-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

331.O1.6 331. Thrombotic Microangiopathies/Thrombocytopenias and COVID-19-related Thrombotic/Vascular Disorders: Clinical and Epidemiological I Clinically Relevant Abstract

Symposia: Thrombotic Microangiopathies/Thrombocytopenias and COVID-19-related Thrombotic/Vascular Disorders: Clinical and Epidemiological Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, clinical trials, Bleeding and Clotting, Anticoagulant Drugs, autoimmune disorders, adult, Translational Research, Non-Biological therapies, epidemiology, Clinical Research, Genetic Disorders, platelet disorders, thromboembolism, pediatric, Diseases, Immune Disorders, thrombocytopenias, SARS-CoV-2/COVID-19, Therapies, Infectious Diseases, thrombotic disorders, Biological Processes, Technology and Procedures, Study Population, Human, pathogenesis, imaging
Saturday, December 10, 2022: 12:00 PM-1:30 PM
Great Hall AD (Ernest N. Morial Convention Center)
Moderators:
Alfred I Lee, MD, PhD, Yale University School of Medicine and PAUL Coppo, APHP - Hôpital St Antoine
Disclosures:
Coppo: SANOFI ALEXION TAKEDA: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding.
The thrombotic microangiopathies (TMA), which include thrombotic thrombocytopenia purpura (TTP), hemolytic uremic syndrome, and other complement-mediated TMA, are a heterogeneous group of microvascular diseases whose hallmark is the development of microvascular occlusion. A number of studies have demonstrated shared biological processes between TMA and COVID-19, where hemostatic and complement derangements give rise to immunothrombotic complications. This session will review cutting-edge abstracts on TMA and COVID-19, including new data on anticoagulation in COVID-19, silent strokes in immune TTP, biology of ADAMTS13, clinical presentation of hereditary TTP, and thromboembolic complications in COVID-19 in pediatric and cancer patients.
12:00 PM

Zoe McQuilten, MBBS, PhD1,2*, Balasubramanian Venkatesh, MD3,4*, Vivekanand Jha, MD5,6*, Jason Roberts, PhD3*, Susan Morpeth, PhD7*, James Totterdell, MBiostat8*, Grace McPhee, PhD9*, John Abraham, MBBS10*, Niraj Bam, MD11*, Methma Bandara, BH-BMED9*, Ashpak Bangi, MD12*, Lauren Barina, MBE13*, Bhupendra Basnet, MD14*, Hasan Bhally, MD15*, Khemr Bhusal, MD16*, Umesh Bogati, MD14*, Asha Bowen, PhD17,18*, Andrew Burke, MBBS3,19*, Devasahayam Christopher, MD20*, Sanjeev Chunilal, FRACP21*, Belinda Cochrane, MD22,23*, Jennifer Curnow, MBBS FRACP FRCPA PhD24,25*, Varaprasad Babu Dara Reddy, MD26*, Santa Das, MD16*, Ashesh Dhungana, MD, DM14*, Gian Luca Di Tanna, PhD4*, Ravindra Dotel, MBBS27*, Hyjel DSouza, BSc28*, Jack Dummer, PhD29,30*, Sourabh Dutta, PhD31*, Hong Foo, MBBS32*, Timothy Gilbey, MBBS33*, Michelle Giles, PhD9*, Kasiram Goli, MD34*, Adrienne Gordon, PhD8,35*, Pradip Gyanwali, MD36*, Bernard Hudson, MD32*, Manoj Jani, MBBS37*, Purnima Jevaji, MDHA5*, Sachin Jhawar, MS37*, Aikaj Jindal, MD38*, M. Joseph John, MD, DM39, Mary John, MD10*, Flavita John, MBBS20*, Oommen John, MD5*, Mark Jones, MBiostat8*, Rajesh Joshi, BHMS5*, Prashanthi Kamath, MPH5*, Gagandeep Kang, MD, PhD20*, Achyut Karki, MDGP14*, Abhishek Karmalkar, MD4*, Baldeep Kaur, MIS4*, Kalyan Chakravarthy Koganti, MD26*, Jency Koshy, MD40*, S K Mathew, MD40*, Jilllian Lau, PhD41*, Sharon Lewin, PhD9,42*, Lyn-li Lim, MPH42*, Ian Marschner, PhD8*, Julie Marsh, PhD17*, Michael Maze, PhD29*, James McGree, PhD43*, James McMahon, PhD42*, Robert Medcalf, PhD44*, Eileen Merriman, MD, PhD45*, Amol Misal, MD46*, Jocelyn Mora, MSc9*, Vijaybabu Mudaliar, MSc5*, Vi Nguyen, BH-BMED9*, Matthew O'Sullivan, PhD47*, Suman Pant, MBBS16*, Pankaj Pant, MBBS16*, David Paterson, MBBS48*, David Price, PhD9*, Megan Rees, MBBS, PhD49*, James Owen Robinson, MD50*, Benjamin Rogers, PhD51*, Sandhya Samuel, MD10*, Joe Sasadeusz, PhD9,49*, Deepak Sharma, MBBS52*, Prabhat Sharma, MD52*, Roshan Shrestha, MD14*, Sailesh Shrestha, MD14*, Prajowl Shrestha, MD53*, Urvi Shukla, MD53*, Omar Shum, MSc54*, Christine Sommerville, BH-SCI9*, Tim Spelman, PhD55*, Richard Sullivan, MBBS56*, Umashankar Thatavarthi, MD26*, Huyen Tran, MD, PhD57*, Nanette Trask58*, Claire Whitehead, PhD59*, Robert Mahar, PhD60*, Naomi Hammond, PhD4*, James David McFadyen, PhD61,62*, Thomas Snelling, PhD8,17*, Joshua Davis, PhD56,63*, Justin Denholm, PhD9* and Steven YC Tong, PhD9,49*

1School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia
2Monash Health, Melbourne, Australia
3University of Queensland, Brisbane, Australia
4The George Institute for Global Health, Sydney, Australia
5The George Institute for Global Health, New Delhi, India
6Imperial College, London, United Kingdom
7Middlemore Hospital, Auckland, New Zealand
8University of Sydney, Sydney, Australia
9The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
10Christian Medical College, Ludhiana, India
11Maharajgunj Medical Campus, Kathmandu, Nepal
12Jivanrekha Multispeciality Hospital, Pune, India
13The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melburne, Australia
14National Academy of Medical Sciences, Bir Hospital, Kathmandu, Nepal
15North Shore Hospital, Auckland, New Zealand
16Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu, Nepal
17Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth, Australia
18Perth Children's Hospital, Perth, Australia
19The Prince Charles Hospital, Brisbane, Australia
20Christian Medical College, Vellore, India
21Monash Health, Melbourne, AUS
22Campbelltown Hospital, Sydney, Australia
23Western Sydney University, Sydney, Australia
24Department of Haematology, Westmead Hospital, Western Sydney Local Health District, Sydney, Australia
25Faculty of Health and Medicine, University of Sydney, Sydney, NSW, Australia
26Samishta Hospital & Research Institute, Guntur, India
27Blacktown Hospital, Sydney, Australia
28The George Institute for Global Health, Delhi, India
29University of Otago, Dunedin, New Zealand
30Dunedin Hospital, Dunedin, New Zealand
31Postgraduate Institute of Medical Education and Research, Chandigarh, India
32NSW Health Pathology, Sydney, Australia
33Wagga Wagga Base Hospital, Wagga Wagga, Australia
34Aditya Multi-speciality Hospital, Guntur, India
35Royal Prince Alfred Hospital, Sydney, Australia
36Institute of Medicine, Maharajgunj Medical Campus, Kathmandu, Nepal
37Apex Hospitals Pvt Ltd, Jaipur, India
38Satguru Partap Singh Hospitals, Ludhiana, India
39Department of Clinical Haematology and BMT, Christian Medical College & Hospital, Ludhiana, India
40Believers Church Medical College Hospital, Thiruvalla, India
41Eastern Health, Melbourne, Australia
42Monash University, Melbourne, Australia
43Queensland University of Technology, Brisbane, Australia
44Monash, Melbourne, AUS
45North Shore Hospital, Auckland, AL, NZL
46Core Hospital, Pune, India
47Westmead Hospital, Sydney, Australia
48National Institute of Singapore, Singapore, Singapore
49The Royal Melbourne Hospital, Melbourne, Australia
50Murdoch University, Perth, Australia
51Monash University, Clayton, Victoria, AUS
52Maharaja Agrasen Superspeciality Hospital, Jaipur, India
53Symbiosis University Hospital & Research Centre, Pune, India
54The Wollongong Hospital, Wollongong, Australia
55Burnet Institute, Melbourne, AUS
56Charles Darwin University, Darwin, Australia
57Australian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia
58Chartered Accountants Australia and New Zealand, Perth, Australia
59The Royal Women's Hospital, Melbourne, Australia
60The University of Melbourne, Melbourne, Australia
61Atherothrombosis and Vascular Biology, Baker Heart and Diabetes Institute, Melbourne, Australia
62Alfred Hospital, Melbourne, Australia
63University of Newcastle, Newcastle, Australia

12:15 PM

Riten Kumar, MD, MSc1, Nan Chen, MS2*, Laura Lehman, MD, MPH3* and Wendy B. London, PhD4,5

1Dana Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA
2Dana Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA
3Division of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA
4Dana-Farber Boston Children’s Cancer and Blood Disorders Center, Boston, MA
5Pediatrics, Harvard Medical School, Boston, MA

12:30 PM

Szumam Liu, Ph.D.1*, Xinyang Zhao, Ph.D.2* and X. Long Zheng, MD, PhD1

1Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, Kansas City, KS
2Department of Biochemistry and Genetics, The University of Alabama at Birmingham, Birmingham, AL

12:45 PM

Alok A Khorana, MD1, Ana Best2*, Andrea Denicoff, RN, MS3*, Melissa Bowman, MS4*, Marwa Shekfeh, PhD2*, Larry V. Rubinstein, PhD5*, Steven A. Pergam, MD, MPH6*, Lisa McShane7*, Brian Rini, MD8* and Larissa Korde, MD7*

1Cleveland Clinic and Case Comprehensive Cancer Center, Cleveland Clinic, Cleveland, OH
2Biometric Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, MD
3National Cancer Institute, Clinical Investigations Branch, Division of Cancer Treatment and Diagnosis, Rockville, MD
4Emmes Corporation, Rockville, MD
5Division of Cancer Treatment and Diagnosis, National Institutes of Health, Bethesda
6Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA
7National Cancer Institute, Bethesda, MD
8Vanderbilt Ingram Cancer Center at Vanderbilt University Medical Center, Nashville, TN

1:00 PM

Erika Tarasco, PhD1,2*, Kenneth D. Friedman, MD3, James N. George, MD4, Paul Knöbl, MD5*, Ingrid Hrachovinova, PhD6*, Masanori Matsumoto, MD7, Reinhard Schneppenheim, MD, PhD8, Anne Sophie Von Krogh, MD9,10*, Bernhard Lammle, MD2,11 and Johanna A. Kremer Hovinga Strebel, MD1,2

1Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland
2Department of Hematology and Central Hematology Laboratory, Bern University Hospital, Bern, Switzerland
3Division of Hematology and Oncology, Medical College of Wisconsin, Versiti BloodCenter of Wisconsin, Milwaukee, WI
4Department of Biostatistics & Epidemiology, Hudson College of Public Health, University of Oklahoma, Oklahoma City, OK
5Division of Hematology and Hemostasis, Department of Medicine, University of Vienna, Vienna, Austria
6NRL for Hemostasis, Institute of Hematology and Blood Transfusion, Prague, Czech Republic
7Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Nara, Japan
8Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
9Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, NOR
10Department of Hematology, St Olavs Hospital Trondheim University Hospital, Trondheim, Norway
11Center for Thrombosis and Hemostasis, Universitätsklinik Für Hämatologie Bern, Mainz, Germany

1:15 PM

Jia Yu1, Jenna Brown2*, Eli Salzberg3*, Aria Wei, BS4*, Gloria Gerber, MD2,5, Xiang-Zuo Pan2*, Alison R. Moliterno, MD6, MIchael B. Streiff, MD7, Peggy Kraus, PharmD8*, Claire Logue9*, Jennifer Yui, MD, MS10*, Rakhi P. Naik, MD, MHS5, Hira Latif11*, Sophie M. Lanzkron, MD12, Evan M. Braunstein, MD, PhD13, Robert Brodsky, MD2, Michael R. DeBaun, MD, MPH14, Doris Lin, MD, PhD15* and Shruti Chaturvedi, MBBS16

1School of Medicine, University of Pittsburgh, Pittsburgh, PA
2Division of Hematology, Department of Medicine, Johns Hopkins University, Baltimore, MD
3Brandeis University, Waltham, MA
4Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD
5Division of Hematology, Johns Hopkins University, Baltimore, MD
6Division of Hematology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD
7Johns Hopkins Medical Institutions, Baltimore, MD
8Department of Pharmacy, Johns Hopkins Hospital, Baltimore, MD
9Johns Hopkins University School of Medicine, Baltimore, MD
10Medicine/Hematology, Johns Hopkins University, Baltimore, MD
11Georgetown University, Washington, DC
12Division of Hematology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD
13Division of Hematology, Department of Medicine, Johns Hopkins, Baltimore, MD
14Department of Pediatrics, Division of Hematology & Oncology, Vanderbilt University School of Medicine, Nashville, TN
15Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD
16Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD

*signifies non-member of ASH