64th ASH Annual Meeting and Exposition: 301. Vasculature, Endothelium, Thrombosis and Platelets: Basic and Translational: Mechanistic Insights That Suggest Novel Diagnostic or Therapeutic Strategies

Symposia: Vasculature, Endothelium, Thrombosis and Platelets: Basic and Translational Oral and Poster Abstracts
Oral

Research, Fundamental Science, clinical trials, Bleeding and Clotting, bleeding disorders, autoimmune disorders, Biological therapies, Anticoagulant Drugs, adult, Translational Research, Non-Biological therapies, assays, elderly, Clinical Research, platelet disorders, Chemotherapy, thromboembolism, pediatric, Diseases, thrombocytopenias, Immune Disorders, thrombotic disorders, Therapies, Lymphoid Malignancies, young adult , Adverse Events, metabolism, Biological Processes, Technology and Procedures, molecular biology, Study Population, Human, Animal model, omics technologies

353-355 (Ernest N. Morial Convention Center)

Moderators:

Freda H. Passam, MD, PhD, St. George Hospital and Claudia Lorena Buitrago, PhD, The Rockefeller University

Disclosures:

No relevant conflicts of interest to declare.

2:45 PM

811

“Autoimmune HIT”, a Potential Diagnostic Artifact Due to Remnant Heparin in HIT Samples, Is Not Associated with More Severe Outcomes

Adam Kanack, PhD¹^*, Rachel Leger, BAE¹^*, Abdulrahman Saadalla¹^*, Nahla Heikal, M.D.¹^*, Dong Chen, M.D., Ph.D², David Garcia³, Rajiv K. Pruthi, M.B.B.S⁴ and Anand Padmanabhan, M.B.B.S., Ph.D.¹^*

¹Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
²Mayo Clinic, Rochester, MN
³University of Washington, Seattle, WA
⁴Division of Hematology, Mayo Clinic, Rochester, MN

3:00 PM

812

Role of Glycogen Mobilization and Mitochondrial Bioenergetics in Platelet Function, Hemostasis, and Thrombosis

Shravani Prakhya, MS¹^*, Linda Omali¹^*, Joshua Lykins¹^*, Daniëlle Coenen, PhD¹^*, Hemendra Vekaria, PhD²^* and Sidney W Whiteheart, PhD¹

¹Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY
²Department of Neuroscience, University of Kentucky College of Medicine, Lexington, KY

3:15 PM

813

Platelet ERO1α Is Crucial for Ca²⁺ Mobilization and Platelet Activation in Atherothrombosis

Vishwanath Jha, PhD¹^*, Tripti Kumari²^*, Bei Xiong³^*, Kyungho Kim, PhD⁴^*, Jingzhi Wang, Ph.D⁵^*, Gavriel Brown, BS⁶^*, Nathan Asquith, PhD⁷^*, John Gallagher, BS⁶^*, Lillian Asherman⁸^*, Yanyan Bai⁹^*, Xiaoping Du, MD, PhD¹⁰^*, Jeong-Ki Min¹¹^*, Babak Razani¹²^*, Joseph E. Italiano Jr., Ph.D.¹³, Jin-Moo Lee, MD, PhD¹⁴^* and Jaehyung Cho, PhD¹⁵

¹Division of Hematology, Washington University in St. Louis, SAINT LOUIS, MO
²Washington University in St. Louis, St. Louis, MO
³Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, China
⁴Department of Pharmacology, University of Illinois At Chicago, Chicago, IL
⁵Washington University, St. Louis
⁶Washington University School of Medicine, Washington University, Saint Louis, MO
⁷Boston Childrens Hospital, Boston, MA
⁸Washington University, Saint Louis, MO
⁹University of Illinois at Chicago, Chicago, IL
¹⁰Department of Pharmacology, The University of Illinois, Chicago, IL
¹¹5Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Korea, Republic of (South)
¹²Department of Pathology and Immunology, Washington university, St. Louis, MO
¹³Department of Medicine, Harvard Medical School and Boston Childrens Hospital, Boston, MA
¹⁴Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO
¹⁵Division of Hematology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO

3:30 PM

814

Fusion of uPA to Anti-aII_bb3 Scfv Facilitates Its Uptake By in Vitro-Generated CD34+ Megakaryocytes (MKs) to Promote Targeted Fibrinolysis

Sergey Zaytsev, PhD¹^*, Hyunsook Ahn, MS¹^*, M. Anna Kowalska, PhD², Rodney Camire, PhD^1,3^*, Douglas B. Cines, MD⁴, Mortimer Poncz, MD^1,3^* and Victoria Stepanova, PhD³^*

¹Children's Hospital of Philadelphia, Philadelphia, PA
²Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
³Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA
⁴University of Pennsylvania PSOM, Philadelphia, PA

3:45 PM

815

Children with Acute Lymphoblastic Leukemia and Early Thrombosis Have Dysregulated Coagulation-Related Genes and Pathways

Raoul Santiago, MD, MSc^1,2, Marie-Claude Pelland-Marcotte, MD, PhD^1,2^*, Arnaud Droit, PhD¹^*, Jeyani George Clement, BSc¹^*, Lara Herrmann, MSc¹^*, Meredith Michelle Rémy, MBBS³^*, Yan Ma, BSc¹^*, Virgile Raufaste-Cazavieille, MSc¹^*, Jessica Liu, MBBS⁴^*, Charles Joly-Beauparlant, PhD¹^*, Mickael Leclercq, PhD¹^*, Camille Jimenez-Cortes, MSc⁴^*, Thomas Sontag, BSc⁴^*, Maxime Caron, PhD⁴^*, Pascal St-Onge, MSc⁴^*, Sylvie Langlois, MSc⁴^*, Victoria Koch, BA⁵^*, Daniel Sinnett, PhD^4,6^*, Lewis B. Silverman, MD⁵ and Thai Hoa Tran, MD^4,6

¹Centre de recherche du CHU de Québec, Université Laval, Quebec City, QC, Canada
²CHU de Québec, Université Laval, Department de Pédiatrie, Quebec City, QC, Canada
³Faculté de Médecine, Université Laval, Quebec City, QC, Canada
⁴Centre de recherche du CHU Sainte-Justine, CHU Sainte-Justine, Montréal, QC, Canada
⁵Dana-Farber Cancer Institute and Boston Children's Hospital, Department of Pediatric Oncology, Boston, MA
⁶Centre de cancérologie Charles-Bruneau, Département de pédiatrie, CHU Sainte-Justine, Université de Montréal, Montréal, QC, Canada

4:00 PM

816

Multi-Omics Analysis of Human Mesenchymal Stem Cell Guides Perinatal MSC Based Cellular Therapy for Splenectomy-Nonresponsive Refractory Immune Thrombocytopenia: A Phase I Clinical Trial

Yuchen Gao¹^*, Ying Chi²^*, Yunfei Chen, MD²^*, Hui Yuan Li²^*, Wentian Wang, PhD²^*, Wenting Zheng²^*, Ping Zhu, PhD²^*, Jinying An³^*, Yanan Duan³^*, Ting Sun, MD²^*, Liu Xiaofan, MD⁴^*, Feng Xue, MD⁴^*, Wei Liu²^*, Rongfeng Fu, MD⁴^*, Zhibo Han²^*, Yingchi Zhang, PhD²^*, Renchi Yang, MD²^*, Cheng Tao, MD, PhD²^*, Jun Wei²^*, Xiaomin Zhang³^* and Lei Zhang, MD⁴^*

¹State Key Laboratory of Experimental Hematology, Institute of Hematology and Blo, Tianjin, China
²State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin, China
³Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, CHN
⁴CAMS Key Laboratory of Gene Therapy for Blood Diseases, Tianjin Key Laboratory of Gene Therapy for Blood Diseases, Tianjin, China

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^*signifies non-member of ASH

301.O2.6 301. Vasculature, Endothelium, Thrombosis and Platelets: Basic and Translational: Mechanistic Insights That Suggest Novel Diagnostic or Therapeutic Strategies