-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

321.O2.6 321. Coagulation and Fibrinolysis: Basic and Translational II

Symposia: Coagulation and Fibrinolysis: Basic and Translational Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, Fundamental Science, Bleeding and Clotting, bleeding disorders, Biological therapies, Viral, adult, Translational Research, hemophilia, Non-Biological therapies, platelet disorders, genomics, Coagulant Drugs, drug development, pediatric, Diseases, SARS-CoV-2/COVID-19, thrombotic disorders, immunology, Therapies, Infectious Diseases, VWD, Biological Processes, Monoclonal Antibody Therapy, molecular biology, Technology and Procedures, gene editing, multi-systemic interactions, Study Population, Human, pathogenesis, Animal model
Monday, December 12, 2022: 10:30 AM-12:00 PM
291-292 (Ernest N. Morial Convention Center)
Moderators:
Tyler W Buckner, MD, MSc, University of North Carolina-Chapel Hill and Duc Q Tran Jr., MD, MSc, Hemophilia of Georgia Center for Bleeding & Clotting Disorders of Emory, Emory University School of Medicine
Disclosures:
Tran: Takeda: Consultancy; HEMA Biologics: Consultancy; Biomarin: Consultancy.
This the second oral session that presents salient scientific data of either a basic or translational investigation focused on hemostasis, anti-hemostasis and or fibrinolysis.  In particular the emphases of the presentations are primary mechanistic delineations and/or translational applications of these mechanisms.
10:30 AM

Lilley Leong, PhD*, Tony Byun, PhD*, Benjamin Kim, MD, MPhil, Ian Huck, PhD*, Abel Silva*, Joanne Chan*, Young Cho*, John Liu, PhD*, Christopher J. Horvath, DVM, MS, DACVP*, Stephen J. Moore* and Sandip Panicker, PhD

Vega Therapeutics, South San Francisco, CA

10:45 AM

Shekhar Kumar, PhD1,2*, Haixiang Yu, PhD3, Bruce A. Sullenger, PhD3* and Sriram Krishnaswamy, PhD1,2

1Pediatrics, University of Pennsylvania, Philadelphia, PA
2Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA
3Department of Surgery, Duke University Medical Center, Durham, NC

11:00 AM

Raja Eladnani Prince1,2*, Ute Schaeper, PhD3*, Julia Aretz, PhD3*, Bojun Li, PhD1,2*, Maria Desiré Reina Caro, BMA1,2*, Kristina vrotniakaite-Bajerciene, MD1,2*, Mona Eisermann3*, Sibylle Dames3*, Kathrin Löffner3*, Alberto Martinez, PhD4*, Michael Laffan, MD-PhD5, Josefin Ahnstrom, PhD5* and Anne Angelillo-Scherrer, MD-PhD1,2

1Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, Bern, Switzerland
2Department for BioMedical Research, University of Bern, Bern, Switzerland
3Silence Therapeutics GmbH, Berlin, Germany
4Silence Therapeutics, London, United Kingdom
5Centre for Haematology, Imperial College London, London, United Kingdom

11:15 AM

Lauren Shevell, MD1, Krista Golden, MS2*, Ginette Balbin-Cuesta, MD, PhD3, Rami Khoriaty, MD1, Brian Emmer, MD, MPH4* and Karl Desch, MD2

1Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI
2University of Michigan, Ann Arbor, MI
3Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI
4Department of Internal medicine, University of Michigan, Ann Arbor, MI

11:30 AM

Roberto Aiolfi, PhD1*, Hiroshi Deguchi1*, Jose F. Fernández, Ph.D.2*, Jeanine Ahmed1*, Miriam Hauer-Jensen2*, Juan Carlos de la Torre, PhD3* and Laurent O. Mosnier, PhD4

1Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA
2Molecular Medicine, The Scripps Research Institute, La Jolla, CA
3Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA
4Department of Molecular Medicine, The Scripps Research Inst., La Jolla, CA

11:45 AM

Amanda P. Waller, PhD1, Katelyn J. Wolfgang, BS2*, Zachary S Stevenson3* and Bryce A. Kerlin, MD4,5

1Center for Clinical & Translational Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Whitehall, OH
2Center for Clinical and Translational Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH
3Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH
4Center for Clinical and Translational Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Center For Clinical & Translational Research, Columbus, OH
5The Ohio State University College of Medicine, Columbus, OH

*signifies non-member of ASH