biomedical Engineering, Toronto, ON, CAN

3:15 PM

819

Hematopoietic Flt3+ Multipotent Progenitors Are Organized in Discrete Functionally and Hierarchically Distinct Populations

Michael Solomon¹^*, Baobao (Annie) Song², Vinothini Govindarajah¹^*, Samantha Good¹^*, James Bartram¹^*, Jose Cancelas¹^*, Marie-Dominique Filippi^1,3, Nathan Salomonis, PhD^3,4^*, H. Leighton Grimes, PhD^2,3 and Damien Reynaud^1,3

¹Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
³Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH
⁴Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

3:30 PM

820

Cap-Independent Protein Translation in Hematopoiesis

Michael Mazzola, BS^1,2,3, Ting Zhao^1,2,4^*, Karin Gustafsson, PhD^1,2,4^*, Trine Kristiansen, PhD^1,2,4^*, Giulia Schiroli, PhD^1,2,4^*, Jelena Milosevic, PhD^2,4^*, Youmna Kfoury, PhD^1,2,4, Tsuyoshi Fukushima, MD, PhD^1,2,4^*, Anna Kiem^1,2,4^*, Azeem Sharda, MS^1,2,4^*, Hiroki Kato, MD, PhD^1,2,4^*, David Sykes, MD, PhD^2,4, Pavel Ivanov, PhD^5,6^*, Vijay G. Sankaran, MD, PhD^7,8 and David T. Scadden, MD^1,2,4

¹Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA
²Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA
³Harvard Stem Cell Institute, Boston, MA
⁴Harvard Stem Cell Institute, Cambridge, MA
⁵Harvard Initiative for RNA Medicine, Boston, MA
⁶Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
⁷Division of Hematology/Oncology, Department of Pediatric Oncology, Boston Children's Hospital, Boston, MA
⁸Broad Institute, Cambridge, MA

3:45 PM

821

A Link between Blood Flow and the Inflammatory Networks That Govern Hematopoietic Stem Cell Specification

Clyde Allen Campbell Jr.¹^*, Radwa Barakat, Ph.D²^*, Rodolfo Calderon¹^* and Raquel Espin Palazon, PhD¹^*

¹Iowa State University, Ames, IA
²Iowa State University, Ames

4:00 PM

822

Novel Evidence That Intracellular Complement Network (complosome) Is Expressed in Hematopoietic Stem Cells (HSPCs) and Regulates Their Trafficking, Metabolism, and Proliferation in an Intracrine-Dependent Manner By Engaging Pattern Recognition Receptor Nlrp3 Inflammasome

Vira Chumak, PhD¹^*, Andrzej Ciechanowicz, PhD²^*, Mateusz Adamiak, PhD²^*, Arjun Thapa, PhD³^*, Ahmed Abdelbaset-Ismail, PhD⁴^*, Kamila Bujko, MSc¹^*, Janina Ratajczak, MD, PhD⁵, Magda Kucia, PhD, DSci^2,6 and Mariusz Z Ratajczak, MD, PhD, DSci^2,5

¹Warsaw Medical University, Department of Regenerative Medicine, Warsaw, Poland
²Department of Regenerative Medicine, Warsaw Medical University, Warsaw, Poland
³Stem Cell Program at JGB Cancer Center, University of Louisville, Louisville, KY
⁴Stem Cell Institute at JGB CC, University of Louisville, Louisville
⁵Stem Cell Institute at JGB CC, University of Louisville, Louisville, KY
⁶Stem Cell Institute, University Of Louisville Brown Cancer Center, Louisville, KY

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^*signifies non-member of ASH

501.O1.6 501. Hematopoietic Stem and Progenitor Cells and Hematopoiesis: Basic and Translational: Basic and Developmental