64th ASH Annual Meeting and Exposition: 321. Coagulation and Fibrinolysis: Basic and Translational II

Symposia: Coagulation and Fibrinolysis: Basic and Translational Oral and Poster Abstracts
Oral

Research, Fundamental Science, Bleeding and Clotting, bleeding disorders, Biological therapies, Viral, adult, Translational Research, hemophilia, Non-Biological therapies, platelet disorders, genomics, Coagulant Drugs, drug development, pediatric, Diseases, SARS-CoV-2/COVID-19, thrombotic disorders, immunology, Therapies, Infectious Diseases, VWD, Biological Processes, Monoclonal Antibody Therapy, molecular biology, Technology and Procedures, gene editing, multi-systemic interactions, Study Population, Human, pathogenesis, Animal model

291-292 (Ernest N. Morial Convention Center)

Moderators:

Tyler W Buckner, MD, MSc, University of North Carolina-Chapel Hill and Duc Q Tran Jr., MD, MSc, Hemophilia of Georgia Center for Bleeding & Clotting Disorders of Emory, Emory University School of Medicine

Disclosures:

Tran: Takeda: Consultancy; HEMA Biologics: Consultancy; Biomarin: Consultancy.

This the second oral session that presents salient scientific data of either a basic or translational investigation focused on hemostasis, anti-hemostasis and or fibrinolysis. In particular the emphases of the presentations are primary mechanistic delineations and/or translational applications of these mechanisms.

10:30 AM

691

Pre-Clinical Characterization of VGA039, an Anti-Protein S Monoclonal Antibody Being Developed As a Universal Hemostatic Agent for Various Bleeding Disorders

Lilley Leong, PhD^*, Tony Byun, PhD^*, Benjamin Kim, MD, MPhil, Ian Huck, PhD^*, Abel Silva^*, Joanne Chan^*, Young Cho^*, John Liu, PhD^*, Christopher J. Horvath, DVM, MS, DACVP^*, Stephen J. Moore^* and Sandip Panicker, PhD

Vega Therapeutics, South San Francisco, CA

10:45 AM

692

X-Ray Structure of Thrombin Bound to a Heterobifunctional Aptamer-Drug Conjugate Reveals the Mechanistic Basis for a Novel Tethered Inhibition Strategy

Shekhar Kumar, PhD^1,2^*, Haixiang Yu, PhD³, Bruce A. Sullenger, PhD³^* and Sriram Krishnaswamy, PhD^1,2

¹Pediatrics, University of Pennsylvania, Philadelphia, PA
²Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA
³Department of Surgery, Duke University Medical Center, Durham, NC

11:00 AM

693

SLN140 a Small Interfering RNA Targeting Protein S Improves Hemostasis Potency in Hemophilia

Raja Eladnani Prince^1,2^*, Ute Schaeper, PhD³^*, Julia Aretz, PhD³^*, Bojun Li, PhD^1,2^*, Maria Desiré Reina Caro, BMA^1,2^*, Kristina vrotniakaite-Bajerciene, MD^1,2^*, Mona Eisermann³^*, Sibylle Dames³^*, Kathrin Löffner³^*, Alberto Martinez, PhD⁴^*, Michael Laffan, MD-PhD⁵, Josefin Ahnstrom, PhD⁵^* and Anne Angelillo-Scherrer, MD-PhD^1,2

¹Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, Bern, Switzerland
²Department for BioMedical Research, University of Bern, Bern, Switzerland
³Silence Therapeutics GmbH, Berlin, Germany
⁴Silence Therapeutics, London, United Kingdom
⁵Centre for Haematology, Imperial College London, London, United Kingdom

11:15 AM

694

Identification of Critical Proteins Required for Efficient Von Willebrand Factor Secretion Using CRISPR Knockout Screening

Lauren Shevell, MD¹, Krista Golden, MS²^*, Ginette Balbin-Cuesta, MD, PhD³, Rami Khoriaty, MD¹, Brian Emmer, MD, MPH⁴^* and Karl Desch, MD²

¹Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI
²University of Michigan, Ann Arbor, MI
³Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI
⁴Department of Internal medicine, University of Michigan, Ann Arbor, MI

11:30 AM

695

Sex-Specific Differences in the Pathogenesis, Endothelial Dysfunction, and Hypercoagulability of Sars-Cov-2 Infection in K18-hACE2 Mice

Roberto Aiolfi, PhD¹^*, Hiroshi Deguchi¹^*, Jose F. Fernández, Ph.D.²^*, Jeanine Ahmed¹^*, Miriam Hauer-Jensen²^*, Juan Carlos de la Torre, PhD³^* and Laurent O. Mosnier, PhD⁴

¹Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA
²Molecular Medicine, The Scripps Research Institute, La Jolla, CA
³Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA
⁴Department of Molecular Medicine, The Scripps Research Inst., La Jolla, CA

11:45 AM

696

Hypoalbuminemia Increases Clot Fibrin Network Density and Impairs Fibrinolysis during Glomerular Proteinuria

Amanda P. Waller, PhD¹, Katelyn J. Wolfgang, BS²^*, Zachary S Stevenson³^* and Bryce A. Kerlin, MD^4,5

¹Center for Clinical & Translational Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Whitehall, OH
²Center for Clinical and Translational Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH
³Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH
⁴Center for Clinical and Translational Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Center For Clinical & Translational Research, Columbus, OH
⁵The Ohio State University College of Medicine, Columbus, OH

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^*signifies non-member of ASH

321.O2.6 321. Coagulation and Fibrinolysis: Basic and Translational II